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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-arginine
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Accession:CHEBI:16467 term browser browse the term
Definition:An L-alpha-amino acid that is the L-isomer of arginine.
Synonyms:related_synonym: (2S)-2-amino-5-(carbamimidamido)pentanoic acid;   (2S)-2-amino-5-guanidinopentanoic acid;   (S)-2-Amino-5-guanidinovaleric acid;   (S)-2-amino-5-guanidinopentanoic acid;   Arg;   Formula=C6H14N4O2;   InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1;   InChIKey=ODKSFYDXXFIFQN-BYPYZUCNSA-N;   L-Arg;   L-Arginin;   R;   SMILES=N[C@@H](CCCNC(N)=N)C(O)=O;   arginine
 alt_id: CHEBI:13077;   CHEBI:21235;   CHEBI:42927;   CHEBI:6185
 xref: Beilstein:1725413;   CAS:74-79-3;   DrugBank:DB00125;   Drug_Central:1549;   ECMDB:ECMDB00517;   Gmelin:83283;   HMDB:HMDB0000517;   KEGG:C00062;   KEGG:D02982;   KNApSAcK:C00001340
 xref_mesh: MESH:D001120
 xref: MetaCyc:ARG;   PDBeChem:ARG;   PDBeChem:GND;   PMID:10848923;   PMID:11139824;   PMID:11300497;   PMID:11898853;   PMID:12812828;   PMID:15016745;   PMID:15465805;   PMID:16056256;   PMID:16416365;   PMID:17168727;   PMID:17439666;   PMID:19030957;   PMID:21600268;   PMID:21814794;   PMID:22179117;   PMID:22243793;   PMID:22251130;   PMID:22361732;   PMID:22425811;   PMID:22428068;   PMID:22439203;   PMID:22553931;   PMID:22619480;   PMID:22626826;   PMID:22652429;   PMID:22667467;   PMID:22709481;   PMID:8070089;   Reaxys:1725413;   Wikipedia:L-arginine;   YMDB:YMDB00592
 cyclic_relationship: is_conjugate_acid_of CHEBI:32681;   is_conjugate_base_of CHEBI:32682;   is_enantiomer_of CHEBI:15816

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L-arginine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions		 EXP Arginine results in decreased activity of CAT protein
Carvedilol inhibits the reaction [Arginine results in decreased activity of CAT protein]		 CTD PMID:32569593 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Crp C-reactive protein multiple interactions
increases expression		 EXP Carvedilol inhibits the reaction [Arginine results in increased expression of CRP protein] CTD PMID:32569593 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine] CTD PMID:22689575 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Arginine results in increased expression of IL1B protein
Carvedilol inhibits the reaction [Arginine results in increased expression of IL1B protein]		 CTD PMID:32569593 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Mpo myeloperoxidase increases expression
multiple interactions		 EXP Arginine results in increased expression of MPO protein
Carvedilol inhibits the reaction [Arginine results in increased expression of MPO protein]		 CTD PMID:32569593 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions
increases expression		 EXP Carvedilol inhibits the reaction [Arginine results in increased expression of PTAFR mRNA] CTD PMID:32569593 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672 		JBrowse link
G Reg3b regenerating family member 3 beta multiple interactions
increases expression		 EXP Carvedilol inhibits the reaction [Arginine results in increased expression of REG3B mRNA] CTD PMID:32569593 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression		 EXP Carvedilol inhibits the reaction [Arginine results in increased expression of RELA protein] CTD PMID:32569593 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression
multiple interactions		 EXP Arginine results in increased expression of STAT1 protein
Carvedilol inhibits the reaction [Arginine results in increased expression of STAT1 protein]		 CTD PMID:32569593 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP Arginine results in increased expression of TNF protein
Carvedilol inhibits the reaction [Arginine results in increased expression of TNF protein]		 CTD PMID:32569593 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
(N(omega)-L-arginino)succinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
decreases abundance		 ISO Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Argininosuccinic Acid] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Argininosuccinic Acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
N(gamma)-nitro-L-arginine methyl ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases expression
multiple interactions		 EXP NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of ACHE protein]		 CTD PMID:32428650 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Ada adenosine deaminase multiple interactions
increases activity		 EXP [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein] CTD PMID:32428650 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947 		JBrowse link
G Agt angiotensinogen multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein] CTD PMID:15502880 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression
multiple interactions		 EXP NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein]		 CTD PMID:32479886 NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 EXP [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [bisphenol A results in increased expression of CASP9 protein] CTD PMID:32428650 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein] CTD PMID:29423081 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression
multiple interactions		 EXP NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein]		 CTD PMID:32479886 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]] CTD PMID:28624453 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein] CTD PMID:29423081 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of IL1A mRNA] CTD PMID:32142722 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of IL1B protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of IL1B protein]		 CTD PMID:32428650 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein] CTD PMID:29423081 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Maoa monoamine oxidase A increases expression
multiple interactions		 EXP NG-Nitroarginine Methyl Ester results in increased expression of MAOA protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of MAOA protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of MAOA protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of MAOA protein]		 CTD PMID:32428650 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein] CTD PMID:29423081 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
multiple interactions		 ISO
EXP		 NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein
Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]
[Folic Acid co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of NOS3 protein		 CTD PMID:28624453, PMID:32479886 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Panx3 pannexin 3 multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of PANX3 mRNA] CTD PMID:32142722 NCBI chr 8:40,126,379...40,137,390
Ensembl chr 8:40,126,342...40,137,390 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [AGT protein results in increased activity of PARP1 protein] CTD PMID:15502880 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pde5a phosphodiesterase 5A increases activity
multiple interactions		 EXP NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]		 CTD PMID:32428650 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]]; NG-Nitroarginine Methyl Ester inhibits the reaction [Folic Acid inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] CTD PMID:28624453 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Spn sialophorin multiple interactions
increases expression		 EXP [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein] CTD PMID:32428650 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression		 EXP Sildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein] CTD PMID:32479886 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein] CTD PMID:29423081, PMID:32428650 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 EXP NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of TP53 protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of TP53 protein]		 CTD PMID:32428650 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases response to substance ISO TRPA1 gene mutant form results in decreased susceptibility to NG-Nitroarginine Methyl Ester CTD PMID:32634517 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein] CTD PMID:29423081 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
N(omega),N(omega)-dimethyl-L-arginine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco4c1 solute carrier organic anion transporter family, member 4C1 increases uptake ISO SLCO4C1 protein results in increased uptake of N,N-dimethylarginine CTD PMID:30865704 NCBI chr 9:104,301,935...104,350,262
Ensembl chr 9:104,299,277...104,350,308 		JBrowse link
N(omega)-methyl-L-arginine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma multiple interactions ISO omega-N-Methylarginine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO omega-N-Methylarginine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO omega-N-Methylarginine inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein] CTD PMID:32526215 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO omega-N-Methylarginine inhibits the reaction [Chlorpyrifos results in increased expression of VEGFA protein]; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein] CTD PMID:32526215 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
S-methyl-L-thiocitrulline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] CTD PMID:16380457 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases activity		 EXP
ISO		 [S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine		 CTD PMID:11006970, PMID:12511180 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:17683483 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        indicator 8651
          biomarker 6423
            L-arginine 40
              5-methyl-L-arginine + 0
              Ala-Arg 0
              Ala-Met-Ser-Arg 0
              Arg-Asn-Gln-Arg 0
              Arg-Asn-Gly-Ser 0
              Arg-Asp-Asp 0
              Arg-Asp-Gln-Ser 0
              Arg-Lys-Cys-Gly 0
              Arg-Phe-Phe-Cys 0
              Arg-Pro 0
              Arg-Thr-Cys-Cys 0
              Arg-Thr-Thr-Asp 0
              Arg-Trp-Pro 0
              Arg-Trp-Ser-Tyr 0
              Asn-Arg 0
              Asp-Arg 0
              Asp-Gln-Arg 0
              Glu-Asp-Arg 0
              Glu-Glu-Arg 0
              Glu-Gly-Arg-chloromethylketone 0
              Glu-Trp-Asp-Arg 0
              Gly-Arg-Pro 0
              L-arginine derivative + 32
              L-arginine residue 0
              L-arginyl group 0
              L-arginyl-L-amino acid 0
              Leu-Arg 0
              N(2)-L-arginino group 0
              N(omega)-L-arginino group 0
              N-acyl-L-arginine + 0
              Phe-Arg 0
              Phe-Arg-Thr 0
              Pro-Arg-Pro 0
              poly(glycyl-L-arginine) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        amino acid 14085
                                          alpha-amino acid 11550
                                            L-alpha-amino acid 11385
                                              glutamine family amino acid 10246
                                                L-arginine 40
                                                  5-methyl-L-arginine + 0
                                                  Ala-Arg 0
                                                  Ala-Met-Ser-Arg 0
                                                  Arg-Asn-Gln-Arg 0
                                                  Arg-Asn-Gly-Ser 0
                                                  Arg-Asp-Asp 0
                                                  Arg-Asp-Gln-Ser 0
                                                  Arg-Lys-Cys-Gly 0
                                                  Arg-Phe-Phe-Cys 0
                                                  Arg-Pro 0
                                                  Arg-Thr-Cys-Cys 0
                                                  Arg-Thr-Thr-Asp 0
                                                  Arg-Trp-Pro 0
                                                  Arg-Trp-Ser-Tyr 0
                                                  Asn-Arg 0
                                                  Asp-Arg 0
                                                  Asp-Gln-Arg 0
                                                  Glu-Asp-Arg 0
                                                  Glu-Glu-Arg 0
                                                  Glu-Gly-Arg-chloromethylketone 0
                                                  Glu-Trp-Asp-Arg 0
                                                  Gly-Arg-Pro 0
                                                  L-arginine derivative + 32
                                                  L-arginine residue 0
                                                  L-arginyl group 0
                                                  L-arginyl-L-amino acid 0
                                                  Leu-Arg 0
                                                  N(2)-L-arginino group 0
                                                  N(omega)-L-arginino group 0
                                                  N-acyl-L-arginine + 0
                                                  Phe-Arg 0
                                                  Phe-Arg-Thr 0
                                                  Pro-Arg-Pro 0
                                                  poly(glycyl-L-arginine) 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.