Gene: RBBP6 (RB binding protein 6, ubiquitin ligase) Homo sapiens
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Symbol:
RBBP6
Name:
RB binding protein 6, ubiquitin ligase
Description:
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
DKFZp686P0638; DKFZp761B2423; E3 ubiquitin-protein ligase RBBP6; MY038; P2P-R; p53-associated cellular protein of testis; PACT; proliferation potential-related protein; RB-binding Q-protein 1; RBQ-1; retinoblastoma binding protein 6; retinoblastoma-binding protein 6; retinoblastoma-binding protein 6, isoform 3; retinoblastoma-binding Q protein 1; RING-type E3 ubiquitin transferase RBBP6; SNAMA
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Rbbp6 (retinoblastoma binding protein 6, ubiquitin ligase) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Rbbp6 (RB binding protein 6, ubiquitin ligase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Rbbp6 (RB binding protein 6, ubiquitin ligase) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
RBBP6 (RB binding protein 6, ubiquitin ligase) NCBI
Ortholog
Canis lupus familiaris (dog):
RBBP6 (RB binding protein 6, ubiquitin ligase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Rbbp6 (RB binding protein 6, ubiquitin ligase) NCBI
Ortholog
Sus scrofa (pig):
RBBP6 (RB binding protein 6, ubiquitin ligase) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Rbbp6 (RB binding protein 6, ubiquitin ligase)
Alliance
DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Mus musculus (house mouse):
Rbbp6 (retinoblastoma binding protein 6, ubiquitin ligase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
zgc:174354
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
si:dkey-27d5.10
Alliance
DIOPT (Ensembl Compara, OrthoFinder, TreeFam)
Danio rerio (zebrafish):
zgc:174357
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
si:dkey-23f9.6
Alliance
DIOPT (Ensembl Compara, OrthoFinder, TreeFam)
Danio rerio (zebrafish):
si:dkey-23f9.12
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
zgc:77614
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
si:dkey-27d5.4
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
zgc:174353
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, Roundup)
Danio rerio (zebrafish):
si:dkey-23f9.7
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
rbbp6 (retinoblastoma binding protein 6)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam, ZFIN)
Danio rerio (zebrafish):
si:dkey-23f9.9
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
si:dkey-23f9.11
Alliance
DIOPT (Ensembl Compara, OrthoFinder, TreeFam)
Danio rerio (zebrafish):
si:busm1-37i06.3
Alliance
DIOPT (Ensembl Compara, OrthoFinder, TreeFam)
Danio rerio (zebrafish):
zgc:173948
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Danio rerio (zebrafish):
si:dkey-27d5.14
Alliance
DIOPT (OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
si:dkey-23f9.13
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
si:rp71-45g20.10
Alliance
DIOPT (Ensembl Compara, OrthoFinder, TreeFam)
Danio rerio (zebrafish):
si:dkey-23f9.8
Alliance
DIOPT (Ensembl Compara, OrthoFinder, TreeFam)
Danio rerio (zebrafish):
zgc:174355
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, Roundup, TreeFam)
Danio rerio (zebrafish):
si:rp71-45g20.4
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
si:dkey-27d5.5
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
MPE1
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
rbpl-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
snama
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Related Pseudogenes:
RBBP6P1
