PTGS1 (prostaglandin-endoperoxide synthase 1) - Rat Genome Database

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Gene: PTGS1 (prostaglandin-endoperoxide synthase 1) Homo sapiens
Analyze
Symbol: PTGS1
Name: prostaglandin-endoperoxide synthase 1
RGD ID: 736739
HGNC Page HGNC:9604
Description: Enables prostaglandin-endoperoxide synthase activity. Involved in cyclooxygenase pathway. Located in Golgi apparatus. Biomarker of several diseases, including Creutzfeldt-Jakob disease; brain ischemia; female reproductive organ cancer (multiple); glioblastoma; and salivary gland carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: COX-1; COX1; COX3; cyclooxygenase-1; PCOX1; PES-1; PGG/HS; PGH synthase 1; PGHS-1; PGHS1; PHS 1; PHS1; prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; prostaglandin H2 synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); PTGHS
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389122,370,533 - 122,395,703 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9122,370,530 - 122,395,703 (+)EnsemblGRCh38hg38GRCh38
GRCh379125,132,812 - 125,157,982 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,173,050 - 124,197,802 (+)NCBINCBI36Build 36hg18NCBI36
Build 349122,212,782 - 122,237,535NCBI
Celera995,781,549 - 95,806,298 (+)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef994,747,532 - 94,772,698 (+)NCBIHuRef
CHM1_19125,280,871 - 125,306,038 (+)NCBICHM1_1
T2T-CHM13v2.09134,568,002 - 134,593,163 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-amygdalin  (EXP)
(S)-naringenin  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
12-HHTrE  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3,4-Methylenedioxyamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
8-Br-cAMP  (EXP)
8-hydroxy-2'-deoxyguanosine  (EXP)
9-cis-retinoic acid  (EXP)
acetaldehyde  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aliskiren  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
alpha-pinene  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
aminophenazone  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
antipyrine  (EXP)
antirheumatic drug  (EXP)
apocynin  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (EXP,ISO)
arsenous acid  (EXP)
astemizole  (ISO)
atrazine  (EXP)
benzidine  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (EXP)
Benzoylpaeoniflorin  (EXP)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
budesonide  (ISO)
bumetanide  (ISO)
bupivacaine  (EXP)
buta-1,3-diene  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (EXP)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
celastrol  (EXP)
celecoxib  (EXP,ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
creatinine  (ISO)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyfluthrin  (EXP)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
DDT  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
diclofenac  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (EXP)
dioxygen  (EXP,ISO)
docebenone  (ISO)
donepezil hydrochloride  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
DuP 697  (EXP)
enalapril  (ISO)
endosulfan  (ISO)
enniatin  (EXP)
entinostat  (EXP)
ethanol  (ISO)
etodolac  (EXP)
famotidine  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
ferulic acid  (EXP)
fipronil  (ISO)
flavonoids  (ISO)
flunixin  (ISO)
fluoxetine  (ISO)
flupenthixol  (EXP)
flurbiprofen  (EXP,ISO)
flutamide  (ISO)
formaldehyde  (ISO)
furan  (ISO)
furosemide  (ISO)
geldanamycin  (EXP)
gemcitabine  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
histamine  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
indometacin  (EXP,ISO)
isoliquiritigenin  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
ivermectin  (EXP)
ketorolac  (EXP)
L-ascorbic acid  (ISO)
leukotriene C4  (ISO)
leukotriene D4  (ISO)
leukotriene E4  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lornoxicam  (EXP)
lutein  (ISO)
lysophosphatidylcholine  (ISO)
Malabaricone C  (ISO)
MeIQx  (EXP)
mercury dibromide  (EXP)
metamizole sodium  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
miconazole  (ISO)
mifepristone  (EXP,ISO)
minocycline  (ISO)
Mitragynine  (ISO)
Mofezolac (TN)  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nabumetone  (ISO)
naproxen  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
NS-398  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
paeoniflorin  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
patchouli alcohol  (ISO)
Pentagastrin  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenacetin  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
pyrazines  (ISO)
pyrethrins  (ISO)
Pyridostigmine bromide  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rivastigmine  (EXP)
rofecoxib  (EXP)
romidepsin  (EXP)
rotenone  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (EXP)
SC-58125  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium hydrogensulfite  (ISO)
sodium sulfite  (ISO)
streptozocin  (ISO)
succimer  (EXP,ISO)
sulforaphane  (EXP)
sulindac  (ISO)
sulindac sulfide  (EXP)
sulindac sulfone  (ISO)
Sulpyrine  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiostrepton  (EXP)
thromboxane A2  (EXP,ISO)
thromboxane B2  (EXP,ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
trans-piceid  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
troglitazone  (EXP)
urethane  (ISO)
usnic acid  (EXP)
valproic acid  (EXP)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP)
wogonin  (ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc pyrithione  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (EXP)
antipyrine drug pathway  (EXP)
arachidonic acid metabolic pathway  (EXP,IEA)
celecoxib pharmacodynamics pathway  (EXP)
celecoxib pharmacokinetics pathway   (EXP)
cyclooxygenase mediated pathway of arachidonic acid metabolism  (TAS)
diclofenac pharmacodynamics pathway  (EXP)
diflunisal pharmacodynamics pathway  (EXP)
etodolac pharmacodynamics pathway  (EXP)
etoposide pharmacodynamics pathway  (EXP)
etoposide pharmacokinetics pathway  (EXP)
fenoprofen pharmacodynamics pathway  (EXP)
flurbiprofen pharmacodynamics pathway  (EXP)
ibuprofen pharmacodynamics pathway  (EXP)
ibuprofen pharmacokinetics pathway  (EXP)
indometacin pharmacodynamics pathway  (EXP)
indometacin pharmacodynamics pathway  (EXP)
ketoprofen pharmacodynamics pathway  (EXP)
ketorolac pharmacodynamics pathway  (EXP)
leukotriene C4 synthase deficiency pathway  (EXP)
lornoxicam pharmacodynamics pathway  (EXP)
magnesium salicylate pharmacodynamics pathway  (EXP)
mefenamic acid pharmacodynamics pathway  (EXP)
meloxicam pharmacodynamics pathway  (EXP)
nabumetone pharmacodynamics pathway  (EXP)
naproxen pharmacodynamics pathway   (EXP)
paracetamol drug pathway  (EXP,TAS)
piroxicam pharmacodynamics pathway   (EXP)
prostanoid biosynthetic pathway  (TAS)
salicylic acid pharmacodynamics pathway  (EXP)
sodium salicylate pharmacodynamics pathway  (EXP)
sulindac pharmacodynamics pathway  (EXP)
tenoxicam pharmacodynamics pathway  (EXP)
tiaprofenic acid pharmacodynamics pathway  (EXP)
tolmetin pharmacodynamics pathway  (EXP)
valdecoxib pharmacodynamics pathway  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival. Athavale R, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1303-8.
2. Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). Ayoub SS, etal., Inflamm Res. 2011 Oct;60(10):919-28. Epub 2011 Jun 12.
3. [Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)] Boldarian NA, etal., Vopr Onkol. 2008;54(1):40-6.
4. Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat. Chang CC, etal., Eur J Pharmacol. 2011 Sep;666(1-3):226-32. Epub 2011 May 10.
5. Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Choi SH and Bosetti F, Aging (Albany NY). 2009 Feb 11;1(2):234-44.
6. Anti-inflammatory effect of low intensity ultrasound (LIUS) on complete Freund's adjuvant-induced arthritis synovium. Chung JI, etal., Osteoarthritis Cartilage. 2012 Jan 24.
7. Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic fibrosis patients. Czerska K, etal., J Appl Genet. 2010;51(3):323-30.
8. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Daikoku T, etal., Cancer Res. 2005 May 1;65(9):3735-44.
9. Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. Deininger MH and Schluesener HJ, J Neuroimmunol. 1999 Mar 1;95(1-2):202-8.
10. Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. Deininger MH, etal., Brain Res. 2000 Dec 1;885(1):111-6.
11. Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease. Deininger MH, etal., J Mol Neurosci. 2003 Feb;20(1):25-30.
12. Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer's Disease in Rats. Dhull DK, etal., J Mol Neurosci. 2012 Jan;46(1):223-35. Epub 2011 Jun 24.
13. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Freshwater JD, etal., Diabetes 2002 Jul;51(7):2249-55.
14. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
15. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Graham GG, etal., Inflammopharmacology. 2013 Jun;21(3):201-32. doi: 10.1007/s10787-013-0172-x. Epub 2013 May 30.
16. Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. Gupta RA, etal., Cancer Res. 2003 Mar 1;63(5):906-11.
17. Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats. Harada N, etal., J Neurotrauma. 2006 Dec;23(12):1739-49.
18. Minor salivary gland carcinoma: a review of 35 cases. Haymerle G, etal., Eur Arch Otorhinolaryngol. 2016 Sep;273(9):2717-26. doi: 10.1007/s00405-015-3805-4. Epub 2015 Oct 23.
19. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
20. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. Hwang D, etal., J Natl Cancer Inst. 1998 Mar 18;90(6):455-60.
21. Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice. Iadecola C, etal., J Cereb Blood Flow Metab. 2001 Dec;21(12):1436-41.
22. The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition. Kadowaki H, etal., Biomed Res. 2008 Apr;29(2):113-7.
23. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
24. Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice. Kelso ML, etal., BMC Neurosci. 2009 Aug 31;10:108.
25. Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients. Kim HW, etal., Mol Psychiatry. 2011 Apr;16(4):419-28. Epub 2009 Dec 29.
26. Cyclooxygenase-1-derived prostaglandins in the periaqueductal gray differentially control C- versus A-fiber-evoked spinal nociception. Leith JL, etal., J Neurosci. 2007 Oct 17;27(42):11296-305.
27. 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. Lin TN, etal., Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):481-7. Epub 2005 Dec 29.
28. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
29. Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation. O'Rielly DD and Loomis CW, Anesthesiology. 2007 Apr;106(4):795-805.
30. Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model. Okamoto T, etal., Cancer Sci. 2003 Jan;94(1):22-5.
31. Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. Okayama M, etal., Dig Dis Sci. 2007 Sep;52(9):2095-103. Epub 2007 Apr 12.
32. Characterization of the Prostaglandin E2 path way in a Rat Model of Esophageal Adenocarcinoma. Piazuelo E, etal., Curr Cancer Drug Targets. 2011 Oct 27.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
35. Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain. Prochazkova M, etal., Physiol Res. 2008 Jul 18.
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis. Roca-Ferrer J, etal., Thorax. 2006 Jul;61(7):592-6. Epub 2006 Mar 3.
39. Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cy rats with inherited kidney disease. Sankaran D, etal., Am J Physiol Renal Physiol. 2007 Sep;293(3):F821-30. Epub 2007 May 30.
40. Selective accumulation of cyclooxygenase-1-expressing microglial cells/macrophages in lesions of human focal cerebral ischemia. Schwab JM, etal., Acta Neuropathol. 2000 Jun;99(6):609-14.
41. Persistent accumulation of cyclooxygenase-1 (COX-1) expressing microglia/macrophages and upregulation by endothelium following spinal cord injury. Schwab JM, etal., J Neuroimmunol. 2000 Nov 1;111(1-2):122-30.
42. Persistent accumulation of cyclooxygenase-1-expressing microglial cells and macrophages and transient upregulation by endothelium in human brain injury. Schwab JM, etal., J Neurosurg. 2002 May;96(5):892-9.
43. Traumatic brain injury induces prolonged accumulation of cyclooxygenase-1 expressing microglia/brain macrophages in rats. Schwab JM, etal., J Neurotrauma. 2001 Sep;18(9):881-90.
44. Involvement of cyclooxygenase-1 and -2 in the sciatic nerve of rats with experimental autoimmune neuritis. Shin T, etal., Immunol Invest. 2003 Aug;32(3):123-30.
45. Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension. Welch WJ, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2644-9. Epub 2007 Aug 31.
46. Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis. Westergren VS, etal., Clin Exp Allergy. 2009 Jun;39(6):820-8. Epub 2009 Apr 2.
47. A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. Yeoh AS, etal., Mol Cancer Ther. 2007 Aug;6(8):2319-27.
48. Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. Yermakova AV, etal., J Neuropathol Exp Neurol. 1999 Nov;58(11):1135-46.
49. Activated microglia in the human glaucomatous optic nerve head. Yuan L and Neufeld AH, J Neurosci Res. 2001 Jun 1;64(5):523-32.
50. Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. Zhu X and Eisenach JC, Anesthesiology. 2003 Nov;99(5):1175-9.
