Rap2a (RAP2A, member of RAS oncogene family) - Rat Genome Database

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Gene: Rap2a (RAP2A, member of RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rap2a
Name: RAP2A, member of RAS oncogene family
RGD ID: 620590
Description: Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including Rap protein signal transduction; actin cytoskeleton reorganization; and microvillus assembly. Predicted to act upstream of or within establishment of protein localization; negative regulation of cell migration; and positive regulation of protein autophosphorylation. Is active in synaptic membrane. Orthologous to human RAP2A (RAP2A, member of RAS oncogene family); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: rap2A-like protein; RAS related protein 2a; RAS related protein 2a inverted question mark; RAS related protein 2a¿; ras-related protein Rap-2a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21597,596,848 - 97,597,338 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1597,596,020 - 97,624,138 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15101,525,715 - 101,526,205 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.015102,627,849 - 102,628,339 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01599,570,678 - 99,571,168 (+)NCBIRnor_WKY
Rnor_6.015105,851,543 - 105,852,033 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15105,851,542 - 105,878,666 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015109,253,818 - 109,254,308 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415105,570,094 - 105,570,584 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115105,585,873 - 105,586,364 (+)NCBI
Celera1596,415,072 - 96,415,562 (+)NCBICelera
Cytogenetic Map15q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Kawabe H, etal., Neuron. 2010 Feb 11;65(3):358-72. doi: 10.1016/j.neuron.2010.01.007.
3. The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis. Lerosey I, etal., J Biol Chem 1991 Mar 5;266(7):4315-21.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9312017   PMID:10591105   PMID:14966141   PMID:15342639   PMID:19061864   PMID:22797597   PMID:23376485   PMID:28546426   PMID:30826466  


Genomics

Comparative Map Data
Rap2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21597,596,848 - 97,597,338 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1597,596,020 - 97,624,138 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15101,525,715 - 101,526,205 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.015102,627,849 - 102,628,339 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01599,570,678 - 99,571,168 (+)NCBIRnor_WKY
Rnor_6.015105,851,543 - 105,852,033 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15105,851,542 - 105,878,666 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015109,253,818 - 109,254,308 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415105,570,094 - 105,570,584 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115105,585,873 - 105,586,364 (+)NCBI
Celera1596,415,072 - 96,415,562 (+)NCBICelera
Cytogenetic Map15q24NCBI
RAP2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381397,434,169 - 97,469,128 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1397,434,169 - 97,469,128 (+)EnsemblGRCh38hg38GRCh38
GRCh371398,086,423 - 98,121,382 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361396,884,475 - 96,918,245 (+)NCBINCBI36Build 36hg18NCBI36
Build 341396,884,476 - 96,918,245NCBI
Celera1378,933,883 - 78,967,659 (+)NCBICelera
Cytogenetic Map13q32.1NCBI
HuRef1378,683,568 - 78,717,183 (+)NCBIHuRef
CHM1_11398,056,856 - 98,090,631 (+)NCBICHM1_1
T2T-CHM13v2.01396,640,480 - 96,675,445 (+)NCBIT2T-CHM13v2.0
Rap2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914120,715,873 - 120,744,606 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14120,715,856 - 120,744,606 (+)EnsemblGRCm39 Ensembl
GRCm3814120,478,461 - 120,507,194 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14120,478,444 - 120,507,194 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714120,877,683 - 120,906,416 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614119,613,641 - 119,642,374 (+)NCBIMGSCv36mm8
Celera14119,033,268 - 119,060,662 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1464.72NCBI
Rap2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540412,897,240 - 12,936,964 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540412,897,518 - 12,936,964 (-)NCBIChiLan1.0ChiLan1.0
RAP2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11397,751,799 - 97,785,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1397,751,799 - 97,785,194 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01378,595,330 - 78,629,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RAP2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12247,777,621 - 47,814,061 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2247,778,780 - 47,810,802 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2247,559,218 - 47,594,502 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02248,211,859 - 48,247,160 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2248,211,942 - 48,247,137 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12247,868,639 - 47,903,847 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02247,902,104 - 47,937,396 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02247,938,446 - 47,973,594 (+)NCBIUU_Cfam_GSD_1.0
Rap2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945183,280,494 - 183,317,599 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647212,634,445 - 12,671,662 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647212,634,563 - 12,671,656 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAP2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1166,679,253 - 66,720,045 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11166,679,162 - 66,718,565 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21173,763,506 - 73,765,553 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAP2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1376,146,124 - 76,184,649 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl376,146,340 - 76,184,664 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604632,596,706 - 32,643,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rap2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248793,972,582 - 4,015,335 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rap2a
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:91
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000032395
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)158226252098288169Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)158226252098288169Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 26 23 14 18 14 1 1 74 22 33 11 1
Low 2 17 34 27 1 27 7 10 13 8 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086959   ⟹   ENSRNOP00000068867
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1597,596,020 - 97,624,138 (+)Ensembl
Rnor_6.0 Ensembl15105,851,542 - 105,878,666 (+)Ensembl
RefSeq Acc Id: NM_053741   ⟹   NP_446193
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21597,596,848 - 97,597,338 (+)NCBI
Rnor_6.015105,851,543 - 105,852,033 (+)NCBI
Rnor_5.015109,253,818 - 109,254,308 (+)NCBI
RGSC_v3.415105,570,094 - 105,570,584 (+)RGD
Celera1596,415,072 - 96,415,562 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446193 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK68851 (Get FASTA)   NCBI Sequence Viewer  
  EDM02551 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446193   ⟸   NM_053741
- UniProtKB: Q78P65 (UniProtKB/TrEMBL),   G3V980 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068867   ⟸   ENSRNOT00000086959

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTW1-F1-model_v2 AlphaFold A0A0G2JTW1 1-183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620590 AgrOrtholog
BioCyc Gene G2FUF-12392 BioCyc
Ensembl Genes ENSRNOG00000051564 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068867.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086959.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Rap2 UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/TrEMBL
  Ras_small_GTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
KEGG Report rno:114560 UniProtKB/TrEMBL
NCBI Gene 114560 ENTREZGENE
PANTHER PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rap2a PhenoGen
PROSITE RAS UniProtKB/TrEMBL
SMART RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
TIGRFAMs Small_GTP UniProtKB/TrEMBL
UniProt A0A0G2JTW1_RAT UniProtKB/TrEMBL
  G3V980 ENTREZGENE
  Q78P65 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary G3V980 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-14 Rap2a  RAP2A, member of RAS oncogene family  Rap2a  RAS related protein 2a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-03-16 Rap2a  RAS related protein 2a  Rap2a  RAS related protein 2a¿  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Rap2a  RAS related protein 2a¿    rap2A-like protein  Name updated 1299863 APPROVED
2005-01-20 Rap2a  rap2A-like protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rap2a  rap2A-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL