YAP1 (Yes1 associated transcriptional regulator) - Rat Genome Database

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Gene: YAP1 (Yes1 associated transcriptional regulator) Homo sapiens
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Symbol: YAP1
Name: Yes1 associated transcriptional regulator
RGD ID: 1314421
HGNC Page HGNC:16262
Description: Enables DNA-binding transcription factor binding activity; transcription cis-regulatory region binding activity; and transcription coregulator activity. Involved in several processes, including cellular response to gamma radiation; hippo signaling; and regulation of gene expression. Acts upstream of or within regulation of neurogenesis and regulation of stem cell proliferation. Located in several cellular components, including cytosol; mitochondrion; and nucleoplasm. Part of TEAD-YAP complex. Is active in nucleus. Implicated in uveal coloboma-cleft lip and palate-intellectual disability. Biomarker of colorectal cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 65 kDa Yes-associated protein; COB1; transcriptional coactivator YAP1; YAP; YAP-1; YAP2; YAP65; Yes associated protein 1; Yes-associated protein 1; Yes-associated protein 1, 65kDa; yes-associated protein 2; yes-associated protein beta; yes-associated protein delta; yes-associated protein YAP65 homolog; YKI; yorkie homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: YAP1P1   YAP1P2   YAP1P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,110,447 - 102,233,424 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,110,447 - 102,233,424 (+)EnsemblGRCh38hg38GRCh38
GRCh3711101,981,178 - 102,104,155 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,486,541 - 101,609,359 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411101,486,540 - 101,609,356NCBI
Celera1199,142,746 - 99,265,700 (+)NCBICelera
Cytogenetic Map11q22.1NCBI
HuRef1197,907,865 - 98,030,476 (+)NCBIHuRef
CHM1_111101,864,181 - 101,987,123 (+)NCBICHM1_1
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
YAP1Humancolorectal cancer treatmentIEP 153297782human cells in mouse modelRGD 
YAP1HumanSubarachnoid Hemorrhage treatmentIEP 151893490 RGD 
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YAP1Humanasphyxiating thoracic dystrophy  IAGPRGD:1518869698554872ClinVar Annotator: match by term: Jeune thoracic dystrophyClinVarPMID:23339108|PMID:24781753|PMID:28492532|PMID:31413057|PMID:32753734
YAP1Humanataxia telangiectasia  IAGPRGD:1272337728554872ClinVar Annotator: match by term: Ataxia-telangiectasia syndromeClinVarPMID:23807571|PMID:25614872|PMID:28492532
YAP1Humancoloboma  IAGPRGD:85910998554872ClinVar Annotator: match by term: Congenital ocular colobomaClinVarPMID:24462371
YAP1Humanintellectual disability  IAGPRGD:427234668554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
YAP1Humanmultiple myeloma  IAGPRGD:151734678554872ClinVar Annotator: match by term: Multiple myelomaClinVar 
YAP1Humanuveal coloboma-cleft lip and palate-intellectual disability  IAGPRGD:85911008554872ClinVar Annotator: match by term: Uveal coloboma-cleft lip and palate-intellectual disabilityClinVarPMID:24462371|PMID:4997531
YAP1Humanuveal coloboma-cleft lip and palate-intellectual disability  IAGPRGD:15172780|RGD:4019027178554872ClinVar Annotator: match by term: YAP1-related conditionClinVarPMID:25741868|PMID:28492532
YAP1Humanuveal coloboma-cleft lip and palate-intellectual disability  IAGPRGD:15169329|RGD:15172334|RGD:21072067|RGD:4050793708554872ClinVar Annotator: match by term: YAP1-related conditionClinVarPMID:28492532
YAP1Humanuveal coloboma-cleft lip and palate-intellectual disability  IAGPRGD:126739176|RGD:150477760|RGD:38462921|RGD:409037318554872ClinVar Annotator: match by term: Uveal coloboma-cleft lip and palate-intellectual disabilityClinVarPMID:25741868
YAP1Humanuveal coloboma-cleft lip and palate-intellectual disability  IAGPRGD:1529799648554872ClinVar Annotator: match by term: Uveal coloboma-cleft lip and palate-intellectual disabilityClinVar 
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Original Reference(s)
YAP1HumanBrain Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:27935819
YAP1HumanBreast Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:28114269|PMID:28524356
YAP1HumanColorectal Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:30510241|PMID:34351699
YAP1HumanDisease Progression  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:30703373
YAP1Humanembryonal rhabdomyosarcoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:31494105
YAP1Humanhead and neck squamous cell carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20729916
YAP1Humanhemangioma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:31351048
YAP1Humanhepatocellular carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:29698666
YAP1HumanNeoplasm Invasiveness  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:34351699
YAP1HumanNeoplasm Metastasis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:28114269
YAP1Humanneuroblastoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:26121086
YAP1HumanOvarian Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20947521
YAP1HumanRecurrence  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:26121086
YAP1HumanTriple Negative Breast Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:30703373
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YAP1Humancone dystrophy  ISSRGD:155037813592920OMIM:180020 | OMIM:610024 | OMIM:610356 | OMIM:610478 | OMIM:613093MouseDO 
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YAP1Humanuveal coloboma-cleft lip and palate-intellectual disability  IAGP 7240710 OMIM 

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Original Reference(s)
YAP1Human(+)-schisandrin B multiple interactionsISORGD:13060356480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of YAP1 mRNA]CTDPMID:31150632
YAP1Human(1->4)-beta-D-glucan multiple interactionsISORGD:15503786480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of YAP1 mRNACTDPMID:36331819
