Comp (cartilage oligomeric matrix protein) - Rat Genome Database

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Gene: Comp (cartilage oligomeric matrix protein) Rattus norvegicus
Analyze
Symbol: Comp
Name: cartilage oligomeric matrix protein
RGD ID: 2378
Description: Enables fibronectin binding activity and vitamin D binding activity. An extracellular matrix structural constituent. Predicted to be involved in cartilage homeostasis; negative regulation of apoptotic process; and protein homooligomerization. Predicted to act upstream of or within several processes, including cartilage development; chondrocyte proliferation; and vasculature development. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in carpal tunnel syndrome; multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to human COMP (cartilage oligomeric matrix protein); PARTICIPATES IN cell-extracellular matrix signaling pathway; malaria pathway; phagocytosis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21619,047,206 - 19,055,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1619,047,207 - 19,055,845 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1619,086,958 - 19,095,161 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01620,219,417 - 20,227,820 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01619,139,921 - 19,148,124 (-)NCBIRnor_WKY
Rnor_6.01620,798,437 - 20,807,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,798,437 - 20,807,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,647,382 - 20,657,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1619,237,609 - 19,245,998 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene. Briggs MD, etal., Nat Genet. 1995 Jul;10(3):330-6.
2. Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin. Di Cesare PE, etal., Matrix Biol 2002 Aug;21(5):461-70.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia. Hecht JT, etal., Nat Genet. 1995 Jul;10(3):325-9.
6. Localization and distribution of cartilage oligomeric matrix protein in the rat intervertebral disc. Ishii Y, etal., Spine. 2006 Jun 15;31(14):1539-46.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins. Oldberg A, etal., J Biol Chem 1992 Nov 5;267(31):22346-50.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3). Ozbek S, etal., EMBO J 2002 Nov 15;21(22):5960-8.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin. Wang L, etal., Circ Res. 2010 Feb 19;106(3):514-25. doi: 10.1161/CIRCRESAHA.109.202762. Epub 2009 Dec 17.
Additional References at PubMed
PMID:8864111   PMID:10852928   PMID:11084047   PMID:15579310   PMID:15749701   PMID:16542502   PMID:16611630   PMID:17307734   PMID:17588949   PMID:17588960   PMID:17882701   PMID:17993464  
PMID:18191556   PMID:18467703   PMID:18485748   PMID:19681593   PMID:19808781   PMID:20138147   PMID:20551380   PMID:21350216   PMID:22006726   PMID:22154936   PMID:23376485   PMID:23533145  
PMID:23850469   PMID:23951406   PMID:24006456   PMID:24312420   PMID:25446117   PMID:26045608   PMID:26746240   PMID:27068509   PMID:27151399   PMID:27498005   PMID:28860005   PMID:29030641  
PMID:29867124   PMID:34395611   PMID:35468843  