Additional References at PubMed
PMID:1380156   PMID:1587858   PMID:1734857   PMID:1907252   PMID:2512924   PMID:7510883   PMID:7521167   PMID:7559624   PMID:7864630   PMID:8121489   PMID:8181472   PMID:8349699  
PMID:8365485   PMID:8581564   PMID:8643612   PMID:8900446   PMID:9435560   PMID:9630216   PMID:9639560   PMID:10585854   PMID:10900130   PMID:10988074   PMID:10999846   PMID:11121413  
PMID:11318639   PMID:11477109   PMID:11809691   PMID:11877441   PMID:11897504   PMID:11920472   PMID:11981837   PMID:12050227   PMID:12192304   PMID:12193665   PMID:12213900   PMID:12237309  
PMID:12242329   PMID:12354292   PMID:12355421   PMID:12477932   PMID:12519124   PMID:12545150   PMID:12600754   PMID:12664596   PMID:12665651   PMID:12711701   PMID:12711844   PMID:12720297  
PMID:12730088   PMID:12784332   PMID:12835322   PMID:12842195   PMID:14507922   PMID:14625295   PMID:14988266   PMID:15028279   PMID:15041270   PMID:15086459   PMID:15159324   PMID:15167967  
PMID:15190260   PMID:15230350   PMID:15301234   PMID:15308583   PMID:15328521   PMID:15361066   PMID:15367379   PMID:15375804   PMID:15453269   PMID:15489334   PMID:15504548   PMID:15589421  
PMID:15607906   PMID:15654517   PMID:15705965   PMID:15720413   PMID:15870920   PMID:15963707   PMID:16055872   PMID:16105649   PMID:16115753   PMID:16141368   PMID:16150050   PMID:16181776  
PMID:16323955   PMID:16344560   PMID:16344721   PMID:16411757   PMID:16493486   PMID:16678543   PMID:16702043   PMID:16787416   PMID:16857763   PMID:16875891   PMID:16930602   PMID:17062130  
PMID:17071117   PMID:17078001   PMID:17130490   PMID:17264103   PMID:17301694   PMID:17320986   PMID:17322116   PMID:17355643   PMID:17495879   PMID:17559347   PMID:17624243   PMID:17631383  
PMID:17640058   PMID:17671743   PMID:17673564   PMID:17681165   PMID:17868881   PMID:17926541   PMID:17977913   PMID:18029348   PMID:18173552   PMID:18214026   PMID:18280718   PMID:18287876  
PMID:18459455   PMID:18511850   PMID:18570454   PMID:18571838   PMID:18582172   PMID:18612540   PMID:18618313   PMID:18636124   PMID:18657230   PMID:18676680   PMID:18705313   PMID:18753249  
PMID:18818748   PMID:18838483   PMID:18992148   PMID:18997734   PMID:19019335   PMID:19046748   PMID:19056482   PMID:19060633   PMID:19064572   PMID:19091535   PMID:19124506   PMID:19132198  
PMID:19132974   PMID:19170196   PMID:19205707   PMID:19235530   PMID:19258012   PMID:19276290   PMID:19282863   PMID:19336370   PMID:19350112   PMID:19390185   PMID:19399588   PMID:19433337  
PMID:19527514   PMID:19530321   PMID:19625176   PMID:19692168   PMID:19723114   PMID:19740098   PMID:19769727   PMID:19887674   PMID:19913121   PMID:19948975   PMID:20225218   PMID:20227045  
PMID:20227521   PMID:20308035   PMID:20382140   PMID:20437058   PMID:20452482   PMID:20453000   PMID:20530583   PMID:20538124   PMID:20628086   PMID:20628624   PMID:20673868   PMID:20691446  
PMID:21035466   PMID:21094252   PMID:21097517   PMID:21256536   PMID:21266582   PMID:21301321   PMID:21351261   PMID:21434767   PMID:21478098   PMID:21561892   PMID:21699462   PMID:21812955  
PMID:21873635   PMID:22049022   PMID:22268729   PMID:22397921   PMID:22406532   PMID:22609818   PMID:22758658   PMID:22860421   PMID:22940005   PMID:22972377   PMID:22982857   PMID:23029430  
PMID:23038044   PMID:23074965   PMID:23242413   PMID:23660496   PMID:23668350   PMID:23677911   PMID:23886173   PMID:23985963   PMID:24008976   PMID:24022467   PMID:24022862   PMID:24171795  
PMID:24244288   PMID:24254970   PMID:24333447   PMID:24370448   PMID:24535852   PMID:24651623   PMID:24758697   PMID:24930730   PMID:25243161   PMID:25339146   PMID:25398544   PMID:25645360  
PMID:25721048   PMID:25906828   PMID:25972361   PMID:25988363   PMID:26067486   PMID:26081267   PMID:26245672   PMID:26339385   PMID:26562384   PMID:26672987   PMID:26703471   PMID:26748901  
PMID:26870959   PMID:27060751   PMID:27129261   PMID:27318652   PMID:27401285   PMID:27522738   PMID:27548026   PMID:27629384   PMID:28244682   PMID:28431615   PMID:28708434   PMID:29225187  
PMID:29507755   PMID:29676528   PMID:30240925   PMID:30312731   PMID:30320345   PMID:30760327   PMID:31339092   PMID:31552592   PMID:31617661   PMID:31734845   PMID:31735164   PMID:31760051  
PMID:32131611   PMID:32171274   PMID:32299908   PMID:32584621   PMID:32814053   PMID:33326144   PMID:33450390   PMID:33800915   PMID:33961781   PMID:35000048   PMID:35253629   PMID:35631221  
PMID:35696571   PMID:35705023   PMID:36056535   PMID:36282419   PMID:36302763  


Genomics

Comparative Map Data
PTGS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389122,370,533 - 122,395,703 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9122,370,530 - 122,395,703 (+)EnsemblGRCh38hg38GRCh38
GRCh379125,132,812 - 125,157,982 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,173,050 - 124,197,802 (+)NCBINCBI36Build 36hg18NCBI36
Build 349122,212,782 - 122,237,535NCBI
Celera995,781,549 - 95,806,298 (+)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef994,747,532 - 94,772,698 (+)NCBIHuRef
CHM1_19125,280,871 - 125,306,038 (+)NCBICHM1_1
T2T-CHM13v2.09134,568,002 - 134,593,163 (+)NCBIT2T-CHM13v2.0
Ptgs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39236,106,758 - 36,142,287 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl236,120,438 - 36,142,284 (+)EnsemblGRCm39 Ensembl
GRCm38236,216,742 - 36,258,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl236,230,426 - 36,252,272 (+)EnsemblGRCm38mm10GRCm38
MGSCv37236,085,946 - 36,107,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36236,052,536 - 36,074,271 (+)NCBIMGSCv36mm8
Celera235,934,252 - 35,956,092 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
Ptgs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8339,981,419 - 40,002,993 (+)NCBIGRCr8