YAP1Human(20S)-ginsenoside Rg3 decreases expressionEXP 6480464ginsenoside Rg3 results in decreased expression of YAP1 mRNACTDPMID:31916386
YAP1Human1,2-dimethylhydrazine increases expressionISORGD:155037864804641,2-Dimethylhydrazine results in increased expression of YAP1 mRNACTDPMID:22206623
YAP1Human17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of YAP1 mRNACTDPMID:22574217
YAP1Human17beta-estradiol increases expressionISORGD:15503786480464Estradiol results in increased expression of YAP1 mRNACTDPMID:39298647
YAP1Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of YAP1 mRNA; YAP1 affects the reaction more ...CTDPMID:19684285|PMID:31536130|PMID:34403729
YAP1Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:13060356480464Tetrachlorodibenzodioxin results in decreased expression of YAP1 mRNACTDPMID:33387578
YAP1Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:15503786480464Tetrachlorodibenzodioxin results in decreased expression of YAP1 mRNACTDPMID:33956508
YAP1Human2,3,7,8-tetrachlorodibenzodioxine affects response to substanceEXP 6480464YAP1 affects the susceptibility to TetrachlorodibenzodioxinCTDPMID:31536130
YAP1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:15503786480464Tetrachlorodibenzodioxin affects the expression of YAP1 mRNACTDPMID:21570461|PMID:36222588
YAP1Human2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of YAP1 mRNACTDPMID:19684285
YAP1Human2,3,7,8-Tetrachlorodibenzofuran decreases expressionISORGD:130603564804642,3,7,8-tetrachlorodibenzofuran results in decreased expression of YAP1 mRNACTDPMID:32109520
YAP1Human2,6-dimethoxyphenol multiple interactionsEXP 6480464[Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether] results in increased expression of and affects the more ...CTDPMID:38598786
YAP1Human3-isobutyl-1-methyl-7H-xanthine multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...CTDPMID:28628672
YAP1Human4,4'-sulfonyldiphenol increases expressionISORGD:15503786480464bisphenol S results in increased expression of YAP1 mRNACTDPMID:39298647
YAP1Human4,4'-sulfonyldiphenol increases expressionEXP 6480464bisphenol S results in increased expression of YAP1 proteinCTDPMID:34186270
YAP1Humanacetamide decreases expressionISORGD:13060356480464acetamide results in decreased expression of YAP1 mRNACTDPMID:31881176
YAP1Humanacetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester decreases expressionEXP 6480464nitazoxanide results in decreased expression of YAP1 proteinCTDPMID:39084502
YAP1Humanaconitine increases expressionISORGD:13060356480464Aconitine results in increased expression of YAP1 proteinCTDPMID:33236894

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Biological Process
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Original Reference(s)
YAP1Humanblastocyst development acts_upstream_ofIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanbud elongation involved in lung branching acts_upstream_of_or_withinIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humancanonical Wnt signaling pathway acts_upstream_ofIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humancardiac muscle tissue regeneration involved_inIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humancell morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humancell population proliferation acts_upstream_ofIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humancellular response to gamma radiation involved_inIDA 150520179 PMID:18280240UniProtPMID:18280240
YAP1Humancellular response to retinoic acid acts_upstream_of_or_withinIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1HumanDNA damage response involved_inIDA 150520179 PMID:18280240UniProtPMID:18280240
YAP1Humanembryonic heart tube morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanenterocyte differentiation acts_upstream_ofIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanepithelial cell differentiation acts_upstream_ofIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanepithelial cell proliferation involved_inISSUniProtKB:P46938150520179 UniProtGO_REF:0000024
YAP1Humanepithelial cell proliferation acts_upstream_ofIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanextrinsic apoptotic signaling pathway acts_upstream_ofIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanglandular epithelial cell differentiation acts_upstream_ofIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanheart process involved_inIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanhippo signaling involved_inIDA 150520179 PMID:35429439UniProtPMID:35429439
YAP1Humanhippo signaling involved_inNAS 150520179 PMID:21808241ComplexPortalPMID:21808241
YAP1Humanhippo signaling involved_inIBAFB:FBgn0034970|MGI:103262|PANTHER:PTN000427153|UniProtKB:P46937|UniProtKB:Q9GZV5150520179 GO_CentralGO_REF:0000033
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Cellular Component
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Original Reference(s)
YAP1Humananchoring junction located_inIEAUniProtKB-KW:KW-0965150520179 UniProtGO_REF:0000043
YAP1Humanbicellular tight junction located_inIEAUniProtKB-SubCell:SL-0265150520179 UniProtGO_REF:0000044
YAP1Humanbicellular tight junction located_inIEAUniProtKB-KW:KW-0796150520179 UniProtGO_REF:0000043
YAP1Humancell junction located_inIDA 150520179 HPAGO_REF:0000052
YAP1Humancell-cell junction located_inISSUniProtKB:P46938150520179 UniProtGO_REF:0000024
YAP1Humancell-cell junction located_inIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humancytoplasm located_inIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
YAP1Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
YAP1Humancytoplasm located_inIDA 150520179 PMID:17974916, PMID:18158288, PMID:21205866, PMID:25849865, PMID:29400695, PMID:31835537UniProtPMID:17974916|PMID:18158288|PMID:21205866|PMID:25849865|PMID:29400695|PMID:31835537
YAP1Humancytosol located_inIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-1254248|Reactome:R-HSA-1254251|Reactome:R-HSA-2028583|Reactome:R-HSA-2028598|Reactome:R-HSA-2028644|Reactome:R-HSA-2028724|Reactome:R-HSA-2032770|Reactome:R-HSA-2064406|Reactome:R-HSA-2064421|Reactome:R-HSA-9865176|Reactome:R-HSA-9865196|Reactome:R-HSA-9865226
