Cbr4 (carbonyl reductase 4) - Rat Genome Database

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Pathways
Gene: Cbr4 (carbonyl reductase 4) Rattus norvegicus
Analyze
Symbol: Cbr4
Name: carbonyl reductase 4
RGD ID: 727826
Description: Predicted to enable several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Predicted to be involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Predicted to be located in mitochondrial matrix. Predicted to be part of oxidoreductase complex. Orthologous to human CBR4 (carbonyl reductase 4); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; carbonic reductase 4; carbonyl reductase family member 4; KAR beta subunit; LOC100911522; MGC105271; quinone reductase CBR4; uncharacterized LOC100911522
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81633,625,734 - 33,695,067 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1633,617,399 - 33,656,832 (-)EnsemblGRCr8
mRatBN7.21628,629,928 - 28,684,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1628,617,224 - 28,645,712 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1632,224,831 - 32,240,582 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01635,658,872 - 35,674,623 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01631,860,531 - 31,876,269 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01631,944,328 - 31,972,553 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1631,956,753 - 31,972,507 (-)Ensemblrn6Rnor6.0
Rnor_5.01631,794,520 - 31,810,263 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41631,943,125 - 31,957,556 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1628,625,441 - 28,641,135 (-)NCBICelera
RGSC_v3.11631,943,200 - 31,957,630 (-)NCBI
Cytogenetic Map16p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrial matrix  (IEA,ISO,ISS)
mitochondrion  (IEA)
oxidoreductase complex  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18614015   PMID:19000905   PMID:20837989   PMID:25203508   PMID:34800366  


