Stath (statherin) - Rat Genome Database

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Gene: Stath (statherin) Rattus norvegicus
Analyze
Symbol: Stath
Name: statherin
RGD ID: 1589974
Description: Predicted to be involved in defense response to bacterium. Predicted to be located in extracellular region. Orthologous to several human genes including HTN1 (histatin 1); INTERACTS WITH acrylamide; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histatin-1; LOC689604; theobromine induced protein; uncharacterized protein LOC689604
RGD Orthologs
Human
Bonobo
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,586,563 - 20,590,421 (-)NCBIGRCr8
mRatBN7.21420,307,324 - 20,311,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,307,324 - 20,311,182 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1420,237,364 - 20,241,223 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01421,556,250 - 21,560,109 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,293,461 - 20,297,320 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,957,013 - 21,960,871 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,957,013 - 21,960,871 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01421,871,823 - 21,875,681 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41421,832,720 - 21,836,578 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1419,710,408 - 19,714,266 (-)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Stath
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,586,563 - 20,590,421 (-)NCBIGRCr8
mRatBN7.21420,307,324 - 20,311,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,307,324 - 20,311,182 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1420,237,364 - 20,241,223 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01421,556,250 - 21,560,109 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,293,461 - 20,297,320 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,957,013 - 21,960,871 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,957,013 - 21,960,871 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01421,871,823 - 21,875,681 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41421,832,720 - 21,836,578 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1419,710,408 - 19,714,266 (-)NCBICelera
Cytogenetic Map14p21NCBI
STATH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38469,995,966 - 70,002,570 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl469,995,966 - 70,002,570 (+)EnsemblGRCh38hg38GRCh38
GRCh37470,861,683 - 70,868,287 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36470,896,237 - 70,902,762 (+)NCBINCBI36Build 36hg18NCBI36
Build 34471,042,407 - 71,048,933NCBI
Celera468,215,077 - 68,221,603 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef466,659,309 - 66,665,835 (+)NCBIHuRef
CHM1_1470,898,027 - 70,904,554 (+)NCBICHM1_1
T2T-CHM13v2.0473,330,761 - 73,337,367 (+)NCBIT2T-CHM13v2.0
HTN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2360,027,609 - 60,036,008 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1460,230,561 - 60,238,964 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0454,174,923 - 54,183,320 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1460,511,987 - 60,520,407 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl460,511,983 - 60,520,436 (-)Ensemblpanpan1.1panPan2
Stath
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528516,037,609 - 16,065,984 (+)NCBIHiC_Itri_2
STATH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl866,944,849 - 66,949,826 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1866,944,851 - 66,953,345 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28148,259,197 - 148,267,691 (+)NCBISscrofa10.2Sscrofa10.2susScr3


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 4 3 1 1 1 2 2 3

Sequence


Ensembl Acc Id: ENSRNOT00000085234   ⟹   ENSRNOP00000075467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,307,324 - 20,311,182 (-)Ensembl
Rnor_6.0 Ensembl1421,957,013 - 21,960,871 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113554   ⟹   ENSRNOP00000092453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,307,324 - 20,309,407 (-)Ensembl
RefSeq Acc Id: NM_001316999   ⟹   NP_001303928
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,586,563 - 20,590,421 (-)NCBI
mRatBN7.21420,307,324 - 20,311,182 (-)NCBI
Rnor_6.01421,957,013 - 21,960,871 (-)NCBI
Celera1419,710,408 - 19,714,266 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001303928 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS75549 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075467.1
  ENSRNOP00000092453.1
RefSeq Acc Id: NP_001303928   ⟸   NM_001316999
- Peptide Label: precursor
- UniProtKB: Q5J6K0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075467   ⟸   ENSRNOT00000085234
Ensembl Acc Id: ENSRNOP00000092453   ⟸   ENSRNOT00000113554

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5J6K0-F1-model_v2 AlphaFold Q5J6K0 1-68 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589974 AgrOrtholog
BioCyc Gene G2FUF-16130 BioCyc
Ensembl Genes ENSRNOG00000054677 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085234.2 UniProtKB/TrEMBL
  ENSRNOT00000113554.1 UniProtKB/TrEMBL
InterPro Histatin/statherin UniProtKB/TrEMBL
KEGG Report rno:689604 UniProtKB/TrEMBL
NCBI Gene 689604 ENTREZGENE
PANTHER HISTATIN-3 UniProtKB/TrEMBL
  PTHR15057 UniProtKB/TrEMBL
PhenoGen Stath PhenoGen
RatGTEx ENSRNOG00000054677 RatGTEx
UniProt A0A8I6AGK7_RAT UniProtKB/TrEMBL
  Q5J6K0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-10-17 Stath  statherin  LOC689604  theobromine induced protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689604  theobromine induced protein  LOC686440  hypothetical protein LOC686440  Data merged from RGD:1597644 1643240 APPROVED
2006-11-20 LOC689604  theobromine induced protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC686440  hypothetical protein LOC686440      Symbol and Name status set to provisional 70820 PROVISIONAL