RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
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Adgrb1
adhesion G protein-coupled receptor B1
ISO
mRNA:decreased expression:pancreas
RGD
PMID:11875720
RGD:13831350
NCBI chr 7:106,404,827...106,476,902
Ensembl chr 7:106,404,958...106,476,902
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Akt3
AKT serine/threonine kinase 3
severity
ISO
mRNA:increased expression:pancreas (human)
RGD
PMID:27919956
RGD:13451128
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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Birc2
baculoviral IAP repeat-containing 2
exacerbates
ISO
mRNA:increased expression:pancreas (human)
RGD
PMID:31964418
RGD:153344516
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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Birc3
baculoviral IAP repeat-containing 3
disease_progression
ISO
mRNA:increased expression:pancreas (human)
RGD
PMID:31964418
RGD:153344516
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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Birc5
baculoviral IAP repeat-containing 5
exacerbates
ISO
mRNA:increased expression:pancreas (human)
RGD
PMID:31964418
RGD:153344516
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Birc7
baculoviral IAP repeat-containing 7
exacerbates
ISO
mRNA:increased expression:pancreas (human)
RGD
PMID:31964418
RGD:153344516
NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606
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Cbr4
carbonyl reductase 4
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:9536098 PMID:17576681 PMID:25741868 PMID:28166811 PMID:28492532
NCBI chr16:28,629,928...28,684,230
Ensembl chr16:28,617,224...28,645,712
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Ccnd1
cyclin D1
severity
ISO
protein:increased expression:pancreas (human)
RGD
PMID:25053516
RGD:13462053
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdk4
cyclin-dependent kinase 4
treatment
ISO
human cells in a mouse model
RGD
PMID:22509328
RGD:13792559
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdk6
cyclin-dependent kinase 6
treatment
ISO
human cells in a mouse model
RGD
PMID:25050737
RGD:13782144
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
ISO
DNA:missense mutations:cds:p.V126D, p.A148T (human) ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar RGD
PMID:7780957 PMID:8521414 PMID:8573142 PMID:8595405 PMID:8723678 PMID:9324288 PMID:9536098 PMID:9751050 PMID:9823374 PMID:10491434 PMID:11477665 PMID:11500805 PMID:11687599 PMID:12072543 PMID:14508519 PMID:16234564 PMID:16896043 PMID:16905682 PMID:17576681 PMID:18573309 PMID:21462282 PMID:25157968 PMID:25356972 PMID:25741868 PMID:26619011 PMID:26681309 PMID:26775776 PMID:28492532 PMID:28830827 PMID:29464027 PMID:29983899 PMID:32455486 PMID:35001868 PMID:16397522 More...
RGD:8552283
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Ctnnb1
catenin beta 1
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:9065402 PMID:9294210 PMID:9500465 PMID:9927029 PMID:10192393 PMID:10398436 PMID:10435629 PMID:10655994 PMID:10666372 PMID:25157968 PMID:25741868 PMID:26619011 PMID:26822237 More...
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Cxcr4
C-X-C motif chemokine receptor 4
ISO
RGD
PMID:21448932
RGD:11352272
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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E2f1
E2F transcription factor 1
treatment
ISO
Human cells in a mouse model
RGD
PMID:28797284
RGD:13838736
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Erbb2
erb-b2 receptor tyrosine kinase 2
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:16397024 PMID:23220880 PMID:26619011 PMID:28492532
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Gnas
GNAS complex locus
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:1517386 PMID:1594625 PMID:1944469 PMID:2549426 PMID:3720010 PMID:7739708 PMID:8766942 PMID:9626141 PMID:10571700 PMID:11093740 PMID:12727968 PMID:12970318 PMID:15126527 PMID:15952988 PMID:16507630 PMID:16543670 PMID:17873334 PMID:20197676 PMID:21835143 PMID:23403822 PMID:23536913 PMID:23843956 PMID:24855271 PMID:25157968 PMID:25719192 PMID:25741868 PMID:26341786 PMID:26574629 PMID:26619011 PMID:27398169 PMID:27506760 PMID:28492532 PMID:29991465 PMID:30702195 More...
NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
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Gstt1
glutathione S-transferase theta 1
ISO
RGD
PMID:11854392
RGD:14700985
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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Hras
HRas proto-oncogene, GTPase
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 PMID:16443854 PMID:16835863 PMID:16881968 PMID:16969868 PMID:17054105 PMID:17211612 PMID:17384584 PMID:17412879 PMID:17601930 PMID:17979197 PMID:18039947 PMID:18042262 PMID:18247425 PMID:18978862 PMID:19206176 PMID:19213030 PMID:19255327 PMID:19371735 PMID:19382114 PMID:19669404 PMID:19773371 PMID:20301680 PMID:20660566 PMID:20859122 PMID:20937837 PMID:20979192 PMID:21438134 PMID:21495179 PMID:21686750 PMID:21834037 PMID:21850009 PMID:22087699 PMID:22256804 PMID:22317973 PMID:22420426 PMID:22495892 PMID:22499344 PMID:22683711 PMID:22726224 PMID:22926243 PMID:23093928 PMID:23096712 PMID:23406027 PMID:23429430 PMID:23751039 PMID:23884457 PMID:24006476 PMID:24033266 PMID:24129065 PMID:24169525 PMID:24224811 PMID:24390138 PMID:24803665 PMID:25157968 PMID:25326635 PMID:25741868 PMID:25914166 PMID:26467025 PMID:26619011 PMID:27195699 PMID:27283355 PMID:27444071 PMID:27589201 PMID:28027064 PMID:28139825 PMID:28492532 PMID:29493581 PMID:30191474 PMID:31222966 PMID:31394527 PMID:31775759 PMID:32732226 PMID:33027564 PMID:33372952 PMID:34008892 PMID:34958143 PMID:168335863 More...
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Hrg
histidine-rich glycoprotein
disease_progression
ISO
RGD
PMID:21713765
RGD:11041886
NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389
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Jak1
Janus kinase 1
treatment
ISO
human cell line in a mouse model
RGD
PMID:29328487
RGD:13838743
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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Kras
KRAS proto-oncogene, GTPase
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 PMID:16434492 PMID:16618717 PMID:18316791 PMID:18794081 PMID:19075190 PMID:19114683 PMID:19679400 PMID:20921462 PMID:20921465 PMID:21228335 PMID:22407852 PMID:22722830 PMID:23325582 PMID:25157968 PMID:26619011 More...
NCBI chr 4:178,185,418...178,218,484
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Lrrc56
leucine rich repeat containing 56
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 PMID:16443854 PMID:16835863 PMID:16881968 PMID:16969868 PMID:17054105 PMID:17211612 PMID:17384584 PMID:17412879 PMID:17601930 PMID:17979197 PMID:18039947 PMID:18042262 PMID:18247425 PMID:18978862 PMID:19206176 PMID:19213030 PMID:19255327 PMID:19371735 PMID:19382114 PMID:19669404 PMID:19773371 PMID:20301680 PMID:20660566 PMID:20859122 PMID:20937837 PMID:20979192 PMID:21438134 PMID:21495179 PMID:21686750 PMID:21834037 PMID:21850009 PMID:22087699 PMID:22256804 PMID:22317973 PMID:22420426 PMID:22495892 PMID:22499344 PMID:22683711 PMID:22726224 PMID:22926243 PMID:23093928 PMID:23096712 PMID:23406027 PMID:23429430 PMID:23751039 PMID:23884457 PMID:24006476 PMID:24033266 PMID:24129065 PMID:24169525 PMID:24224811 PMID:24390138 PMID:24803665 PMID:25157968 PMID:25326635 PMID:25741868 PMID:25914166 PMID:26467025 PMID:26619011 PMID:27195699 PMID:27283355 PMID:27444071 PMID:27589201 PMID:28027064 PMID:28139825 PMID:28492532 PMID:29493581 PMID:30191474 PMID:31222966 PMID:31394527 PMID:31775759 PMID:32732226 PMID:33027564 PMID:33372952 PMID:34008892 PMID:34958143 PMID:168335863 More...
NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172
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Map2k1
mitogen activated protein kinase kinase 1
treatment severity
ISO
human tissue in a mouse model protein:increased expression:pancreas (human)
RGD
PMID:28849200 PMID:19513748
RGD:13838804 , RGD:13838840
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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Map2k2
mitogen activated protein kinase kinase 2
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:18042262 PMID:26619011
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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Mapk1
mitogen activated protein kinase 1
severity
ISO
mRNA:increased expression:pancreas (human)
RGD
PMID:27919956
RGD:13451128
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk10
mitogen activated protein kinase 10
severity
ISO
DNA:SNP:intron: (rs2589506) (human)
RGD
PMID:
RGD:13838853
NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
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Mapk8
mitogen-activated protein kinase 8
exacerbates
ISO
protein:increased phosphorylation:pancreas (human)
RGD
PMID:24395444
RGD:150340683
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
ISO
RGD
PMID:22517435
RGD:14348976
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Med12
mediator complex subunit 12
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:26619011
NCBI chr X:66,404,807...66,427,775
Ensembl chr X:66,404,760...66,428,387
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Mycn
MYCN proto-oncogene, bHLH transcription factor
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:26619011
NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
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Nfkb1
nuclear factor kappa B subunit 1
severity
ISO
mRNA:increased expression:pancreas (human)
RGD
PMID:27919956
RGD:13451128
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Palld
palladin, cytoskeletal associated protein
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:9536098 PMID:10454945 PMID:11474289 PMID:17194196 PMID:17415588 PMID:17576681 PMID:19336541 PMID:24033266 PMID:25741868 PMID:28166811 PMID:28492532 More...
NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 PMID:15805248 PMID:15930273 PMID:16906227 PMID:16930767 PMID:17376864 PMID:17673550 PMID:18676830 PMID:18725974 PMID:19029981 PMID:19223544 PMID:19366826 PMID:19513541 PMID:19903786 PMID:20453058 PMID:20593314 PMID:20619739 PMID:21078999 PMID:21430269 PMID:21558396 PMID:21824802 PMID:22120714 PMID:22162582 PMID:22162589 PMID:22271473 PMID:22370636 PMID:22658544 PMID:22729222 PMID:22729223 PMID:22729224 PMID:22949682 PMID:23066039 PMID:23100325 PMID:23246288 PMID:23408298 PMID:23888070 PMID:23946963 PMID:24033266 PMID:24265155 PMID:24782230 PMID:25157968 PMID:25599672 PMID:25681199 PMID:25741868 PMID:25880439 PMID:26266975 PMID:26266985 PMID:26619011 PMID:26627007 PMID:26637981 PMID:26822237 PMID:27126994 PMID:27283355 PMID:27626068 PMID:27631024 PMID:28151489 PMID:28425981 PMID:28492532 PMID:29446767 PMID:29661094 PMID:29988677 PMID:30376034 PMID:30543347 PMID:31536475 PMID:31775759 PMID:32778138 PMID:34008892 PMID:34496175 PMID:34568242 PMID:34606700 PMID:37667289 PMID:37712948 More...
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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Plat
plasminogen activator, tissue type
ISO
mRNA:increased expression:pancreas (human)
RGD
PMID:16733850
RGD:11541045
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Pole
DNA polymerase epsilon, catalytic subunit
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:23263490 PMID:23447401 PMID:24525744 PMID:24844595 PMID:25224212 PMID:25228659 PMID:26619011 PMID:28492532 PMID:32424176 More...
NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
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Rac1
Rac family small GTPase 1
treatment
ISO
human cells in a mouse model
RGD
PMID:21037555
RGD:14392805
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
treatment
ISO
human cells in a mouse model
RGD
PMID:15014358
RGD:14392893
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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Ralb
RAS like proto-oncogene B
treatment
ISO
human cells in a mouse model
RGD
PMID:17174914
RGD:14394417
NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202
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Ralbp1
ralA binding protein 1
treatment
ISO
human cells in a mouse model
RGD
PMID:22509328
RGD:13792559
NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707
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Rxra
retinoid X receptor alpha
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:26619011
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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Sf3b2
splicing factor 3b, subunit 2
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:26619011
NCBI chr 1:202,570,423...202,590,774
Ensembl chr 1:202,570,423...202,590,759
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Smad4
SMAD family member 4
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:6604412 PMID:8898652 PMID:9214508 PMID:9285566 PMID:9582123 PMID:9679244 PMID:9811934 PMID:10479724 PMID:10764709 PMID:10775259 PMID:10797267 PMID:11274206 PMID:11583957 PMID:12116240 PMID:12821112 PMID:14715079 PMID:15014009 PMID:15031030 PMID:15235019 PMID:15799969 PMID:16613914 PMID:17132729 PMID:17873119 PMID:17994767 PMID:18823382 PMID:20101697 PMID:20301642 PMID:22316667 PMID:22331366 PMID:25741868 PMID:26572829 PMID:26619011 PMID:27595937 PMID:28492532 PMID:31837202 PMID:32300199 PMID:32573726 PMID:32944796 PMID:33326750 More...
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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Smad7
SMAD family member 7
severity
ISO
human cell and construct in a mouse model
RGD
PMID:10498890
RGD:14394510
NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
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Stat1
signal transducer and activator of transcription 1
ameliorates
ISO
protein:increased expression:pancreas (human)
RGD
PMID:24658320
RGD:155630608
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Tp53
tumor protein p53
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:124622 PMID:253702 PMID:960674 PMID:1349175 PMID:1565143 PMID:1565144 PMID:1569604 PMID:1591732 PMID:1631137 PMID:1644930 PMID:1673792 PMID:1683921 PMID:1686725 PMID:1737852 PMID:1915267 PMID:1918170 PMID:1978757 PMID:2046748 PMID:2259385 PMID:2654466 PMID:3784963 PMID:4122735 PMID:6736287 PMID:7478555 PMID:7565304 PMID:7651740 PMID:7707106 PMID:7718482 PMID:7732013 PMID:7737263 PMID:7750099 PMID:7761089 PMID:7783166 PMID:7791795 PMID:7881428 PMID:7885831 PMID:7887414 PMID:8001119 PMID:8023157 PMID:8062826 PMID:8080050 PMID:8099841 PMID:8118819 PMID:8164043 PMID:8242631 PMID:8276238 PMID:8308926 PMID:8336941 PMID:8364550 PMID:8401536 PMID:8402598 PMID:8423216 PMID:8425176 PMID:8479749 PMID:8527048 PMID:8550239 PMID:8631304 PMID:8633021 PMID:8649776 PMID:8688334 PMID:8718514 PMID:8816796 PMID:8825920 PMID:8829627 PMID:8843196 PMID:8869100 PMID:9020384 PMID:9049183 PMID:9049184 PMID:9096669 PMID:9150393 PMID:9157982 PMID:9218725 PMID:9242456 PMID:9268986 PMID:9290701 PMID:9364015 PMID:9399658 PMID:9399838 PMID:9407971 PMID:9418900 PMID:9525742 PMID:9546439 PMID:9569050 PMID:9572492 PMID:9598730 PMID:9627118 PMID:9632751 PMID:9635828 PMID:9662334 PMID:9667734 PMID:9704930 PMID:9825943 PMID:10064694 