Genomics

Comparative Map Data
Comp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21619,047,206 - 19,055,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1619,047,207 - 19,055,845 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1619,086,958 - 19,095,161 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01620,219,417 - 20,227,820 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01619,139,921 - 19,148,124 (-)NCBIRnor_WKY
Rnor_6.01620,798,437 - 20,807,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,798,437 - 20,807,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,647,382 - 20,657,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1619,237,609 - 19,245,998 (-)NCBICelera
Cytogenetic Map16p14NCBI
COMP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,782,773 - 18,791,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1918,782,773 - 18,791,305 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,893,583 - 18,902,114 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,754,583 - 18,763,114 (-)NCBINCBI36Build 36hg18NCBI36
Build 341918,754,583 - 18,763,114NCBI
Celera1918,798,378 - 18,806,909 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1918,458,025 - 18,466,569 (-)NCBIHuRef
CHM1_11918,893,587 - 18,902,107 (-)NCBICHM1_1
T2T-CHM13v2.01918,918,369 - 18,926,902 (-)NCBIT2T-CHM13v2.0
Comp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,826,186 - 70,834,721 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl870,826,208 - 70,834,716 (+)EnsemblGRCm39 Ensembl
GRCm38870,373,548 - 70,382,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,373,558 - 70,382,066 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,897,447 - 72,905,965 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,302,547 - 73,311,055 (+)NCBIMGSCv36mm8
Celera872,929,973 - 72,938,489 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
COMP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11919,229,420 - 19,238,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,229,562 - 19,238,008 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01918,222,270 - 18,230,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
COMP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,306,813 - 44,314,575 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,306,859 - 44,314,625 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,221,457 - 44,229,145 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02044,793,007 - 44,800,779 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2044,793,063 - 44,800,711 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,030,270 - 44,038,042 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,440,677 - 44,448,355 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02044,715,955 - 44,723,648 (+)NCBIUU_Cfam_GSD_1.0
Comp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118202,995,236 - 203,002,126 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,544,389 - 2,551,164 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365962,544,389 - 2,551,155 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COMP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,061,426 - 59,069,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,061,409 - 59,068,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,815,756 - 58,823,293 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COMP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1617,246,617 - 17,255,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl617,246,762 - 17,255,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,070,833 - 2,079,420 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Comp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,871,002 - 1,877,369 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,870,975 - 1,877,434 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Comp
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:100
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000072536
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 7
Low 3 20 9 1 1 7 10 22 15 11 7
Below cutoff 19 42 34 19 34 1 1 46 32 19 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072536   ⟹   ENSRNOP00000067037
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1619,047,207 - 19,055,584 (-)Ensembl
Rnor_6.0 Ensembl1620,798,437 - 20,807,070 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083281   ⟹   ENSRNOP00000070348
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1620,798,570 - 20,800,646 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092334
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1619,047,207 - 19,054,228 (-)Ensembl
Rnor_6.0 Ensembl1620,803,585 - 20,805,482 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120265   ⟹   ENSRNOP00000095935
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1619,047,207 - 19,055,845 (-)Ensembl
RefSeq Acc Id: NM_012834   ⟹   NP_036966
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21619,047,206 - 19,055,584 (-)NCBI
Rnor_6.01620,798,437 - 20,807,070 (-)NCBI
Rnor_5.01620,647,382 - 20,657,932 (-)NCBI
Celera1619,237,609 - 19,245,998 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252822   ⟹   XP_006252884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21619,047,206 - 19,053,818 (-)NCBI
Rnor_6.01620,798,437 - 20,805,681 (-)NCBI
Rnor_5.01620,647,382 - 20,657,932 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036966 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252884 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA51419 (Get FASTA)   NCBI Sequence Viewer  
  EDL90681 (Get FASTA)   NCBI Sequence Viewer  
  P35444 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036966   ⟸   NM_012834
- Peptide Label: precursor
- UniProtKB: M0RBU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252884   ⟸   XM_006252822
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000067037   ⟸   ENSRNOT00000072536
RefSeq Acc Id: ENSRNOP00000070348   ⟸   ENSRNOT00000083281
RefSeq Acc Id: ENSRNOP00000095935   ⟸   ENSRNOT00000120265
Protein Domains
EGF-like   TSP C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35444-F1-model_v2 AlphaFold P35444 1-755 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700034
Promoter ID:EPDNEW_R10557
Type:single initiation site
Name:Comp_1
Description:cartilage oligomeric matrix protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,807,085 - 20,807,145EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2378 AgrOrtholog
BioCyc Gene G2FUF-11776 BioCyc
Ensembl Genes ENSRNOG00000048472 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067037 ENTREZGENE
  ENSRNOP00000067037.1 UniProtKB/TrEMBL
  ENSRNOP00000089337 ENTREZGENE
  ENSRNOP00000089337.1 UniProtKB/TrEMBL
  ENSRNOP00000095935.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072536 ENTREZGENE
  ENSRNOT00000072536.3 UniProtKB/TrEMBL
  ENSRNOT00000092334 ENTREZGENE
  ENSRNOT00000092334.2 UniProtKB/TrEMBL
  ENSRNOT00000120265.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thbs/COMP_coiled-coil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombospondin_3-like_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombospondin_3_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombospondin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP-5_cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_type-3_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25304 UniProtKB/Swiss-Prot
NCBI Gene 25304 ENTREZGENE
PANTHER PTHR10199:SF88 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Comp PhenoGen
PROSITE EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103647 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218086
UniProt A0A8I6A7Z1_RAT UniProtKB/TrEMBL
  A0A8I6AP06_RAT UniProtKB/TrEMBL
  COMP_RAT UniProtKB/Swiss-Prot
  M0RBU0 ENTREZGENE, UniProtKB/TrEMBL
  P35444 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Comp  Cartilage oligomeric matrix protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology homologous to carboxy-terminal half of thrombospondin 1298776
gene_physical_interaction interacts with fibronectin in extracellular matrix 1298778
gene_process may play a role in extracellular matrix molecular interactions and in extracellular matrix assembly 1298778
gene_protein 755 amino acids; calculated molecular weight of 82,700 Da 1298776
gene_protein homopolymer composed of five disulfide-linked subunits 1298776