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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitrogen dioxide
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Accession:CHEBI:33101 term browser browse the term
Definition:A nitrogen oxide that has formula NO2.
Synonyms:exact_synonym: dioxidonitrogen(.);   nitrogen(IV) oxide;   nitrosooxidanyl
 related_synonym: Formula=NO2;   InChI=1S/NO2/c2-1-3;   InChIKey=JCXJVPUVTGWSNB-UHFFFAOYSA-N;   NO2;   ONO(.);   SMILES=O=[N]=O;   Stickstoffdioxid;   nitryl
 alt_id: CHEBI:29332;   CHEBI:29784;   CHEBI:39851
 xref: CAS:10102-44-0;   Gmelin:976
 xref_mesh: MESH:D009585
 xref: MolBase:939;   PDBeChem:2NO


show annotations for term's descendants           Sort by:
nitrogen dioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aamdc adipogenesis associated Mth938 domain containing multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of AAMDC 5' UTR CTD PMID:28843141 NCBI chr 7:97,199,538...97,228,723
Ensembl chr 7:97,199,538...97,228,704 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions ISO ABCC2 gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Nitrogen Dioxide] CTD PMID:29681089 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Adora2b adenosine A2b receptor multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of ADORA2B gene CTD PMID:29935799 NCBI chr11:62,139,810...62,157,278
Ensembl chr11:62,139,810...62,157,279 		JBrowse link
G Alb albumin increases expression ISO Nitrogen Dioxide results in increased expression of ALB mRNA CTD PMID:27206323 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Ankrd45 ankyrin repeat domain 45 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of ANKRD45 gene CTD PMID:29935799 NCBI chr 1:160,970,017...160,998,077
Ensembl chr 1:160,970,261...160,998,068 		JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Nitrogen Dioxide results in increased expression of AOX1 mRNA CTD PMID:27206323 NCBI chr 1:58,068,963...58,145,569
Ensembl chr 1:58,069,090...58,145,572 		JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO Nitrogen Dioxide results in decreased expression of AQP1 mRNA CTD PMID:27206323 NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540 		JBrowse link
G B3galt4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of B3GALT4 gene CTD PMID:29935799 NCBI chr17:34,168,886...34,170,462
Ensembl chr17:34,168,883...34,170,462 		JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO
EXP		 Nitrogen Dioxide results in increased expression of BAX mRNA; Nitrogen Dioxide results in increased expression of BAX protein
[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of BAX protein		 CTD PMID:22621880 PMID:27521637 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO Nitrogen Dioxide results in increased expression of BBC3 mRNA CTD PMID:27206323 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression ISO Nitrogen Dioxide results in increased expression of BNIP3 mRNA CTD PMID:27206323 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of CACNA2D1 gene CTD PMID:28843141 NCBI chr 5:16,139,390...16,579,509
Ensembl chr 5:16,139,786...16,579,502 		JBrowse link
G Cat catalase increases expression
multiple interactions		 ISO
EXP		 Nitrogen Dioxide results in increased expression of CAT mRNA
CAT protein inhibits the reaction [Nitrogen Dioxide results in decreased expression of CCND1 mRNA]
[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of CAT mRNA; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of CAT gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased expression of CAT mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of CAT gene		 CTD PMID:12600834 PMID:15336314 PMID:27448387 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cbs cystathionine beta-synthase decreases activity ISO Nitrogen Dioxide results in decreased activity of CBS protein CTD PMID:19733148 NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression EXP Nitrogen Dioxide results in increased expression of CCL11 mRNA CTD PMID:10715624 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
decreases expression		 EXP
ISO		 Nitrogen Dioxide results in increased expression of CCL2 mRNA; Nitrogen Dioxide results in increased expression of CCL2 protein
Nitrogen Dioxide results in decreased expression of CCL2 mRNA		 CTD PMID:10715624 PMID:11498801 PMID:27206323 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression EXP Nitrogen Dioxide results in increased expression of CCL3 mRNA CTD PMID:10715624 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Nitrogen Dioxide results in increased expression of CCL5 mRNA CTD PMID:27206323 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 EXP CAT protein inhibits the reaction [Nitrogen Dioxide results in decreased expression of CCND1 mRNA]