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 16 24,539,566 - 24,572,863 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 16 24,550,866 - 24,584,184 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 16 24,458,409 - 24,491,685 (+) NCBI NCBI36 hg18 NCBI36 Build 34 16 24,458,408 - 24,468,222 NCBI Celera 16 23,328,786 - 23,362,062 (+) NCBI Cytogenetic Map 16 p12.1 NCBI HuRef 16 22,641,252 - 22,674,528 (+) NCBI HuRef CHM1_1 16 25,564,378 - 25,597,648 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of RBBP6 mRNA CTD PMID:16949557 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of RBBP6 mRNA CTD PMID:12588870 (S)-nicotine multiple interactions EXP 6480464 alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] more ... CTD PMID:12588870 17alpha-ethynylestradiol affects expression ISO RGD:1323691 6480464 Ethinyl Estradiol affects the expression of RBBP6 mRNA CTD PMID:17555576 17alpha-ethynylestradiol decreases expression ISO RGD:1311964 6480464 Ethinyl Estradiol results in decreased expression of RBBP6 mRNA CTD PMID:29097150 17beta-estradiol multiple interactions EXP 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of RBBP6 mRNA CTD PMID:17404688 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of RBBP6 mRNA CTD PMID:19167446 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1323691 6480464 Tetrachlorodibenzodioxin results in increased expression of RBBP6 mRNA CTD PMID:21354282 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1323691 6480464 Tetrachlorodibenzodioxin affects the expression of RBBP6 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:1311964 6480464 2, 4-dinitrotoluene affects the expression of RBBP6 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1311964 6480464 2, 6-dinitrotoluene affects the expression of RBBP6 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression EXP 6480464 Lactic Acid results in decreased expression of RBBP6 mRNA CTD PMID:30851411 2-methylcholine affects expression EXP 6480464 beta-methylcholine affects the expression of RBBP6 mRNA CTD PMID:21179406 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1323691 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of RBBP6 mRNA CTD PMID:26251327 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1323691 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of RBBP6 mRNA CTD PMID:18648102 aflatoxin B1 increases expression ISO RGD:1323691 6480464 Aflatoxin B1 results in increased expression of RBBP6 mRNA CTD PMID:19770486 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of RBBP6 mRNA CTD PMID:21641981 antirheumatic drug increases expression EXP 6480464 Antirheumatic Agents results in increased expression of RBBP6 mRNA CTD PMID:24449571 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of RBBP6 mRNA CTD PMID:16934159 Aroclor 1254 decreases expression ISO RGD:1323691 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of RBBP6 mRNA CTD PMID:23650126 benzo[a]pyrene increases expression ISO RGD:1323691 6480464 Benzo(a)pyrene results in increased expression of RBBP6 mRNA CTD PMID:19770486 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of RBBP6 mRNA CTD PMID:20064835 more ... benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:20018196 benzo[a]pyrene diol epoxide I increases expression EXP 6480464 7 more ... CTD PMID:19150397 bisphenol A decreases methylation ISO RGD:1323691 6480464 bisphenol A results in decreased methylation of RBBP6 promoter CTD PMID:27312807 carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of RBBP6 mRNA CTD PMID:25979313 carbon nanotube decreases expression ISO RGD:1323691 6480464 Nanotubes, Carbon analog results in decreased expression of RBBP6 mRNA CTD PMID:25554681 carbon nanotube increases expression ISO RGD:1323691 6480464 Nanotubes, Carbon results in increased expression of RBBP6 mRNA CTD PMID:25620056 chloroprene increases expression ISO RGD:1311964 6480464 Chloroprene results in increased expression of RBBP6 mRNA CTD PMID:23125180 clobetasol decreases expression ISO RGD:1323691 6480464 Clobetasol results in decreased expression of RBBP6 mRNA CTD PMID:27462272 copper(II) sulfate increases expression EXP 6480464 Copper Sulfate results in increased expression of RBBP6 mRNA CTD PMID:19549813 crocidolite asbestos increases expression EXP 6480464 Asbestos, Crocidolite results in increased expression of RBBP6 mRNA CTD PMID:18687144 , PMID:25351596 CU-O LINKAGE increases expression EXP 6480464 cupric oxide results in increased expression of RBBP6 mRNA CTD PMID:22077320 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of