YAP1Humancytosol located_inIDA 150520179 PMID:30865227FlyBasePMID:30865227
YAP1Humanfemale germ cell nucleus located_inIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanmembrane located_inIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
YAP1Humanmitochondrion located_inIDA 150520179 HPAGO_REF:0000052
YAP1Humannucleoplasm located_inIDA 150520179 HPAGO_REF:0000052
YAP1Humannucleoplasm located_inTAS 150520179 ReactomeReactome:R-HSA-1254248|Reactome:R-HSA-2032770|Reactome:R-HSA-2032775|Reactome:R-HSA-2064406|Reactome:R-HSA-8871260|Reactome:R-HSA-8871265|Reactome:R-HSA-8871266|Reactome:R-HSA-8951676|Reactome:R-HSA-8951695|Reactome:R-HSA-8956639|Reactome:R-HSA-8956649|Reactome:R-HSA-8956659|Reactome:R-HSA-8956676|Reactome:R-HSA-9618559|Reactome:R-HSA-9865176
YAP1Humannucleus is_active_inIDA 150520179 PMID:35429439UniProtPMID:35429439
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Molecular Function
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Original Reference(s)
YAP1Humanchromatin binding enablesIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1HumanDNA-binding transcription factor binding enablesIPIUniProtKB:P28347150520179 PMID:20123905CAFAPMID:20123905
YAP1Humanproline-rich region binding enablesIEAUniProtKB:P46938|ensembl:ENSMUSP00000069554150520179 EnsemblGO_REF:0000107
YAP1Humanprotein binding enablesIPIUniProtKB:O15169|UniProtKB:O35625|UniProtKB:P35222|UniProtKB:Q9Y297150520179 PMID:24976009IntActPMID:24976009
YAP1Humanprotein binding enablesIPIUniProtKB:P35222150520179 PMID:21376238, PMID:22234184, PMID:36959122IntActPMID:21376238|PMID:22234184|PMID:36959122
YAP1Humanprotein binding  ISORGD:6313479068941 RGDPMID:31298560|REF_RGD_ID:401793755
YAP1Humanprotein binding enablesIPIUniProtKB:P31946|UniProtKB:P62258|UniProtKB:P63104150520179 PMID:36931259IntActPMID:36931259
YAP1Humanprotein binding enablesIPIUniProtKB:A3RM21150520179 PMID:37100772IntActPMID:37100772
YAP1Humanprotein binding enablesIPIUniProtKB:O95835|UniProtKB:P28347|UniProtKB:P31946|UniProtKB:P62258|UniProtKB:P63104|UniProtKB:Q15599|UniProtKB:Q15678|UniProtKB:Q969T9150520179 PMID:24255178IntActPMID:24255178
YAP1Humanprotein binding enablesIPIUniProtKB:O15350|UniProtKB:O95835|UniProtKB:Q8IV31|UniProtKB:Q96G27|UniProtKB:Q96PN7|UniProtKB:Q9BZD6|UniProtKB:Q9H3D4|UniProtKB:Q9P2Y5150520179 PMID:35044719IntActPMID:35044719
YAP1Humanprotein binding enablesIPIUniProtKB:O15350|UniProtKB:Q96PN7|UniProtKB:Q9BZD6|UniProtKB:Q9P2Y5150520179 PMID:37219487IntActPMID:37219487
YAP1Humanprotein binding enablesIPIUniProtKB:O15350-1|UniProtKB:Q9H3D4150520179 PMID:11278685IntActPMID:11278685
YAP1Humanprotein binding enablesIPIUniProtKB:Q15678150520179 PMID:22525271, PMID:22948661UniProtPMID:22525271|PMID:22948661
YAP1Humanprotein binding enablesIPIUniProtKB:Q15561150520179 PMID:24525233, PMID:26592798IntActPMID:24525233|PMID:26592798
YAP1Humanprotein binding enablesIPIUniProtKB:P62491150520179 PMID:28468127IntActPMID:28468127
YAP1Humanprotein binding enablesIPIUniProtKB:Q15599150520179 PMID:16166090, PMID:27173435IntActPMID:16166090|PMID:27173435
YAP1Humanprotein binding enablesIPIUniProtKB:Q15562150520179 PMID:20368466IntActPMID:20368466
YAP1Humanprotein binding enablesIPIUniProtKB:P28347|UniProtKB:Q92841150520179 PMID:24581491IntActPMID:24581491
YAP1Humanprotein binding enablesIPIUniProtKB:Q16621150520179 PMID:9305852BHF-UCLPMID:9305852
YAP1Humanprotein binding enablesIPIUniProtKB:Q02750150520179 PMID:24211253IntActPMID:24211253
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Imported Annotations - PID (archival)

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Original Reference(s)
YAP1Humantransforming growth factor-beta Smad dependent signaling pathway   EXP 6484113 PIDPID:200227
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Original Reference(s)
YAP1HumanAutosomal dominant inheritance  IAGP 8699517 HPOMIM:120433|PMID:24462371
YAP1HumanBilateral cleft palate  IAGP 8699517 HPOORPHA:1473
YAP1HumanCataract  IAGP 8699517 HPOMIM:120433|PMID:24462371|ORPHA:1473
YAP1HumanChorioretinal coloboma  IAGP 8699517 HPOMIM:120433|PMID:24462371|ORPHA:1473
YAP1HumanCleft palate  IAGP 8699517 HPOMIM:120433|PMID:24462371
YAP1HumanCleft upper lip  IAGP 8699517 HPOMIM:120433|PMID:24462371
YAP1HumanCongenital onset  IAGP 8699517 HPOMIM:120433|PMID:24462371
YAP1HumanCorneal opacity  IAGP 8699517 HPOORPHA:1473
YAP1HumanGlaucoma  IAGP 8699517 HPOORPHA:1473
YAP1HumanHearing impairment  IAGP 8699517 HPOMIM:120433|PMID:24462371
YAP1HumanHematuria  IAGP 8699517 HPOMIM:120433|PMID:24462371|ORPHA:1473
YAP1HumanIntellectual disability  IAGP 8699517 HPOMIM:120433|PMID:24462371|ORPHA:1473
YAP1HumanIris coloboma  IAGP 8699517 HPOMIM:120433|PMID:24462371|ORPHA:1473
YAP1HumanMicrophthalmia  IAGP 8699517 HPOMIM:120433|PMID:24462371|ORPHA:1473
YAP1HumanNystagmus  IAGP 8699517 HPOORPHA:1473
YAP1HumanOptic atrophy  IAGP 8699517 HPOORPHA:1473
YAP1HumanPosterior embryotoxon  IAGP 8699517 HPOORPHA:1473
YAP1HumanPtosis  IAGP 8699517 HPOORPHA:1473
YAP1HumanRetinal detachment  IAGP 8699517 HPOORPHA:1473
YAP1HumanSensorineural hearing impairment  IAGP 8699517 HPOORPHA:1473
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Original Reference(s)
YAP1HumanIntellectual disability  IAGPRGD:427234668554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
YAP1HumanMultiple myeloma  IAGPRGD:151734678554872ClinVar Annotator: match by term: Multiple myelomaClinVar 

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Reference Title
Reference Citation
1. LINC00689 participates in proliferation, chemoresistance and metastasis via miR-31-5p/YAP/β-catenin axis in colorectal cancer. Du YL, etal., Exp Cell Res. 2020 Oct 1;395(1):112176. doi: 10.1016/j.yexcr.2020.112176. Epub 2020 Jul 16.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
8. ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage. Yan F, etal., Exp Neurol. 2017 Nov;297:92-100. doi: 10.1016/j.expneurol.2017.07.014. Epub 2017 Jul 27.
