|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions increases expression |
EXP |
Nicotine promotes the reaction [Arginine results in increased expression of ACTA2 protein] |
CTD |
PMID:34153408 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression |
ISO |
coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of BCL2 protein]]; limonin inhibits the reaction [Arginine results in increased expression of BCL2 mRNA]; limonin inhibits the reaction [Arginine results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Arginine results in increased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Arginine results in increased expression of BCL2 protein] Arginine results in increased expression of BCL2 mRNA; Arginine results in increased expression of BCL2 protein |
CTD |
PMID:34423886 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
Arginine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form] |
CTD |
PMID:32135237 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Cat |
catalase |
decreases activity multiple interactions |
EXP ISO |
Arginine results in decreased activity of CAT protein Arginine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein] Carvedilol inhibits the reaction [Arginine results in decreased activity of CAT protein] |
CTD |
PMID:32135237 PMID:32569593 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases secretion |
ISO |
coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of CCL2 protein]]; limonin inhibits the reaction [Arginine results in increased secretion of CCL2 protein]; Resveratrol inhibits the reaction [Arginine results in increased secretion of CCL2 protein] |
CTD |
PMID:34423886 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Ccnd1 |
cyclin D1 |
increases expression multiple interactions |
ISO |
Arginine results in increased expression of CCND1 mRNA; Arginine results in increased expression of CCND1 protein coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of CCND1 protein]]; limonin inhibits the reaction [Arginine results in increased expression of CCND1 mRNA]; limonin inhibits the reaction [Arginine results in increased expression of CCND1 protein]; Resveratrol inhibits the reaction [Arginine results in increased expression of CCND1 mRNA]; Resveratrol inhibits the reaction [Arginine results in increased expression of CCND1 protein] |
CTD |
PMID:34423886 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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|
G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions increases expression |
EXP |
Nicotine promotes the reaction [Arginine results in increased expression of COL1A2 protein] |
CTD |
PMID:34153408 |
|
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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|
G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions increases expression |
EXP |
Nicotine promotes the reaction [Arginine results in increased expression of COL3A1 protein] |
CTD |
PMID:34153408 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
|
|
G |
Crp |
C-reactive protein |
multiple interactions increases expression |
EXP |
Carvedilol inhibits the reaction [Arginine results in increased expression of CRP protein] |
CTD |
PMID:32569593 |
|
NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
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|
G |
Ddah2 |
dimethylarginine dimethylaminohydrolase 2 |
multiple interactions |
ISO |
Arginine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; Arginine inhibits the reaction [Iron-Dextran Complex results in decreased expression of DDAH2 protein] |
CTD |
PMID:32135237 |
|
NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
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|
G |
Egf |
epidermal growth factor |
multiple interactions |
EXP |
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine] |
CTD |
PMID:22689575 |
|
NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
Arginine results in increased expression of HMOX1 protein coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of HMOX1 protein]]; limonin inhibits the reaction [Arginine results in increased expression of HMOX1 protein]; Resveratrol inhibits the reaction [Arginine results in increased expression of HMOX1 protein] |
CTD |
PMID:34423886 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions increases secretion |
EXP ISO |
Arginine results in increased expression of IL1B protein coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of IL1B protein]]; limonin inhibits the reaction [Arginine results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Arginine results in increased secretion of IL1B protein] Carvedilol inhibits the reaction [Arginine results in increased expression of IL1B protein] |
CTD |
PMID:32569593 PMID:34423886 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il6 |
interleukin 6 |
multiple interactions increases secretion |
ISO |
coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of IL6 protein]]; limonin inhibits the reaction [Arginine results in increased secretion of IL6 protein]; Resveratrol inhibits the reaction [Arginine results in increased secretion of IL6 protein] |
CTD |
PMID:34423886 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Jak2 |
Janus kinase 2 |
multiple interactions increases expression |
ISO |
coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of JAK2 protein]]; limonin inhibits the reaction [Arginine results in increased expression of JAK2 protein]; Resveratrol inhibits the reaction [Arginine results in increased expression of JAK2 protein] |
CTD |
PMID:34423886 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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|
G |
Mpo |
myeloperoxidase |
increases expression multiple interactions |
EXP |
Arginine results in increased expression of MPO protein Carvedilol inhibits the reaction [Arginine results in increased expression of MPO protein] |
CTD |
PMID:32569593 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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|
G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Arginine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein] |
CTD |
PMID:32135237 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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|
G |
Ptafr |
platelet-activating factor receptor |
multiple interactions increases expression |
EXP |
Carvedilol inhibits the reaction [Arginine results in increased expression of PTAFR mRNA] |
CTD |
PMID:32569593 |
|
NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251
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G |
Reg3b |
regenerating family member 3 beta |
multiple interactions increases expression |
EXP |
Carvedilol inhibits the reaction [Arginine results in increased expression of REG3B mRNA] |
CTD |
PMID:32569593 |
|
NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
