Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:selenomethionine
go back to main search page
Accession:CHEBI:27585 term browser browse the term
Definition:A selenoamino acid that is the selenium analogue of methionine.
Synonyms:related_synonym: 2-amino-4-methylseleno-butanoic acid;   Formula=C5H11NO2Se;   InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8);   InChIKey=RJFAYQIBOAGBLC-UHFFFAOYSA-N;   SMILES=C[Se]CCC(N)C(O)=O;   Selenium methionine;   Seleno-DL-methionine
 alt_id: CHEBI:26638;   CHEBI:9098
 xref: CAS:1464-42-2;   HMDB:HMDB0003966
 xref_mesh: MESH:D012645
 xref: MetaCyc:SELENOMETHIONINE;   PMID:14969538;   PMID:20740325;   PMID:21259435;   PMID:21286848;   PMID:21366307;   PMID:21524942;   PMID:21603917;   PMID:21766323;   PMID:21870603;   PMID:21877325;   Reaxys:1758204;   Wikipedia:Selenomethionine


show annotations for term's descendants           Sort by:
selenomethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor affects expression ISO Selenomethionine affects the expression of ACD mRNA CTD PMID:17222674 NCBI chr19:33,586,739...33,589,481
Ensembl chr19:33,586,745...33,589,461 		JBrowse link
G Aco2 aconitase 2 affects expression ISO Selenomethionine affects the expression of ACO2 mRNA CTD PMID:17222674 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO Selenomethionine inhibits the reaction [Selenium deficiency results in increased expression of ALOX15 protein] CTD PMID:34970773 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Selenomethionine inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of GPX1 protein] CTD PMID:17280487 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions
decreases activity		 ISO AR protein promotes the reaction [Selenomethionine results in decreased expression of KLK3 protein]; AR protein promotes the reaction [Selenomethionine results in increased expression of TP53 mRNA]
Selenomethionine results in decreased activity of AR protein		 CTD PMID:16239064 PMID:17205524 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf2 activating transcription factor 2 affects expression ISO Selenomethionine affects the expression of ATF2 mRNA CTD PMID:17222674 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 affects expression ISO Selenomethionine affects the expression of ATP6V0A1 mRNA CTD PMID:17222674 NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895 		JBrowse link
G Casp3 caspase 3 increases activity ISO Selenomethionine results in increased activity of CASP3 protein CTD PMID:21215776 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO [SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of CAT mRNA CTD PMID:28495429 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbx6 chromobox 6 affects expression ISO Selenomethionine affects the expression of CBX6 mRNA CTD PMID:17222674 NCBI chr 7:111,372,979...111,383,026
Ensembl chr 7:111,372,980...111,383,091 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of CDKN1A protein] CTD PMID:21515331 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cfl2 cofilin 2 affects expression ISO Selenomethionine affects the expression of CFL2 protein CTD PMID:18444160 NCBI chr 6:72,355,664...72,359,709
Ensembl chr 6:72,355,664...72,359,674 		JBrowse link
G Clstn3 calsyntenin 3 affects expression ISO Selenomethionine affects the expression of CLSTN3 mRNA CTD PMID:17222674 NCBI chr 4:157,331,494...157,364,769
Ensembl chr 4:157,331,494...157,364,769 		JBrowse link
G Cnnm3 cyclin and CBS domain divalent metal cation transport mediator 3 affects expression ISO Selenomethionine affects the expression of CNNM3 mRNA CTD PMID:17222674 NCBI chr 9:38,755,374...38,770,740
Ensembl chr 9:38,755,390...38,770,740 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain affects expression ISO Selenomethionine affects the expression of COL6A1 mRNA CTD PMID:17222674 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Crmp1 collapsin response mediator protein 1 affects expression ISO Selenomethionine affects the expression of CRMP1 mRNA CTD PMID:17222674 NCBI chr14:73,509,933...73,556,192
Ensembl chr14:73,509,933...73,556,177 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 mRNA]; Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of DDIT3 protein] CTD PMID:29454614 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dst dystonin affects expression ISO Selenomethionine affects the expression of DST mRNA CTD PMID:17222674 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615 		JBrowse link
G Dusp3 dual specificity phosphatase 3 affects expression ISO Selenomethionine affects the expression of DUSP3 mRNA CTD PMID:17222674 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Ece2 endothelin-converting enzyme 2 affects expression ISO Selenomethionine affects the expression of ECE2 mRNA CTD PMID:17222674 NCBI chr11:80,259,130...80,278,446