1 to 10 of 125 rows
PMID:7644498   PMID:7782338   PMID:9202023   PMID:9305852   PMID:10228168   PMID:10358088   PMID:10562288   PMID:11278422   PMID:11278685   PMID:11358867   PMID:11604498   PMID:11743730  
PMID:12118366   PMID:12477932   PMID:12535517   PMID:12807903   PMID:14744259   PMID:15023535   PMID:15096513   PMID:15161933   PMID:15302935   PMID:15324660   PMID:15800888   PMID:15893728  
PMID:16061658   PMID:16166090   PMID:16596258   PMID:16772533   PMID:16894141   PMID:16964243   PMID:17081983   PMID:17110958   PMID:17353931   PMID:17438369   PMID:17502622   PMID:17823615  
PMID:17889654   PMID:17889669   PMID:17974916   PMID:17980593   PMID:18158288   PMID:18175224   PMID:18280240   PMID:18413746   PMID:18565851   PMID:18579750   PMID:18617895   PMID:18640976  
PMID:18701449   PMID:18703216   PMID:18725387   PMID:18953429   PMID:19015275   PMID:19047365   PMID:19111660   PMID:19158374   PMID:19322201   PMID:19371381   PMID:19439659   PMID:19615732  
PMID:19705503   PMID:19797269   PMID:19914168   PMID:19919647   PMID:19935651   PMID:19952108   PMID:20016275   PMID:20048001   PMID:20123905   PMID:20153295   PMID:20219076   PMID:20226166  
PMID:20368466   PMID:20379614   PMID:20677011   PMID:20729916   PMID:20823509   PMID:20841485   PMID:20842732   PMID:20868367   PMID:20947521   PMID:20951342   PMID:21041410   PMID:21041411  
PMID:21076472   PMID:21112960   PMID:21116278   PMID:21118971   PMID:21145499   PMID:21170084   PMID:21187284   PMID:21205866   PMID:21224387   PMID:21278236   PMID:21317925   PMID:21346147  
PMID:21364637   PMID:21376238   PMID:21383157   PMID:21399893   PMID:21454516   PMID:21610251   PMID:21654799   PMID:21666501   PMID:21685363   PMID:21685940   PMID:21708480   PMID:21800344  
PMID:21808241   PMID:21832154   PMID:21856745   PMID:21873635   PMID:21874045   PMID:21900206   PMID:21909427   PMID:21981024   PMID:22012126   PMID:22017875   PMID:22024089   PMID:22042863  
1 to 10 of 125 rows



YAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,110,447 - 102,233,424 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,110,447 - 102,233,424 (+)EnsemblGRCh38hg38GRCh38
GRCh3711101,981,178 - 102,104,155 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,486,541 - 101,609,359 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411101,486,540 - 101,609,356NCBI
Celera1199,142,746 - 99,265,700 (+)NCBICelera
Cytogenetic Map11q22.1NCBI
HuRef1197,907,865 - 98,030,476 (+)NCBIHuRef
CHM1_111101,864,181 - 101,987,123 (+)NCBICHM1_1
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBIT2T-CHM13v2.0
Yap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,932,000 - 8,004,890 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,932,000 - 8,004,597 (-)EnsemblGRCm39 Ensembl
GRCm3897,931,999 - 8,004,638 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,931,999 - 8,004,596 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,931,999 - 8,004,596 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,932,520 - 8,005,109 (-)NCBIMGSCv36mm8
Celera95,324,108 - 5,396,890 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Yap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,380,551 - 13,451,640 (-)NCBIGRCr8
mRatBN7.285,095,705 - 5,166,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl85,095,722 - 5,167,010 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx89,049,437 - 9,120,258 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,347,114 - 7,417,927 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,355,414 - 5,426,296 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,133,014 - 6,204,240 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,135,493 - 6,203,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,131,653 - 6,202,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,780,845 - 4,848,881 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,780,674 - 4,881,302 (-)NCBI
Celera86,655,412 - 6,723,571 (-)NCBICelera
Cytogenetic Map8q11NCBI
Yap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,423,855 - 5,534,408 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,423,866 - 5,533,728 (+)NCBIChiLan1.0ChiLan1.0
YAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29102,911,890 - 103,039,644 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,002,427 - 104,128,009 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,061,367 - 97,186,961 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,556,689 - 100,681,301 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,552,424 - 100,681,301 (+)Ensemblpanpan1.1panPan2
YAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,394,760 - 29,495,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,394,541 - 29,496,251 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,340,746 - 29,445,498 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,444,603 - 29,550,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,447,525 - 29,551,237 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,501,168 - 29,606,791 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,358,262 - 29,463,735 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,533,412 - 29,638,553 (-)NCBIUU_Cfam_GSD_1.0