PMID:10089074 PMID:10229196 PMID:10411893 PMID:10432928 PMID:10519380 PMID:10567903 PMID:10589545 PMID:10616528 PMID:10629033 PMID:10713666 PMID:10732753 PMID:10753186 PMID:10761705 PMID:10797439 PMID:10864200 PMID:10871862 PMID:10922393 PMID:10949938 PMID:11051239 PMID:11051241 PMID:11139324 PMID:11180592 PMID:11313981 PMID:11370630 PMID:11429705 PMID:11479205 PMID:11590071 PMID:11593407 PMID:11668501 PMID:11782540 PMID:11793474 PMID:11867759 PMID:11896595 PMID:11900253 PMID:11920788 PMID:11920959 PMID:12007217 PMID:12034820 PMID:12406399 PMID:12506399 PMID:12509279 PMID:12672316 PMID:12695689 PMID:12700230 PMID:12702523 PMID:12726864 PMID:12782597 PMID:12792784 PMID:12826609 PMID:12885464 PMID:12901974 PMID:12909720 PMID:12917626 PMID:14559903 PMID:14584079 PMID:14673037 PMID:14743206 PMID:15004724 PMID:15017592 PMID:15037740 PMID:15077194 PMID:15138567 PMID:15221755 PMID:15381368 PMID:15390294 PMID:15541116 PMID:15580553 PMID:15607980 PMID:15607981 PMID:15611505 PMID:15722483 PMID:15781620 PMID:15825182 PMID:15850016 PMID:15925506 PMID:15951970 PMID:15958617 PMID:15977174 PMID:15982667 PMID:15993273 PMID:16206219 PMID:16209708 PMID:16247456 PMID:16258005 PMID:16312222 PMID:16322298 PMID:16337994 PMID:16401470 PMID:16474844 PMID:16489069 PMID:16492679 PMID:16494995 PMID:16508005 PMID:16551709 PMID:16633321 PMID:16682957 PMID:16736287 PMID:16741917 PMID:16778209 PMID:16793544 PMID:16818505 PMID:16827139 PMID:16861262 PMID:17015838 PMID:17308077 PMID:17311302 PMID:17390010 PMID:17401428 PMID:17417627 PMID:17427234 PMID:17530187 PMID:17540308 PMID:17541742 PMID:17567834 PMID:17572079 PMID:17606709 PMID:17636407 PMID:17724467 PMID:17875924 PMID:17881637 PMID:17974978 PMID:17999388 PMID:18208484 PMID:18307025 PMID:18453682 PMID:18511570 PMID:18555592 PMID:18628487 PMID:18685109 PMID:18689542 PMID:18818522 PMID:18937320 PMID:18978813 PMID:18989156 PMID:19012332 PMID:19101993 PMID:19147582 PMID:19171880 PMID:19336573 PMID:19367569 PMID:19378321 PMID:19405127 PMID:19454241 PMID:19462533 PMID:19468865 PMID:19556618 PMID:19681600 PMID:19850740 PMID:19913028 PMID:19930417 PMID:20013323 PMID:20028212 PMID:20113312 PMID:20127978 PMID:20128691 PMID:20182602 PMID:20195489 PMID:20234365 PMID:20364130 PMID:20407015 PMID:20505364 PMID:20506564 PMID:20516128 PMID:20522432 PMID:20586629 PMID:20589832 PMID:20593220 PMID:20693561 PMID:20805372 PMID:20878954 PMID:20972454 PMID:21056685 PMID:21059199 PMID:21080251 PMID:21113594 PMID:21115975 PMID:21118481 PMID:21159183 PMID:21187651 PMID:21188122 PMID:21232794 PMID:21305319 PMID:21319261 PMID:21343334 PMID:21356188 PMID:21445056 PMID:21483000 PMID:21484931 PMID:21514416 PMID:21519010 PMID:21522129 PMID:21535297 PMID:21552135 PMID:21590121 PMID:21601526 PMID:21626334 PMID:21674059 PMID:21747090 PMID:21760960 PMID:21760996 PMID:21761402 PMID:22006311 PMID:22052707 PMID:22090360 PMID:22109999 PMID:22110706 PMID:22186996 PMID:22198284 PMID:22265402 PMID:22427690 PMID:22484423 PMID:22553421 PMID:22672556 PMID:22710932 PMID:22713868 PMID:22768918 PMID:22811390 PMID:22822097 PMID:22862161 PMID:22869713 PMID:22887876 PMID:22915647 PMID:22919068 PMID:22923379 PMID:22955915 PMID:22983585 PMID:23028800 PMID:23031740 PMID:23124483 PMID:23161690 PMID:23165212 PMID:23172776 PMID:23175693 PMID:23246812 PMID:23259501 PMID:23263379 PMID:23264849 PMID:23340422 PMID:23406775 PMID:23484829 PMID:23538418 PMID:23612969 PMID:23625637 PMID:23630318 PMID:23667202 PMID:23713777 PMID:23792586 PMID:23894400 PMID:23950206 PMID:23967324 PMID:24033266 PMID:24038938 PMID:24065105 PMID:24076587 PMID:24122735 PMID:24256616 PMID:24381225 PMID:24384472 PMID:24487413 PMID:24501221 PMID:24549055 PMID:24573247 PMID:24590827 PMID:24603336 PMID:24641375 PMID:24651012 PMID:24651015 PMID:24677579 