MIR141 (microRNA 141) - Rat Genome Database

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Pathways
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Gene: MIR141 (microRNA 141) Homo sapiens
Analyze
Symbol: MIR141
Name: microRNA 141
RGD ID: 1345345
HGNC Page HGNC:31528
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing; negative regulation of leukocyte adhesion to vascular endothelial cell; and positive regulation of cell population proliferation. Located in extracellular space.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-141; MIRN141
RGD Orthologs
Mouse
Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,964,097 - 6,964,191 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,964,097 - 6,964,191 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,073,260 - 7,073,354 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,943,520 - 6,943,614 (+)NCBINCBI36Build 36hg18NCBI36
Celera128,694,279 - 8,694,373 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,931,725 - 6,931,819 (+)NCBIHuRef
CHM1_1127,072,213 - 7,072,307 (+)NCBICHM1_1
T2T-CHM13v2.0126,977,572 - 6,977,666 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
3. Correlation analysis of miR-200b, miR-200c, and miR-141 with liver metastases in colorectal cancer patients. Zhu SH, etal., Eur Rev Med Pharmacol Sci. 2017 May;21(10):2357-2363.
Additional References at PubMed
PMID:12007417   PMID:14573789   PMID:15131085   PMID:16381832   PMID:16762633   PMID:17604727   PMID:17616659   PMID:18381893   PMID:19363643   PMID:19830559   PMID:20053927   PMID:20084174  
PMID:20514023   PMID:20967756   PMID:21037258   PMID:21238947   PMID:21289630   PMID:21445232   PMID:21723797   PMID:21726338   PMID:21827717   PMID:22101765   PMID:22314666   PMID:22384255  
PMID:22479552   PMID:22537031   PMID:23045278   PMID:23377530   PMID:23554918   PMID:23559187   PMID:23574937   PMID:23635949   PMID:23663545   PMID:23874542   PMID:24000293   PMID:24013097  
PMID:24091627   PMID:24101728   PMID:24143167   PMID:24163379   PMID:24195082   PMID:24242138   PMID:24276755   PMID:24285464   PMID:24288670   PMID:24307282   PMID:24334875   PMID:24424572  
PMID:24551096   PMID:24616104   PMID:24628843   PMID:24647573   PMID:24732377   PMID:24810210   PMID:24937190   PMID:24945731   PMID:25003366   PMID:25004804   PMID:25008569   PMID:25017828  
PMID:25116353   PMID:25142234   PMID:25261470   PMID:25304156   PMID:25349304   PMID:25421593   PMID:25425543   PMID:25502084   PMID:25505268   PMID:25521481   PMID:25633292   PMID:25636451  
PMID:25703910   PMID:25746592   PMID:25813250   PMID:25884322   PMID:25885099   PMID:25896253   PMID:25938517   PMID:25975736   PMID:26025929   PMID:26045795   PMID:26062412   PMID:26160158  
PMID:26164002   PMID:26179333   PMID:26233544   PMID:26371161   PMID:26548909   PMID:26631297   PMID:26646931   PMID:26681225   PMID:26790956   PMID:26806656   PMID:26823756   PMID:26828359  
PMID:26936280   PMID:26996957   PMID:27010857   PMID:27012474   PMID:27081781   PMID:27105531   PMID:27121316   PMID:27198154   PMID:27358122   PMID:27412940   PMID:27558368   PMID:27616325  
PMID:27644195   PMID:27753010   PMID:27840955   PMID:27956179   PMID:27974706   PMID:27995756   PMID:28008308   PMID:28061435   PMID:28095864   PMID:28112170   PMID:28112364   PMID:28115163  
PMID:28135713   PMID:28220627   PMID:28431233   PMID:28453628   PMID:28535010   PMID:28619509   PMID:28637482   PMID:28739727   PMID:28854064   PMID:28901523   PMID:28944840   PMID:29105802  
PMID:29202848   PMID:29411538   PMID:29522969   PMID:29523781   PMID:29540201   PMID:29559001   PMID:29562494   PMID:29620289   PMID:29738771   PMID:29775889   PMID:29901110   PMID:30001838  
PMID:30041660   PMID:30119680   PMID:30138915   PMID:30194772   PMID:30222949   PMID:30352165   PMID:30420300   PMID:30429233   PMID:30465119   PMID:30502321   PMID:30599110   PMID:30611568  
