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Gene: CYP7B1 (cytochrome P450 family 7 subfamily B member 1) Homo sapiens
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Symbol: CYP7B1
Name: cytochrome P450 family 7 subfamily B member 1
Description: Predicted to have oxysterol 7-alpha-hydroxylase activity. Predicted to be involved in B cell chemotaxis; bile acid biosynthetic process; and cholesterol homeostasis. Predicted to localize to endoplasmic reticulum membrane. Implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 24-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; CBAS3; CP7B; cytochrome P450 7B1; cytochrome P450, family 7, subfamily B, polypeptide 1; cytochrome p450, subfamily 7b, polypeptide 1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1; oxysterol 7-alpha-hydroxylase; oxysterol 7alpha-hydroxylase; spastic paraplegia 5A (autosomal recessive); SPG5A
Orthologs:
Mus musculus (house mouse) : Cyp7b1 (cytochrome P450, family 7, subfamily b, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyp7b1 (cytochrome P450 family 7 subfamily B member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102022645 (25-hydroxycholesterol 7-alpha-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)
Canis lupus familiaris (dog) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101955077 (25-hydroxycholesterol 7-alpha-hydroxylase)
Sus scrofa (pig) : LOC100738003 (25-hydroxycholesterol 7-alpha-hydroxylase-like)
Chlorocebus sabaeus (African green monkey) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)
Heterocephalus glaber (naked mole-rat) : LOC101721563 (25-hydroxycholesterol 7-alpha-hydroxylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl864,587,763 - 64,798,737 (-)EnsemblGRCh38hg38GRCh38
GRCh38864,586,575 - 64,798,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37865,508,529 - 65,711,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36865,671,246 - 65,873,902 (-)NCBINCBI36hg18NCBI36
Build 34865,671,245 - 65,873,902NCBI
Celera861,498,536 - 61,701,760 (-)NCBI
Cytogenetic Map8q12.3NCBI
HuRef860,998,772 - 61,201,422 (-)NCBIHuRef
CHM1_1865,562,219 - 65,765,057 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CYP7B1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735270
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-04-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.