mRatBN7.2319,584,015 - 19,605,589 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl319,584,015 - 19,605,586 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx322,661,928 - 22,683,470 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0331,246,853 - 31,268,395 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0329,494,672 - 29,516,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0315,560,685 - 15,582,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl315,560,712 - 15,582,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0320,869,915 - 20,891,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4315,343,832 - 15,365,412 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1315,240,203 - 15,261,784 (+)NCBI
Celera314,295,836 - 14,317,392 (+)NCBICelera
Cytogenetic Map3p11NCBI
Ptgs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554195,678,694 - 5,699,305 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554195,678,750 - 5,699,305 (-)NCBIChiLan1.0ChiLan1.0
PTGS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,953,759 - 16,975,988 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1916,953,703 - 16,978,307 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0993,495,365 - 93,517,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19121,837,095 - 121,859,283 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9121,837,095 - 121,859,283 (+)Ensemblpanpan1.1panPan2
PTGS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1960,195,118 - 60,216,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl960,195,124 - 60,216,819 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha959,390,579 - 59,412,227 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0961,110,468 - 61,132,351 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl961,110,470 - 61,132,343 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1959,884,516 - 59,906,289 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0960,200,281 - 60,222,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0960,289,919 - 60,311,671 (-)NCBIUU_Cfam_GSD_1.0
Ptgs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947190,976,385 - 190,990,294 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648710,745,327 - 10,758,823 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648710,745,465 - 10,758,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1262,456,155 - 262,483,035 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11262,456,106 - 262,482,159 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21294,753,789 - 294,779,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTGS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11217,195,403 - 17,218,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1217,192,628 - 17,218,315 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603525,831,631 - 25,856,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476012,915,206 - 12,937,824 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476012,917,244 - 12,937,858 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTGS1
47 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121112395-138075224)x3 copy number gain See cases [RCV000051009] Chr9:121112395..138075224 [GRCh38]
Chr9:123874673..140969676 [GRCh37]
Chr9:122914494..140089497 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
NM_000962.3(PTGS1):c.1610C>T (p.Pro537Leu) single nucleotide variant Malignant melanoma [RCV000061881] Chr9:122392354 [GRCh38]
Chr9:125154633 [GRCh37]
Chr9:124194454 [NCBI36]
Chr9:9q33.2
not provided
GRCh38/hg38 9q33.2-33.3(chr9:120938041-123469664)x1 copy number loss See cases [RCV000052922] Chr9:120938041..123469664 [GRCh38]
Chr9:123700319..126231943 [GRCh37]
Chr9:122740140..125271764 [NCBI36]
Chr9:9q33.2-33.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121586837-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|See cases [RCV000053776] Chr9:121586837..138179445 [GRCh38]
Chr9:124349116..141073897 [GRCh37]
Chr9:123388937..140193718 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
NM_000962.3(PTGS1):c.1587C>T (p.Ser529=) single nucleotide variant Malignant melanoma [RCV000068526] Chr9:122392331 [GRCh38]
Chr9:125154610 [GRCh37]
Chr9:124194431 [NCBI36]
Chr9:9q33.2
not provided
NM_000962.3(PTGS1):c.1733C>T (p.Ser578Phe) single nucleotide variant Malignant melanoma [RCV000068527] Chr9:122392477 [GRCh38]
Chr9:125154756 [GRCh37]
Chr9:124194577 [NCBI36]
Chr9:9q33.2
not provided
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
NM_000962.3(PTGS1):c.-842A>G single nucleotide variant aspirin response - Efficacy [RCV000211226] Chr9:122370243 [GRCh38]
Chr9:125132522 [GRCh37]
Chr9:9q33.2
drug response
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121073102-138179445)x3 copy number gain See cases [RCV000134920] Chr9:121073102..138179445 [GRCh38]
Chr9:123835380..141073897 [GRCh37]
Chr9:122875201..140193718 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic|conflicting data from submitters
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NM_000962.4(PTGS1):c.719A>C (p.Gln240Pro) single nucleotide variant Hemorrhage [RCV003313823]|Inborn genetic diseases [RCV003295931] Chr9:122381704 [GRCh38]
Chr9:125143983 [GRCh37]
Chr9:9q33.2
uncertain significance
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.3-33.3(chr9:113083182-126779494)x1 copy number loss not provided [RCV000748606] Chr9:113083182..126779494 [GRCh37]
Chr9:9q31.3-33.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain not specified [RCV003986800] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.1-33.3(chr9:104604851-126253089)x1 copy number loss See cases [RCV000447763] Chr9:104604851..126253089 [GRCh37]
Chr9:9q31.1-33.3
pathogenic
GRCh37/hg19 9q33.2-34.3(chr9:124642754-141146461)x3 copy number gain See cases [RCV000448784] Chr9:124642754..141146461 [GRCh37]
Chr9:9q33.2-34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NM_000962.4(PTGS1):c.38TGCTCC[1] (p.Leu15_Leu16del) microsatellite not provided [RCV000882385] Chr9:122371213..122371218 [GRCh38]