Genomics

Comparative Map Data
Cbr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81633,625,734 - 33,695,067 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1633,617,399 - 33,656,832 (-)EnsemblGRCr8
mRatBN7.21628,629,928 - 28,684,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1628,617,224 - 28,645,712 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1632,224,831 - 32,240,582 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01635,658,872 - 35,674,623 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01631,860,531 - 31,876,269 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01631,944,328 - 31,972,553 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1631,956,753 - 31,972,507 (-)Ensemblrn6Rnor6.0
Rnor_5.01631,794,520 - 31,810,263 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41631,943,125 - 31,957,556 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1628,625,441 - 28,641,135 (-)NCBICelera
RGSC_v3.11631,943,200 - 31,957,630 (-)NCBI
Cytogenetic Map16p12NCBI
CBR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384168,894,486 - 169,010,255 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4168,863,770 - 169,010,275 (-)Ensemblhg38GRCh38
GRCh374169,908,741 - 169,931,406 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364170,145,316 - 170,167,997 (-)NCBIBuild 36Build 36hg18NCBI36
Celera4167,240,084 - 167,262,804 (-)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4165,662,191 - 165,684,917 (-)NCBIHuRef
CHM1_14169,885,180 - 169,907,907 (-)NCBICHM1_1
T2T-CHM13v2.04172,254,054 - 172,369,681 (-)NCBIT2T-CHM13v2.0
Cbr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,940,768 - 61,956,534 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl861,940,768 - 61,959,728 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38861,487,734 - 61,503,500 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl861,487,734 - 61,506,694 (+)Ensemblmm10GRCm38
MGSCv37863,966,531 - 63,982,297 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36864,379,926 - 64,395,624 (+)NCBIMGSCv36mm8
MGSCv36860,656,117 - 60,671,212 (+)NCBIMGSCv36mm8
Celera864,050,917 - 64,066,676 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map831.18NCBI
Cbr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540337,206,634 - 37,226,407 (+)Ensembl
ChiLan1.0NW_00495540337,201,474 - 37,226,414 (+)NCBIChiLan1.0ChiLan1.0
CBR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23166,663,224 - 166,794,172 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14167,015,483 - 167,149,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04161,103,477 - 161,235,840 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14173,182,755 - 173,309,905 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4173,282,162 - 173,309,905 (-)EnsemblpanPan2panpan1.1
CBR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12519,475,562 - 19,618,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2519,597,518 - 19,618,180 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2519,566,496 - 19,649,192 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02519,673,638 - 19,756,294 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2519,734,924 - 19,756,246 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12519,541,290 - 19,623,984 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02519,541,898 - 19,624,490 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02519,604,132 - 19,686,873 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cbr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494320,768,596 - 20,791,385 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365161,181,524 - 1,205,760 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365161,184,859 - 1,205,668 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1420,621,981 - 20,682,240 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11420,621,960 - 20,642,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21421,908,782 - 21,929,179 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17115,223,813 - 115,246,925 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7115,223,386 - 115,246,818 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603795,082,408 - 95,160,389 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cbr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624769581,800 - 604,075 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624769564,148 - 603,402 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cbr4
234 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:74
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000032199
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032199   ⟹   ENSRNOP00000038351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1633,626,614 - 33,656,832 (-)Ensembl
mRatBN7.2 Ensembl1628,629,927 - 28,645,712 (-)Ensembl
Rnor_6.0 Ensembl1631,956,753 - 31,972,507 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095468   ⟹   ENSRNOP00000085638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1633,617,399 - 33,656,832 (-)Ensembl
mRatBN7.2 Ensembl1628,617,224 - 28,645,712 (-)Ensembl
RefSeq Acc Id: NM_182672   ⟹   NP_872613
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81633,640,815 - 33,656,572 (-)NCBI
mRatBN7.21628,629,928 - 28,645,691 (-)NCBI
Rnor_6.01631,956,752 - 31,972,507 (-)NCBI
Rnor_5.01631,794,520 - 31,810,263 (-)NCBI
RGSC_v3.41631,943,125 - 31,957,556 (-)RGD
Celera1628,625,441 - 28,641,135 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094606   ⟹   XP_038950534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81633,640,815 - 33,695,067 (-)NCBI
mRatBN7.21628,629,928 - 28,684,230 (-)NCBI
RefSeq Acc Id: XM_039094607   ⟹   XP_038950535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81633,640,815 - 33,695,067 (-)NCBI
mRatBN7.21628,629,928 - 28,684,230 (-)NCBI
RefSeq Acc Id: XM_039094609   ⟹   XP_038950537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81633,640,815 - 33,695,067 (-)NCBI
mRatBN7.21628,629,928 - 28,684,230 (-)NCBI
RefSeq Acc Id: XM_063275479   ⟹   XP_063131549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81633,625,734 - 33,656,609 (-)NCBI
RefSeq Acc Id: NP_872613   ⟸   NM_182672
- UniProtKB: Q7TS56 (UniProtKB/Swiss-Prot),   A6KIR4 (UniProtKB/TrEMBL),   A0A8I6A1W1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038351   ⟸   ENSRNOT00000032199
RefSeq Acc Id: XP_038950534   ⟸   XM_039094606
- Peptide Label: isoform X2
- UniProtKB: A6KIR6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950537   ⟸   XM_039094609
- Peptide Label: isoform X2
- UniProtKB: A6KIR6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950535   ⟸   XM_039094607
- Peptide Label: isoform X2
- UniProtKB: A6KIR6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085638   ⟸   ENSRNOT00000095468
RefSeq Acc Id: XP_063131549   ⟸   XM_063275479
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TS56-F1-model_v2 AlphaFold Q7TS56 1-236 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700071
Promoter ID:EPDNEW_R10593
Type:single initiation site
Name:Cbr4_1
Description:carbonyl reductase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01631,972,528 - 31,972,588EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727826 AgrOrtholog
BioCyc Gene G2FUF-11584 BioCyc
Ensembl Genes ENSRNOG00000024411 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032199.7 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7302014 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report rno:359725 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105271 IMAGE-MGC_LOAD
NCBI Gene 359725 ENTREZGENE
PANTHER 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE UniProtKB/Swiss-Prot
  SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER UniProtKB/Swiss-Prot
Pfam adh_short_C2 UniProtKB/Swiss-Prot
PhenoGen Cbr4 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot
  SDRFAMILY UniProtKB/Swiss-Prot
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000024411 RatGTEx
SMART PKS_KR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A0A8I6A1W1 ENTREZGENE, UniProtKB/TrEMBL
  A6KIR4 ENTREZGENE, UniProtKB/TrEMBL
  A6KIR5_RAT UniProtKB/TrEMBL
  A6KIR6 ENTREZGENE, UniProtKB/TrEMBL
  CBR4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cbr4  carbonyl reductase 4  LOC100911522  uncharacterized LOC100911522  Data merged from RGD:6492350 737654 PROVISIONAL
2012-07-05 LOC100911522  uncharacterized LOC100911522      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-03 Cbr4  carbonyl reductase 4  Cbr4  carbonic reductase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Cbr4  carbonic reductase 4    carbonyl reductase 4  Name updated 1299863 APPROVED