RBBP6 mRNA CTD PMID:25562108 daunorubicin increases expression EXP 6480464 Daunorubicin results in increased expression of RBBP6 mRNA CTD PMID:12656675 dibutyl phthalate increases expression ISO RGD:1311964 6480464 Dibutyl Phthalate results in increased expression of RBBP6 mRNA CTD PMID:21266533 disodium selenite affects expression EXP 6480464 Sodium Selenite affects the expression of RBBP6 mRNA CTD PMID:16705456 diuron decreases expression ISO RGD:1311964 6480464 Diuron results in decreased expression of RBBP6 mRNA CTD PMID:21551480 , PMID:25152437 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RBBP6 mRNA CTD PMID:27188386 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of RBBP6 mRNA CTD PMID:29803840 elemental selenium decreases expression EXP 6480464 Selenium results in decreased expression of RBBP6 mRNA CTD PMID:19244175 elemental selenium multiple interactions EXP 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of RBBP6 mRNA CTD PMID:19244175 enzyme inhibitor multiple interactions EXP 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RBBP6 protein CTD PMID:23301498 ethanol affects expression ISO RGD:1323691 6480464 Ethanol affects the expression of RBBP6 mRNA CTD PMID:30319688 formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of RBBP6 mRNA CTD PMID:17938736 gentamycin increases expression ISO RGD:1311964 6480464 Gentamicins results in increased expression of RBBP6 mRNA CTD PMID:22061828 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of RBBP6 mRNA CTD PMID:20044591 ketamine increases expression ISO RGD:1311964 6480464 Ketamine results in increased expression of RBBP6 mRNA CTD PMID:20080153 leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of RBBP6 mRNA CTD PMID:28988120 Mecamylamine multiple interactions EXP 6480464 Mecamylamine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] CTD PMID:12588870 MeIQx decreases expression EXP 6480464 2-amino-3 more ... CTD PMID:20816883 menadione affects expression EXP 6480464 Vitamin K 3 affects the expression of RBBP6 mRNA CTD PMID:20044591 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of RBBP6 mRNA CTD PMID:28001369 miconazole decreases expression ISO RGD:1323691 6480464 Miconazole results in decreased expression of RBBP6 mRNA CTD PMID:27462272 N-methyl-4-phenylpyridinium affects expression EXP 6480464 1-Methyl-4-phenylpyridinium affects the expression of RBBP6 mRNA CTD PMID:12710931 N-methyl-4-phenylpyridinium increases expression ISO RGD:1323691 6480464 1-Methyl-4-phenylpyridinium results in increased expression of RBBP6 protein CTD PMID:26558463 N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of RBBP6 mRNA] CTD PMID:12710931 nicotine increases expression EXP 6480464 Nicotine results in increased expression of RBBP6 mRNA CTD PMID:16949557 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of RBBP6 mRNA CTD PMID:12588870 nicotine multiple interactions EXP 6480464 alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] more ... CTD PMID:12588870 nitric oxide decreases expression ISO RGD:1323691 6480464 Nitric Oxide deficiency results in decreased expression of RBBP6 mRNA CTD PMID:15878706 ochratoxin A decreases expression ISO RGD:1311964 6480464 ochratoxin A results in decreased expression of RBBP6 mRNA CTD PMID:22124623 ochratoxin A increases expression ISO RGD:1311964 6480464 ochratoxin A results in increased expression of RBBP6 mRNA CTD PMID:17483316 p-menthan-3-ol increases expression EXP 6480464 Menthol results in increased expression of RBBP6 mRNA CTD PMID:26760959 phenethyl isothiocyanate decreases expression ISO RGD:1311964 6480464 phenethyl isothiocyanate results in decreased expression of RBBP6 mRNA CTD PMID:17616710 phenobarbital affects expression ISO RGD:1323691 6480464 Phenobarbital affects the expression of RBBP6 mRNA CTD PMID:23091169 progesterone multiple interactions EXP 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of RBBP6 mRNA CTD PMID:17404688 quercetin increases expression EXP 6480464 Quercetin results in increased expression of RBBP6 mRNA CTD PMID:21632981 rac-lactic acid decreases