Yap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494785,795,986 - 85,901,455 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,634,751 - 5,740,567 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,638,383 - 5,740,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl932,811,226 - 32,925,606 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1932,811,629 - 32,924,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,760,481 - 36,872,904 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,479,478 - 93,605,340 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl193,479,135 - 93,606,808 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604332,256,708 - 32,382,950 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624878621,214 - 776,363 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in YAP1
94 total Variants

1 to 10 of 122 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_001130145.3(YAP1):c.115_144dup (p.Ala39_Pro48dup) duplication not provided [RCV000722718] Chr11:102110955..102110956 [GRCh38]
Chr11:101981686..101981687 [GRCh37]
Chr11:11q22.1
uncertain significance
NM_001130145.3(YAP1):c.370C>T (p.Arg124Ter) single nucleotide variant Congenital ocular coloboma [RCV000106407] Chr11:102114192 [GRCh38]
Chr11:101984923 [GRCh37]
Chr11:11q22.1
pathogenic
NM_001130145.3(YAP1):c.1066G>T (p.Glu356Ter) single nucleotide variant Uveal coloboma-cleft lip and palate-intellectual disability [RCV000106408] Chr11:102223655 [GRCh38]
Chr11:102094386 [GRCh37]
Chr11:11q22.1
pathogenic
GRCh38/hg38 11q22.1-22.2(chr11:102130109-102368261)x3 copy number gain See cases [RCV000051934] Chr11:102130109..102368261 [GRCh38]
Chr11:102000840..102238992 [GRCh37]
Chr11:101506050..101744202 [NCBI36]
Chr11:11q22.1-22.2
uncertain significance
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3
pathogenic
GRCh38/hg38 11q14.1-22.2(chr11:85242847-102920097)x1 copy number loss See cases [RCV000052711] Chr11:85242847..102920097 [GRCh38]
Chr11:84953891..102738968 [GRCh37]
Chr11:84631539..102296037 [NCBI36]
Chr11:11q14.1-22.2
pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
NM_001130145.2(YAP1):c.745A>G (p.Ile249Val) single nucleotide variant Lung cancer [RCV000109528] Chr11:102186074 [GRCh38]
Chr11:102056805 [GRCh37]
Chr11:11q22.1
uncertain significance
GRCh38/hg38 11q22.1-22.3(chr11:98357901-106059146)x1 copy number loss See cases [RCV000136574] Chr11:98357901..106059146 [GRCh38]
Chr11:98228629..105929873 [GRCh37]
Chr11:97733839..105435083 [NCBI36]
Chr11:11q22.1-22.3
pathogenic
GRCh38/hg38 11q22.1-22.3(chr11:101452984-104044105)x3 copy number gain See cases [RCV000136846] Chr11:101452984..104044105 [GRCh38]
Chr11:101323715..103914833 [GRCh37]
Chr11:100828925..103420043 [NCBI36]
Chr11:11q22.1-22.3
pathogenic
1 to 10 of 122 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR200Ahsa-miR-200a-3pMirtarbaseexternal_infoWestern blotFunctional MTI23340296
MIR200Ahsa-miR-200a-3pOncomiRDBexternal_infoNANA23340296
MIR375hsa-miR-375Mirecordsexternal_infoNANA20100814
MIR375hsa-miR-375OncomiRDBexternal_infoNANA21856745
MIR375hsa-miR-375OncomiRDBexternal_infoNANA20226166
MIR141hsa-miR-141-3pOncomiRDBexternal_infoNANA21289630

Predicted Target Of
Summary Value
Count of predictions:4277
Count of miRNA genes:825
Interacting mature miRNAs:932
Transcripts:ENST00000282441, ENST00000345877, ENST00000524575, ENST00000526343, ENST00000526594, ENST00000528834, ENST00000529029, ENST00000531439, ENST00000537274
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597075477GWAS1171551_HCleft palate QTL GWAS1171551 (human)0.0000006Cleft palate11102208982102208983Human
597020381GWAS1116455_Hpolycystic ovary syndrome QTL GWAS1116455 (human)8e-11polycystic ovary syndrome11102172509102172510Human
597478230GWAS1574304_Hsex hormone-binding globulin measurement QTL GWAS1574304 (human)2e-12sex hormone-binding globulin measurement11102186337102186338Human
597098265GWAS1194339_Hsex hormone-binding globulin measurement QTL GWAS1194339 (human)5e-18sex hormone-binding globulin measurement11102212964102212965Human
597189591GWAS1285665_Hsex hormone-binding globulin measurement QTL GWAS1285665 (human)4e-16sex hormone-binding globulin measurement11102214209102214210Human
597294920GWAS1390994_Hmigraine disorder QTL GWAS1390994 (human)2e-13migraine disorder11102200245102200246Human
597098375GWAS1194449_Hsex hormone-binding globulin measurement QTL GWAS1194449 (human)9e-15sex hormone-binding globulin measurement11102214209102214210Human
597166210GWAS1262284_Hopen-angle glaucoma QTL GWAS1262284 (human)3e-09open-angle glaucoma11102215051102215052Human
1559115SCL20_HSerum cholesterol level QTL 20 (human)3.220.001213Lipid levelLDL cholesterol11100442501126442501Human
597114315GWAS1210389_Hpolycystic ovary syndrome QTL GWAS1210389 (human)5e-11polycystic ovary syndrome11102172509102172510Human

1 to 10 of 30 rows
D11S1339  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,057,505 - 102,057,632UniSTSGRCh37
GRCh3711102,057,512 - 102,057,633UniSTSGRCh37
Build 3611101,562,715 - 101,562,842RGDNCBI36
Celera1199,219,055 - 99,219,182RGD
Celera1199,219,062 - 99,219,183UniSTS
Cytogenetic Map11q13UniSTS
HuRef1197,983,970 - 97,984,095UniSTS
HuRef1197,983,977 - 97,984,096UniSTS
