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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrogen dioxide
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Accession:CHEBI:33101 term browser browse the term
Definition:A nitrogen oxide that has formula NO2.
Synonyms:exact_synonym: dioxidonitrogen(.);   nitrogen(IV) oxide;   nitrosooxidanyl
 related_synonym: Formula=NO2;   InChI=1S/NO2/c2-1-3;   InChIKey=JCXJVPUVTGWSNB-UHFFFAOYSA-N;   NO2;   ONO(.);   SMILES=O=[N]=O;   Stickstoffdioxid;   nitryl
 alt_id: CHEBI:29332;   CHEBI:29784;   CHEBI:39851
 xref: CAS:10102-44-0;   Gmelin:976
 xref_mesh: MESH:D009585
 xref: MolBase:939;   PDBeChem:2NO


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nitrogen dioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aamdc adipogenesis associated Mth938 domain containing multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of AAMDC 5' UTR CTD PMID:28843141 NCBI chr 7:97,550,329...97,579,557
Ensembl chr 7:97,550,331...97,579,497
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 multiple interactions ISO ABCC2 gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Nitrogen Dioxide] CTD PMID:29681089 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Adora2b adenosine A2b receptor multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of ADORA2B gene CTD PMID:29935799 NCBI chr11:62,248,984...62,266,452
Ensembl chr11:62,248,984...62,266,453
JBrowse link
G Alb albumin increases expression ISO Nitrogen Dioxide results in increased expression of ALB mRNA CTD PMID:27206323 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Ankrd45 ankyrin repeat domain 45 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of ANKRD45 gene CTD PMID:29935799 NCBI chr 1:161,142,447...161,170,510
Ensembl chr 1:161,142,691...161,170,498
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Nitrogen Dioxide results in increased expression of AOX1 mRNA CTD PMID:27206323 NCBI chr 1:58,029,809...58,106,410
Ensembl chr 1:58,029,931...58,106,413
JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO Nitrogen Dioxide results in decreased expression of AQP1 mRNA CTD PMID:27206323 NCBI chr 6:55,336,299...55,348,555
Ensembl chr 6:55,336,432...55,348,555
JBrowse link
G B3galt4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of B3GALT4 gene CTD PMID:29935799 NCBI chr17:33,949,912...33,951,488
Ensembl chr17:33,949,909...33,951,488
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO
EXP
Nitrogen Dioxide results in increased expression of BAX mRNA; Nitrogen Dioxide results in increased expression of BAX protein
[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of BAX protein
CTD PMID:22621880, PMID:27521637 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO Nitrogen Dioxide results in increased expression of BBC3 mRNA CTD PMID:27206323 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression ISO Nitrogen Dioxide results in increased expression of BNIP3 mRNA CTD PMID:27206323 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519
JBrowse link
G Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of CACNA2D1 gene CTD PMID:28843141 NCBI chr 5:15,934,264...16,374,511
Ensembl chr 5:15,934,691...16,374,511
JBrowse link
G Cat catalase increases expression
multiple interactions
ISO
EXP
Nitrogen Dioxide results in increased expression of CAT mRNA
[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of CAT mRNA; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of CAT gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased expression of CAT mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of CAT gene
CAT protein inhibits the reaction [Nitrogen Dioxide results in decreased expression of CCND1 mRNA]
CTD PMID:12600834, PMID:15336314, PMID:27448387 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cbs cystathionine beta-synthase decreases activity ISO Nitrogen Dioxide results in decreased activity of CBS protein CTD PMID:19733148 NCBI chr17:31,612,623...31,637,233
Ensembl chr17:31,608,894...31,637,238
JBrowse link
G Ccl11 chemokine (C-C motif) ligand 11 increases expression EXP Nitrogen Dioxide results in increased expression of CCL11 mRNA CTD PMID:10715624 NCBI chr11:82,057,832...82,062,955
Ensembl chr11:82,057,823...82,062,955
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression
decreases expression
EXP