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|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases expression |
EXP |
Carvedilol inhibits the reaction [Arginine results in increased expression of RELA protein] |
CTD |
PMID:32569593 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Stat1 |
signal transducer and activator of transcription 1 |
increases expression multiple interactions |
EXP |
Arginine results in increased expression of STAT1 protein Carvedilol inhibits the reaction [Arginine results in increased expression of STAT1 protein] |
CTD |
PMID:32569593 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions increases phosphorylation |
ISO |
coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased phosphorylation of STAT3 protein]]; limonin inhibits the reaction [Arginine results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Arginine results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:34423886 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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|
G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions increases secretion |
EXP ISO |
Arginine results in increased expression of TNF protein coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of TNF protein]]; limonin inhibits the reaction [Arginine results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Arginine results in increased secretion of TNF protein] Carvedilol inhibits the reaction [Arginine results in increased expression of TNF protein] |
CTD |
PMID:32569593 PMID:34423886 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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|
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
multiple interactions decreases abundance |
ISO |
Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Argininosuccinic Acid] |
CTD |
PMID:27469509 |
|
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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G |
Lepr |
leptin receptor |
affects abundance |
ISO |
LEPR affects the abundance of Argininosuccinic Acid |
CTD |
PMID:20567778 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
argatroban inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein] |
CTD |
PMID:22841818 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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|
G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
multiple interactions |
ISO |
argatroban inhibits the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA] |
CTD |
PMID:22841818 |
|
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
argatroban inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]; argatroban inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein] |
CTD |
PMID:22841818 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cd68 |
Cd68 molecule |
multiple interactions |
ISO |
argatroban inhibits the reaction [Dietary Fats results in increased expression of CD68 mRNA] |
CTD |
PMID:22841818 |
|
NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
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|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
argatroban inhibits the reaction [Dietary Fats results in increased expression of COL1A1 mRNA] |
CTD |
PMID:22841818 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
argatroban affects the reaction [Dietary Fats results in increased expression of CXCL2 mRNA] |
CTD |
PMID:22841818 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
F2 |
coagulation factor II |
multiple interactions |
ISO |
argatroban inhibits the reaction [Dietary Fats results in increased expression of F2 protein] argatroban binds to and results in decreased activity of F2 protein |
CTD |
PMID:15080313 PMID:16084352 PMID:18449412 PMID:22841818 |
|
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
argatroban inhibits the reaction [Dietary Fats results in increased expression of ICAM1 mRNA] |
CTD |
PMID:22841818 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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|
G |
Ldlr |
low density lipoprotein receptor |
multiple interactions |
ISO |
argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]; argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Triglycerides] |
CTD |
PMID:22841818 |
|
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
ISO |
argatroban inhibits the reaction [Dietary Fats results in increased expression of TIMP1 mRNA] |
CTD |
PMID:22841818 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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|
G |
Ace |
angiotensin I converting enzyme |
multiple interactions increases activity |
EXP |
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein] |
CTD |
PMID:32172062 PMID:32810514 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ache |
acetylcholinesterase |
increases expression increases activity multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of ACHE protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Ada |
adenosine deaminase |
multiple interactions increases activity |
EXP |
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein] |
CTD |
PMID:15502880 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1b |
angiotensin II receptor, type 1b |
increases expression multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein] |
CTD |
PMID:32479886 |
|
NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
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G |
Bche |
butyrylcholinesterase |
multiple interactions increases activity |
EXP |
[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of BCHE protein] |
CTD |
PMID:32172062 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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|
G |
Casp9 |
caspase 9 |
multiple interactions increases expression |
EXP |
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [bisphenol A results in increased expression of CASP9 protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP |
[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein] |
CTD |
PMID:29423081 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
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G |
Cybb |
cytochrome b-245 beta chain |
increases expression multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein] |
CTD |
PMID:32479886 |
|
NCBI chr X:13,360,583...13,392,517
Ensembl chr X:13,359,430...13,392,586
|
|
G |
Ednra |
endothelin receptor type A |
multiple interactions increases expression |
EXP |
Atrasentan inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of EDNRA mRNA] |
CTD |
PMID:34102242 |
|
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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|
G |
Ednrb |
endothelin receptor type B |
decreases expression multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in decreased expression of EDNRB mRNA Atrasentan inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of EDNRB mRNA] |
CTD |
PMID:34102242 |
|