PMID:30643007   PMID:30672021   PMID:30674952   PMID:30718276   PMID:30737360   PMID:31004838   PMID:31026335   PMID:31075732   PMID:31078266   PMID:31087707   PMID:31129698   PMID:31213574  
PMID:31256424   PMID:31310393   PMID:31383782   PMID:31389101   PMID:31411001   PMID:31437458   PMID:31439810   PMID:31505568   PMID:31522595   PMID:31530272   PMID:31545479   PMID:31562019  
PMID:31629025   PMID:31635993   PMID:31704502   PMID:31722554   PMID:31841191   PMID:31906774   PMID:31937854   PMID:32034251   PMID:32092085   PMID:32196573   PMID:32247266   PMID:32282121  
PMID:32299022   PMID:32316405   PMID:32317619   PMID:32373221   PMID:32436353   PMID:32481368   PMID:32484203   PMID:32614237   PMID:32633365   PMID:32814766   PMID:32842442   PMID:32897647  
PMID:32958011   PMID:33202602   PMID:33215427   PMID:33382472   PMID:33506255   PMID:33536459   PMID:33627047   PMID:33784000   PMID:33818249   PMID:33836533   PMID:33845141   PMID:33853871  
PMID:33977869   PMID:34086186   PMID:34086253   PMID:34128295   PMID:34143861   PMID:34180758   PMID:34389752   PMID:34400146   PMID:34607540   PMID:34611295   PMID:34881475   PMID:34911533  
PMID:34931214   PMID:34933711   PMID:34956562   PMID:34972164   PMID:35039872   PMID:35081536   PMID:35164653   PMID:35259051   PMID:35306455   PMID:35655727   PMID:35710767   PMID:35947965  
PMID:36427432   PMID:36631017   PMID:36680208   PMID:36814156   PMID:36988403   PMID:37017808   PMID:37227531   PMID:37511619   PMID:37596622  


Genomics

Comparative Map Data
MIR141
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,964,097 - 6,964,191 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,964,097 - 6,964,191 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,073,260 - 7,073,354 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,943,520 - 6,943,614 (+)NCBINCBI36Build 36hg18NCBI36
Celera128,694,279 - 8,694,373 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,931,725 - 6,931,819 (+)NCBIHuRef
CHM1_1127,072,213 - 7,072,307 (+)NCBICHM1_1
T2T-CHM13v2.0126,977,572 - 6,977,666 (+)NCBIT2T-CHM13v2.0
Mir141
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,694,877 - 124,694,948 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,694,877 - 124,694,948 (-)EnsemblGRCm39 Ensembl
GRCm386124,717,914 - 124,717,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,717,914 - 124,717,985 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,667,932 - 124,668,003 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera6126,399,639 - 126,399,710 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Mir141
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,209,525 - 159,209,618 (-)NCBIGRCr8
mRatBN7.24157,523,239 - 157,523,332 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,523,239 - 157,523,332 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,751,729 - 163,751,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,534,634 - 159,534,727 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,176,198 - 158,176,291 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,236,346 - 157,236,439 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,236,346 - 157,236,439 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,253,942 - 224,254,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4146,261,901 - 146,261,994 (-)NCBICelera
Cytogenetic Map4q42NCBI


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22		 pathogenic
GRCh38/hg38 12p13.31(chr12:6728665-7705620)x1 copy number loss See cases [RCV000052779] Chr12:6728665..7705620 [GRCh38]
Chr12:6837831..7858216 [GRCh37]
Chr12:6708092..7749483 [NCBI36]
Chr12:12p13.31		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1		 pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:121055-7272606)x3 copy number gain See cases [RCV000053663] Chr12:121055..7272606 [GRCh38]
Chr12:282465..7425202 [GRCh37]
Chr12:100482..7316469 [NCBI36]