ISO
Nitrogen Dioxide results in increased expression of CCL2 mRNA; Nitrogen Dioxide results in increased expression of CCL2 protein
Nitrogen Dioxide results in decreased expression of CCL2 mRNA
CTD PMID:10715624, PMID:11498801, PMID:27206323 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 increases expression EXP Nitrogen Dioxide results in increased expression of CCL3 mRNA CTD PMID:10715624 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 increases expression ISO Nitrogen Dioxide results in increased expression of CCL5 mRNA CTD PMID:27206323 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP CAT protein inhibits the reaction [Nitrogen Dioxide results in decreased expression of CCND1 mRNA]
Nitrogen Dioxide results in decreased expression of CCND1 mRNA; Nitrogen Dioxide results in decreased expression of CCND1 protein
CTD PMID:12600834 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cd72 CD72 antigen multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of CD72 3' UTR CTD PMID:28843141 NCBI chr 4:43,447,724...43,455,102
Ensembl chr 4:43,446,462...43,454,628
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions ISO [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of CDKN2A gene CTD PMID:26778509 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO Nitrogen Dioxide results in increased expression of CRP protein CTD PMID:18629312, PMID:22306530 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Csde1 cold shock domain containing E1, RNA binding increases expression ISO Nitrogen Dioxide results in increased expression of CSDE1 mRNA CTD PMID:27206323 NCBI chr 3:103,020,431...103,058,186
Ensembl chr 3:103,020,426...103,058,186
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) increases secretion ISO Nitrogen Dioxide results in increased secretion of CSF2 protein CTD PMID:8398164 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression
increases secretion
ISO Nitrogen Dioxide results in increased expression of CXCL8 mRNA
Nitrogen Dioxide results in increased secretion of CXCL8 protein
CTD PMID:8398164, PMID:8584542, PMID:22331494, PMID:27206323 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 multiple interactions
increases expression
ISO
EXP
[Ozone co-treated with Nitrogen Dioxide] results in increased expression of CXCL2 mRNA
Nitrogen Dioxide results in increased expression of CXCL2 mRNA; Nitrogen Dioxide results in increased expression of CXCL2 protein
CTD PMID:10715624, PMID:10986008, PMID:11498801 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Dgkk diacylglycerol kinase kappa increases expression ISO Nitrogen Dioxide results in increased expression of DGKK mRNA CTD PMID:27206323 NCBI chr  X:6,779,306...6,948,363
Ensembl chr  X:6,779,306...6,948,363
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of DNM1L protein CTD PMID:27521637 NCBI chr16:16,312,228...16,359,038
Ensembl chr16:16,312,230...16,358,959
JBrowse link
G Drd2 dopamine receptor D2 increases expression ISO Nitrogen Dioxide results in increased expression of DRD2 mRNA CTD PMID:19733627 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G E2f2 E2F transcription factor 2 decreases activity EXP Nitrogen Dioxide results in decreased activity of E2F2 protein CTD PMID:12600834 NCBI chr 4:136,172,274...136,196,057
Ensembl chr 4:136,172,394...136,196,057
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of EDN1 protein CTD PMID:30090456 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ephb2 Eph receptor B2 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of EPHB2 gene CTD PMID:28843141 NCBI chr 4:136,647,536...136,836,326
Ensembl chr 4:136,647,539...136,835,988
JBrowse link
G Faap20 Fanconi anemia core complex associated protein 20 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of FAAP20 gene CTD PMID:29935799 NCBI chr 4:155,246,904...155,256,687
Ensembl chr 4:155,249,802...155,256,687
JBrowse link
G Fam124b family with sequence similarity 124, member B multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of FAM124B gene CTD PMID:29935799 NCBI chr 1:80,198,699...80,214,205
Ensembl chr 1:80,198,706...80,218,473
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of FIS1 protein CTD PMID:27521637 NCBI chr 5:136,953,275...136,966,234
Ensembl chr 5:136,953,275...136,966,234
