CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: aluminium oxide
Accession: CHEBI:30187
browse the term
Synonyms: exact_synonym: aluminium(III) oxide; dialuminium trioxide
related_synonym: Al2O3; Aluminiumoxid; Formula=Al2O3; Tonerde; alumina; aluminum oxide
xref: CAS:1344-28-1; Gmelin:11099
xref_mesh: MESH:D000537
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Acp5
acid phosphatase 5, tartrate resistant
decreases expression
ISO
Aluminum Oxide results in decreased expression of ACP5 mRNA
CTD
PMID:15585240
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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Actr2
actin related protein 2
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of ACTR2 protein
CTD
PMID:25598225
NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524
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Alpl
alkaline phosphatase, biomineralization associated
increases expression
ISO
Aluminum Oxide results in increased expression of ALPL mRNA
CTD
PMID:19464052
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Bcl2l1
Bcl2-like 1
increases expression
ISO
Aluminum Oxide analog results in increased expression of BCL2L1 mRNA
CTD
PMID:23132795
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bglap
bone gamma-carboxyglutamate protein
increases expression
ISO
Aluminum Oxide results in increased expression of BGLAP mRNA
CTD
PMID:19464052
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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Bgn
biglycan
increases expression
ISO
Aluminum Oxide results in increased expression of BGN mRNA
CTD
PMID:19464052
NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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Bmp1
bone morphogenetic protein 1
increases expression
ISO
Aluminum Oxide results in increased expression of BMP1 mRNA
CTD
PMID:19464052
NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776
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Bmp2
bone morphogenetic protein 2
increases expression
ISO
Aluminum Oxide results in increased expression of BMP2 mRNA
CTD
PMID:19464052
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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Bmp4
bone morphogenetic protein 4
increases expression
ISO
Aluminum Oxide results in increased expression of BMP4 mRNA
CTD
PMID:19464052
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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Bmp6
bone morphogenetic protein 6
decreases expression
ISO
Aluminum Oxide results in decreased expression of BMP6 mRNA
CTD
PMID:19464052
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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C3
complement C3
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of C3 protein
CTD
PMID:25598225
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Camp
cathelicidin antimicrobial peptide
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of CAMP protein
CTD
PMID:25598225
NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
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Casp3
caspase 3
increases expression multiple interactions
ISO EXP
Aluminum Oxide results in increased expression of CASP3 sesamol inhibits the reaction [Aluminum Oxide results in increased expression of CASP3 mRNA]
CTD
PMID:21329562 PMID:35403826
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions decreases activity
EXP
sesamol inhibits the reaction [Aluminum Oxide results in decreased activity of CAT protein]
CTD
PMID:35403826
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
increases secretion
ISO
Aluminum Oxide results in increased secretion of CCL2 protein
CTD
PMID:17618502
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cd14
CD14 molecule
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of CD14 protein
CTD
PMID:25598225
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd36
CD36 molecule
increases expression
ISO
Aluminum Oxide results in increased expression of CD36 mRNA
CTD
PMID:19464052
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cdh11
cadherin 11
increases expression
ISO
Aluminum Oxide results in increased expression of CDH11 mRNA
CTD
PMID:19464052
NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Aluminum Oxide analog results in increased expression of CDKN1A mRNA
CTD
PMID:23132795
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Clu
clusterin
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of CLU protein
CTD
PMID:25598225
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Col10a1
collagen type X alpha 1 chain
increases expression
ISO
Aluminum Oxide results in increased expression of COL10A1 mRNA
CTD
PMID:19464052
NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494
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Col11a1
collagen type XI alpha 1 chain
increases expression
ISO
Aluminum Oxide results in increased expression of COL11A1 mRNA
CTD
PMID:19464052
NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
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Col15a1
collagen type XV alpha 1 chain
increases expression
ISO
Aluminum Oxide results in increased expression of COL15A1 mRNA
CTD
PMID:19464052
NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591
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Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
[Aluminum Oxide co-treated with Magnesium] results in increased expression of COL1A1 protein
CTD
PMID:12209937
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col1a2
collagen type I alpha 2 chain
increases expression
ISO
Aluminum Oxide results in increased expression of COL1A2 mRNA
CTD
PMID:19464052
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Comp
cartilage oligomeric matrix protein
increases expression
ISO
Aluminum Oxide results in increased expression of COMP mRNA
CTD
PMID:19464052
NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845
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Csf2
colony stimulating factor 2
increases secretion
ISO
Aluminum Oxide results in increased secretion of CSF2 protein
CTD
PMID:15046894
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Ctsk
cathepsin K
increases expression
ISO
Aluminum Oxide results in increased expression of CTSK mRNA
CTD
PMID:19464052
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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Egfr
