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Gene: RBBP6 (RB binding protein 6, ubiquitin ligase) Homo sapiens
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Symbol: RBBP6
Name: RB binding protein 6, ubiquitin ligase
Description: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686P0638; DKFZp761B2423; E3 ubiquitin-protein ligase RBBP6; MY038; P2P-R; p53-associated cellular protein of testis; PACT; proliferation potential-related protein; RB-binding Q-protein 1; RBQ-1; retinoblastoma binding protein 6; retinoblastoma-binding protein 6; retinoblastoma-binding protein 6, isoform 3; retinoblastoma-binding Q protein 1; RING-type E3 ubiquitin transferase RBBP6; SNAMA
Orthologs:
Mus musculus (house mouse) : Rbbp6 (retinoblastoma binding protein 6, ubiquitin ligase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rbbp6 (RB binding protein 6, ubiquitin ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rbbp6 (RB binding protein 6, ubiquitin ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : RBBP6 (RB binding protein 6, ubiquitin ligase)
Canis lupus familiaris (dog) : RBBP6 (RB binding protein 6, ubiquitin ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rbbp6 (RB binding protein 6, ubiquitin ligase)
Sus scrofa (pig) : RBBP6 (RB binding protein 6, ubiquitin ligase)
more info ...
Related Pseudogenes: RBBP6P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381624,539,566 - 24,572,863 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371624,550,866 - 24,584,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361624,458,409 - 24,491,685 (+)NCBINCBI36hg18NCBI36
Build 341624,458,408 - 24,468,222NCBI
Celera1623,328,786 - 23,362,062 (+)NCBI
Cytogenetic Map16p12.1NCBI
HuRef1622,641,252 - 22,674,528 (+)NCBIHuRef
CHM1_11625,564,378 - 25,597,648 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
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References - curated
References - uncurated
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Sequence

Nucleotide Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on RBBP6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323690
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.