Chr12:12p13.33-13.31		 pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:121255-8361746)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053664]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053664]|See cases [RCV000053664] Chr12:121255..8361746 [GRCh38]
Chr12:282465..8514342 [GRCh37]
Chr12:100682..8405609 [NCBI36]
Chr12:12p13.33-13.31		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
NC_000012.11:g.(?_6945914)_(9027627_?)dup duplication Developmental and epileptic encephalopathy, 21 [RCV001325295]|Klippel-Feil syndrome 3, autosomal dominant [RCV001301079]|Temtamy syndrome [RCV000816630]|not provided [RCV001859243] Chr12:6945914..9027627 [GRCh37]
Chr12:12p13.31		 uncertain significance|no classifications from unflagged records
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3 copy number gain See cases [RCV000141905] Chr12:1258274..20657577 [GRCh38]
Chr12:1367440..20810511 [GRCh37]
Chr12:1237701..20701778 [NCBI36]
Chr12:12p13.33-12.2		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4 copy number gain See cases [RCV000240164] Chr12:148034..34178799 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3 copy number gain See cases [RCV000240487] Chr12:89061..34178799 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3 copy number gain See cases [RCV000449191] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)x3 copy number gain See cases [RCV000449287] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain See cases [RCV000447551] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-12.2(chr12:173786-20026080)x3 copy number gain See cases [RCV000446050] Chr12:173786..20026080 [GRCh37]
Chr12:12p13.33-12.2		 pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-8257049)x3 copy number gain See cases [RCV000446749] Chr12:173786..8257049 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150) copy number gain See cases [RCV000446017] Chr12:189578..34756150 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3 copy number gain See cases [RCV000511580] Chr12:565369..34835837 [GRCh37]
Chr12:12p13.33-11.1		 likely pathogenic
GRCh37/hg19 12p13.33-13.2(chr12:173786-11677456)x3 copy number gain See cases [RCV000510853] Chr12:173786..11677456 [GRCh37]
Chr12:12p13.33-13.2		 pathogenic
GRCh37/hg19 12p13.33-11.22(chr12:173786-28219229)x3 copy number gain See cases [RCV000510961] Chr12:173786..28219229 [GRCh37]
Chr12:12p13.33-11.22		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3 copy number gain not provided [RCV000683478] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3 copy number gain not provided [RCV000683480] Chr12:173786..37869107 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:191242-8122785)x3 copy number gain not provided [RCV000683477] Chr12:191242..8122785 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain not provided [RCV000683479] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3 copy number gain not provided [RCV000750245] Chr12:191619..31733044 [GRCh37]
Chr12:12p13.33-11.21		 pathogenic
GRCh37/hg19 12p13.31(chr12:6911437-9381254)x3 copy number gain not provided [RCV000750277] Chr12:6911437..9381254 [GRCh37]
Chr12:12p13.31		 uncertain significance
NC_000012.12:g.(1_3750000)_(5250000_9000000)del deletion Tumoral calcinosis, hyperphosphatemic, familial, 1 [RCV000758697] Chr12:3750000..5250000 [GRCh38]
Chr12:12p13.33-13.31		 pathogenic|not provided
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4 copy number gain not provided [RCV001006470] Chr12:274676..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:189216-8185497) copy number gain not provided [RCV000767819] Chr12:189216..8185497 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
NC_000012.11:g.(?_6945914)_(9027627_?)dup duplication Temtamy syndrome [RCV000816630] Chr12:6945914..9027627 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-12.3(chr12:189216-15001420) copy number gain not provided [RCV000767817] Chr12:189216..15001420 [GRCh37]