Ensembl chr11:80,263,162...80,278,428 		JBrowse link
G Ecsit ECSIT signaling integrator affects expression ISO Selenomethionine affects the expression of ECSIT mRNA CTD PMID:17222674 NCBI chr 8:20,605,583...20,618,453
Ensembl chr 8:20,605,583...20,618,390 		JBrowse link
G Eeig1 estrogen-induced osteoclastogenesis regulator 1 affects expression ISO Selenomethionine affects the expression of EEIG1 mRNA CTD PMID:17222674 NCBI chr 3:15,822,441...15,854,651
Ensembl chr 3:15,823,144...15,854,643 		JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Selenomethionine results in increased expression of EGFR mRNA CTD PMID:17205524 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ehd1 EH-domain containing 1 affects expression ISO Selenomethionine affects the expression of EHD1 mRNA CTD PMID:17222674 NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Selenomethionine inhibits the reaction [T-2 Toxin results in increased phosphorylation of EIF2S1 protein] CTD PMID:29454614 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Selenomethionine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenomethionine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] CTD PMID:14572605 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fus Fus RNA binding protein affects localization
multiple interactions		 ISO Selenomethionine affects the localization of FUS protein
Selenomethionine promotes the reaction [TUBA4A protein binds to FUS protein]		 CTD PMID:31585128 NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414 		JBrowse link
G Gck glucokinase increases expression ISO Selenomethionine results in increased expression of GCK mRNA CTD PMID:28810182 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Selenomethionine results in increased expression of GCLC mRNA CTD PMID:22807314 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression
increases activity
increases expression
multiple interactions		 ISO
EXP		 Selenomethionine affects the expression of GPX1 mRNA
Selenomethionine results in increased activity of GPX1 protein
Selenomethionine results in increased expression of GPX1 mRNA; Selenomethionine results in increased expression of GPX1 protein
Selenomethionine inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of GPX1 protein]
Selenomethionine inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of GPX1 protein]; Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased activity of GPX1 protein]
[SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of GPX1 mRNA		 CTD PMID:16632112 PMID:17222674 PMID:17280487 PMID:20659492 PMID:28495429 More... NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Selenomethionine inhibits the reaction [Selenium deficiency results in decreased expression of GPX4 protein] CTD PMID:34970773 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 affects expression ISO Selenomethionine affects the expression of GRK6 mRNA CTD PMID:17222674 NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Selenomethionine results in increased expression of GSR protein CTD PMID:21215776 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases methylation
increases expression		 ISO Selenomethionine results in decreased methylation of GSTP1 promoter
Selenomethionine results in increased expression of GSTP1 mRNA; Selenomethionine results in increased expression of GSTP1 protein		 CTD PMID:18676679 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hpn hepsin affects expression ISO Selenomethionine affects the expression of HPN mRNA CTD PMID:17222674 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO Selenomethionine inhibits the reaction [Mercuric Chloride results in increased expression of HSPA1A mRNA] CTD PMID:16324719 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]; Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein] CTD PMID:29454614 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 affects expression ISO Selenomethionine affects the expression of HSPE1 protein CTD PMID:18444160 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion		 ISO Selenomethionine inhibits the reaction [sodium arsenite results in decreased secretion of IFNG protein]
Selenomethionine results in decreased secretion of IFNG protein		 CTD PMID:24218229 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects expression ISO Selenomethionine affects the expression of IKBKB mRNA CTD PMID:17222674 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases secretion		 ISO Selenomethionine inhibits the reaction [sodium arsenite results in decreased secretion of IL4 protein]