PMID:24702488 PMID:24728327 PMID:24744791 PMID:24763289 PMID:24810334 PMID:24835218 PMID:24857548 PMID:24940547 PMID:25119136 PMID:25157968 PMID:25186627 PMID:25256166 PMID:25293557 PMID:25294809 PMID:25339994 PMID:25381062 PMID:25404506 PMID:25428789 PMID:25433984 PMID:25503501 PMID:25504633 PMID:25525159 PMID:25584008 PMID:25584637 PMID:25612911 PMID:25619955 PMID:25634208 PMID:25669829 PMID:25691460 PMID:25741868 PMID:25757876 PMID:25765855 PMID:25787918 PMID:25896519 PMID:25925845 PMID:25927356 PMID:25945745 PMID:25952993 PMID:25961455 PMID:25980754 PMID:26014290 PMID:26022348 PMID:26024390 PMID:26066407 PMID:26205489 PMID:26225655 PMID:26230955 PMID:26270727 PMID:26271412 PMID:26332594 PMID:26425688 PMID:26467025 PMID:26497680 PMID:26554828 PMID:26556299 PMID:26580448 PMID:26585234 PMID:26619011 PMID:26655088 PMID:26659639 PMID:26681312 PMID:26781615 PMID:26786923 PMID:26787237 PMID:26822237 PMID:26845104 PMID:26878390 PMID:26911350 PMID:26976419 PMID:27022024 PMID:27050224 PMID:27077130 PMID:27179933 PMID:27189670 PMID:27276561 PMID:27328919 PMID:27374712 PMID:27463065 PMID:27489289 PMID:27493922 PMID:27501770 PMID:27523101 PMID:27533082 PMID:27557517 PMID:27616075 PMID:27621308 PMID:27622479 PMID:27680515 PMID:27683180 PMID:27714481 PMID:27724982 PMID:27813088 PMID:27873457 PMID:27895058 PMID:27911860 PMID:27959731 PMID:27993330 PMID:28135145 PMID:28152038 PMID:28160093 PMID:28166194 PMID:28271309 PMID:28279309 PMID:28356770 PMID:28369373 PMID:28453743 PMID:28472496 PMID:28477316 PMID:28492532 PMID:28724667 PMID:28772286 PMID:28802053 PMID:28861920 PMID:28873162 PMID:28973705 PMID:28975465 PMID:29025599 PMID:29058119 PMID:29070607 PMID:29076966 PMID:29126202 PMID:29300620 PMID:29324801 PMID:29470806 PMID:29478780 PMID:29489754 PMID:29581140 PMID:29666004 PMID:29752822 PMID:29753700 PMID:29875428 PMID:29946497 PMID:29979965 PMID:30076369 PMID:30099178 PMID:30128536 PMID:30216591 PMID:30224644 PMID:30287823 PMID:30299350 PMID:30306255 PMID:30311369 PMID:30318520 PMID:30322717 PMID:30327374 PMID:30352134 PMID:30450585 PMID:30546832 PMID:30583724 PMID:30630526 PMID:30675318 PMID:30709381 PMID:30709875 PMID:30720243 PMID:30730202 PMID:30816478 PMID:30840781 PMID:31016814 PMID:31050713 PMID:31081129 PMID:31105275 PMID:31119730 PMID:31121848 PMID:31127191 PMID:31206626 PMID:31296311 PMID:31300551 PMID:31533767 PMID:31748977 PMID:31775759 PMID:31881331 PMID:31882575 PMID:32000721 PMID:32019277 PMID:32156018 PMID:32164171 PMID:32187361 PMID:32295079 PMID:32318955 PMID:32371905 PMID:32401780 PMID:32475984 PMID:32658383 PMID:32817165 PMID:32888145 PMID:32906206 PMID:32980694 PMID:33087929 PMID:33138793 PMID:33163847 PMID:33208383 PMID:33245408 PMID:33300245 PMID:33332384 PMID:33372952 PMID:33407742 PMID:33471991 PMID:33633026 PMID:33635883 PMID:33674644 PMID:33758026 PMID:33818021 PMID:33840814 PMID:34026625 PMID:34240179 PMID:34308366 PMID:34529667 PMID:34675114 PMID:34709361 PMID:34793666 PMID:34805717 PMID:34994652 PMID:35033608 PMID:35127508 PMID:35264596 PMID:35820297 PMID:35938033 PMID:35974385 PMID:36168441 PMID:36219266 PMID:36988593 More...
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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U2af1
U2 small nuclear RNA auxiliary factor 1
ISO
ClinVar Annotator: match by term: Pancreatic adenocarcinoma
ClinVar
PMID:22158538 PMID:23029227 PMID:23861105 PMID:24498085 PMID:26619011
NCBI chr20:9,742,904...9,753,840
Ensembl chr20:9,742,905...9,753,832
G
Vegfc
vascular endothelial growth factor C
exacerbates
ISO
protein:increased expression:pancreas (human)
RGD
PMID:22082308
RGD:155630643
NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848
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Braf
B-Raf proto-oncogene, serine/threonine kinase
