Birc7 (baculoviral IAP repeat-containing 7) - Rat Genome Database

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Gene: Birc7 (baculoviral IAP repeat-containing 7) Rattus norvegicus
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Symbol: Birc7
Name: baculoviral IAP repeat-containing 7
RGD ID: 1562883
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of protein ubiquitination; regulation of apoptotic process; and regulation of signal transduction. Predicted to act upstream of with a negative effect on regulation of apoptotic process. Predicted to act upstream of or within lens development in camera-type eye. Predicted to be located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human BIRC7 (baculoviral IAP repeat containing 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: baculoviral IAP repeat-containing 7 (livin); baculoviral IAP repeat-containing protein 7; LOC296468; RGD1562883; similar to livin inhibitor of apoptosis isoform beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,047,824 - 168,052,606 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,047,824 - 168,052,606 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,428,000 - 172,432,781 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03181,387,091 - 181,391,872 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03178,048,785 - 178,053,567 (+)NCBIRnor_WKY
Rnor_6.03176,438,335 - 176,443,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,439,199 - 176,443,195 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,150,723 - 180,153,671 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,037,778 - 170,043,277 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3164,532,360 - 164,537,207 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesothelioma. Gordon GJ, etal., J Pathol. 2007 Mar;211(4):447-54. doi: 10.1002/path.2121.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. [Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma]. Wu WX, etal., Zhonghua Zhong Liu Za Zhi. 2010 Sep;32(9):671-5.
Additional References at PubMed
PMID:16729033   PMID:17294084   PMID:18034418   PMID:21617971   PMID:26218911  


Genomics

Comparative Map Data
Birc7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,047,824 - 168,052,606 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,047,824 - 168,052,606 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,428,000 - 172,432,781 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03181,387,091 - 181,391,872 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03178,048,785 - 178,053,567 (+)NCBIRnor_WKY
Rnor_6.03176,438,335 - 176,443,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,439,199 - 176,443,195 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,150,723 - 180,153,671 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,037,778 - 170,043,277 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3164,532,360 - 164,537,207 (-)NCBICelera
Cytogenetic Map3q43NCBI
BIRC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,235,905 - 63,240,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2063,235,883 - 63,240,495 (+)EnsemblGRCh38hg38GRCh38
GRCh372061,867,257 - 61,871,847 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,337,721 - 61,342,299 (+)NCBINCBI36Build 36hg18NCBI36
Build 342061,337,720 - 61,342,299NCBI
Celera2058,544,759 - 58,549,338 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,592,772 - 58,597,397 (+)NCBIHuRef
CHM1_12061,768,290 - 61,772,915 (+)NCBICHM1_1
T2T-CHM13v2.02065,041,919 - 65,046,510 (+)NCBIT2T-CHM13v2.0
Birc7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,570,402 - 180,575,803 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,570,816 - 180,575,803 (+)EnsemblGRCm39 Ensembl
GRCm382180,928,609 - 180,934,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,929,023 - 180,934,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv372180,663,728 - 180,668,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362180,850,322 - 180,862,738 (+)NCBIMGSCv36mm8
Celera2185,015,239 - 185,020,226 (+)NCBICelera
Cytogenetic Map2H4NCBI
Birc7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528919,246 - 922,619 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955528919,246 - 922,581 (-)NCBIChiLan1.0ChiLan1.0
BIRC7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12061,156,871 - 61,161,932 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,157,302 - 61,161,932 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02059,618,530 - 59,623,612 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BIRC7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,950,700 - 46,956,375 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2446,952,474 - 46,955,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,136,510 - 46,140,424 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02447,906,319 - 47,910,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2447,906,319 - 47,909,340 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12446,921,701 - 46,925,622 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,045,709 - 47,049,636 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,802,069 - 47,805,983 (+)NCBIUU_Cfam_GSD_1.0
Birc7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,164,678 - 195,169,263 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,618,289 - 10,622,931 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493651410,618,347 - 10,622,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIRC7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11762,351,663 - 62,356,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BIRC7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12965,811 - 970,983 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605048,703,511 - 48,708,637 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Birc7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474128,937,836 - 28,944,000 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Birc7
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:61
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000068252
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
RH134165  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23168,051,897 - 168,052,549 (+)MAPPERmRatBN7.2
Rnor_6.03176,443,149 - 176,443,800NCBIRnor6.0
Rnor_5.03180,152,963 - 180,153,614UniSTSRnor5.0
RGSC_v3.43170,042,569 - 170,043,220UniSTSRGSC3.4
Celera3164,532,417 - 164,533,068UniSTS
RH 3.4 Map31532.2UniSTS
Cytogenetic Map3q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 8 41 4 9
Below cutoff 15 17 7 6 7 2 2 31 6 20 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000068252   ⟹   ENSRNOP00000059533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,047,824 - 168,052,606 (+)Ensembl
Rnor_6.0 Ensembl3176,439,199 - 176,443,195 (+)Ensembl
RefSeq Acc Id: NM_001305210   ⟹   NP_001292139
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,047,824 - 168,052,606 (+)NCBI
Rnor_6.03176,439,075 - 176,443,857 (+)NCBI
Celera3164,532,360 - 164,537,207 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001292139 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88780 (Get FASTA)   NCBI Sequence Viewer  
  EDL88781 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001292139   ⟸   NM_001305210
- UniProtKB: D4A690 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059533   ⟸   ENSRNOT00000068252
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A690-F1-model_v2 AlphaFold D4A690 1-285 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562883 AgrOrtholog
BioCyc Gene G2FUF-46312 BioCyc
Ensembl Genes ENSRNOG00000043311 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059533 ENTREZGENE
  ENSRNOP00000059533.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068252 ENTREZGENE
  ENSRNOT00000068252.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro BIR UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:296468 UniProtKB/TrEMBL
NCBI Gene 296468 ENTREZGENE
Pfam BIR UniProtKB/TrEMBL
PhenoGen Birc7 PhenoGen
PROSITE BIR_REPEAT_1 UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART BIR UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
UniProt D4A690 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Birc7  baculoviral IAP repeat-containing 7  Birc7  baculoviral IAP repeat-containing 7 (livin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Birc7  baculoviral IAP repeat-containing 7 (livin)  RGD1562883_predicted  similar to livin inhibitor of apoptosis isoform beta (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562883_predicted  similar to livin inhibitor of apoptosis isoform beta (predicted)  LOC296468  similar to livin inhibitor of apoptosis isoform beta  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC296468  similar to livin inhibitor of apoptosis isoform beta      Symbol and Name status set to provisional 70820 PROVISIONAL