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Nitrogen Dioxide results in increased expression of FOS protein CTD PMID:22621880 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Foxm1 forkhead box M1 increases expression ISO Nitrogen Dioxide results in increased expression of FOXM1 mRNA CTD PMID:27206323 NCBI chr 6:128,362,994...128,375,886
Ensembl chr 6:128,362,967...128,376,146
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of FOXP3 promoter CTD PMID:29317916 NCBI chr  X:7,579,676...7,595,243
Ensembl chr  X:7,573,644...7,595,245
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit decreases expression ISO Nitrogen Dioxide results in decreased expression of GCLM mRNA CTD PMID:16049373 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression
multiple interactions
ISO Nitrogen Dioxide results in increased expression of GGT1 mRNA
Nitrogen Dioxide results in increased expression of and results in increased activity of GGT1 protein
CTD PMID:9144455, PMID:16049373 NCBI chr10:75,561,076...75,586,193
Ensembl chr10:75,561,604...75,586,200
JBrowse link
G Gpr55 G protein-coupled receptor 55 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of GPR55 mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased expression of GPR55 mRNA CTD PMID:27448387 NCBI chr 1:85,933,221...85,991,583
Ensembl chr 1:85,938,318...85,961,007
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
decreases expression
ISO Nitrogen Dioxide results in increased expression of GPX3 mRNA
Nitrogen Dioxide results in decreased expression of GPX3 mRNA
CTD PMID:15336314, PMID:16049373 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Gpx4 glutathione peroxidase 4 affects expression ISO Nitrogen Dioxide affects the expression of GPX4 mRNA CTD PMID:16049373 NCBI chr10:80,047,166...80,056,439
Ensembl chr10:80,047,166...80,056,439
JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Nitrogen Dioxide results in increased expression of GPX5 mRNA CTD PMID:27206323 NCBI chr13:21,286,429...21,292,727
Ensembl chr13:21,286,429...21,292,731
JBrowse link
G Gsr glutathione reductase increases activity
increases expression
ISO Nitrogen Dioxide results in increased activity of GSR protein
Nitrogen Dioxide results in increased expression of GSR mRNA
CTD PMID:16049373 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gss glutathione synthetase decreases expression ISO Nitrogen Dioxide results in decreased expression of GSS mRNA CTD PMID:16049373 NCBI chr 2:155,563,181...155,592,810
Ensembl chr 2:155,563,181...155,592,810
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Nitrogen Dioxide CTD PMID:22732554 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 affects response to substance
multiple interactions
ISO GSTP1 gene polymorphism affects the susceptibility to Nitrogen Dioxide
GSTP1 gene SNP results in increased susceptibility to [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide]
CTD PMID:22732554, PMID:29624745 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 affects response to substance ISO GSTT1 gene polymorphism affects the susceptibility to Nitrogen Dioxide CTD PMID:22732554 NCBI chr10:75,783,813...75,798,584
Ensembl chr10:75,783,813...75,798,584
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of HIBADH gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of HIBADH gene CTD PMID:27448387 NCBI chr 6:52,546,230...52,640,300
Ensembl chr 6:52,546,228...52,640,389
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression
EXP
ISO
Nitrogen Dioxide results in increased expression of HMOX1 mRNA
Nitrogen Dioxide results in decreased expression of HMOX1 mRNA
CTD PMID:10715624, PMID:20197249, PMID:27206323 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of HSP90AA1 gene CTD PMID:29935799 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Nitrogen Dioxide results in increased expression of ICAM1 mRNA CTD PMID:22331494 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
EXP [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrogen Dioxide; [OVAL protein promotes the reaction [Nitrogen Dioxide results in increased susceptibility to OVAL protein]] which results in decreased expression of IFNG protein
Nitrogen Dioxide results in decreased expression of IFNG protein