Marshfield Genetic Map11100.05RGD
Genethon Genetic Map11104.8UniSTS
TNG Radiation Hybrid Map1147292.0UniSTS
deCODE Assembly Map11104.08UniSTS
Stanford-G3 RH Map114482.0UniSTS
GeneMap99-GB4 RH Map11348.86UniSTS
Whitehead-RH Map11459.6UniSTS
Whitehead-YAC Contig Map11 UniSTS
NCBI RH Map11882.6UniSTS
GeneMap99-G3 RH Map114482.0UniSTS
D11S1762  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,015,494 - 102,015,642UniSTSGRCh37
Build 3611101,520,704 - 101,520,852RGDNCBI36
Celera1199,177,048 - 99,177,196RGD
Cytogenetic Map11q13UniSTS
HuRef1197,941,901 - 97,942,049UniSTS
Marshfield Genetic Map1198.45RGD
Marshfield Genetic Map1198.45UniSTS
Genethon Genetic Map11102.6UniSTS
RH47129  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,103,623 - 102,103,809UniSTSGRCh37
GRCh376147,731,931 - 147,732,117UniSTSGRCh37
Build 366147,773,624 - 147,773,810RGDNCBI36
Celera1199,265,169 - 99,265,355UniSTS
Celera6148,472,375 - 148,472,561RGD
Cytogenetic Map11q13UniSTS
HuRef1198,029,945 - 98,030,131UniSTS
HuRef6145,295,551 - 145,295,737UniSTS
RH91842  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711101,980,560 - 101,980,694UniSTSGRCh37
Build 3611101,485,770 - 101,485,904RGDNCBI36
Celera1199,142,114 - 99,142,248RGD
Cytogenetic Map11q13UniSTS
HuRef1197,907,233 - 97,907,367UniSTS
GeneMap99-GB4 RH Map11344.41UniSTS
RH41050  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,103,685 - 102,103,873UniSTSGRCh37
GRCh376147,731,993 - 147,732,181UniSTSGRCh37
Build 366147,773,686 - 147,773,874RGDNCBI36
Celera1199,265,231 - 99,265,419UniSTS
Celera6148,472,437 - 148,472,625RGD
Cytogenetic Map11q13UniSTS
HuRef1198,030,007 - 98,030,195UniSTS
HuRef6145,295,613 - 145,295,801UniSTS
SHGC-77975  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,011,906 - 102,012,227UniSTSGRCh37
Build 3611101,517,116 - 101,517,437RGDNCBI36
Celera1199,173,460 - 99,173,781RGD
Cytogenetic Map11q13UniSTS
HuRef1197,938,313 - 97,938,634UniSTS
RH123128  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,095,042 - 102,095,321UniSTSGRCh37
Build 3611101,600,252 - 101,600,531RGDNCBI36
Celera1199,256,589 - 99,256,868RGD
Cytogenetic Map11q13UniSTS
HuRef1198,021,367 - 98,021,646UniSTS
TNG Radiation Hybrid Map1147320.0UniSTS
SHGC-32695  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,103,559 - 102,103,708UniSTSGRCh37
GRCh376147,731,865 - 147,732,016UniSTSGRCh37
Build 366147,773,558 - 147,773,709RGDNCBI36
Celera1199,265,105 - 99,265,254UniSTS
Celera6148,472,309 - 148,472,460RGD
Cytogenetic Map11q13UniSTS
HuRef1198,029,881 - 98,030,030UniSTS
HuRef6145,295,485 - 145,295,636UniSTS
TNG Radiation Hybrid Map672432.0UniSTS
SHGC-110032  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711101,989,812 - 101,990,150UniSTSGRCh37
Build 3611101,495,022 - 101,495,360RGDNCBI36
Celera1199,151,367 - 99,151,705RGD
Cytogenetic Map11q13UniSTS
HUM000S656  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,103,701 - 102,103,868UniSTSGRCh37
Build 3611101,608,911 - 101,609,078RGDNCBI36
Celera1199,265,247 - 99,265,414RGD
Cytogenetic Map11q13UniSTS
HuRef1198,030,023 - 98,030,190UniSTS
Stanford-G3 RH Map114404.0UniSTS
NCBI RH Map11867.0UniSTS
GeneMap99-G3 RH Map114404.0UniSTS
D11S2249E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,103,180 - 102,103,263UniSTSGRCh37
Build 3611101,608,390 - 101,608,473RGDNCBI36
Celera1199,264,726 - 99,264,809RGD
Cytogenetic Map11q13UniSTS
HuRef1198,029,502 - 98,029,585UniSTS
GeneMap99-GB4 RH Map11348.76UniSTS
D11S1339  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q13UniSTS
Marshfield Genetic Map11100.05UniSTS
Genethon Genetic Map11104.8UniSTS
deCODE Assembly Map11104.08UniSTS
GeneMap99-GB4 RH Map11348.86UniSTS
Whitehead-RH Map11459.6UniSTS
Whitehead-YAC Contig Map11 UniSTS
NCBI RH Map11885.6UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2438 2788 2250 4973 1725 2343 6 624 1555 465 2269 6914 6080 53 3734 1 852 1744 1608 175 1


1 to 30 of 74 rows
RefSeq Transcripts NG_029530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001195044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001195045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005271378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005271380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005271381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005271383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA854862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB567720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB567721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI128142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 74 rows

Ensembl Acc Id: ENST00000282441   ⟹   ENSP00000282441
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,110,447 - 102,233,424 (+)Ensembl
Ensembl Acc Id: ENST00000345877   ⟹   ENSP00000331023
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,110,461 - 102,233,423 (+)Ensembl
Ensembl Acc Id: ENST00000524575   ⟹   ENSP00000435602
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,112,514 - 102,230,152 (+)Ensembl
Ensembl Acc Id: ENST00000526343   ⟹   ENSP00000434134
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,110,461 - 102,230,592 (+)Ensembl
