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N(gamma)-nitro-L-arginine methyl ester - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N(gamma)-nitro-L-arginine methyl ester
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Accession:CHEBI:7549 term browser browse the term
Definition:An alpha-amino acid ester that is the methyl ester of N(gamma)-nitro-L-arginine.
Synonyms:exact_synonym: methyl N(5)-(N-nitrocarbamimidoyl)-L-ornithinate
 related_synonym: Arg(NO2)-OMe;   Formula=C7H15N5O4;   InChI=1S/C7H15N5O4/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15/h5H,2-4,8H2,1H3,(H3,9,10,11)/t5-/m0/s1;   InChIKey=KCWZGJVSDFYRIX-YFKPBYRVSA-N;   L-NAME;   N(5)-(Imino(nitroamino)methyl)-L-ornithine methyl ester;   N(G)-Nitro-L-arginine methyl ester;   N(G)-Nitroarginine methyl ester;   N-Nitroarginine methyl ester;   NG-Nitroarginine methyl ester;   Ngamma-Nitro-L-arginine methyl ester;   SMILES=[C@@H](CCCNC(N[N+](=O)[O-])=N)(N)C(OC)=O;   methyl N(gamma)-nitro-L-argininate
 xref: CAS:50903-99-6;   KEGG:C04337
 xref_mesh: MESH:D019331
 xref: PMID:20304164;   PMID:26510967;   PMID:26519026;   PMID:26551598;   PMID:26593708;   PMID:26606650;   PMID:26619941;   PMID:26698393;   PMID:26747502;   PMID:26753696;   PMID:26774228;   PMID:26836124;   PMID:26852741;   PMID:26888719;   Reaxys:1714622
 cyclic_relationship: is_conjugate_base_of CHEBI:131183

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N(gamma)-nitro-L-arginine methyl ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
increases activity 		EXP [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein] CTD PMID:32172062 PMID:32810514 PMID:34797181 PMID:37718616 PMID:38029875 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ache acetylcholinesterase increases expression
multiple interactions
increases activity 		EXP NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of ACHE protein] 		CTD PMID:32172062 PMID:32428650 PMID:32772714 PMID:32810514 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression 		ISO
EXP 		[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of ACTA2 mRNA]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of ACTA2 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of ACTA2 protein
bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACTA2 mRNA] 		CTD PMID:37718616 PMID:38282657 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ada adenosine deaminase multiple interactions
increases activity 		EXP [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein] CTD PMID:32172062 PMID:32428650 PMID:32810514 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adm adrenomedullin increases expression EXP NG-Nitroarginine Methyl Ester results in increased expression of ADM mRNA CTD PMID:16040721 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Agt angiotensinogen multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein] CTD PMID:15502880 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression
multiple interactions 		EXP NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein] 		CTD PMID:32479886 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule multiple interactions
decreases expression 		ISO ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of ALCAM protein] CTD PMID:34995009 NCBI chr11:61,804,932...62,005,250
Ensembl chr11:48,336,169...48,537,954 		JBrowse link
G Alkbh5 alkB homolog 5, RNA demethylase multiple interactions
increases expression
increases response to substance 		ISO ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of ALCAM protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of CTNNB1 protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of MYC protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of PPARG protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of VIM protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of WNT2 protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CDH1 protein]; ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ENG protein]
NG-Nitroarginine Methyl Ester results in increased expression of ALKBH5 protein
ALKBH5 protein results in increased susceptibility to NG-Nitroarginine Methyl Ester 		CTD PMID:34995009 NCBI chr10:45,844,411...45,865,853
Ensembl chr10:45,343,395...45,366,331 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of ATF3 protein CTD PMID:38282657 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases activity 		EXP [bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of BCHE protein] CTD PMID:32172062 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BECN1 protein; Berberine promotes the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BECN1 protein] CTD PMID:38705399 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BNIP3 protein; Berberine promotes the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BNIP3 protein] CTD PMID:38705399 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of and results in increased cleavage of CASP1 protein; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CASP1 mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of and results in increased cleavage of CASP1 protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CASP1 mRNA] CTD PMID:38705399 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression 		EXP [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [bisphenol A results in increased expression of CASP9 protein] CTD PMID:32172062 PMID:32428650 PMID:32810514 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions
decreases activity 		EXP bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of CAT protein]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of CAT protein] CTD PMID:37718616 PMID:38029875 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO 		[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]