epidermal growth factor receptor
increases expression
ISO
Aluminum Oxide results in increased expression of EGFR mRNA
CTD
PMID:19464052
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Fgb
fibrinogen beta chain
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of FGB protein
CTD
PMID:25598225
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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Flt1
Fms related receptor tyrosine kinase 1
increases expression
ISO
Aluminum Oxide results in increased expression of FLT1 mRNA
CTD
PMID:19464052
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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Fn1
fibronectin 1
increases expression
ISO
Aluminum Oxide results in increased expression of FN1 mRNA
CTD
PMID:19464052
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
Aluminum Oxide results in decreased expression of FOS mRNA
CTD
PMID:15585240
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gsta1
glutathione S-transferase alpha 1
increases expression multiple interactions
EXP
Aluminum Oxide results in increased expression of GSTA1 mRNA sesamol inhibits the reaction [Aluminum Oxide results in increased expression of GSTA1 mRNA]
CTD
PMID:35403826
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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Ibsp
integrin-binding sialoprotein
increases expression
ISO
Aluminum Oxide results in increased expression of IBSP mRNA
CTD
PMID:19464052
NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
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Icam1
intercellular adhesion molecule 1
increases expression
ISO
Aluminum Oxide results in increased expression of ICAM1 protein
CTD
PMID:18456438
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Igf1
insulin-like growth factor 1
affects expression
ISO
Aluminum Oxide affects the expression of IGF1 mRNA
CTD
PMID:19464052
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Il10
interleukin 10
increases expression
ISO
Aluminum Oxide results in increased expression of IL10 mRNA
CTD
PMID:15183442
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1a
interleukin 1 alpha
increases expression
ISO
Aluminum Oxide results in increased expression of IL1A mRNA
CTD
PMID:15183442
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
increases expression multiple interactions increases secretion
ISO
Aluminum Oxide results in increased expression of IL1B mRNA [Aluminum Oxide co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein; [Aluminum Oxide co-treated with Nanotubes, Carbon co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein; [Aluminum Oxide co-treated with Nanotubes, Carbon] promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Aluminum Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Aluminum Oxide promotes the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein] [Aluminum Oxide co-treated with Nanotubes, Carbon] results in decreased secretion of IL1B protein; Aluminum Oxide inhibits the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein] Aluminum Oxide results in increased secretion of IL1B protein
CTD
PMID:15183442 PMID:16488289 PMID:17618502 PMID:25216247
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
increases expression multiple interactions decreases secretion
ISO
Aluminum Oxide results in increased expression of IL6 mRNA; Aluminum Oxide results in increased expression of IL6 protein Aluminum Oxide inhibits the reaction [Nanotubes, Carbon results in increased secretion of IL6 protein] Aluminum Oxide results in decreased secretion of IL6 protein [Aluminum Oxide co-treated with Nanotubes, Carbon] results in increased secretion of IL6 protein
CTD
PMID:11771709 PMID:25216247
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itga1
integrin subunit alpha 1
increases expression
ISO
Aluminum Oxide results in increased expression of ITGA1 mRNA
CTD
PMID:19464052
NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
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Itga3
integrin subunit alpha 3
increases expression
ISO
Aluminum Oxide results in increased expression of ITGA3 mRNA
CTD
PMID:19464052
NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
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Itga5
integrin subunit alpha 5
multiple interactions
ISO
[Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGA5 protein
CTD
PMID:12209937
NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
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Itgb1
integrin subunit beta 1
multiple interactions
ISO
[Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGB1 protein
CTD
PMID:12209937
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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Itih4
inter-alpha-trypsin inhibitor heavy chain 4
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of ITIH4 protein
CTD
PMID:25598225
NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Aluminum Oxide results in increased expression of JUN mRNA
CTD
PMID:16488289
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Lcn2
lipocalin 2
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of LCN2 protein
CTD
PMID:25598225
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Ltf
lactotransferrin
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of LTF protein
CTD
PMID:25598225
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
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Mmp1
matrix metallopeptidase 1
increases expression
ISO
Aluminum Oxide results in increased expression of MMP1 mRNA
CTD
PMID:16488289
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp2
matrix metallopeptidase 2
increases expression
ISO
Aluminum Oxide results in increased expression of MMP2 mRNA
CTD
PMID:14661256
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp3
matrix metallopeptidase 3
increases expression
ISO
Aluminum Oxide results in increased expression of MMP3 mRNA
CTD
PMID:16488289
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mmp8
matrix metallopeptidase 8
decreases expression
ISO
Aluminum Oxide results in decreased expression of MMP8 mRNA
CTD
PMID:19464052
NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520
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Mmp9
matrix metallopeptidase 9
increases expression
ISO
Aluminum Oxide results in increased expression of MMP9 mRNA
CTD
PMID:16488289
