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Gene: RBBP6 (RB binding protein 6, ubiquitin ligase) Homo sapiens
Symbol: RBBP6
Name: RB binding protein 6, ubiquitin ligase
Description: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686P0638; DKFZp761B2423; E3 ubiquitin-protein ligase RBBP6; MY038; P2P-R; p53-associated cellular protein of testis; PACT; proliferation potential-related protein; RB-binding Q-protein 1; RBQ-1; retinoblastoma binding protein 6; retinoblastoma-binding protein 6; retinoblastoma-binding protein 6, isoform 3; retinoblastoma-binding Q protein 1; RING-type E3 ubiquitin transferase RBBP6; SNAMA
Mus musculus (house mouse) : Rbbp6 (retinoblastoma binding protein 6, ubiquitin ligase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rbbp6 (RB binding protein 6, ubiquitin ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rbbp6 (RB binding protein 6, ubiquitin ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : RBBP6 (RB binding protein 6, ubiquitin ligase)
Canis lupus familiaris (dog) : RBBP6 (RB binding protein 6, ubiquitin ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rbbp6 (RB binding protein 6, ubiquitin ligase)
Sus scrofa (pig) : RBBP6 (RB binding protein 6, ubiquitin ligase)
more info ...
Related Pseudogenes: RBBP6P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381624,539,566 - 24,572,863 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371624,550,866 - 24,584,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361624,458,409 - 24,491,685 (+)NCBINCBI36hg18NCBI36
Build 341624,458,408 - 24,468,222NCBI
Celera1623,328,786 - 23,362,062 (+)NCBI
Cytogenetic Map16p12.1NCBI
HuRef1622,641,252 - 22,674,528 (+)NCBIHuRef
CHM1_11625,564,378 - 25,597,648 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RBBP6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323690
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.