ISO
DNA:missense mutation, gene fusions:multiple (human)
RGD
PMID:25266736
RGD:13462041
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
disease_progression
IEP
RGD
PMID:8569183
RGD:150523792
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Tgfb2
transforming growth factor, beta 2
ameliorates
ISO
human cells in a mouse model
RGD
PMID:21366804
RGD:155630611
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Agr2
anterior gradient 2, protein disulphide isomerase family member
ISO
protein:increased expression:pancreas
RGD
PMID:19714807
RGD:2325658
NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
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Akr7a2
aldo-keto reductase family 7, member A2
ISO
protein:increased expression:pancreas
RGD
PMID:19077459
RGD:2325696
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
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Calr
calreticulin
ameliorates
ISO
human cells in mouse model human cells in a mouse model
RGD
PMID:33028359 PMID:29072694
RGD:150520160 , RGD:150521706
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Ccnd1
cyclin D1
severity
ISO
DNA:snp:exon:c.870G>A (human) protein:increased expression:pancreas (human)
RGD
PMID:25470788 PMID:22939953
RGD:13462050 , RGD:13462062
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cd59b
CD59b molecule
disease_progression
ISO
protein:increased expression:blood (human)
RGD
PMID:32663515
RGD:151660329
NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
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Cdk4
cyclin-dependent kinase 4
severity
ISO
protein:increased expression:pancreas, islet of Langerhans (human)
RGD
PMID:29735403
RGD:13781899
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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E2f1
E2F transcription factor 1
severity
ISO
protein:increased expression:pancreatic ductal cell, nucleus (human) DNA:amplification: : (human)
RGD
PMID:12650514 PMID:17233815 PMID:27573434
RGD:13838735 , RGD:13838739 , RGD:13838738
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Foxm1
forkhead box M1
disease_progression
ISO
RGD
PMID:24859161
RGD:156430321
NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
G
Fubp1
far upstream element binding protein 1
ISO
mRNA:increased expression:pancreatic duct (human)
RGD
PMID:32481602
RGD:151361197
NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602
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Glipr2
GLI pathogenesis-related 2
disease_progression
ISO
protein:decreased expression:blood (human)
RGD
PMID:32663515
RGD:151660329
NCBI chr 5:58,170,417...58,202,258
Ensembl chr 5:58,170,425...58,202,272
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Got1
glutamic-oxaloacetic transaminase 1
treatment
ISO
human cells in a mouse model
RGD
PMID:23535601
RGD:13504844
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Hspa8
heat shock protein family A (Hsp70) member 8
disease_progression
ISO
protein:decreased expression:blood (human)
RGD
PMID:32663515
RGD:151660329
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
susceptibility
ISO
RGD
PMID:22264792
RGD:13838741
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Jak1
Janus kinase 1
ISO
mRNA:decreased expression:pancreatic ductal cell (human)
RGD
PMID:28677798
RGD:13838745
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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Mapk8
mitogen-activated protein kinase 8
severity disease_progression
ISO
protein:increased phosphorylation:pancreas (mouse)
RGD
PMID:28837246 PMID:23237571
RGD:14348974 , RGD:14348975
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mir155
microRNA 155
disease_progression
ISO
RGD
PMID:28198398
RGD:25314300
