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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glyburide
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Accession:CHEBI:5441 term browser browse the term
Definition:An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Synonyms:exact_synonym: 5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
 related_synonym: 1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea;   1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea;   5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide;   Diabeta;   Formula=C23H28ClN3O5S;   Glynase;   InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29);   InChIKey=ZNNLBTZKUZBEKO-UHFFFAOYSA-N;   Micronase;   SMILES=COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1;   glibenclamida;   glibenclamide;   glibenclamidum
 xref: Beilstein:2230085;   CAS:10238-21-8;   DrugBank:DB01016;   Drug_Central:1314;   KEGG:C07022;   KEGG:D00336;   LINCS:LSM-2811
 xref_mesh: MESH:D005905
 xref: PMID:16081479;   PMID:20797618;   Patent:NL6603398;   Patent:NL6610580;   Patent:US3454635;   Wikipedia:Glibenclamide


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glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity
increases expression		 ISO
EXP		 [Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Glyburide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
[Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium
Glyburide results in increased expression of ABCB11 mRNA
[Bile Acids and Salts co-treated with Glyburide] results in decreased expression of ABCB11 mRNA		 CTD PMID:11343252 PMID:15465654 PMID:15618715 PMID:19853032 PMID:20147439 More... NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 increases expression ISO Glyburide results in increased expression of ABCB4 mRNA CTD PMID:27765674 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 decreases activity ISO Glyburide results in decreased activity of ABCC1 protein CTD PMID:15652236 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 increases expression ISO
EXP		 Glyburide results in increased expression of ABCC2 mRNA CTD PMID:27765674 PMID:35708773 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 increases expression ISO Glyburide results in increased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 increases expression EXP Glyburide results in increased expression of ABCC4 mRNA CTD PMID:35708773 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcc8 ATP-binding cassette, sub-family C member 8 increases response to substance
multiple interactions
affects binding		 ISO ABCC8 protein results in increased susceptibility to Glyburide
Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein mutant form]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]; resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein]
Glyburide binds to ABCC8 protein; Glyburide binds to ABCC8 protein mutant form		 CTD PMID:17138562 PMID:19095654 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457 		JBrowse link
G Abcc9 ATP-binding cassette, sub-family C member 9 affects binding
multiple interactions
decreases activity		 EXP Glyburide binds to ABCC9 protein mutant form
[Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein; Estradiol inhibits the reaction [Glyburide binds to ABCC9 protein mutant form]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]; resveratrol inhibits the reaction [Glyburide binds to ABCC9 protein]		 CTD PMID:17138562 PMID:19095654 PMID:22622455 PMID:28842488 NCBI chr 6:142,533,592...142,648,472
Ensembl chr 6:142,533,588...142,648,041 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases export
increases export
multiple interactions		 ISO ABCG2 protein polymorphism results in decreased export of Glyburide
ABCG2 protein results in increased export of Glyburide
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Glyburide]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester promotes the reaction [ABCG2 protein polymorphism results in decreased export of Glyburide]; Genistein inhibits the reaction [ABCG2 protein results in increased export of Glyburide]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of Glyburide]		 CTD PMID:26850786 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Glyburide results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Glyburide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of ACTA2 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of ACTA2 protein]] CTD PMID:35305975 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein] CTD PMID:36999408 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO Glyburide inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:10799337 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO
EXP		 Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]
Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein]		 CTD PMID:32375810 PMID:32522579 PMID:32860822 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases activity ISO Glyburide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 decreases activity ISO Glyburide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 decreases activity ISO Glyburide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Glyburide inhibits the reaction [sodium bisulfide results in increased phosphorylation of AKT1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein] CTD PMID:21800153 PMID:33724628 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin affects binding ISO Glyburide binds to ALB protein CTD PMID:20974553 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions ISO Glyburide promotes the reaction [1,2-linoleoylphosphatidylcholine results in increased secretion of APOA1 protein]; Glyburide promotes the reaction [Clofibrate results in increased secretion of APOA1 protein] CTD PMID:19717637 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Arg1 arginase, liver multiple interactions ISO
EXP		 Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ARG1 mRNA]		 CTD PMID:32522579 PMID:32860822 PMID:34052309 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:33724628 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Glyburide inhibits the reaction [sodium bisulfide results in increased expression of BCL2 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:21800153 PMID:33724628 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Capn2 calpain 2 increases expression ISO Glyburide results in increased expression of CAPN2 mRNA CTD PMID:33652124 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP		 [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of CASP1 protein]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Ozone results in increased cleavage of CASP1 protein]		 CTD PMID:25338942 PMID:32167222 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 ISO Glyburide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Glyburide promotes the reaction [Isoproterenol results in increased activity of CASP3 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased activity of CASP3 protein]]
Glyburide results in increased expression of CASP3 mRNA
Glyburide results in increased activity of CASP3 protein		 CTD PMID:16310184 PMID:33652124 PMID:35305975 PMID:36504472 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Glyburide promotes the reaction [Isoproterenol results in decreased activity of CAT protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in decreased activity of CAT protein]]		 CTD PMID:23716880 PMID:24760747 PMID:26700463 PMID:26748309 PMID:28757134 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions
decreases activity		 ISO
EXP		 Glyburide binds to and results in decreased activity of CFTR protein; Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; Glyburide inhibits the reaction [Colforsin results in increased activity of CFTR protein]
Glyburide inhibits the reaction [CFTR protein affects the transport of Bicarbonates]; Glyburide inhibits the reaction [CFTR protein affects the transport of Chlorides]
Glyburide results in decreased activity of CFTR protein
Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein]		 CTD PMID:14502435 PMID:14967738 PMID:15131065 PMID:15236628 PMID:15371258 More... NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression EXP Glyburide results in decreased expression of COL1A1 mRNA CTD PMID:35708773 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Cp ceruloplasmin multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of CP protein] CTD PMID:26748309 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309 		JBrowse link
G Cst3 cystatin C multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of CST3 protein] CTD PMID:33387473 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Glyburide co-treated with Isoproterenol] results in increased expression of CTNNB1 mRNA; Glyburide promotes the reaction [Isoproterenol results in increased expression of CTNNB1 protein]; pyrvinium inhibits the reaction [[Glyburide co-treated with Isoproterenol] results in increased expression of CTNNB1 mRNA]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of CTNNB1 protein]] CTD PMID:35305975 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions EXP Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CYBB protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein] CTD PMID:32375810 PMID:34052309 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Glyburide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Glyburide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:10799337 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]] CTD PMID:27890915 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of FN1 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of FN1 protein]] CTD PMID:35305975 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions EXP Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of FTH1 mRNA] CTD PMID:27246103 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein] CTD PMID:25641191 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729 		JBrowse link
G G6pc3 glucose 6 phosphatase, catalytic, 3 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PC3 protein] CTD PMID:31345080 NCBI chr11:102,080,525...102,084,907
Ensembl chr11:102,080,446...102,084,907 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:25641191 PMID:31345080 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased activity of GPT protein] CTD PMID:29223569 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein] CTD PMID:32522579 PMID:32860822 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of GSR protein] CTD PMID:26748309 PMID:33724628 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA] CTD PMID:30817903 PMID:36999408 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Ifng interferon gamma multiple interactions EXP Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein] CTD PMID:36999408 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il12b interleukin 12b multiple interactions EXP Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of IL17A protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL17A protein]] CTD PMID:35305975 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO
EXP		 Glyburide inhibits the reaction [Paraquat results in increased expression of IL18 protein]
Glyburide inhibits the reaction [Ozone results in increased expression of IL18 protein]; Glyburide inhibits the reaction [Paraquat results in increased secretion of IL18 protein]		 CTD PMID:25338942 PMID:32167222 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta affects secretion
multiple interactions		 EXP
ISO		 Glyburide affects the secretion of IL1B protein
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Ozone results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Paraquat results in increased secretion of IL1B protein]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]]		 CTD PMID:15578659 PMID:25338942 PMID:30817903 PMID:32167222 PMID:32375810 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 protein]		 CTD PMID:24760747 PMID:24849676 PMID:26748309 PMID:30817903 PMID:33724628 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions
increases secretion		 EXP
ISO		 Glyburide inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Glyburide inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]
Glyburide inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased secretion of INS1 protein]
Glyburide results in increased secretion of INS1 protein		 CTD PMID:26700463 PMID:26748309 PMID:29658312 PMID:30445784 PMID:30582900 More... NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II multiple interactions
decreases expression
increases expression
increases secretion
increases response to substance		 ISO [Glyburide co-treated with Glucose] results in increased expression of INS protein; Glyburide inhibits the reaction [Glucose results in decreased secretion of INS protein]; IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein]
Glyburide results in decreased expression of INS protein
Glyburide results in increased expression of INS mRNA
Glyburide results in increased susceptibility to INS protein		 CTD PMID:3116364 PMID:10430617 PMID:11305519 PMID:15642492 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of IRAK1 protein] CTD PMID:36504472 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein] CTD PMID:10430617 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein] CTD PMID:33724628 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458 		JBrowse link
G Itgam integrin alpha M multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein] CTD PMID:32522579 PMID:32860822 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Glyburide results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions
decreases response to substance		 EXP Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]
KCNJ11 protein mutant form results in decreased susceptibility to Glyburide		 CTD PMID:15949470 PMID:28842488 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 decreases activity
decreases response to substance		 ISO Glyburide results in decreased activity of KCNJ8 protein
KCNJ8 protein mutant form results in decreased susceptibility to Glyburide		 CTD PMID:20050851 PMID:28842488 NCBI chr 6:142,510,563...142,517,340
Ensembl chr 6:142,510,563...142,517,340 		JBrowse link
G Kcnk18 potassium channel, subfamily K, member 18 multiple interactions ISO Glyburide inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr19:59,208,080...59,225,802
Ensembl chr19:59,207,646...59,225,806 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Lyz2 lysozyme 2 decreases secretion
increases secretion		 ISO Glyburide results in decreased secretion of LYZ protein