[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CCL2 mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CCL2 mRNA] 		CTD PMID:29423081 PMID:38705399 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions 		ISO NG-Nitroarginine Methyl Ester results in increased expression of CDH1 protein
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CDH1 protein] 		CTD PMID:34995009 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Celf2 CUGBP, Elav-like family member 2 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CELF2 protein CTD PMID:38282657 NCBI chr17:75,813,928...76,639,300
Ensembl chr17:71,210,853...71,728,333 		JBrowse link
G Cpeb2 cytoplasmic polyadenylation element binding protein 2 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB2 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB2 protein] CTD PMID:38282657 NCBI chr14:71,999,958...72,056,012
Ensembl chr14:67,787,507...67,840,743 		JBrowse link
G Cpeb4 cytoplasmic polyadenylation element binding protein 4 multiple interactions ISO [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB4 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of CPEB4 protein CTD PMID:38282657 NCBI chr10:16,222,271...16,284,248
Ensembl chr10:15,717,794...15,780,603 		JBrowse link
G Cst3 cystatin C multiple interactions ISO [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CST3 protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CST3 protein] CTD PMID:38705399 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression 		ISO ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of CTNNB1 protein] CTD PMID:34995009 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression
multiple interactions 		EXP NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein] 		CTD PMID:32479886 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of DDIT3 mRNA]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of DDIT3 mRNA CTD PMID:38282657 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 mRNA]; [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 mRNA; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of EDEM3 protein CTD PMID:38282657 NCBI chr13:66,403,022...66,470,496
Ensembl chr13:63,858,716...63,920,523 		JBrowse link
G Edn1 endothelin 1 increases expression EXP NG-Nitroarginine Methyl Ester results in increased expression of EDN1 mRNA CTD PMID:16040721 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A multiple interactions
increases expression 		EXP Atrasentan inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of EDNRA mRNA] CTD PMID:34102242 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B decreases expression
multiple interactions 		EXP NG-Nitroarginine Methyl Ester results in decreased expression of EDNRB mRNA
Atrasentan inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of EDNRB mRNA] 		CTD PMID:34102242 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Eng endoglin increases expression
multiple interactions 		ISO NG-Nitroarginine Methyl Ester results in increased expression of ENG protein
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ENG protein] 		CTD PMID:34995009 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of FN1 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of FN1 protein CTD PMID:38282657 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions EXP NG-Nitroarginine Methyl Ester inhibits the reaction [Quinolinic Acid results in decreased activity of FYN protein] CTD PMID:17265464 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP NG-Nitroarginine Methyl Ester promotes the reaction [cupric nitrilotriacetate results in increased activity of GPT protein] CTD PMID:36305384 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity
multiple interactions 		EXP NG-Nitroarginine Methyl Ester results in decreased activity of GPX1 protein
bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of GPX1 protein] 		CTD PMID:38029875 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]] CTD PMID:28624453 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of HMGB1 protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of HMGB1 protein] CTD PMID:38705399 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of HSPA5 mRNA]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of HSPA5 mRNA CTD PMID:38282657 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 decreases activity
multiple interactions 		EXP NG-Nitroarginine Methyl Ester results in decreased activity of IDH1 protein
bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of IDH1 protein] 		CTD PMID:38029875 NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein] CTD PMID:29423081 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of IL1A mRNA] CTD PMID:32142722 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions 		EXP
ISO 		NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of IL1B protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of IL1B protein]
[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B mRNA; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B protein] 		CTD PMID:32172062 PMID:32428650 PMID:32810514 PMID:38705399 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		EXP
ISO 		[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL6 mRNA]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL6 protein]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]
NG-Nitroarginine Methyl Ester results in increased expression of IL6 mRNA; NG-Nitroarginine Methyl Ester results in increased expression of IL6 protein