Selenomethionine results in decreased secretion of IL4 protein		 CTD PMID:24218229 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Itm2c integral membrane protein 2C affects expression ISO Selenomethionine affects the expression of ITM2C mRNA CTD PMID:17222674 NCBI chr 9:86,545,927...86,559,745
Ensembl chr 9:86,545,921...86,559,742 		JBrowse link
G Klhdc3 kelch domain containing 3 affects expression ISO Selenomethionine affects the expression of KLHDC3 mRNA CTD PMID:17222674 NCBI chr 9:14,302,345...14,308,736
Ensembl chr 9:14,302,354...14,308,736 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression
multiple interactions		 ISO Selenomethionine results in decreased expression of KLK3 protein
AR protein promotes the reaction [Selenomethionine results in decreased expression of KLK3 protein]		 CTD PMID:17205524 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G L3mbtl4 L3MBTL histone methyl-lysine binding protein 4 affects expression ISO Selenomethionine affects the expression of L3MBTL4 mRNA CTD PMID:17222674 NCBI chr 9:108,295,004...108,747,879
Ensembl chr 9:108,329,669...108,747,774 		JBrowse link
G Lasp1 LIM and SH3 protein 1 affects expression ISO Selenomethionine affects the expression of LASP1 mRNA CTD PMID:17222674 NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292 		JBrowse link
G Ltbr lymphotoxin beta receptor affects expression ISO Selenomethionine affects the expression of LTBR mRNA CTD PMID:17222674 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 affects expression ISO Selenomethionine affects the expression of MAP3K11 mRNA CTD PMID:17222674 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Selenomethionine results in decreased phosphorylation of MAPK1 protein CTD PMID:21215776 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Selenomethionine results in decreased phosphorylation of MAPK3 protein CTD PMID:21215776 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Selenomethionine inhibits the reaction [Spermine results in increased activity of MAPK8 protein] CTD PMID:20121705 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 affects expression ISO Selenomethionine affects the expression of MRPL54 mRNA CTD PMID:17222674 NCBI chr 7:8,452,801...8,455,321
Ensembl chr 7:8,452,716...8,455,321 		JBrowse link
G Narf nuclear prelamin A recognition factor affects expression ISO Selenomethionine affects the expression of NARF mRNA CTD PMID:17222674 NCBI chr10:106,519,508...106,537,494
Ensembl chr10:106,519,444...106,537,486 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 affects expression ISO Selenomethionine affects the expression of NDUFV1 mRNA CTD PMID:17222674 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466 		JBrowse link
G Nme6 NME/NM23 nucleoside diphosphate kinase 6 affects expression ISO Selenomethionine affects the expression of NME6 protein CTD PMID:18444160 NCBI chr 8:109,832,085...109,839,301
Ensembl chr 8:109,832,589...109,839,301 		JBrowse link
G Nos1 nitric oxide synthase 1 increases expression ISO Selenomethionine results in increased expression of NOS1 protein CTD PMID:21215776 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Selenomethionine inhibits the reaction [Spermine results in increased activity of NOS2 protein] CTD PMID:20121705 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Selenomethionine results in increased expression of NQO1 mRNA; Selenomethionine results in increased expression of NQO1 protein CTD PMID:22807314 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parvb parvin, beta affects expression ISO Selenomethionine affects the expression of PARVB mRNA CTD PMID:17222674 NCBI chr 7:115,360,254...115,445,767
Ensembl chr 7:115,360,261...115,445,766 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) affects expression ISO Selenomethionine affects the expression of PCK2 mRNA CTD PMID:17222674 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Selenomethionine results in decreased expression of PCNA protein CTD PMID:17431106 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pcnx3 pecanex 3 affects expression ISO Selenomethionine affects the expression of PCNX3 mRNA CTD PMID:17222674 NCBI chr 1:202,951,322...202,974,167
Ensembl chr 1:202,951,322...202,976,561 		JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U affects expression ISO Selenomethionine affects the expression of PIGU mRNA CTD PMID:17222674 NCBI chr 3:143,784,831...143,881,268
Ensembl chr 3:143,784,832...143,880,807 		JBrowse link
G Plg plasminogen affects expression ISO Selenomethionine affects the expression of PLG mRNA CTD PMID:17222674 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Pmvk phosphomevalonate kinase affects expression ISO Selenomethionine affects the expression of PMVK mRNA CTD PMID:17222674 NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364 		JBrowse link
