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ONTOLOGY REPORT - ANNOTATIONS


Term:MeIQx
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Accession:CHEBI:76604 term browser browse the term
Definition:An imidazoquinoxaline that is 3H-imidazo[4,5-f]quinoxaline substituted at positions 3 and 8 by methyl groups and at position 2 by an amino group. A mutagenic compound found in cooked beef.
Synonyms:exact_synonym: 3,8-dimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine
 related_synonym: 2-Amino-3,8-dimethyl-3H-imidazo(4,5-f)quinoxaline;   2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline;   8-MeIQX;   8-Methyl-IQX;   Formula=C11H11N5;   InChI=1S/C11H11N5/c1-6-5-13-7-3-4-8-10(9(7)14-6)15-11(12)16(8)2/h3-5H,1-2H3,(H2,12,15);   InChIKey=DVCCCQNKIYNAKB-UHFFFAOYSA-N;   SMILES=Cc1cnc2ccc3n(C)c(N)nc3c2n1
 xref: Beilstein:4188271 "ChemIDplus";   CAS:77500-04-0 "ChemIDplus";   CAS:77500-04-0 "KEGG COMPOUND";   HMDB:HMDB0029864;   KEGG:C19255
 xref_mesh: MESH:C036990
 xref: PMID:22138251 "Europe PMC";   PMID:23600962 "Europe PMC";   PMID:23624435 "Europe PMC";   PMID:23681119 "Europe PMC";   PMID:23810796 "Europe PMC";   PMID:23862679 "Europe PMC";   PMID:23898916 "Europe PMC";   PMID:24168237 "Europe PMC";   PMID:24200580 "Europe PMC";   Reaxys:4188271 "Reaxys"


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MeIQx term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc9 ATP binding cassette subfamily C member 9 JBrowse link 4 176,806,098 176,928,540 RGD:6480464
G Abcd3 ATP binding cassette subfamily D member 3 JBrowse link 2 225,335,708 225,389,120 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Acss1 acyl-CoA synthetase short-chain family member 1 JBrowse link 3 146,420,346 146,470,293 RGD:6480464
G Adora2b adenosine A2B receptor JBrowse link 10 48,569,563 48,586,366 RGD:6480464
G Adss adenylosuccinate synthase JBrowse link 13 95,913,426 95,943,761 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 JBrowse link 10 47,490,168 47,499,855 RGD:6480464
G Anln anillin, actin binding protein JBrowse link 8 23,336,455 23,397,122 RGD:6480464
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:6480464
G Arg1 arginase 1 JBrowse link 1 21,525,421 21,537,872 RGD:6480464
G Arnt aryl hydrocarbon receptor nuclear translocator JBrowse link 2 196,594,178 196,651,486 RGD:6480464
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 JBrowse link 7 104,670,076 104,951,090 RGD:6480464
G Atp11b ATPase phospholipid transporting 11B (putative) JBrowse link 2 122,337,757 122,445,090 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G C1qtnf7 C1q and TNF related 7 JBrowse link 14 72,011,518 72,122,257 RGD:6480464
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ccdc47 coiled-coil domain containing 47 JBrowse link 10 94,388,425 94,406,949 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6480464
G Ccl7 C-C motif chemokine ligand 7 JBrowse link 10 69,423,083 69,424,933 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Ccnb2 cyclin B2 JBrowse link 8 76,847,972 76,861,165 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6480464
G Ccr2 C-C motif chemokine receptor 2 RGD:6480464
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:6480464
G Cdc25c cell division cycle 25C JBrowse link 18 27,528,768 27,550,316 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdk13 cyclin-dependent kinase 13 JBrowse link 17 49,833,194 49,922,932 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Cep55 centrosomal protein 55 JBrowse link 1 256,745,251 256,760,794 RGD:6480464
G Cfap45 cilia and flagella associated protein 45 JBrowse link 13 90,909,551 90,932,958 RGD:6480464
G Cfhr2 complement factor H-related 2 JBrowse link 13 56,641,657 56,713,305 RGD:6480464
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:6480464
G Cldn14 claudin 14 JBrowse link 11 34,132,581 34,142,813 RGD:6480464
G Clybl citrate lyase beta like JBrowse link 15 108,608,203 108,838,222 RGD:6480464
G Col9a2 collagen type IX alpha 2 chain JBrowse link 5 139,962,684 139,979,865 RGD:6480464
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 JBrowse link 16 22,704,318 23,075,071 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 JBrowse link 1 83,653,248 83,662,118 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 JBrowse link 2 102,701,903 102,871,257 RGD:6480464
G Dapl1 death associated protein-like 1 JBrowse link 3 45,538,408 45,559,281 RGD:6480464
G Ddx42 DEAD-box helicase 42 JBrowse link 10 94,407,094 94,439,052 RGD:6480464
G Dhrs2 dehydrogenase/reductase 2 JBrowse link 15 33,876,701 33,891,559 RGD:6480464
G Diaph3 diaphanous-related formin 3 JBrowse link 15 69,928,507 70,400,077 RGD:6480464
G Dmxl2 Dmx-like 2 JBrowse link 8 58,932,575 59,077,788 RGD:6480464
G Duox2 dual oxidase 2 JBrowse link 3 114,218,187 114,237,808 RGD:6480464
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:6480464
G E2f7 E2F transcription factor 7 JBrowse link 7 53,275,659 53,318,261 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Eps8l3 EPS8 like 3 JBrowse link 2 210,668,249 210,681,930 RGD:6480464
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:6480464
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase JBrowse link X 72,018,373 72,034,140 RGD:6480464
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 JBrowse link 15 42,500,929 42,519,019 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Exo1 exonuclease 1 JBrowse link 13 93,936,989 93,962,749 RGD:6480464
G Fhit fragile histidine triad diadenosine triphosphatase JBrowse link 15 15,697,292 16,862,873 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Fsd1 fibronectin type III and SPRY domain containing 1 JBrowse link 9 11,076,670 11,080,190 RGD:6480464
G Gabpb1 GA binding protein transcription factor subunit beta 1 JBrowse link 3 119,091,739 119,135,391 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G Gjc3 gap junction protein, gamma 3 JBrowse link 12 19,166,074 19,177,701 RGD:6480464
G Gnat1 G protein subunit alpha transducin 1 JBrowse link 8 116,433,302 116,438,038 RGD:6480464
G Gnmt glycine N-methyltransferase JBrowse link 9 16,565,274 16,568,626 RGD:6480464
G Gpatch1 G patch domain containing 1 JBrowse link 1 91,529,096 91,578,032 RGD:6480464
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) JBrowse link 5 166,994,683 167,030,441 RGD:6480464
G Hipk3 homeodomain interacting protein kinase 3 JBrowse link 3 94,349,778 94,419,185 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hprt1 hypoxanthine phosphoribosyltransferase 1 JBrowse link X 158,196,640 158,228,815 RGD:6480464
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il36b interleukin 36, beta JBrowse link 3 1,366,123 1,464,851 RGD:6480464
G Il3ra interleukin 3 receptor subunit alpha JBrowse link 12 18,534,762 18,542,508 RGD:6480464
G Impg2 interphotoreceptor matrix proteoglycan 2 JBrowse link 11 46,615,091 46,693,565 RGD:6480464
G Incenp inner centromere protein JBrowse link 1 225,923,448 225,953,384 RGD:6480464
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Kcnv1 potassium voltage-gated channel modifier subfamily V member 1 JBrowse link 7 84,016,864 84,023,205 RGD:6480464
G Kctd2 potassium channel tetramerization domain containing 2 JBrowse link 10 103,972,700 103,984,398 RGD:6480464
G Kif1b kinesin family member 1B JBrowse link 5 165,994,803 166,133,497 RGD:6480464
G Kifc1 kinesin family member C1 JBrowse link 20 5,509,059 5,526,175 RGD:6480464
G Klf1 Kruppel like factor 1 JBrowse link 19 26,016,289 26,019,557 RGD:6480464
G Klf6 Kruppel-like factor 6 JBrowse link 17 67,887,939 67,945,052 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Lama1 laminin subunit alpha 1 JBrowse link 9 115,916,907 116,042,123 RGD:6480464
G Lif LIF, interleukin 6 family cytokine JBrowse link 14 84,482,652 84,500,574 RGD:6480464
G LOC100911204 protein CASC5-like JBrowse link 3 112,531,429 112,560,698 RGD:6480464
G Lrrc58 leucine rich repeat containing 58 JBrowse link 11 65,747,235 65,759,558 RGD:6480464
G Ltf lactotransferrin JBrowse link 8 119,290,416 119,313,261 RGD:6480464
G Mat2a methionine adenosyltransferase 2A JBrowse link 4 100,297,478 100,303,047 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Mt-cyb mitochondrially encoded cytochrome b JBrowse link MT 14,136 15,278 RGD:6480464
G Nat2 N-acetyltransferase 2 JBrowse link 16 23,960,709 23,991,570 RGD:6480464
G Nek2 NIMA-related kinase 2 JBrowse link 13 110,511,546 110,524,750 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:6480464
G Nmu neuromedin U JBrowse link 14 34,353,683 34,381,968 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 5 151,776,004 151,779,319 RGD:6480464
G Oat ornithine aminotransferase JBrowse link 1 204,562,289 204,582,070 RGD:6480464
G Orc1 origin recognition complex, subunit 1 JBrowse link 5 128,186,651 128,212,901 RGD:6480464
G Pdzd7 PDZ domain containing 7 JBrowse link 1 264,776,393 264,796,206 RGD:6480464