Chr9:125133492..125133497 [GRCh37]
Chr9:9q33.2
likely benign
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NM_000962.4(PTGS1):c.906G>A (p.Thr302=) single nucleotide variant not provided [RCV000936541] Chr9:122383652 [GRCh38]
Chr9:125145931 [GRCh37]
Chr9:9q33.2
likely benign
NM_000962.4(PTGS1):c.762+10G>A single nucleotide variant not provided [RCV000975223] Chr9:122381757 [GRCh38]
Chr9:125144036 [GRCh37]
Chr9:9q33.2
benign
NM_000962.4(PTGS1):c.204C>T (p.Cys68=) single nucleotide variant PTGS1-related condition [RCV003905954]|not provided [RCV000968651] Chr9:122378008 [GRCh38]
Chr9:125140287 [GRCh37]
Chr9:9q33.2
benign
NM_000962.4(PTGS1):c.1497G>A (p.Ala499=) single nucleotide variant not provided [RCV000955405] Chr9:122392241 [GRCh38]
Chr9:125154520 [GRCh37]
Chr9:9q33.2
benign
NM_000962.4(PTGS1):c.123G>A (p.Gln41=) single nucleotide variant not provided [RCV001647692] Chr9:122377927 [GRCh38]
Chr9:125140206 [GRCh37]
Chr9:9q33.2
benign
GRCh37/hg19 9q32-34.11(chr9:116422275-131713233) copy number gain not specified [RCV002052831] Chr9:116422275..131713233 [GRCh37]
Chr9:9q32-34.11
pathogenic
GRCh37/hg19 9p24.3-q34.11(chr9:203861-131603223)x3 copy number gain See cases [RCV002292402] Chr9:203861..131603223 [GRCh37]
Chr9:9p24.3-q34.11
pathogenic
GRCh37/hg19 9q33.2-33.3(chr9:124018736-129995568)x1 copy number loss not provided [RCV002474540] Chr9:124018736..129995568 [GRCh37]
Chr9:9q33.2-33.3
pathogenic
NM_000962.4(PTGS1):c.1169T>C (p.Met390Thr) single nucleotide variant Inborn genetic diseases [RCV002732988] Chr9:122386605 [GRCh38]
Chr9:125148884 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.730C>T (p.Arg244Trp) single nucleotide variant Inborn genetic diseases [RCV002973115] Chr9:122381715 [GRCh38]
Chr9:125143994 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.1396C>A (p.Arg466Ser) single nucleotide variant Inborn genetic diseases [RCV002926570] Chr9:122390297 [GRCh38]
Chr9:125152576 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.1699G>A (p.Val567Ile) single nucleotide variant Inborn genetic diseases [RCV002694105] Chr9:122392443 [GRCh38]
Chr9:125154722 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.1654G>A (p.Glu552Lys) single nucleotide variant Inborn genetic diseases [RCV003003589] Chr9:122392398 [GRCh38]
Chr9:125154677 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.731G>A (p.Arg244Gln) single nucleotide variant Inborn genetic diseases [RCV002803229] Chr9:122381716 [GRCh38]
Chr9:125143995 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.989C>T (p.Thr330Met) single nucleotide variant Inborn genetic diseases [RCV002743949] Chr9:122383735 [GRCh38]
Chr9:125146014 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.179G>A (p.Arg60His) single nucleotide variant Inborn genetic diseases [RCV002804998] Chr9:122377983 [GRCh38]
Chr9:125140262 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.716G>A (p.Arg239His) single nucleotide variant Inborn genetic diseases [RCV002940227] Chr9:122381701 [GRCh38]
Chr9:125143980 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.1118G>A (p.Arg373His) single nucleotide variant Inborn genetic diseases [RCV002703459] Chr9:122386554 [GRCh38]
Chr9:125148833 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.532C>T (p.Arg178Cys) single nucleotide variant Inborn genetic diseases [RCV002959317] Chr9:122381406 [GRCh38]
Chr9:125143685 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.1739G>A (p.Arg580His) single nucleotide variant Inborn genetic diseases [RCV003369957] Chr9:122392483 [GRCh38]
Chr9:125154762 [GRCh37]
Chr9:9q33.2
likely benign
NM_000962.4(PTGS1):c.769G>T (p.Asp257Tyr) single nucleotide variant Inborn genetic diseases [RCV003361861] Chr9:122383515 [GRCh38]
Chr9:125145794 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.568C>A (p.Pro190Thr) single nucleotide variant Inborn genetic diseases [RCV003371698] Chr9:122381442 [GRCh38]
Chr9:125143721 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.786G>A (p.Pro262=) single nucleotide variant not provided [RCV003425779] Chr9:122383532 [GRCh38]
Chr9:125145811 [GRCh37]
Chr9:9q33.2
likely benign
NM_000962.4(PTGS1):c.994C>T (p.Arg332Cys) single nucleotide variant not specified [RCV003494345] Chr9:122383740 [GRCh38]
Chr9:125146019 [GRCh37]
Chr9:9q33.2
uncertain significance
GRCh37/hg19 9q33.2-33.3(chr9:122755951-127551056)x1 copy number loss not specified [RCV003986827] Chr9:122755951..127551056 [GRCh37]
Chr9:9q33.2-33.3
pathogenic
NM_000962.4(PTGS1):c.1441G>A (p.Val481Ile) single nucleotide variant not provided [RCV003885762] Chr9:122390342 [GRCh38]
Chr9:125152621 [GRCh37]
Chr9:9q33.2
likely benign
NM_000962.4(PTGS1):c.1342G>A (p.Val448Met) single nucleotide variant PTGS1-related condition [RCV003963993] Chr9:122390243 [GRCh38]
Chr9:125152522 [GRCh37]
Chr9:9q33.2
likely benign
NM_000962.4(PTGS1):c.960C>G (p.Pro320=) single nucleotide variant not provided [RCV003430235] Chr9:122383706 [GRCh38]
Chr9:125145985 [GRCh37]
Chr9:9q33.2
likely benign
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q33.2-33.3(chr9:124604592-126306080)x1 copy number loss not provided [RCV001006270] Chr9:124604592..126306080 [GRCh37]
Chr9:9q33.2-33.3
uncertain significance
NM_000962.4(PTGS1):c.412T>C (p.Trp138Arg) single nucleotide variant Hemorrhage [RCV003314539] Chr9:122378834 [GRCh38]
Chr9:125141113 [GRCh37]
Chr9:9q33.2
uncertain significance
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3
pathogenic
NM_000962.4(PTGS1):c.1571T>C (p.Ile524Thr) single nucleotide variant Hemorrhage [RCV003313871] Chr9:122392315 [GRCh38]
Chr9:125154594 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.1098C>T (p.Phe366=) single nucleotide variant not provided [RCV000934067] Chr9:122386534 [GRCh38]
Chr9:125148813 [GRCh37]
Chr9:9q33.2
likely benign