[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL6 mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL6 mRNA] 		CTD PMID:29423081 PMID:37718616 PMID:38029875 PMID:38705399 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lama1 laminin subunit alpha 1 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of LAMA1 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of LAMA1 protein CTD PMID:38282657 NCBI chr 9:115,139,548...115,263,620
Ensembl chr 9:107,692,770...107,817,478 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions EXP NG-Nitroarginine Methyl Ester inhibits the reaction [Quinolinic Acid results in decreased activity of LYN protein] CTD PMID:17265464 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Maoa monoamine oxidase A increases expression
multiple interactions
increases activity 		EXP NG-Nitroarginine Methyl Ester results in increased expression of MAOA protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of MAOA protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of MAOA protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of MAOA protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of MAOA protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of MAOA protein] 		CTD PMID:32172062 PMID:32428650 PMID:32810514 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP NG-Nitroarginine Methyl Ester results in decreased expression of MCL1 mRNA CTD PMID:36260529 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mdh2 malate dehydrogenase 2 multiple interactions
decreases activity 		EXP bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of MDH2 protein] CTD PMID:38029875 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
G Mir377 microRNA 377 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR377]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR377 CTD PMID:38282657 NCBI chr 6:134,576,456...134,576,527 JBrowse link
G Mir494 microRNA 494 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR494]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of MIR494 CTD PMID:38282657 NCBI chr 6:134,550,115...134,550,197
Ensembl chr 6:128,728,709...128,728,793 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [Dibutyl Phthalate results in increased activity of MMP2 protein] CTD PMID:38944327 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]] CTD PMID:33301711 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions 		ISO NG-Nitroarginine Methyl Ester results in decreased expression of MYC protein
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of MYC protein] 		CTD PMID:34995009 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions EXP NG-Nitroarginine Methyl Ester inhibits the reaction [Arginine inhibits the reaction [Indomethacin results in increased expression of NFKBIB mRNA]] CTD PMID:37483153 NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 mRNA; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 protein] CTD PMID:38705399 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; NG-Nitroarginine Methyl Ester inhibits the reaction [Arginine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein] CTD PMID:29423081 PMID:37483153 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
multiple interactions 		ISO
EXP 		NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein
[Folic Acid co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of NOS3 protein
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein] 		CTD PMID:28624453 PMID:32479886 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A increases expression EXP NG-Nitroarginine Methyl Ester results in increased expression of NPPA mRNA CTD PMID:16040721 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B increases expression EXP NG-Nitroarginine Methyl Ester results in increased expression of NPPB mRNA CTD PMID:16040721 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Ogdh oxoglutarate dehydrogenase decreases activity
multiple interactions 		EXP NG-Nitroarginine Methyl Ester results in decreased activity of OGDH protein
bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of OGDH protein] 		CTD PMID:37718616 PMID:38029875 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Panx3 pannexin 3 multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of PANX3 mRNA] CTD PMID:32142722 NCBI chr 8:45,554,474...45,566,378
Ensembl chr 8:37,366,862...37,377,640 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein] CTD PMID:15502880 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pde5a phosphodiesterase 5A increases activity
multiple interactions 		EXP NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein] 		CTD PMID:32172062 PMID:32428650 PMID:32810514 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression 		ISO ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of PPARG protein] CTD PMID:34995009 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP 		NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]]; NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]
NG-Nitroarginine Methyl Ester inhibits the reaction [Arginine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]] 		CTD PMID:28624453 PMID:37483153 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of PYCARD mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of PYCARD mRNA] CTD PMID:38705399 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Ramp2 receptor activity modifying protein 2 increases expression EXP NG-Nitroarginine Methyl Ester results in increased expression of RAMP2 mRNA CTD PMID:16040721 NCBI chr10:86,689,148...86,690,956