G Poll DNA polymerase lambda affects expression ISO Selenomethionine affects the expression of POLL mRNA CTD PMID:17222674 NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662 		JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B affects expression ISO Selenomethionine affects the expression of PPM1B mRNA CTD PMID:17222674 NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974 		JBrowse link
G Prkcz protein kinase C, zeta affects expression ISO Selenomethionine affects the expression of PRKCZ mRNA CTD PMID:17222674 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Rap2a RAP2A, member of RAS oncogene family affects expression ISO Selenomethionine affects the expression of RAP2A mRNA CTD PMID:17222674 NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation		 ISO Selenomethionine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; Selenomethionine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]
Selenomethionine results in increased phosphorylation of RELA protein		 CTD PMID:14572605 PMID:21215776 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rpusd1 RNA pseudouridine synthase domain containing 1 affects expression ISO Selenomethionine affects the expression of RPUSD1 mRNA CTD PMID:17222674 NCBI chr10:14,751,310...14,755,213
Ensembl chr10:14,751,384...14,755,207 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 affects expression ISO Selenomethionine affects the expression of SCARB1 mRNA CTD PMID:17222674 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Selenoh selenoprotein H increases expression ISO Selenomethionine results in increased expression of SELENOH mRNA CTD PMID:28810182 NCBI chr 3:69,751,850...69,753,417
Ensembl chr 3:69,752,757...69,753,417 		JBrowse link
G Sema5a semaphorin 5A affects expression ISO Selenomethionine affects the expression of SEMA5A mRNA CTD PMID:17222674 NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084 		JBrowse link
G Shc1 SHC adaptor protein 1 affects expression ISO Selenomethionine affects the expression of SHC1 mRNA CTD PMID:17222674 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Slc25a1 solute carrier family 25 member 1 affects expression ISO Selenomethionine affects the expression of SLC25A1 mRNA CTD PMID:17222674 NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781 		JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake ISO SLC3A1 protein results in increased uptake of Selenomethionine CTD PMID:18845132 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907 		JBrowse link
G Slc6a19 solute carrier family 6 member 19 increases uptake ISO SLC6A19 protein results in increased uptake of Selenomethionine CTD PMID:18845132 NCBI chr 1:29,586,191...29,604,964
Ensembl chr 1:29,586,195...29,604,962 		JBrowse link
G Slc6a20a solute carrier family 6 member 20a increases uptake ISO SLC6A20B protein results in increased uptake of Selenomethionine CTD PMID:18845132 NCBI chr 8:123,282,325...123,322,609
Ensembl chr 8:123,281,472...123,322,573 		JBrowse link
G Sod1 superoxide dismutase 1 affects localization
multiple interactions
decreases expression		 ISO Selenomethionine affects the localization of SOD1 protein
[SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of SOD1 mRNA
Selenomethionine results in decreased expression of SOD1 protein		 CTD PMID:21215776 PMID:28495429 PMID:31585128 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
affects response to substance		 ISO Selenomethionine results in increased expression of SOD2 protein
[SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of CAT mRNA; [SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of GPX1 mRNA; [SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of SOD1 mRNA; [SOD2 protein polymorphism affects the susceptibility to Selenomethionine analog] which affects the expression of SOD2 mRNA		 CTD PMID:21215776 PMID:28495429 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
decreases methylation		 ISO Selenomethionine results in increased expression of SREBF1 mRNA
Selenomethionine results in decreased methylation of SREBF1 exon		 CTD PMID:28810182 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srrt serrate, RNA effector molecule affects expression ISO Selenomethionine affects the expression of SRRT mRNA CTD PMID:17222674 NCBI chr12:19,392,578...19,406,098
Ensembl chr12:19,392,625...19,406,095 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 affects expression ISO Selenomethionine affects the expression of SSBP1 protein CTD PMID:18444160 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135 		JBrowse link
G Stx17 syntaxin 17 affects expression ISO Selenomethionine affects the expression of STX17 mRNA CTD PMID:17222674 NCBI chr 5:62,446,138...62,506,108
Ensembl chr 5:62,446,187...62,504,451 		JBrowse link
G Taok2 TAO kinase 2 affects expression ISO Selenomethionine affects the expression of TAOK2 mRNA CTD PMID:17222674 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613 		JBrowse link
G Tbx1 T-box transcription factor 1 affects expression ISO Selenomethionine affects the expression of TBX1 mRNA CTD PMID:17222674 NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380 		JBrowse link
G Tead3 TEA domain transcription factor 3 affects expression ISO Selenomethionine affects the expression of TEAD3 mRNA CTD PMID:17222674 NCBI chr20:6,392,053...6,411,446
Ensembl chr20:6,392,053...6,411,446 		JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein multiple interactions ISO Selenomethionine promotes the reaction [TUBA4A protein binds to TIA1 protein] CTD PMID:31585128 NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases activity
increases expression
decreases expression		 ISO AR protein promotes the reaction [Selenomethionine results in increased expression of TP53 mRNA]; Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of TP53 protein]
Selenomethionine results in decreased activity of TP53 protein
Diethylhexyl Phthalate inhibits the reaction [Selenomethionine results in decreased expression of TRP53 protein]; Selenomethionine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of TRP53 protein]		 CTD PMID:17100737 PMID:17205524 PMID:20659492 PMID:21515331 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trex1 three prime repair exonuclease 1 affects expression ISO Selenomethionine affects the expression of TREX1 mRNA CTD PMID:17222674 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Tsc22d4 TSC22 domain family, member 4 affects expression ISO Selenomethionine affects the expression of TSC22D4 mRNA CTD PMID:17222674 NCBI chr12:18,939,150...18,952,008
Ensembl chr12:18,914,398...18,952,008 		JBrowse link
G Tuba4a tubulin, alpha 4A increases glutathionylation
multiple interactions		 ISO Selenomethionine results in increased glutathionylation of TUBA4A protein
Selenomethionine promotes the reaction [TUBA4A protein binds to FUS protein]; Selenomethionine promotes the reaction [TUBA4A protein binds to TIA1 protein]; TUBA4A mutant form results in increased abundance of [Selenomethionine binds to Selenium]		 CTD PMID:28478440 PMID:31585128 NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Selenomethionine results in increased expression of TXNRD1 mRNA; Selenomethionine results in increased expression of TXNRD1 protein CTD PMID:22807314 PMID:31585128 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Txnrd2 thioredoxin reductase 2 affects expression
increases expression		 ISO Selenomethionine affects the expression of TXNRD2 mRNA
Selenomethionine results in increased expression of TXNRD2 protein		 CTD PMID:17222674 PMID:31585128 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
G Ube2s ubiquitin-conjugating enzyme E2S affects expression ISO Selenomethionine affects the expression of UBE2S mRNA CTD PMID:17222674 NCBI chr 1:69,028,853...69,032,914
Ensembl chr 1:69,028,750...69,032,914 		JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A affects expression ISO Selenomethionine affects the expression of VPS4A mRNA CTD PMID:17222674 NCBI chr19:34,934,999...34,948,888
Ensembl chr19:34,934,961...34,948,887 		JBrowse link
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 affects expression ISO Selenomethionine affects the expression of WWP2 mRNA CTD PMID:17222674 NCBI chr19:35,346,826...35,471,251
Ensembl chr19:35,346,814...35,472,699 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor multiple interactions ISO Selenomethionine inhibits the reaction [Zinc binds to XPA protein] CTD PMID:15265038 NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
G Zftraf1 zinc finger TRAF type containing 1 affects expression ISO Selenomethionine affects the expression of ZFTRAF1 mRNA CTD PMID:17222674 NCBI chr 7:108,363,989...108,377,428
Ensembl chr 7:108,364,381...108,380,021 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          selenium atom 3247
            selenium molecular entity 3247
              selenomethionines 100
                selenomethionine 100
                  D-selenomethionine + 0
                  L-selenomethionine + 0
                  Se-methylselenomethionine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organoselenium compound 709
                                  selenoamino acid 164
                                    selenomethionine 100
                                      D-selenomethionine + 0
                                      L-selenomethionine + 0
                                      Se-methylselenomethionine + 0
paths to the root