GRCh37/hg19 9q33.2(chr9:125105375-125616987)x3 copy number gain not provided [RCV001006271] Chr9:125105375..125616987 [GRCh37]
Chr9:9q33.2
uncertain significance
GRCh37/hg19 9q33.2(chr9:125154228-125339689)x1 copy number loss not provided [RCV001259051] Chr9:125154228..125339689 [GRCh37]
Chr9:9q33.2
likely benign
GRCh37/hg19 9p24.3-q34.3(chr9:353349-141020389) copy number gain not specified [RCV002053823] Chr9:353349..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q33.1-33.3(chr9:120045175-127335905)x1 copy number loss not provided [RCV001834516] Chr9:120045175..127335905 [GRCh37]
Chr9:9q33.1-33.3
pathogenic
GRCh37/hg19 9q31.1-33.3(chr9:104604851-126253089) copy number loss not specified [RCV002052825] Chr9:104604851..126253089 [GRCh37]
Chr9:9q31.1-33.3
pathogenic
NM_000962.4(PTGS1):c.1729G>A (p.Val577Ile) single nucleotide variant Inborn genetic diseases [RCV003341314] Chr9:122392473 [GRCh38]
Chr9:125154752 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.821A>G (p.Tyr274Cys) single nucleotide variant Inborn genetic diseases [RCV003361561] Chr9:122383567 [GRCh38]
Chr9:125145846 [GRCh37]
Chr9:9q33.2
uncertain significance
NM_000962.4(PTGS1):c.1777G>A (p.Glu593Lys) single nucleotide variant Inborn genetic diseases [RCV003370012] Chr9:122392521 [GRCh38]
Chr9:125154800 [GRCh37]
Chr9:9q33.2
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR760hsa-miR-760Mirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
MIR146Bhsa-miR-146b-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Target Of
Summary Value
Count of predictions:2464
Count of miRNA genes:1043
Interacting mature miRNAs:1280
Transcripts:ENST00000223423, ENST00000362012, ENST00000373698, ENST00000426608, ENST00000540753
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH98513  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371567,937 - 568,064UniSTSGRCh37
GRCh37MT7,386 - 7,513UniSTSGRCh37
Build 361557,800 - 557,927RGDNCBI36
Cytogenetic Map5q35.2UniSTS
HuRef14,191 - 4,318UniSTS
D1S2077E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,241 - 568,324UniSTSGRCh37
GRCh37MT7,690 - 7,773UniSTSGRCh37
Build 361558,104 - 558,187RGDNCBI36
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map9q21.32UniSTS
HuRef14,495 - 4,578UniSTS
RH45319  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379125,155,349 - 125,155,542UniSTSGRCh37
Build 369124,195,170 - 124,195,363RGDNCBI36
Celera995,803,666 - 95,803,859RGD
Cytogenetic Map9q32-q33.3UniSTS
HuRef994,770,065 - 94,770,258UniSTS
GeneMap99-GB4 RH Map9377.21UniSTS
SHGC-148713  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379125,145,016 - 125,145,314UniSTSGRCh37
Build 369124,184,837 - 124,185,135RGDNCBI36
Celera995,793,336 - 95,793,634RGD
Cytogenetic Map9q32-q33.3UniSTS
HuRef994,759,735 - 94,760,033UniSTS
TNG Radiation Hybrid Map946046.0UniSTS
PMC109173P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37MT7,483 - 8,364UniSTSGRCh37
GRCh371568,034 - 568,913UniSTSGRCh37
Build 361557,897 - 558,776RGDNCBI36
HuRef14,288 - 5,167UniSTS
PMC196577P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37MT7,561 - 7,983UniSTSGRCh37
GRCh371568,112 - 568,534UniSTSGRCh37
Build 361557,975 - 558,397RGDNCBI36
HuRef14,366 - 4,788UniSTS
PMC20756P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37MT7,483 - 7,570UniSTSGRCh37
GRCh371568,034 - 568,121UniSTSGRCh37
Build 361557,897 - 557,984RGDNCBI36
HuRef14,288 - 4,375UniSTS
PMC20756P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37MT7,483 - 8,383UniSTSGRCh37
GRCh371568,034 - 568,932UniSTSGRCh37
Build 361557,897 - 558,795RGDNCBI36
HuRef14,288 - 5,186UniSTS
PMC55343P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37MT7,358 - 7,937UniSTSGRCh37
GRCh371567,909 - 568,488UniSTSGRCh37
Build 361557,772 - 558,351RGDNCBI36
HuRef14,163 - 4,742UniSTS
PMC55343P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37MT8,280 - 8,366UniSTSGRCh37
GRCh371568,829 - 568,915UniSTSGRCh37
Build 361558,692 - 558,778RGDNCBI36
HuRef15,083 - 5,169UniSTS
PMC55343P5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37MT8,280 - 8,882UniSTSGRCh37
GRCh371568,829 - 569,431UniSTSGRCh37
Build 361558,692 - 559,294RGDNCBI36
HuRef15,083 - 5,685UniSTS
PMC55343P6  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371569,328 - 569,431UniSTSGRCh37
GRCh37MT8,779 - 8,882UniSTSGRCh37
Build 361559,191 - 559,294RGDNCBI36
Cytogenetic Map5q31.3UniSTS
Cytogenetic Map10q22.1UniSTS
Cytogenetic Map3q29UniSTS
HuRef15,582 - 5,685UniSTS
PTGS1_1841  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379125,154,939 - 125,155,562UniSTSGRCh37
Build 369124,194,760 - 124,195,383RGDNCBI36
Celera995,803,256 - 95,803,879RGD
HuRef994,769,655 - 94,770,278UniSTS
SHGC-30513  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379125,157,818 - 125,157,955UniSTSGRCh37
Build 369124,197,639 - 124,197,776RGDNCBI36
Celera995,806,135 - 95,806,272RGD
Cytogenetic Map9q32-q33.3UniSTS
HuRef994,772,534 - 94,772,671UniSTS
GeneMap99-GB4 RH Map9377.11UniSTS
Whitehead-RH Map9453.5UniSTS
NCBI RH Map91171.1UniSTS
GeneMap99-G3 RH Map92141.0UniSTS
D9S2049  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379125,154,849 - 125,154,938UniSTSGRCh37
Build 369124,194,670 - 124,194,759RGDNCBI36
Celera995,803,166 - 95,803,255RGD
Cytogenetic Map9q32-q33.3UniSTS
HuRef994,769,565 - 94,769,654UniSTS
Stanford-G3 RH Map92186.0UniSTS
NCBI RH Map91168.7UniSTS
GeneMap99-G3 RH Map92141.0UniSTS
SHGC-57364  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,715 - 568,840UniSTSGRCh37
GRCh37MT8,164 - 8,291UniSTSGRCh37
Build 361558,578 - 558,703RGDNCBI36
Cytogenetic Map9q21.32UniSTS
Cytogenetic Map11q23.3UniSTS
HuRef14,969 - 5,094UniSTS
PMC55343P8  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37412,642,181 - 12,642,255UniSTSGRCh37
GRCh371569,891 - 569,965UniSTSGRCh37
GRCh37MT9,342 - 9,416UniSTSGRCh37
Celera413,108,985 - 13,109,059UniSTS
Cytogenetic Map4q12UniSTS
HuRef411,978,471 - 11,978,545UniSTS