Nitrogen Dioxide results in decreased expression of CCND1 mRNA; Nitrogen Dioxide results in decreased expression of CCND1 protein		 CTD PMID:12600834 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cd72 CD72 antigen multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of CD72 3' UTR CTD PMID:28843141 NCBI chr 4:43,447,724...43,454,708
Ensembl chr 4:43,446,462...43,454,628 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions ISO [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of CDKN2A gene CTD PMID:26778509 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO Nitrogen Dioxide results in increased expression of CRP protein CTD PMID:18629312 PMID:22306530 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Csde1 cold shock domain containing E1, RNA binding increases expression ISO Nitrogen Dioxide results in increased expression of CSDE1 mRNA CTD PMID:27206323 NCBI chr 3:102,927,347...102,965,502
Ensembl chr 3:102,927,742...102,965,502 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) increases secretion ISO Nitrogen Dioxide results in increased secretion of CSF2 protein CTD PMID:8398164 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression
increases secretion		 ISO Nitrogen Dioxide results in increased expression of CXCL8 mRNA
Nitrogen Dioxide results in increased secretion of CXCL8 protein		 CTD PMID:8398164 PMID:8584542 PMID:22331494 PMID:27206323 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO
EXP		 [Ozone co-treated with Nitrogen Dioxide] results in increased expression of CXCL2 mRNA
Nitrogen Dioxide results in increased expression of CXCL2 mRNA; Nitrogen Dioxide results in increased expression of CXCL2 protein		 CTD PMID:10715624 PMID:10986008 PMID:11498801 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Dgkk diacylglycerol kinase kappa increases expression ISO Nitrogen Dioxide results in increased expression of DGKK mRNA CTD PMID:27206323 NCBI chr  X:6,691,103...6,814,602
Ensembl chr  X:6,690,410...6,814,602 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of DNM1L protein CTD PMID:27521637 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G Drd2 dopamine receptor D2 increases expression ISO Nitrogen Dioxide results in increased expression of DRD2 mRNA CTD PMID:19733627 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G E2f2 E2F transcription factor 2 decreases activity EXP Nitrogen Dioxide results in decreased activity of E2F2 protein CTD PMID:12600834 NCBI chr 4:135,899,585...135,923,368
Ensembl chr 4:135,899,705...135,923,368 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of EDN1 protein CTD PMID:30090456 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Ephb2 Eph receptor B2 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of EPHB2 gene CTD PMID:28843141 NCBI chr 4:136,374,850...136,563,637
Ensembl chr 4:136,374,850...136,563,299 		JBrowse link
G Ezr ezrin multiple interactions ISO [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which results in decreased expression of EZR protein CTD PMID:37141245 NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183 		JBrowse link
G Faap20 Fanconi anemia core complex associated protein 20 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of FAAP20 gene CTD PMID:29935799 NCBI chr 4:155,333,168...155,341,144
Ensembl chr 4:155,334,259...155,341,144 		JBrowse link
G Fam124b family with sequence similarity 124, member B multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of FAM124B gene CTD PMID:29935799 NCBI chr 1:80,176,416...80,192,050
Ensembl chr 1:80,176,423...80,196,190 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of FIS1 protein CTD PMID:27521637 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088 		JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the expression of FLT1 protein; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of FLT1 protein CTD PMID:37556304 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821 		JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Nitrogen Dioxide results in decreased expression of FN1 mRNA CTD PMID:33064461 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Nitrogen Dioxide results in increased expression of FOS protein CTD PMID:22621880 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Foxm1 forkhead box M1 increases expression ISO Nitrogen Dioxide results in increased expression of FOXM1 mRNA CTD PMID:27206323 NCBI chr 6:128,339,957...128,352,849
Ensembl chr 6:128,339,930...128,353,109 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of FOXP3 promoter CTD PMID:29317916 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit decreases expression ISO Nitrogen Dioxide results in decreased expression of GCLM mRNA CTD PMID:16049373 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression
multiple interactions		 ISO Nitrogen Dioxide results in increased expression of GGT1 mRNA