Glyburide results in increased secretion of LYZ protein		 CTD PMID:15194485 PMID:15234967 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases expression		 ISO Quercetin promotes the reaction [Glyburide results in increased expression of MAPK1 protein modified form] CTD PMID:20860660 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases expression		 ISO Quercetin promotes the reaction [Glyburide results in increased expression of MAPK3 protein modified form] CTD PMID:20860660 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mbp myelin basic protein multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein] CTD PMID:32522579 PMID:32860822 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762 		JBrowse link
G Mir146 microRNA 146 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of MIR146A mRNA] CTD PMID:36504472 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Glyburide inhibits the reaction [Paraquat results in increased activity of MPO protein]; Glyburide promotes the reaction [Isoproterenol results in increased activity of MPO protein] CTD PMID:25338942 PMID:35305975 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA] CTD PMID:32522579 PMID:32860822 NCBI chr 2:14,234,225...14,336,834
Ensembl chr 2:14,234,203...14,336,868 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NCF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein] CTD PMID:32375810 PMID:34052309 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein] CTD PMID:32522579 PMID:32860822 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544 		JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 multiple interactions EXP Glyburide inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein]; Glyburide inhibits the reaction [Lipopolysaccharides promotes the reaction [NFATC1 protein binds to NOS2 promoter]] CTD PMID:27246103 NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA] CTD PMID:30817903 PMID:36999408 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein] CTD PMID:36999408 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP		 [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [Ozone results in increased expression of NLRP3 protein]		 CTD PMID:25338942 PMID:32167222 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [Lipopolysaccharides promotes the reaction [NFATC1 protein binds to NOS2 promoter]]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; KN 93 inhibits the reaction [Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]		 CTD PMID:16257489 PMID:27246103 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nppb natriuretic peptide type B multiple interactions ISO Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]] CTD PMID:27890915 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Glyburide results in decreased expression of NR1H4 mRNA CTD PMID:28391356 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of PCK1 mRNA] CTD PMID:20363216 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pklr pyruvate kinase liver and red blood cell multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of PKLR mRNA] CTD PMID:20363216 NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG protein] CTD PMID:29223569 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA] CTD PMID:30817903 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Glyburide inhibits the reaction [Paraquat results in increased expression of PYCARD protein] CTD PMID:25338942 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:33724628 PMID:36504472 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression
multiple interactions		 ISO
EXP		 Glyburide results in decreased expression of SLC10A1 mRNA
[Bile Acids and Salts co-treated with Glyburide] results in decreased expression of SLC10A1 mRNA		 CTD PMID:27765674 PMID:28391356 PMID:35708773 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A2 protein] CTD PMID:33724628 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:29223569 PMID:33724628 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions EXP Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein] CTD PMID:16725203 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions ISO Glyburide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Glyburide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547 		JBrowse link
G Snca synuclein, alpha multiple interactions EXP Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of SNCA protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of SNCA protein] CTD PMID:32375810 PMID:34052309 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein] CTD PMID:36999408 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of TGFB1 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TGFB1 protein]] CTD PMID:35305975 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:16725203 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:36504472 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Glyburide promotes the reaction [Isoproterenol results in increased expression of TNF protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TNF protein]]		 CTD PMID:16257489 PMID:24760747 PMID:26748309 PMID:30817903 PMID:32375810 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of TNNI3 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TNNI3 protein]] CTD PMID:35305975 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228 		JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of TRAF6 protein] CTD PMID:36504472 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression		 ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TP53 protein]
Glyburide results in increased expression of TP53 mRNA		 CTD PMID:30817903 PMID:33387473 PMID:33652124 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 decreases activity ISO
EXP		 Glyburide results in decreased activity of TRPM4 protein CTD PMID:16966582 PMID:17188667 NCBI chr 7:44,952,579...44,983,495
Ensembl chr 7:44,952,056...44,983,204 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein CTD PMID:22622455 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      application 21752
        pharmaceutical 21167
          drug 21167
            hypoglycemic agent 4276
              glyburide 102
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    p-block element atom 22108
                      carbon group element atom 21909
                        carbon atom 21835
                          organic molecular entity 21835
                            heteroorganic entity 21490
                              organochalcogen compound 20980
                                organooxygen compound 20821
                                  carbon oxoacid 19614
                                    carboxylic acid 19610
                                      carboacyl group 18280
                                        univalent carboacyl group 18280
                                          carbamoyl group 18092
                                            carboxamide 18092
                                              monocarboxylic acid amide 15826
                                                urea 5737
                                                  ureas 5735
                                                    N-sulfonylurea 155
                                                      glyburide 102
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