Chr12:12p13.33-12.3		 pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:237588-8278292) copy number gain not provided [RCV000767818] Chr12:237588..8278292 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3 copy number gain not provided [RCV000847209] Chr12:173786..34496628 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-8393815)x3 copy number gain not provided [RCV000846343] Chr12:173786..8393815 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
NC_000012.11:g.(?_6945914)_(8248706_?)dup duplication Temtamy syndrome [RCV001031096] Chr12:6945914..8248706 [GRCh37]
Chr12:12p13.31		 uncertain significance
NC_000012.11:g.(?_4368352)_(9027607_?)dup duplication Lymphoproliferative syndrome 2 [RCV003105682] Chr12:4368352..9027607 [GRCh37]
Chr12:12p13.32-13.31		 uncertain significance
NC_000012.11:g.(?_6438458)_(7362839_?)dup duplication Peroxisome biogenesis disorder 2B [RCV001031288] Chr12:6438458..7362839 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-13.31(chr12:189145-7730395)x3 copy number gain not provided [RCV001537906] Chr12:189145..7730395 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
NC_000012.11:g.(?_6438478)_(7362819_?)dup duplication Temtamy syndrome [RCV001365174] Chr12:6438478..7362819 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-13.31(chr12:146240-8330229)x3 copy number gain Obesity [RCV001801197] Chr12:146240..8330229 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
NC_000012.11:g.(?_6438478)_(8248686_?)dup duplication Temtamy syndrome [RCV003120743]|not provided [RCV001913769] Chr12:6438478..8248686 [GRCh37]
Chr12:12p13.31		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865) copy number gain not specified [RCV002052955] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1		 pathogenic
NC_000012.11:g.(?_6438478)_(8756953_?)dup duplication not provided [RCV001970781] Chr12:6438478..8756953 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837) copy number gain not specified [RCV002052957] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.31(chr12:6530146-7376398) copy number gain not specified [RCV002052968] Chr12:6530146..7376398 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301) copy number gain not specified [RCV002052958] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.31(chr12:6872634-7244086) copy number gain not specified [RCV002052969] Chr12:6872634..7244086 [GRCh37]
Chr12:12p13.31		 uncertain significance
NC_000012.11:g.(?_6978008)_(9010204_?)dup duplication Peroxisome biogenesis disorder 2B [RCV001877402] Chr12:6978008..9010204 [GRCh37]
Chr12:12p13.31		 uncertain significance
NC_000012.11:g.(?_6438478)_(9027607_?)dup duplication not provided [RCV001943267] Chr12:6438478..9027607 [GRCh37]
Chr12:12p13.31		 uncertain significance
NC_000012.11:g.(?_6945914)_(7362819_?)dup duplication not provided [RCV001943326] Chr12:6945914..7362819 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-13.31(chr12:173787-8320544)x3 copy number gain not provided [RCV002472514] Chr12:173787..8320544 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
Single allele duplication not provided [RCV003448692] Chr12:188053..34856694 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835641)x3 copy number gain not specified [RCV003986979] Chr12:173786..34835641 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:176047-34179852)x4 copy number gain Pallister-Killian syndrome [RCV003154827] Chr12:176047..34179852 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.31(chr12:7069980-7094188)x3 copy number gain See cases [RCV000447567] Chr12:7069980..7094188 [GRCh37]
Chr12:12p13.31		 uncertain significance
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MAPK14hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI22101765
ZEB2hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19830559
ZEB2hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRNon-Functional MTI18411277
