RGD Reference Report - MicroRNA-155 Controls Exosome Synthesis and Promotes Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma. - Rat Genome Database

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MicroRNA-155 Controls Exosome Synthesis and Promotes Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma.

Authors: Mikamori, Manabu  Yamada, Daisaku  Eguchi, Hidetoshi  Hasegawa, Shinichiro  Kishimoto, Tomoya  Tomimaru, Yoshito  Asaoka, Tadafumi  Noda, Takehiro  Wada, Hiroshi  Kawamoto, Koichi  Gotoh, Kunihito  Takeda, Yutaka  Tanemura, Masahiro  Mori, Masaki  Doki, Yuichiro 
Citation: Mikamori M, etal., Sci Rep. 2017 Feb 15;7:42339. doi: 10.1038/srep42339.
RGD ID: 25314300
Pubmed: PMID:28198398   (View Abstract at PubMed)
PMCID: PMC5309735   (View Article at PubMed Central)
DOI: DOI:10.1038/srep42339   (Journal Full-text)

The cancer drug gemcitabine (GEM) is a key drug for treating pancreatic ductal adenocarcinoma (PDAC), but PDAC cells develop chemoresistance after long-term administration. Since the tolerance was immediately spread to every PDAC tissue in a patient, it is assumed that some certain efficient mechanisms underlay in the development of chemoresistance. Changes in the levels of particular microRNAs or alterations in intercellular communication play a dominant role in chemoresistance development, and recent data also suggest that exosomes play an important role in this process. In this study, we revealed that the loop conferred chemoresistance in PDAC cells. The loop was as follows; 1, The long-term exposure of GEM increased miR-155 expression in PDAC cells. 2, The increase of miR-155 induced two different functions; exosome secretion and chemoresistance ability via facilitating the anti-apoptotic activity. 3, Exosome deliver the miR-155 into the other PDAC cells and induce the following function. The target therapy to miR-155 or the exosome secretion effectively attenuated the chemoresistance, and these results were validated with both clinical samples and in vivo experiments. This mechanism represents a novel therapeutic target in GEM treatment to PDAC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR155Humanpancreatic ductal adenocarcinoma disease_progressionIEP  RGD 
Mir155Mousepancreatic ductal adenocarcinoma disease_progressionISOMIR155 (Homo sapiens) RGD 
Mir155Ratpancreatic ductal adenocarcinoma disease_progressionISOMIR155 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir155  (microRNA 155)

Genes (Mus musculus)
Mir155  (microRNA 155)

Genes (Homo sapiens)
MIR155  (microRNA 155)


Additional Information