PMC55343P7  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37599,387,412 - 99,388,049UniSTSGRCh37
GRCh371569,328 - 569,965UniSTSGRCh37
GRCh37MT8,779 - 9,416UniSTSGRCh37
Cytogenetic Map5q21.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 6
Medium 2147 1072 149 27 955 20 1573 905 157 137 438 649 18 437 871
Low 227 1882 1487 525 911 374 2463 946 2909 262 971 862 155 1 767 1641 4 1
Below cutoff 51 35 79 66 66 65 306 331 657 16 33 73 2 276 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_032900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005252105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF086438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF129755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF440204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI813317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ420464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL162424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY449688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD014048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD014049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA392280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ180740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ180741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ180742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN341826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN341828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI519546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S36219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S36271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000223423   ⟹   ENSP00000223423
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9122,371,080 - 122,393,178 (+)Ensembl
RefSeq Acc Id: ENST00000362012   ⟹   ENSP00000354612
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9122,371,024 - 122,395,703 (+)Ensembl
RefSeq Acc Id: ENST00000373698   ⟹   ENSP00000362802
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9122,375,322 - 122,392,788 (+)Ensembl
RefSeq Acc Id: ENST00000426608   ⟹   ENSP00000411606
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9122,371,071 - 122,383,570 (+)Ensembl
RefSeq Acc Id: ENST00000540753   ⟹   ENSP00000437709
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9122,370,542 - 122,392,654 (+)Ensembl
RefSeq Acc Id: ENST00000619306   ⟹   ENSP00000483540
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9122,371,039 - 122,392,608 (+)Ensembl
RefSeq Acc Id: ENST00000643576
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9122,371,085 - 122,392,544 (+)Ensembl
RefSeq Acc Id: ENST00000643810   ⟹   ENSP00000494717
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9122,370,530 - 122,392,388 (+)Ensembl
RefSeq Acc Id: ENST00000645132
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9122,371,012 - 122,393,114 (+)Ensembl
RefSeq Acc Id: ENST00000647067   ⟹   ENSP00000495728
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9122,371,025 - 122,393,254 (+)Ensembl
RefSeq Acc Id: NM_000962   ⟹   NP_000953
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389122,371,024 - 122,395,703 (+)NCBI
GRCh379125,132,809 - 125,157,982 (+)NCBI
Build 369124,173,050 - 124,197,802 (+)NCBI Archive
HuRef994,747,532 - 94,772,698 (+)NCBI
CHM1_19125,281,346 - 125,306,038 (+)NCBI
T2T-CHM13v2.09134,568,493 - 134,593,163 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271164   ⟹   NP_001258093
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389122,371,024 - 122,395,703 (+)NCBI
GRCh379125,132,809 - 125,157,982 (+)NCBI
HuRef994,747,532 - 94,772,698 (+)NCBI
CHM1_19125,281,346 - 125,306,038 (+)NCBI
T2T-CHM13v2.09134,568,493 - 134,593,163 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271165   ⟹   NP_001258094
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389122,375,302 - 122,395,703 (+)NCBI
GRCh379125,132,809 - 125,157,982 (+)NCBI
HuRef994,747,532 - 94,772,698 (+)NCBI
CHM1_19125,285,663 - 125,306,038 (+)NCBI
T2T-CHM13v2.09134,572,771 - 134,593,163 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271166   ⟹   NP_001258095
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389122,370,533 - 122,395,703 (+)NCBI
HuRef994,747,532 - 94,772,698 (+)NCBI
CHM1_19125,280,871 - 125,306,038 (+)NCBI
T2T-CHM13v2.09134,568,002 - 134,593,163 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271367   ⟹   NP_001258296
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389122,371,024 - 122,395,703 (+)NCBI
GRCh379125,132,809 - 125,157,982 (+)NCBI
HuRef994,747,532 - 94,772,698 (+)NCBI
CHM1_19125,281,346 - 125,306,038 (+)NCBI
T2T-CHM13v2.09134,568,493 - 134,593,163 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271368   ⟹   NP_001258297
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389122,370,533 - 122,395,703 (+)NCBI
HuRef994,747,532 - 94,772,698 (+)NCBI
CHM1_19125,280,871 - 125,306,038 (+)NCBI
T2T-CHM13v2.09134,568,002 - 134,593,163 (+)NCBI
Sequence:
RefSeq Acc Id: NM_080591   ⟹   NP_542158
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389122,371,024 - 122,395,703 (+)NCBI
GRCh379125,132,809 - 125,157,982 (+)NCBI
Build 369124,173,050 - 124,197,802 (+)NCBI Archive
HuRef994,747,532 - 94,772,698 (+)NCBI
CHM1_19125,281,346 - 125,306,038 (+)NCBI
T2T-CHM13v2.09134,568,493 - 134,593,163 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_000953 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258093 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258094 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258095 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258296 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258297 (Get FASTA)   NCBI Sequence Viewer  
  NP_542158 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA03630 (Get FASTA)   NCBI Sequence Viewer  
  AAA36439 (Get FASTA)   NCBI Sequence Viewer  