CTD PMID:22303861, PMID:28935613 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 increases expression ISO Nitrogen Dioxide results in increased expression of IL10 mRNA; Nitrogen Dioxide results in increased expression of IL10 protein CTD PMID:28669936 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il13 interleukin 13 decreases methylation
increases expression
multiple interactions
EXP
ISO
Nitrogen Dioxide results in decreased methylation of IL13 promoter
Nitrogen Dioxide results in increased expression of IL13 mRNA
Nitrogen Dioxide results in increased expression of IL13 protein
[OVAL protein promotes the reaction [Nitrogen Dioxide results in increased susceptibility to OVAL protein]] which results in increased expression of IL13 protein
CTD PMID:28669936, PMID:28935613 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO [Ozone co-treated with Nitrogen Dioxide] results in increased expression of IL1B protein
IL1B gene SNP results in increased susceptibility to [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased abundance of Nitrogen Dioxide]
Nitrogen Dioxide results in decreased expression of IL1B mRNA
CTD PMID:9363475, PMID:10986008, PMID:27640071 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions
decreases methylation
EXP Nitrogen Dioxide results in increased expression of IL4 protein
[[OVAL protein promotes the reaction [Nitrogen Dioxide results in increased susceptibility to OVAL protein]] which results in decreased methylation of IL4 promoter] which results in increased expression of IL4 protein; [Nitrogen Dioxide results in decreased methylation of IL4 gene] which results in increased expression of IL4 promoter; [OVAL protein promotes the reaction [Nitrogen Dioxide results in increased susceptibility to OVAL protein]] which results in decreased methylation of IL4 promoter; [OVAL protein promotes the reaction [Nitrogen Dioxide results in increased susceptibility to OVAL protein]] which results in increased expression of IL4 protein
Nitrogen Dioxide results in decreased methylation of IL4 promoter
CTD PMID:28935613 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
increases secretion
increases expression
ISO [Ozone co-treated with Nitrogen Dioxide] results in increased expression of IL6 protein
Nitrogen Dioxide results in decreased expression of IL6 mRNA
Nitrogen Dioxide results in increased secretion of IL6 protein
Nitrogen Dioxide results in increased expression of IL6 mRNA; Nitrogen Dioxide results in increased expression of IL6 protein
CTD PMID:8584542, PMID:10986008, PMID:18629312, PMID:19750100, PMID:27206323, PMID:28669936 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ipcef1 interaction protein for cytohesin exchange factors 1 decreases expression ISO Nitrogen Dioxide results in decreased expression of IPCEF1 mRNA CTD PMID:27206323 NCBI chr10:6,885,779...7,054,782
Ensembl chr10:6,885,796...7,052,478
JBrowse link
G Jun jun proto-oncogene increases expression ISO Nitrogen Dioxide results in increased expression of JUN protein CTD PMID:22621880 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Lmf1 lipase maturation factor 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of LMF1 gene CTD PMID:29935799 NCBI chr17:25,579,174...25,662,831
Ensembl chr17:25,579,085...25,662,826
JBrowse link
G Lonp1 lon peptidase 1, mitochondrial multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased expression of LONP1 mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased expression of LONP1 mRNA CTD PMID:27448387 NCBI chr17:56,614,297...56,626,903
Ensembl chr17:56,614,297...56,626,887
JBrowse link
G Lztfl1 leucine zipper transcription factor-like 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of LZTFL1 gene CTD PMID:29935799 NCBI chr 9:123,694,404...123,717,625
Ensembl chr 9:123,694,416...123,717,697
JBrowse link
G Mcf2l mcf.2 transforming sequence-like multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of MCF2L gene CTD PMID:28843141 NCBI chr 8:12,873,806...13,020,502
Ensembl chr 8:12,873,806...13,020,905
JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of MEIS2 gene CTD PMID:28843141 NCBI chr 2:115,861,264...116,067,537
Ensembl chr 2:115,863,064...116,065,839
JBrowse link
G Mfn1 mitofusin 1 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MFN1 protein CTD PMID:27521637 NCBI chr 3:32,529,443...32,579,225
Ensembl chr 3:32,529,465...32,579,239
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MFN2 protein CTD PMID:27521637 NCBI chr 4:147,873,586...147,904,909