ZEB2hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19854497
ZEB1hsa-miR-141-3pMirtarbaseexternal_infoqRT-PCR;OtherFunctional MTI (Weak)19502803
DLX5hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19454767
BAP1hsa-miR-141-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17875710
BAP1hsa-miR-141-3pMirtarbaseexternal_infoReporter assayFunctional MTI20005803
ACVR2Bhsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22431721
KLF5hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherNon-Functional MTI15131085
TGFB2hsa-miR-141-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI18483486
BRD3hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI20053927
SFPQhsa-miR-141-3pMirtarbaseexternal_infoImmunoprecipitaion//Luciferase reporter assay//WesFunctional MTI17637574
CLOCKhsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayFunctional MTI15131085
CLOCKhsa-miR-141-3pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blotFunctional MTI16762633
ZFPM2hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI20005803
YWHAGhsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22537031
EIF4Ehsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI21238947
PPARAhsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22479552
NR0B2hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22314666
ELAVL4hsa-miR-141-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20584986
MAPK9hsa-miR-141-3pMirtarbaseexternal_infoWestern blotFunctional MTI20053927
STK3hsa-miR-141-3pTarbaseexternal_infoReporter GeneNEGATIVE
CLOCKhsa-miR-141-3pTarbaseexternal_infoReporter GenePOSITIVE
ZEB1hsa-miR-141-3pTarbaseexternal_infoqPCRPOSITIVE
ZEB1hsa-miR-141-3pTarbaseexternal_infoOtherPOSITIVE
UBAP1hsa-miR-141-3pTarbaseexternal_infoWesternblitPOSITIVE
CLOCKhsa-miR-141-3pMirecordsexternal_infoNANA15131085
TGFB2hsa-miR-141-3pMirecordsexternal_info{changed}NA18483486
ZFPM2hsa-miR-141-3pMirecordsexternal_infoNANA20005803
MAP2K4hsa-miR-141-3pMirecordsexternal_info{unchanged}NA19861690
ZEB2hsa-miR-141-3pMirecordsexternal_info{unchanged}NA19830559
JAG1hsa-miR-141-3pMirecordsexternal_info{unchanged}NA21224847
KEAP1hsa-miR-141-3pOncomiRDBexternal_infoNANA23045278
ACVR2Bhsa-miR-141-3pOncomiRDBexternal_infoNANA22431721
NR0B2hsa-miR-141-3pOncomiRDBexternal_infoNANA22314666
MAPK14hsa-miR-141-3pOncomiRDBexternal_infoNANA22101765
ZEB2hsa-miR-141-3pMirecordsexternal_info{changed}NA18925646
YAP1hsa-miR-141-3pOncomiRDBexternal_infoNANA21289630
BRD3hsa-miR-141-3pOncomiRDBexternal_infoNANA20053927
ZEB2hsa-miR-141-3pOncomiRDBexternal_infoNANA19830559
TGFB2hsa-miR-141-3pOncomiRDBexternal_infoNANA18483486

Predicted Targets
Summary Value
Count of predictions:32852
Count of gene targets:10942
Count of transcripts:22762
Interacting mature miRNAs:hsa-miR-141-3p, hsa-miR-141-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2 14 1
Low 113 13 146 4 24 8 116 13 77 22 136 191 7 10 59 2
Below cutoff 138 44 110 9 44 1 165 40 94 14 45 87 8 20 92

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384975
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,964,097 - 6,964,191 (+)Ensembl
RefSeq Acc Id: NR_029682
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,964,097 - 6,964,191 (+)NCBI
GRCh37127,073,260 - 7,073,354 (+)RGD
Celera128,694,279 - 8,694,373 (+)RGD
HuRef126,931,725 - 6,931,819 (+)RGD
CHM1_1127,072,213 - 7,072,307 (+)NCBI
T2T-CHM13v2.0126,977,572 - 6,977,666 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31528 AgrOrtholog
COSMIC MIR141 COSMIC
Ensembl Genes ENSG00000207708 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384975 ENTREZGENE
GTEx ENSG00000207708 GTEx
HGNC ID HGNC:31528 ENTREZGENE
Human Proteome Map MIR141 Human Proteome Map
miRBase MI0000457 ENTREZGENE
NCBI Gene 406933 ENTREZGENE
OMIM 612093 OMIM
PharmGKB PA164722490 PharmGKB
RNAcentral URS000003E1A9 RNACentral
  URS000055E199 RNACentral
  URS000075ECD7 RNACentral