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]] |
CTD |
PMID:28624453 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
EXP |
[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein] |
CTD |
PMID:29423081 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of IL1A mRNA] |
CTD |
PMID:32142722 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
|
|
G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of IL1B protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of IL1B protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein] |
CTD |
PMID:29423081 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Maoa |
monoamine oxidase A |
increases expression increases activity multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of MAOA protein NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of MAOA protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of MAOA protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of MAOA protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of MAOA protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of MAOA protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
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NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]] |
CTD |
PMID:33301711 |
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NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein] |
CTD |
PMID:29423081 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
decreases expression multiple interactions |
ISO EXP |
NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein] [Folic Acid co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of NOS3 protein |
CTD |
PMID:28624453 PMID:32479886 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Panx3 |
pannexin 3 |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of PANX3 mRNA] |
CTD |
PMID:32142722 |
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NCBI chr 8:37,366,758...37,377,640
Ensembl chr 8:37,366,862...37,377,640
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein] |
CTD |
PMID:15502880 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pde5a |
phosphodiesterase 5A |
increases activity multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
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NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]]; NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] |
CTD |
PMID:28624453 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Spn |
sialophorin |
multiple interactions increases expression |
EXP |
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein] |
CTD |
PMID:32172062 PMID:32428650 |
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NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions decreases expression |
EXP |
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein] |
CTD |
PMID:32479886 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Tbxa2r |
thromboxane A2 receptor |
increases expression |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of TBXA2R mRNA |
CTD |
PMID:34102242 |
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NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
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G |
Th |
tyrosine hydroxylase |
decreases expression |
ISO |
NG-Nitroarginine Methyl Ester results in decreased expression of TH protein |
CTD |
PMID:31187328 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
EXP ISO |
[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein] [NG-Nitroarginine Methyl Ester co-treated with TNF protein] results in increased secretion of VWF protein |
CTD |
PMID:29423081 PMID:30529211 PMID:32172062 PMID:32428650 PMID:32810514 PMID:34678311 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
EXP |
NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein [bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of TP53 protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of TP53 protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
decreases response to substance |
ISO |
TRPA1 gene mutant form results in decreased susceptibility to NG-Nitroarginine Methyl Ester |
CTD |
PMID:32634517 |
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NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
EXP |
[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein] |
CTD |
PMID:29423081 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vwf |
von Willebrand factor |
multiple interactions |
ISO |
[NG-Nitroarginine Methyl Ester co-treated with TNF protein] results in increased secretion of VWF protein |
CTD |
PMID:34678311 |
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NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
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G |
Ddah2 |
dimethylarginine dimethylaminohydrolase 2 |
multiple interactions |
ISO |
[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine; Arginine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of N,N-dimethylarginine]]; tetramethylpyrazine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine] |
CTD |
PMID:32135237 |
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NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
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G |
Slco4c1 |
solute carrier organic anion transporter family, member 4C1 |
increases uptake |
ISO |
SLCO4C1 protein results in increased uptake of N,N-dimethylarginine |
CTD |
PMID:30865704 |
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NCBI chr 9:97,180,162...97,229,135
Ensembl chr 9:97,178,861...97,229,715
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
omega-N-Methylarginine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] |
CTD |
PMID:23011206 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
omega-N-Methylarginine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] |
CTD |
PMID:23011206 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
omega-N-Methylarginine inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein] |
CTD |
PMID:32526215 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
omega-N-Methylarginine inhibits the reaction [Chlorpyrifos results in increased expression of VEGFA protein]; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein] |
CTD |
PMID:32526215 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] |
CTD |
PMID:16380457 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions decreases activity |
EXP ISO |
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium [S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine |
CTD |
PMID:11006970 PMID:12511180 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Slc18a2 |
solute carrier family 18 member A2 |
multiple interactions |
EXP |
S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] |
CTD |
PMID:17683483 |
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NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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