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Gene: Cbs (cystathionine beta-synthase) Mus musculus
Symbol: Cbs
Name: cystathionine beta-synthase
Description: Exhibits cystathionine beta-synthase activity. Involved in several processes, including endochondral bone morphogenesis; regulation of intracellular signal transduction; and sulfur amino acid metabolic process. Predicted to localize to the cytoplasm and nucleus. Used to study homocystinuria. Human ortholog(s) of this gene implicated in coronary artery disease; homocystinuria; and neural tube defect. Is expressed in several structures, including alimentary system; central nervous system; dorsal root ganglion; liver; and sensory organ. Orthologous to several human genes including CBSL (cystathionine beta-synthase like); PARTICIPATES IN cystathioninuria pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI047524; AI303044; beta-thionase; HIP4; MGC18856; MGC18895; MGC37300; serine sulfhydrase
Homo sapiens (human) : CBS (cystathionine beta-synthase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cbs (cystathionine beta synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cbs (cystathionine beta-synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : CBS (cystathionine beta-synthase)
Canis lupus familiaris (dog) : CBS (cystathionine beta-synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cbs (cystathionine beta-synthase)
Sus scrofa (pig) : CBS (cystathionine beta-synthase)
Chlorocebus sabaeus (green monkey) : CBS (cystathionine beta-synthase)
Heterocephalus glaber (naked mole-rat) : Cbs (cystathionine beta-synthase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1731,608,894 - 31,637,238 (-)Ensembl
GRCm381731,612,623 - 31,637,233 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371731,749,589 - 31,774,086 (-)NCBIGRCm37mm9NCBIm37
MGSCv361731,341,354 - 31,365,851 (-)NCBImm8
Celera1732,529,941 - 32,554,472 (-)NCBICelera
Cytogenetic Map17 B1NCBI
cM Map1716.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cbs
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10297
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.