Nitrogen Dioxide results in increased expression of and results in increased activity of GGT1 protein		 CTD PMID:9144455 PMID:16049373 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Gpr55 G protein-coupled receptor 55 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of GPR55 mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased expression of GPR55 mRNA CTD PMID:27448387 NCBI chr 1:85,860,927...85,924,781
Ensembl chr 1:85,866,039...85,888,729 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
decreases expression		 ISO Nitrogen Dioxide results in increased expression of GPX3 mRNA
Nitrogen Dioxide results in decreased expression of GPX3 mRNA		 CTD PMID:15336314 PMID:16049373 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gpx4 glutathione peroxidase 4 affects expression ISO Nitrogen Dioxide affects the expression of GPX4 mRNA CTD PMID:16049373 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Nitrogen Dioxide results in increased expression of GPX5 mRNA CTD PMID:27206323 NCBI chr13:21,470,599...21,476,897
Ensembl chr13:21,470,599...21,476,901 		JBrowse link
G Gsr glutathione reductase increases activity
increases expression		 ISO Nitrogen Dioxide results in increased activity of GSR protein
Nitrogen Dioxide results in increased expression of GSR mRNA		 CTD PMID:16049373 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gss glutathione synthetase decreases expression ISO Nitrogen Dioxide results in decreased expression of GSS mRNA CTD PMID:16049373 NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Nitrogen Dioxide CTD PMID:22732554 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 affects response to substance
multiple interactions		 ISO GSTP1 gene polymorphism affects the susceptibility to Nitrogen Dioxide
GSTP1 gene SNP results in increased susceptibility to [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide]		 CTD PMID:22732554 PMID:29624745 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 affects response to substance ISO GSTT1 gene polymorphism affects the susceptibility to Nitrogen Dioxide CTD PMID:22732554 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of HIBADH gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of HIBADH gene CTD PMID:27448387 NCBI chr 6:52,523,215...52,617,285
Ensembl chr 6:52,523,213...52,617,374 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression		 EXP
ISO		 Nitrogen Dioxide results in increased expression of HMOX1 mRNA
Nitrogen Dioxide results in decreased expression of HMOX1 mRNA		 CTD PMID:10715624 PMID:20197249 PMID:27206323 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of HSP90AA1 gene CTD PMID:29935799 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Nitrogen Dioxide results in increased expression of ICAM1 mRNA CTD PMID:22331494 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression		 EXP [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrogen Dioxide
Nitrogen Dioxide results in decreased expression of IFNG protein		 CTD PMID:22303861 PMID:28935613 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 increases expression ISO Nitrogen Dioxide results in increased expression of IL10 mRNA; Nitrogen Dioxide results in increased expression of IL10 protein CTD PMID:28669936 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il13 interleukin 13 decreases methylation
increases expression		 EXP
ISO		 Nitrogen Dioxide results in decreased methylation of IL13 promoter
Nitrogen Dioxide results in increased expression of IL13 protein
Nitrogen Dioxide results in increased expression of IL13 mRNA		 CTD PMID:28669936 PMID:28935613 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO [Ozone co-treated with Nitrogen Dioxide] results in increased expression of IL1B protein
Nitrogen Dioxide results in decreased expression of IL1B mRNA
IL1B gene SNP results in increased susceptibility to [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased abundance of Nitrogen Dioxide]		 CTD PMID:9363475 PMID:10986008 PMID:27640071 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il4 interleukin 4 increases expression
decreases methylation
multiple interactions		 EXP Nitrogen Dioxide results in increased expression of IL4 protein
Nitrogen Dioxide results in decreased methylation of IL4 promoter
[Nitrogen Dioxide results in decreased methylation of IL4 gene] which results in increased expression of IL4 promoter		 CTD PMID:28935613 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
increases secretion
decreases expression		 ISO [Ozone co-treated with Nitrogen Dioxide] results in increased expression of IL6 protein
Nitrogen Dioxide results in increased expression of IL6 mRNA; Nitrogen Dioxide results in increased expression of IL6 protein
Nitrogen Dioxide results in increased secretion of IL6 protein
Nitrogen Dioxide results in decreased expression of IL6 mRNA
