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Gene: Cbs (cystathionine beta-synthase) Mus musculus
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Symbol: Cbs
Name: cystathionine beta-synthase
Description: Exhibits cystathionine beta-synthase activity. Involved in several processes, including endochondral bone morphogenesis; regulation of intracellular signal transduction; and sulfur amino acid metabolic process. Predicted to localize to the cytoplasm and nucleus. Used to study homocystinuria. Human ortholog(s) of this gene implicated in coronary artery disease; homocystinuria; and neural tube defect. Is expressed in several structures, including alimentary system; central nervous system; dorsal root ganglion; liver; and sensory organ. Orthologous to several human genes including CBSL (cystathionine beta-synthase like); PARTICIPATES IN cystathioninuria pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI047524; AI303044; beta-thionase; HIP4; MGC18856; MGC18895; MGC37300; serine sulfhydrase
Orthologs:
Homo sapiens (human) : CBS (cystathionine beta-synthase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cbs (cystathionine beta synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cbs (cystathionine beta-synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : CBS (cystathionine beta-synthase)
Canis lupus familiaris (dog) : CBS (cystathionine beta-synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cbs (cystathionine beta-synthase)
Sus scrofa (pig) : CBS (cystathionine beta-synthase)
Chlorocebus sabaeus (green monkey) : CBS (cystathionine beta-synthase)
Heterocephalus glaber (naked mole-rat) : Cbs (cystathionine beta-synthase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1731,608,894 - 31,637,238 (-)Ensembl
GRCm381731,612,623 - 31,637,233 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371731,749,589 - 31,774,086 (-)NCBIGRCm37mm9NCBIm37
MGSCv361731,341,354 - 31,365,851 (-)NCBImm8
Celera1732,529,941 - 32,554,472 (-)NCBICelera
Cytogenetic Map17 B1NCBI
cM Map1716.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cbs
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10297
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.