expression EXP 6480464 Lactic Acid results in decreased expression of RBBP6 mRNA CTD PMID:30851411 rotenone increases expression EXP 6480464 Rotenone results in increased expression of RBBP6 mRNA CTD PMID:29331484 S-butyl-DL-homocysteine (S,R)-sulfoximine decreases expression ISO RGD:1323691 6480464 Buthionine Sulfoximine results in decreased expression of RBBP6 mRNA CTD PMID:15878706 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RBBP6 mRNA CTD PMID:27188386 selenium atom decreases expression EXP 6480464 Selenium results in decreased expression of RBBP6 mRNA CTD PMID:19244175 selenium atom multiple interactions EXP 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of RBBP6 mRNA CTD PMID:19244175 silicon dioxide decreases expression ISO RGD:1323691 6480464 Silicon Dioxide results in decreased expression of RBBP6 mRNA CTD PMID:19073995 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of RBBP6 mRNA CTD PMID:25351596 silver atom increases expression EXP 6480464 Silver results in increased expression of RBBP6 mRNA CTD PMID:26014281 silver(0) increases expression EXP 6480464 Silver results in increased expression of RBBP6 mRNA CTD PMID:26014281 silver(1+) increases expression EXP 6480464 Silver results in increased expression of RBBP6 mRNA CTD PMID:26014281 sodium fluoride increases expression ISO RGD:1323691 6480464 Sodium Fluoride results in increased expression of RBBP6 mRNA CTD PMID:27862939 Soman increases expression ISO RGD:1311964 6480464 Soman results in increased expression of RBBP6 mRNA CTD PMID:19281266 succimer multiple interactions ISO RGD:1323691 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of RBBP6 mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of RBBP6 mRNA CTD PMID:21641980 , PMID:26378955 tamoxifen affects expression ISO RGD:1323691 6480464 Tamoxifen affects the expression of RBBP6 mRNA CTD PMID:17555576 tetrachloromethane affects expression ISO RGD:1323691 6480464 Carbon Tetrachloride affects the expression of RBBP6 mRNA CTD PMID:17484886 tetraphene increases expression ISO RGD:1323691 6480464 benz(a)anthracene results in increased expression of RBBP6 mRNA CTD PMID:26377693 torcetrapib increases expression EXP 6480464 torcetrapib results in increased expression of RBBP6 mRNA CTD PMID:23228038 trichostatin A decreases expression EXP 6480464 trichostatin A results in decreased expression of RBBP6 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A affects expression EXP 6480464 trichostatin A affects the expression of RBBP6 mRNA CTD PMID:28542535 trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RBBP6 mRNA CTD PMID:27188386 tubocurarine multiple interactions EXP 6480464 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] CTD PMID:12588870 urethane increases expression EXP 6480464 Urethane results in increased expression of RBBP6 mRNA CTD PMID:28818685 ursodeoxycholic acid affects expression EXP 6480464 Ursodeoxycholic Acid affects the expression of RBBP6 mRNA CTD PMID:18422935 valdecoxib increases expression ISO RGD:1311964 6480464 valdecoxib results in increased expression of RBBP6 mRNA CTD PMID:24136188 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of RBBP6 mRNA CTD PMID:25979313 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of RBBP6 mRNA CTD PMID:23179753 more ... vinclozolin increases expression ISO RGD:1311964 6480464 vinclozolin results in increased expression of RBBP6 mRNA CTD PMID:20566332 vinclozolin decreases expression ISO RGD:1311964 6480464 vinclozolin results in decreased expression of RBBP6 mRNA CTD PMID:18042343 vitamin E decreases expression EXP 6480464 Vitamin E results in decreased expression of RBBP6 mRNA CTD PMID:19244175 vitamin E multiple interactions EXP 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of RBBP6 mRNA CTD PMID:19244175 zinc atom multiple interactions EXP 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of RBBP6 mRNA CTD PMID:18593933 zinc(0) multiple interactions EXP 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of RBBP6 mRNA CTD PMID:18593933
Gene Ontology Annotations
Gene Ontology Annotations