IL6 gene SNP affects the susceptibility to [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased abundance of Nitrogen Dioxide]		 CTD PMID:8584542 PMID:10986008 PMID:18629312 PMID:19750100 PMID:24056475 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ipcef1 interaction protein for cytohesin exchange factors 1 decreases expression ISO Nitrogen Dioxide results in decreased expression of IPCEF1 mRNA CTD PMID:27206323 NCBI chr10:6,835,779...6,973,185
Ensembl chr10:6,835,796...7,002,478 		JBrowse link
G Jun jun proto-oncogene increases expression ISO Nitrogen Dioxide results in increased expression of JUN protein CTD PMID:22621880 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Lmf1 lipase maturation factor 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of LMF1 gene CTD PMID:29935799 NCBI chr17:25,798,143...25,886,381
Ensembl chr17:25,798,059...25,881,800 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased expression of LONP1 mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased expression of LONP1 mRNA CTD PMID:27448387 NCBI chr17:56,921,297...56,933,903
Ensembl chr17:56,921,297...56,933,887 		JBrowse link
G Lztfl1 leucine zipper transcription factor-like 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of LZTFL1 gene CTD PMID:29935799 NCBI chr 9:123,523,469...123,546,690
Ensembl chr 9:123,523,481...123,546,762 		JBrowse link
G Mcf2l mcf.2 transforming sequence-like multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of MCF2L gene CTD PMID:28843141 NCBI chr 8:12,923,806...13,070,502
Ensembl chr 8:12,923,806...13,070,905 		JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of MEIS2 gene CTD PMID:28843141 NCBI chr 2:115,691,745...115,897,925
Ensembl chr 2:115,693,545...115,896,320 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MFN1 protein CTD PMID:27521637 NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MFN2 protein CTD PMID:27521637 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 increases expression ISO Nitrogen Dioxide results in increased expression of MGST3 mRNA CTD PMID:27206323 NCBI chr 1:167,199,535...167,221,410
Ensembl chr 1:167,199,535...167,221,410 		JBrowse link
G Mir1249 microRNA 1249 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR1249 mRNA CTD PMID:30090456 NCBI chr15:84,835,727...84,835,824
Ensembl chr15:84,835,727...84,835,824 		JBrowse link
G Mir185 microRNA 185 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR185 mRNA CTD PMID:30090456 NCBI chr16:18,145,265...18,145,329
Ensembl chr16:18,145,265...18,145,329 		JBrowse link
G Mir1894 microRNA 1894 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR1894 mRNA CTD PMID:30090456 NCBI chr17:36,228,781...36,228,861
Ensembl chr17:36,228,781...36,228,861 		JBrowse link
G Mir1927 microRNA 1927 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR1927 mRNA CTD PMID:30090456 NCBI chr 1:160,123,434...160,123,542
Ensembl chr 1:160,123,434...160,123,542 		JBrowse link
G Mir205 microRNA 205 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR205 mRNA CTD PMID:30090456 NCBI chr 1:193,189,771...193,189,838
Ensembl chr 1:193,189,771...193,189,838 		JBrowse link
G Mir3070b microRNA 3070b multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR3070B mRNA CTD PMID:30090456 NCBI chr12:109,555,026...109,555,114
Ensembl chr12:109,555,026...109,555,114 		JBrowse link
G Mir3095 microRNA 3095 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR3095 mRNA CTD PMID:30090456 NCBI chr 4:58,441,012...58,441,098
Ensembl chr 4:58,441,012...58,441,098 		JBrowse link
G Mir30e microRNA 30e multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR30E mRNA CTD PMID:30090456 NCBI chr 4:120,629,803...120,629,894
Ensembl chr 4:120,629,803...120,629,894 		JBrowse link
G Mir338 microRNA 338 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR338 mRNA CTD PMID:30090456 NCBI chr11:119,905,591...119,905,688
Ensembl chr11:119,905,591...119,905,688 		JBrowse link
G Mir34b microRNA 34b multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR34B mRNA CTD PMID:30090456 NCBI chr 9:51,014,862...51,014,945
Ensembl chr 9:51,014,862...51,014,945 		JBrowse link
G Mir374c microRNA 374c multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR374C mRNA CTD PMID:30090456 NCBI chr  X:102,616,691...102,616,739
Ensembl chr  X:102,616,691...102,616,739 		JBrowse link
G Mir375 microRNA 375 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR375 mRNA CTD PMID:30090456 NCBI chr 1:74,939,817...74,939,880
Ensembl chr 1:74,939,817...74,939,880 		JBrowse link
G Mir425 microRNA 425 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR425 mRNA CTD PMID:30090456 NCBI chr 9:108,445,976...108,446,060
Ensembl chr 9:108,445,976...108,446,060 		JBrowse link
G Mir434 microRNA 434 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR434 mRNA CTD PMID:30090456 NCBI chr12:109,560,940...109,561,033
Ensembl chr12:109,560,940...109,561,033 		JBrowse link
G Mir450b microRNA 450b multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR450B mRNA CTD PMID:30090456 NCBI chr  X:52,136,874...52,136,955