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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Mir494
microRNA 494
disease_progression ameliorates
ISO
RGD
PMID:24859161 PMID:24859161
RGD:156430321 , RGD:156430321
NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
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Pgf
placental growth factor
severity
ISO
associated with obesity
RGD
PMID:26861455
RGD:14349030
NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ISO
mRNA, protein:increased expression:pancreas (human)
RGD
PMID:20876794
RGD:14390130
NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
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Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
severity
ISO
human cells in a mouse model
RGD
PMID:15591514
RGD:14390084
NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065
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Pld1
phospholipase D1
severity
ISO
protein:increased expression:pancreas (human)
RGD
PMID:27713167
RGD:14392801
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
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Ptprb
protein tyrosine phosphatase, receptor type, B
disease_progression
ISO
protein:decreased expression:blood (human)
RGD
PMID:32663515
RGD:151660329
NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748
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Ptprm
protein tyrosine phosphatase, receptor type, M
disease_progression
ISO
protein:decreased expression:blood (human)
RGD
PMID:32663515
RGD:151660329
NCBI chr 9:106,639,573...107,343,698
Ensembl chr 9:106,639,573...107,343,698
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Rac1
Rac family small GTPase 1
ISO
mRNA:increased expression:pancreas (human) mRNA, protein:increased expression:pancreas (mouse)
RGD
PMID:23334332 PMID:21684285
RGD:14392806 , RGD:14392816
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Rala
RAS like proto-oncogene A
ISO
mRNA:increased expression:pancreas (human)
RGD
PMID:29113235
RGD:14394418
NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063
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S100a8
S100 calcium binding protein A8
disease_progression
ISO
protein:increased expression:blood (human)
RGD
PMID:32663515
RGD:151660329
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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Smad2
SMAD family member 2
severity
ISO
RGD
PMID:26908446
RGD:14394493
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Tgfb1
transforming growth factor, beta 1
ameliorates
ISO
protein:decreased expression:pancreas (human)
RGD
PMID:8253361
RGD:155630628
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgfb2
transforming growth factor, beta 2
ameliorates
ISO
protein:decreased expression:pancreas (human)
RGD
PMID:8253361
RGD:155630628
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Tgfb3
transforming growth factor, beta 3
ameliorates
ISO
protein:decreased expression:pancreas (human)
RGD
PMID:8253361
RGD:155630628
NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
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Tgfbr1
transforming growth factor, beta receptor 1
ameliorates
ISO
human cell line in a mouse model
RGD
PMID:17297450
RGD:155630637
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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Vegfd
vascular endothelial growth factor D
ISO
protein:increased expression:blood serum (human)
RGD
PMID:21410412
RGD:155630646
NCBI chr X:30,073,122...30,108,413
Ensembl chr X:30,074,163...30,108,295
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Vnn1
vanin 1
disease_progression
ISO
protein:increased expression:blood (human)
RGD
PMID:32663515
RGD:151660329
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all