Ensembl Acc Id: ENST00000526594
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,162,456 - 102,186,686 (+)Ensembl
Ensembl Acc Id: ENST00000528834
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,226,973 - 102,230,502 (+)Ensembl
Ensembl Acc Id: ENST00000529029   ⟹   ENSP00000431626
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,186,081 - 102,230,579 (+)Ensembl
Ensembl Acc Id: ENST00000531439   ⟹   ENSP00000431574
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,110,849 - 102,229,963 (+)Ensembl
Ensembl Acc Id: ENST00000537274   ⟹   ENSP00000445635
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,110,461 - 102,233,423 (+)Ensembl
Ensembl Acc Id: ENST00000615667   ⟹   ENSP00000478927
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,110,461 - 102,233,423 (+)Ensembl
Ensembl Acc Id: ENST00000629586   ⟹   ENSP00000487519
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,110,849 - 102,229,940 (+)Ensembl
RefSeq Acc Id: NM_001130145   ⟹   NP_001123617
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
GRCh3711101,981,151 - 102,104,154 (+)NCBI
HuRef1197,907,865 - 98,030,476 (+)ENTREZGENE
CHM1_111101,864,181 - 101,987,123 (+)NCBI
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001195044   ⟹   NP_001181973
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
GRCh3711101,981,151 - 102,104,154 (+)NCBI
HuRef1197,907,865 - 98,030,476 (+)ENTREZGENE
CHM1_111101,864,181 - 101,987,123 (+)NCBI
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001195045   ⟹   NP_001181974
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,112,448 - 102,233,424 (+)NCBI
GRCh3711101,981,151 - 102,104,154 (+)NCBI
HuRef1197,907,865 - 98,030,476 (+)ENTREZGENE
CHM1_111101,866,159 - 101,987,123 (+)NCBI
T2T-CHM13v2.011102,114,538 - 102,235,509 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001282097   ⟹   NP_001269026
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
HuRef1197,907,865 - 98,030,476 (+)NCBI
CHM1_111101,864,181 - 101,987,123 (+)NCBI
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001282098   ⟹   NP_001269027
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
HuRef1197,907,865 - 98,030,476 (+)NCBI
CHM1_111101,864,181 - 101,987,123 (+)NCBI
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001282099   ⟹   NP_001269028
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
HuRef1197,907,865 - 98,030,476 (+)NCBI
CHM1_111101,864,181 - 101,987,123 (+)NCBI
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001282100   ⟹   NP_001269029
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
HuRef1197,907,865 - 98,030,476 (+)NCBI
CHM1_111101,864,181 - 101,987,123 (+)NCBI
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001282101   ⟹   NP_001269030
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
HuRef1197,907,865 - 98,030,476 (+)NCBI
CHM1_111101,864,181 - 101,987,123 (+)NCBI
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006106   ⟹   NP_006097
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
GRCh3711101,981,151 - 102,104,154 (+)NCBI
Build 3611101,486,541 - 101,609,359 (+)NCBI Archive
HuRef1197,907,865 - 98,030,476 (+)ENTREZGENE
CHM1_111101,864,181 - 101,987,123 (+)NCBI
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005271378   ⟹   XP_005271435
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
GRCh3711101,981,151 - 102,104,154 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005271380   ⟹   XP_005271437
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
GRCh3711101,981,151 - 102,104,154 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005271381   ⟹   XP_005271438
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
GRCh3711101,981,151 - 102,104,154 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005271383   ⟹   XP_005271440
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,447 - 102,233,424 (+)NCBI
GRCh3711101,981,151 - 102,104,154 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011542555   ⟹   XP_011540857
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,111,549 - 102,233,424 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054367453   ⟹   XP_054223428
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
RefSeq Acc Id: XM_054367454   ⟹   XP_054223429
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
RefSeq Acc Id: XM_054367455   ⟹   XP_054223430
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
RefSeq Acc Id: XM_054367456   ⟹   XP_054223431
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011102,112,538 - 102,235,509 (+)NCBI
RefSeq Acc Id: XM_054367457   ⟹   XP_054223432
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011102,114,538 - 102,235,509 (+)NCBI
1 to 30 of 80 rows
Protein RefSeqs NP_001123617 (Get FASTA)   NCBI Sequence Viewer  
  NP_001181973 (Get FASTA)   NCBI Sequence Viewer  
  NP_001181974 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269026 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269027 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269028 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269029 (Get FASTA)   NCBI Sequence Viewer  
  NP_001269030 (Get FASTA)   NCBI Sequence Viewer  
  NP_006097 (Get FASTA)   NCBI Sequence Viewer  