  AAB21215 (Get FASTA)   NCBI Sequence Viewer  
  AAB22216 (Get FASTA)   NCBI Sequence Viewer  
  AAB22217 (Get FASTA)   NCBI Sequence Viewer  
  AAC50632 (Get FASTA)   NCBI Sequence Viewer  
  AAH29840 (Get FASTA)   NCBI Sequence Viewer  
  AAL33601 (Get FASTA)   NCBI Sequence Viewer  
  AAR08907 (Get FASTA)   NCBI Sequence Viewer  
  ABA60097 (Get FASTA)   NCBI Sequence Viewer  
  ABA60098 (Get FASTA)   NCBI Sequence Viewer  
  ABA60099 (Get FASTA)   NCBI Sequence Viewer  
  BAF82711 (Get FASTA)   NCBI Sequence Viewer  
  BAG58214 (Get FASTA)   NCBI Sequence Viewer  
  BAG65237 (Get FASTA)   NCBI Sequence Viewer  
  CAY39332 (Get FASTA)   NCBI Sequence Viewer  
  CAY39333 (Get FASTA)   NCBI Sequence Viewer  
  CBX54354 (Get FASTA)   NCBI Sequence Viewer  
  EAW87529 (Get FASTA)   NCBI Sequence Viewer  
  EAW87530 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000223423
  ENSP00000223423.4
  ENSP00000354612
  ENSP00000354612.2
  ENSP00000362802
  ENSP00000362802.5
  ENSP00000411606.2
  ENSP00000437709
  ENSP00000437709.1
  ENSP00000483540
  ENSP00000483540.2
  ENSP00000494717
  ENSP00000494717.1
  ENSP00000495728.1
GenBank Protein P23219 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_000953   ⟸   NM_000962
- Peptide Label: isoform 1 precursor
- UniProtKB: Q5T7T7 (UniProtKB/Swiss-Prot),   Q5T7T6 (UniProtKB/Swiss-Prot),   Q3HY29 (UniProtKB/Swiss-Prot),   Q3HY28 (UniProtKB/Swiss-Prot),   Q15122 (UniProtKB/Swiss-Prot),   B4E2S5 (UniProtKB/Swiss-Prot),   B4DHQ2 (UniProtKB/Swiss-Prot),   A8K1V7 (UniProtKB/Swiss-Prot),   Q5T7T8 (UniProtKB/Swiss-Prot),   P23219 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_542158   ⟸   NM_080591
- Peptide Label: isoform 2 precursor
- UniProtKB: P23219 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258297   ⟸   NM_001271368
- Peptide Label: isoform 6
- UniProtKB: P23219 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258095   ⟸   NM_001271166
- Peptide Label: isoform 5
- UniProtKB: A0A2R8YDM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258093   ⟸   NM_001271164
- Peptide Label: isoform 3 precursor
- UniProtKB: A0A087X296 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258296   ⟸   NM_001271367
- Peptide Label: isoform 5
- UniProtKB: A0A2R8YDM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258094   ⟸   NM_001271165
- Peptide Label: isoform 4
- UniProtKB: A0A2R8YDM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000411606   ⟸   ENST00000426608
RefSeq Acc Id: ENSP00000362802   ⟸   ENST00000373698
RefSeq Acc Id: ENSP00000354612   ⟸   ENST00000362012
RefSeq Acc Id: ENSP00000494717   ⟸   ENST00000643810
RefSeq Acc Id: ENSP00000483540   ⟸   ENST00000619306
RefSeq Acc Id: ENSP00000223423   ⟸   ENST00000223423
RefSeq Acc Id: ENSP00000495728   ⟸   ENST00000647067
RefSeq Acc Id: ENSP00000437709   ⟸   ENST00000540753
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23219-F1-model_v2 AlphaFold P23219 1-599 view protein structure

Promoters
RGD ID:7216085
Promoter ID:EPDNEW_H13781
Type:initiation region
Name:PTGS1_2
Description:prostaglandin-endoperoxide synthase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13782  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389122,370,547 - 122,370,607EPDNEW
RGD ID:7216071
Promoter ID:EPDNEW_H13782
Type:initiation region
Name:PTGS1_1
Description:prostaglandin-endoperoxide synthase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13781  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389122,371,024 - 122,371,084EPDNEW
RGD ID:6808010
Promoter ID:HG_KWN:64808
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000373698,   NM_080591,   OTTHUMT00000053933,   OTTHUMT00000053935,   UC004BMH.1,   UC010MWB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 369124,172,581 - 124,173,242 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9604 AgrOrtholog
COSMIC PTGS1 COSMIC
Ensembl Genes ENSG00000095303 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000223423 ENTREZGENE
  ENST00000223423.8 UniProtKB/Swiss-Prot
  ENST00000362012 ENTREZGENE
  ENST00000362012.7 UniProtKB/Swiss-Prot
  ENST00000373698 ENTREZGENE
  ENST00000373698.7 UniProtKB/Swiss-Prot
  ENST00000426608.6 UniProtKB/TrEMBL
  ENST00000540753 ENTREZGENE
  ENST00000540753.6 UniProtKB/Swiss-Prot
  ENST00000619306 ENTREZGENE
  ENST00000619306.5 UniProtKB/TrEMBL
  ENST00000643810 ENTREZGENE
  ENST00000643810.1 UniProtKB/TrEMBL
  ENST00000647067.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000095303 GTEx
HGNC ID HGNC:9604 ENTREZGENE
Human Proteome Map PTGS1 Human Proteome Map
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5742 UniProtKB/Swiss-Prot
NCBI Gene 5742 ENTREZGENE
OMIM 176805 OMIM
PANTHER PROSTAGLANDIN G/H SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11903:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24346 PharmGKB, RGD
PRINTS ANPEROXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXIDASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087X296 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8Y6S0_HUMAN UniProtKB/TrEMBL
  A0A2R8YDM0 ENTREZGENE, UniProtKB/TrEMBL
  A8K1V7 ENTREZGENE
  B4DHQ2 ENTREZGENE
  B4E2S5 ENTREZGENE
  P23219 ENTREZGENE, UniProtKB/Swiss-Prot
  Q15122 ENTREZGENE
  Q3HY28 ENTREZGENE
  Q3HY29 ENTREZGENE
  Q5T7T6 ENTREZGENE
  Q5T7T7 ENTREZGENE
  Q5T7T8 ENTREZGENE
  Q6LCE7_HUMAN UniProtKB/TrEMBL
  X6RJD6_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8K1V7 UniProtKB/Swiss-Prot
  B4DHQ2 UniProtKB/Swiss-Prot
  B4E2S5 UniProtKB/Swiss-Prot
  Q15122 UniProtKB/Swiss-Prot
  Q3HY28 UniProtKB/Swiss-Prot
  Q3HY29 UniProtKB/Swiss-Prot
  Q5T7T6 UniProtKB/Swiss-Prot
  Q5T7T7 UniProtKB/Swiss-Prot
  Q5T7T8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 PTGS1  prostaglandin-endoperoxide synthase 1    prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)  Symbol and/or name change 5135510 APPROVED