G Pgm5 phosphoglucomutase 5 JBrowse link 1 242,582,591 242,765,837 RGD:6480464
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase JBrowse link X 15,462,621 15,467,890 RGD:6480464
G Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 JBrowse link 3 11,592,156 11,597,513 RGD:6480464
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:6480464
G Prss21 serine protease 21 JBrowse link 10 13,214,343 13,219,994 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rab7b Rab7b, member RAS oncogene family JBrowse link 13 48,456,143 48,483,714 RGD:6480464
G Rad18 RAD18 E3 ubiquitin protein ligase JBrowse link 4 144,537,329 144,620,606 RGD:6480464
G Rad23b RAD23 homolog B, nucleotide excision repair protein JBrowse link 5 72,103,704 72,141,701 RGD:6480464
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:6480464
G Rad51ap1 RAD51 associated protein 1 JBrowse link 4 159,469,803 159,482,869 RGD:6480464
G Rad54l RAD54 like JBrowse link 5 134,948,511 134,978,125 RGD:6480464
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:6480464
G Rbbp6 RB binding protein 6, ubiquitin ligase JBrowse link 1 192,933,264 192,965,160 RGD:6480464
G Rnf125 ring finger protein 125 JBrowse link 18 15,193,226 15,225,454 RGD:6480464
G Rnf186 ring finger protein 186 JBrowse link 5 157,416,897 157,418,121 RGD:6480464
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:6480464
G Rrm2 ribonucleotide reductase regulatory subunit M2 JBrowse link 6 43,884,627 43,890,818 RGD:6480464
G Serpini2 serpin family I member 2 JBrowse link 2 173,640,385 173,670,790 RGD:6480464
G Shcbp1 SHC binding and spindle associated 1 JBrowse link 16 90,613,826 90,642,683 RGD:6480464
G Slc15a1 solute carrier family 15 member 1 JBrowse link 15 106,800,081 106,844,668 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc22a3 solute carrier family 22 member 3 JBrowse link 1 48,433,079 48,521,261 RGD:6480464
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:6480464
G Smyd3 SET and MYND domain containing 3 JBrowse link 13 97,330,120 97,807,813 RGD:6480464
G Tas2r120 taste receptor, type 2, member 120 JBrowse link 4 166,833,320 166,834,207 RGD:6480464
G Tbc1d25 TBC1 domain family, member 25 JBrowse link X 15,064,733 15,088,579 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf9 TNF superfamily member 9 JBrowse link 9 9,909,942 9,912,276 RGD:6480464
G Top2a DNA topoisomerase II alpha JBrowse link 10 86,901,467 86,930,947 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Trappc9 trafficking protein particle complex 9 JBrowse link 7 113,986,363 114,309,090 RGD:6480464
G Trim63 tripartite motif containing 63 JBrowse link 5 152,533,362 152,547,138 RGD:6480464
G Trim72 tripartite motif containing 72 JBrowse link 1 199,450,042 199,457,902 RGD:6480464
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 JBrowse link 5 173,372,659 173,387,084 RGD:6480464
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6480464
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:6480464
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 JBrowse link 14 22,724,399 22,736,148 RGD:6480464
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 JBrowse link 9 10,738,211 10,758,403 RGD:6480464
G Vamp1 vesicle-associated membrane protein 1 JBrowse link 4 157,726,941 157,733,644 RGD:6480464
G Vil1 villin 1 JBrowse link 9 81,689,802 81,717,623 RGD:6480464
G Wasl WASP like actin nucleation promoting factor JBrowse link 4 51,677,722 51,726,212 RGD:6480464
G Yap1 yes-associated protein 1 JBrowse link 8 6,133,014 6,204,240 RGD:6480464
G Zfp799 zinc finger protein 799 JBrowse link 7 15,066,960 15,079,624 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        aetiopathogenetic role 18752
          genotoxin 16036
            MeIQx 164
              N-hydroxy-MeIQx 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        hydrogen molecular entity 19303
                          hydrides 18231
                            inorganic hydride 17095
                              pnictogen hydride 17053
                                nitrogen hydride 16874
                                  azane 16551
                                    ammonia 16548
                                      organic amino compound 16547
                                        aromatic amine 13576
                                          MeIQx 164
                                            N-hydroxy-MeIQx 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.