  XP_005271435 (Get FASTA)   NCBI Sequence Viewer  
  XP_005271437 (Get FASTA)   NCBI Sequence Viewer  
  XP_005271438 (Get FASTA)   NCBI Sequence Viewer  
  XP_005271440 (Get FASTA)   NCBI Sequence Viewer  
  XP_011540857 (Get FASTA)   NCBI Sequence Viewer  
  XP_054223428 (Get FASTA)   NCBI Sequence Viewer  
  XP_054223429 (Get FASTA)   NCBI Sequence Viewer  
  XP_054223430 (Get FASTA)   NCBI Sequence Viewer  
  XP_054223431 (Get FASTA)   NCBI Sequence Viewer  
  XP_054223432 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH38235 (Get FASTA)   NCBI Sequence Viewer  
  AAP92710 (Get FASTA)   NCBI Sequence Viewer  
  BAG62143 (Get FASTA)   NCBI Sequence Viewer  
  BAG65295 (Get FASTA)   NCBI Sequence Viewer  
  BAH14487 (Get FASTA)   NCBI Sequence Viewer  
  BAJ41471 (Get FASTA)   NCBI Sequence Viewer  
  BAJ41472 (Get FASTA)   NCBI Sequence Viewer  
  CAA56672 (Get FASTA)   NCBI Sequence Viewer  
  CAD89963 (Get FASTA)   NCBI Sequence Viewer  
  CCH22597 (Get FASTA)   NCBI Sequence Viewer  
  CCH22598 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 80 rows
1 to 5 of 28 rows
1 to 5 of 28 rows
RefSeq Acc Id: NP_001123617   ⟸   NM_001130145
- Peptide Label: isoform 1
- UniProtKB: Q7Z574 (UniProtKB/Swiss-Prot),   K0L1G3 (UniProtKB/Swiss-Prot),   K0L195 (UniProtKB/Swiss-Prot),   K0KYZ8 (UniProtKB/Swiss-Prot),   K0KQ18 (UniProtKB/Swiss-Prot),   F5H202 (UniProtKB/Swiss-Prot),   E9PRV2 (UniProtKB/Swiss-Prot),   E3WEB6 (UniProtKB/Swiss-Prot),   E3WEB5 (UniProtKB/Swiss-Prot),   B7ZA01 (UniProtKB/Swiss-Prot),   B4DTY1 (UniProtKB/Swiss-Prot),   Q8IUY9 (UniProtKB/Swiss-Prot),   P46937 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001181973   ⟸   NM_001195044
- Peptide Label: isoform 3
- UniProtKB: P46937 (UniProtKB/Swiss-Prot),   Q86T74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_006097   ⟸   NM_006106
- Peptide Label: isoform 2
- UniProtKB: Q86T74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001181974   ⟸   NM_001195045
- Peptide Label: isoform 4
- UniProtKB: Q86T74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005271435   ⟸   XM_005271378
- Peptide Label: isoform X1
- Sequence:
WW

Name Modeler Protein Id AA Range Protein Structure
AF-P46937-F1-model_v2 AlphaFold P46937 1-504 view protein structure

RGD ID:6789585
Promoter ID:HG_KWN:14031
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3
Transcripts:NM_001130145,   NM_006106,   UC001PGU.1,   UC001PGV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3611101,486,106 - 101,487,007 (+)MPROMDB
RGD ID:6810207
Promoter ID:HG_ACW:13998
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:YAP1.EAPR07,   YAP1.FAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 3611101,487,606 - 101,488,106 (+)MPROMDB
RGD ID:7221897
Promoter ID:EPDNEW_H16695
Type:initiation region
Name:YAP1_1
Description:Yes associated protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16696  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,450 - 102,110,510EPDNEW
RGD ID:7221903
Promoter ID:EPDNEW_H16696
Type:initiation region
Name:YAP1_2
Description:Yes associated protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16695  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,110,719 - 102,110,779EPDNEW


1 to 40 of 68 rows
Database
Acc Id
Source(s)
COSMIC YAP1 COSMIC
Ensembl Genes ENSG00000137693 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000282441 ENTREZGENE
  ENST00000282441.10 UniProtKB/Swiss-Prot
  ENST00000345877 ENTREZGENE
  ENST00000345877.6 UniProtKB/Swiss-Prot
  ENST00000524575 ENTREZGENE
  ENST00000524575.5 UniProtKB/Swiss-Prot
  ENST00000526343 ENTREZGENE
  ENST00000526343.5 UniProtKB/Swiss-Prot
  ENST00000531439 ENTREZGENE
  ENST00000531439.5 UniProtKB/Swiss-Prot
  ENST00000537274 ENTREZGENE
  ENST00000537274.5 UniProtKB/Swiss-Prot
  ENST00000615667 ENTREZGENE
  ENST00000615667.4 UniProtKB/Swiss-Prot
  ENST00000629586 ENTREZGENE
  ENST00000629586.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.70.10 UniProtKB/Swiss-Prot
  6.20.430.10 UniProtKB/Swiss-Prot
GTEx ENSG00000137693 GTEx
HGNC ID HGNC:16262 ENTREZGENE
Human Proteome Map YAP1 Human Proteome Map
InterPro TEADIR3_omega_loop UniProtKB/Swiss-Prot
  WW_dom UniProtKB/Swiss-Prot
  WW_dom_sf UniProtKB/Swiss-Prot
  YAP1 UniProtKB/Swiss-Prot
KEGG Report hsa:10413 UniProtKB/Swiss-Prot
NCBI Gene 10413 ENTREZGENE
OMIM 606608 OMIM
PANTHER TRANSCRIPTIONAL COACTIVATOR YAP1 UniProtKB/Swiss-Prot
  YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER UniProtKB/Swiss-Prot
Pfam PF00397 UniProtKB/Swiss-Prot
  TEADIR3 UniProtKB/Swiss-Prot
PharmGKB PA38103 PharmGKB
PROSITE WW_DOMAIN_1 UniProtKB/Swiss-Prot
  WW_DOMAIN_2 UniProtKB/Swiss-Prot
SMART SM00456 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51045 UniProtKB/Swiss-Prot
UniProt B4DTY1 ENTREZGENE
1 to 40 of 68 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-25 YAP1  Yes1 associated transcriptional regulator  YAP1  Yes associated protein 1  Symbol and/or name change 5135510 APPROVED
2015-11-24 YAP1  Yes associated protein 1  YAP1  Yes-associated protein 1  Symbol and/or name change 5135510 APPROVED
2011-07-27 YAP1  Yes-associated protein 1  YAP1  Yes-associated protein 1, 65kDa  Symbol and/or name change 5135510 APPROVED