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Ramp3 receptor activity modifying protein 3 increases expression EXP NG-Nitroarginine Methyl Ester results in increased expression of RAMP3 mRNA CTD PMID:16040721 NCBI chr14:85,741,314...85,758,813
Ensembl chr14:81,527,385...81,544,902 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions
decreases activity 		EXP bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of SDHA protein] CTD PMID:38029875 NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase decreases expression EXP NG-Nitroarginine Methyl Ester results in decreased expression of SETD2 mRNA alternative form CTD PMID:36260529 NCBI chr 8:119,390,207...119,475,863
Ensembl chr 8:110,511,772...110,597,489 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD2 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD2 protein CTD PMID:38282657 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD3 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD3 protein CTD PMID:38282657 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases activity 		EXP bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of SOD1 protein] CTD PMID:38029875 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spn sialophorin multiple interactions
increases expression 		EXP [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein] CTD PMID:32172062 PMID:32428650 NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [Berberine co-treated with Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of SQSTM1 protein CTD PMID:38705399 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP NG-Nitroarginine Methyl Ester inhibits the reaction [Quinolinic Acid results in decreased activity of SRC protein] CTD PMID:17265464 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression 		EXP Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein] CTD PMID:32479886 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tbxa2r thromboxane A2 receptor increases expression EXP NG-Nitroarginine Methyl Ester results in increased expression of TBXA2R mRNA CTD PMID:34102242 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:8,383,378...8,388,176 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TGFB1 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TGFB1 protein CTD PMID:38282657 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Th tyrosine hydroxylase decreases expression ISO NG-Nitroarginine Methyl Ester results in decreased expression of TH protein CTD PMID:31187328 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		EXP
ISO 		[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF mRNA]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]
NG-Nitroarginine Methyl Ester results in increased expression of TNF mRNA; NG-Nitroarginine Methyl Ester results in increased expression of TNF protein
[NG-Nitroarginine Methyl Ester co-treated with TNF protein] results in increased secretion of VWF protein
[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of TNF mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of TNF mRNA] 		CTD PMID:29423081 PMID:30529211 PMID:32172062 PMID:32428650 PMID:32810514 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions 		EXP NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein
[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of TP53 protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of TP53 protein] 		CTD PMID:32172062 PMID:32428650 PMID:32810514 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases response to substance ISO TRPA1 gene mutant form results in decreased susceptibility to NG-Nitroarginine Methyl Ester CTD PMID:32634517 NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein] CTD PMID:29423081 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vim vimentin multiple interactions
decreases expression 		ISO ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of VIM protein] CTD PMID:34995009 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [NG-Nitroarginine Methyl Ester co-treated with TNF protein] results in increased secretion of VWF protein CTD PMID:34678311 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
G Wnt2 Wnt family member 2 decreases expression
multiple interactions 		ISO NG-Nitroarginine Methyl Ester results in decreased expression of WNT2 protein
ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of WNT2 protein] 		CTD PMID:34995009 NCBI chr 4:47,294,300...47,340,284
Ensembl chr 4:46,333,998...46,374,402 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      application 20617
        fuel 11499
          methanol 4013
            methyl ester 3958
              N(gamma)-nitro-L-arginine methyl ester 86
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    main group molecular entity 20777
                      s-block molecular entity 20573
                        hydrogen molecular entity 20557
                          hydrides 19691
                            inorganic hydride 18601
                              pnictogen hydride 18587
                                nitrogen hydride 18502
                                  azane 18261
                                    ammonia 18260
                                      organic amino compound 18260
                                        amino acid 16329
                                          alpha-amino acid 14212
                                            L-alpha-amino acid 12357
                                              glutamine family amino acid 10351
                                                L-arginine 125
                                                  L-arginine derivative 101
                                                    N(gamma)-nitro-L-arginine methyl ester 86
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