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of MPO protein
CTD
PMID:25598225
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Pdgfa
platelet derived growth factor subunit A
increases expression
ISO
Aluminum Oxide results in increased expression of PDGFA mRNA
CTD
PMID:19464052
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
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Phex
phosphate regulating endopeptidase X-linked
increases expression
ISO
Aluminum Oxide results in increased expression of PHEX mRNA
CTD
PMID:19464052
NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469
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Ptk2
protein tyrosine kinase 2
multiple interactions
ISO
[Aluminum Oxide co-treated with Magnesium] results in increased expression of PTK2 protein
CTD
PMID:12209937
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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S100a8
S100 calcium binding protein A8
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of S100A8 protein
CTD
PMID:25598225
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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S100a9
S100 calcium binding protein A9
multiple interactions
ISO
[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of S100A9 protein
CTD
PMID:25598225
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Scarb1
scavenger receptor class B, member 1
decreases expression
ISO
Aluminum Oxide results in decreased expression of SCARB1 mRNA
CTD
PMID:19464052
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Sele
selectin E
increases expression
ISO
Aluminum Oxide results in increased expression of SELE protein
CTD
PMID:18456438
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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Serpinh1
serpin family H member 1
increases expression
ISO
Aluminum Oxide results in increased expression of SERPINH1 mRNA
CTD
PMID:19464052
NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
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Shc1
SHC adaptor protein 1
multiple interactions
ISO
[Aluminum Oxide co-treated with Magnesium] results in increased expression of SHC1 protein; [Aluminum Oxide co-treated with Magnesium] results in increased expression of SHC1 protein alternative form
CTD
PMID:12209937
NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
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Sod1
superoxide dismutase 1
multiple interactions decreases activity
EXP
sesamol inhibits the reaction [Aluminum Oxide results in decreased activity of SOD1 protein]
CTD
PMID:35403826
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sp7
Sp7 transcription factor
increases expression
ISO
Aluminum Oxide results in increased expression of SP7 mRNA
CTD
PMID:19464052
NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
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Spp1
secreted phosphoprotein 1
increases expression multiple interactions decreases secretion
ISO
Aluminum Oxide results in increased expression of SPP1 mRNA [Aluminum Oxide co-treated with Nanotubes, Carbon] inhibits the reaction [Lipopolysaccharides results in increased secretion of SPP1 protein]; Aluminum Oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of SPP1 protein]; Aluminum Oxide inhibits the reaction [Nanotubes, Carbon results in increased secretion of SPP1 protein] Aluminum Oxide results in decreased secretion of SPP1 protein [Aluminum Oxide co-treated with Nanotubes, Carbon] results in increased secretion of SPP1 protein; Aluminum Oxide inhibits the reaction [Nanotubes, Carbon results in increased expression of SPP1 mRNA]; Aluminum Oxide inhibits the reaction [Nanotubes, Carbon results in increased secretion of SPP1 protein]
CTD
PMID:19464052 PMID:25216247
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Stath
statherin
increases expression
ISO
Aluminum Oxide results in increased expression of STATH mRNA
CTD
PMID:19464052
NCBI chr14:20,307,324...20,311,182
Ensembl chr14:20,307,324...20,311,182
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Tgfb1
transforming growth factor, beta 1
increases expression
ISO
Aluminum Oxide results in increased expression of TGFB1 mRNA
CTD
PMID:19464052
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgfbr2
transforming growth factor, beta receptor 2
increases expression
ISO
Aluminum Oxide results in increased expression of TGFBR2 mRNA
CTD
PMID:19464052
NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
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Tnf
tumor necrosis factor
increases activity increases expression affects secretion multiple interactions
EXP ISO
Aluminum Oxide results in increased activity of TNF protein Aluminum Oxide results in increased expression of TNF mRNA Aluminum Oxide affects the secretion of TNF protein Aluminum Oxide inhibits the reaction [Nanotubes, Carbon results in increased secretion of TNF protein] [Aluminum Oxide co-treated with Nanotubes, Carbon] results in increased expression of TNF mRNA sesamol inhibits the reaction [Aluminum Oxide results in increased expression of TNF mRNA]
CTD
PMID:10413987 PMID:11306444 PMID:15183442 PMID:16488289 PMID:25216247 PMID:35403826 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfsf10
TNF superfamily member 10
increases expression
ISO
Aluminum Oxide analog results in increased expression of TNFSF10 mRNA
CTD
PMID:23132795
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tp53
tumor protein p53
increases expression
ISO
Aluminum Oxide analog results in increased expression of TP53 mRNA
CTD
PMID:23132795
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Vcam1
vascular cell adhesion molecule 1
increases expression
ISO
Aluminum Oxide results in increased expression of VCAM1 mRNA; Aluminum Oxide results in increased expression of VCAM1 protein
CTD
PMID:18456438 PMID:19464052
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vegfa
vascular endothelial growth factor A
increases expression
ISO
Aluminum Oxide results in increased expression of VEGFA mRNA
CTD
PMID:19464052
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vegfb
vascular endothelial growth factor B
increases expression
ISO
Aluminum Oxide results in increased expression of VEGFB mRNA
CTD
PMID:19464052
NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
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