Ensembl chr  X:52,136,874...52,136,955 		JBrowse link
G Mir500 microRNA 500 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR500 mRNA CTD PMID:30090456 NCBI chr  X:7,103,922...7,104,013
Ensembl chr  X:7,103,922...7,104,013 		JBrowse link
G Mir504 microRNA 504 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR504 mRNA CTD PMID:30090456 NCBI chr  X:58,143,018...58,143,096
Ensembl chr  X:58,143,018...58,143,096 		JBrowse link
G Mir674 microRNA 674 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR674 mRNA CTD PMID:30090456 NCBI chr 2:117,015,608...117,015,707
Ensembl chr 2:117,015,608...117,015,707 		JBrowse link
G Mirlet7e microRNA let7e multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIRLET7E mRNA CTD PMID:30090456 NCBI chr17:18,050,614...18,050,706
Ensembl chr17:18,050,614...18,050,706 		JBrowse link
G Mpo myeloperoxidase increases expression ISO Nitrogen Dioxide results in increased expression of MPO mRNA CTD PMID:27206323 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mt3 metallothionein 3 increases expression ISO Nitrogen Dioxide results in increased expression of MT3 mRNA CTD PMID:27206323 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression
multiple interactions		 EXP
ISO		 Nitrogen Dioxide results in increased expression of NOS2 mRNA
[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of NOS2 gene		 CTD PMID:10715624 PMID:26778509 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of NOS3 protein CTD PMID:30090456 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 affects response to substance ISO NQO1 gene polymorphism affects the susceptibility to Nitrogen Dioxide CTD PMID:20049212 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nudt1 nudix hydrolase 1 increases expression ISO Nitrogen Dioxide results in increased expression of NUDT1 mRNA CTD PMID:27206323 NCBI chr 5:140,307,375...140,323,892
Ensembl chr 5:140,307,411...140,323,892 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of OPA1 protein CTD PMID:27521637 NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702 		JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of P2RX4 gene CTD PMID:29935799 NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP Nitrogen Dioxide results in decreased expression of PCNA protein CTD PMID:12600834 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pgf placental growth factor multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the expression of PGF protein; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of PGF protein CTD PMID:37556304 NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564 		JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of PIEZO1 gene CTD PMID:29935799 NCBI chr 8:123,208,437...123,278,068
Ensembl chr 8:123,208,437...123,278,068 		JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) affects expression ISO Nitrogen Dioxide affects the expression of PLA2G7 CTD PMID:21356620 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092 		JBrowse link
G Pold4 polymerase (DNA-directed), delta 4 increases expression ISO Nitrogen Dioxide results in increased expression of POLD4 mRNA CTD PMID:33064461 NCBI chr19:4,281,947...4,283,688
Ensembl chr19:4,281,953...4,283,688 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha decreases expression ISO Nitrogen Dioxide results in decreased expression of PPARGC1A mRNA CTD PMID:33064461 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 increases expression ISO Nitrogen Dioxide results in increased expression of PREX1 mRNA CTD PMID:27206323 NCBI chr 2:166,408,265...166,555,752
Ensembl chr 2:166,408,262...166,555,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Nitrogen Dioxide results in increased expression of PTGS2 mRNA CTD PMID:27206323 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation EXP Nitrogen Dioxide results in decreased phosphorylation of RB1 protein CTD PMID:12600834 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rnf2 ring finger protein 2 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of RNF2 5' UTR CTD PMID:28843141 NCBI chr 1:151,345,159...151,376,562
Ensembl chr 1:151,333,755...151,376,706 		JBrowse link
G Selp selectin, platelet increases expression ISO Nitrogen Dioxide results in increased expression of SELP protein modified form CTD PMID:18629312 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Sftpd surfactant associated protein D multiple interactions ISO [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which results in increased expression of SFTPD protein CTD PMID:37141245 NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106 		JBrowse link
G Slc25a28 solute carrier family 25, member 28 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of SLC25A28 gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of SLC25A28 gene CTD PMID:27448387 NCBI chr19:43,652,240...43,663,320
Ensembl chr19:43,652,240...43,663,320 		JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression
multiple interactions
decreases expression
decreases activity		 ISO Nitrogen Dioxide results in increased expression of SOD1 mRNA
[[SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites] which results in increased chemical synthesis of Nitrogen Dioxide
Nitrogen Dioxide results in decreased expression of SOD1 protein
Nitrogen Dioxide results in decreased activity of SOD1 protein		 CTD PMID:15336314 PMID:18629312 PMID:19243126 PMID:22621880 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases activity
multiple interactions		 ISO Nitrogen Dioxide results in decreased activity of SOD2 protein
[[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of SOD2 promoter] which affects the methylation of SOD2 promoter; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of SOD2 promoter		 CTD PMID:22621880 PMID:31220783 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Ozone co-treated with Nitrogen Dioxide] results in increased expression of TGFB1 mRNA CTD PMID:10986008 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thap1 THAP domain containing, apoptosis associated protein 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of THAP1 3' UTR CTD PMID:28843141 NCBI chr 8:26,648,197...26,654,179
Ensembl chr 8:26,648,169...26,654,179 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects response to substance
decreases secretion
increases secretion
increases expression		 ISO [Ozone co-treated with Nitrogen Dioxide] results in increased expression of TNF protein
TNF gene polymorphism affects the susceptibility to Nitrogen Dioxide
Nitrogen Dioxide results in decreased secretion of TNF protein
Nitrogen Dioxide results in increased secretion of TNF protein
Nitrogen Dioxide results in increased expression of TNF mRNA
TNF gene SNP results in increased susceptibility to [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide]		 CTD PMID:8398164 PMID:9363475 PMID:10986008 PMID:20049212 PMID:28669936 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b increases expression ISO Nitrogen Dioxide results in increased expression of TNFRSF1B protein modified form CTD PMID:18629312 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
G Tpo thyroid peroxidase multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of TPO gene; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased expression of TPO mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of TPO gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased expression of TPO mRNA CTD PMID:27448387 NCBI chr12:30,104,658...30,182,983
Ensembl chr12:30,104,658...30,182,623 		JBrowse link
G Trmt10a tRNA methyltransferase 10A multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of TRMT10A CTD PMID:28843141 NCBI chr 3:137,849,214...137,865,582
Ensembl chr 3:137,849,209...137,865,582 		JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions		 ISO
EXP		 Nitrogen Dioxide results in increased expression of TP53 mRNA; Nitrogen Dioxide results in increased expression of TP53 protein
[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of TRP53 protein		 CTD PMID:22621880 PMID:27521637 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ttn titin increases expression ISO Nitrogen Dioxide results in increased expression of TTN mRNA CTD PMID:27206323 NCBI chr 2:76,534,324...76,812,901
Ensembl chr 2:76,534,324...76,812,891 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [Ozone co-treated with Nitrogen Dioxide] results in increased expression of TXN1 mRNA CTD PMID:10986008 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Txndc2 thioredoxin domain containing 2 (spermatozoa) increases expression ISO Nitrogen Dioxide results in increased expression of TXNDC2 mRNA CTD PMID:27206323 NCBI chr17:65,944,498...65,955,871
Ensembl chr17:65,944,502...65,949,163 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Nitrogen Dioxide results in increased expression of TXNRD1 mRNA CTD PMID:27206323 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Nitrogen Dioxide results in increased expression of VCAM1 mRNA CTD PMID:22331494 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    chemical entity 22181
      molecular entity 22173
        inorganic molecular entity 21916
          inorganic oxide 8026
            nitrogen oxide 422
              nitrogen dioxide 126
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    p-block element atom 22108
                      chalcogen 21441
                        oxygen atom 21419
                          oxygen molecular entity 21419
                            oxide 13372
                              inorganic oxide 8026
                                nitrogen oxide 422
                                  nitrogen dioxide 126
paths to the root