Ensembl chr 4:147,873,599...147,904,704
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 increases expression ISO Nitrogen Dioxide results in increased expression of MGST3 mRNA CTD PMID:27206323 NCBI chr 1:167,371,966...167,393,841
Ensembl chr 1:167,371,966...167,393,841
JBrowse link
G Mir1249 microRNA 1249 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR1249 mRNA CTD PMID:30090456 NCBI chr15:84,951,526...84,951,623
Ensembl chr15:84,951,526...84,951,623
JBrowse link
G Mir185 microRNA 185 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR185 mRNA CTD PMID:30090456 NCBI chr16:18,327,401...18,327,465
Ensembl chr16:18,327,401...18,327,465
JBrowse link
G Mir1894 microRNA 1894 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR1894 mRNA CTD PMID:30090456 NCBI chr17:35,917,889...35,917,969
Ensembl chr17:35,917,889...35,917,969
JBrowse link
G Mir1927 microRNA 1927 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR1927 mRNA CTD PMID:30090456 NCBI chr 1:160,295,864...160,295,972
Ensembl chr 1:160,295,864...160,295,972
JBrowse link
G Mir205 microRNA 205 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR205 mRNA CTD PMID:30090456 NCBI chr 1:193,507,463...193,507,530
Ensembl chr 1:193,507,463...193,507,530
JBrowse link
G Mir3070b microRNA 3070b multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR3070B mRNA CTD PMID:30090456 NCBI chr12:109,588,592...109,588,680
Ensembl chr12:109,588,592...109,588,680
JBrowse link
G Mir3095 microRNA 3095 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR3095 mRNA CTD PMID:30090456 NCBI chr 4:58,441,012...58,441,098
Ensembl chr 4:58,441,012...58,441,098
JBrowse link
G Mir30e microRNA 30e multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR30E mRNA CTD PMID:30090456 NCBI chr 4:120,772,606...120,772,697
Ensembl chr 4:120,772,606...120,772,697
JBrowse link
G Mir338 microRNA 338 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR338 mRNA CTD PMID:30090456 NCBI chr11:120,014,765...120,014,862
Ensembl chr11:120,014,765...120,014,862
JBrowse link
G Mir34b microRNA 34b multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR34B mRNA CTD PMID:30090456 NCBI chr 9:51,103,562...51,103,645
Ensembl chr 9:51,103,562...51,103,645
JBrowse link
G Mir374c microRNA 374c multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR374C mRNA CTD PMID:30090456 NCBI chr  X:103,573,085...103,573,133
Ensembl chr  X:103,573,085...103,573,133
JBrowse link
G Mir375 microRNA 375 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR375 mRNA CTD PMID:30090456 NCBI chr 1:74,900,658...74,900,721
Ensembl chr 1:74,900,658...74,900,721
JBrowse link
G Mir425 microRNA 425 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR425 mRNA CTD PMID:30090456 NCBI chr 9:108,568,777...108,568,861
Ensembl chr 9:108,568,777...108,568,861
JBrowse link
G Mir434 microRNA 434 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of MIR434 mRNA CTD PMID:30090456 NCBI chr12:109,594,506...109,594,599
Ensembl chr12:109,594,506...109,594,599
JBrowse link
G Mir450b microRNA 450b multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR450B mRNA CTD PMID:30090456 NCBI chr  X:53,047,997...53,048,078
Ensembl chr  X:53,047,997...53,048,078
JBrowse link
G Mir500 microRNA 500 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR500 mRNA CTD PMID:30090456 NCBI chr  X:7,237,683...7,237,774
Ensembl chr  X:7,237,683...7,237,774
JBrowse link
G Mir504 microRNA 504 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR504 mRNA CTD PMID:30090456 NCBI chr  X:59,097,658...59,097,736
Ensembl chr  X:59,097,658...59,097,736
JBrowse link
G Mir674 microRNA 674 multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIR674 mRNA CTD PMID:30090456 NCBI chr 2:117,185,127...117,185,226
Ensembl chr 2:117,185,127...117,185,226
JBrowse link
G Mirlet7e microRNA let7e multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of MIRLET7E mRNA CTD PMID:30090456 NCBI chr17:17,830,352...17,830,444
Ensembl chr17:17,830,352...17,830,444
JBrowse link
G Mpo myeloperoxidase increases expression ISO Nitrogen Dioxide results in increased expression of MPO mRNA CTD PMID:27206323 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Mt3 metallothionein 3 increases expression ISO Nitrogen Dioxide results in increased expression of MT3 mRNA CTD PMID:27206323 NCBI chr 8:94,152,607...94,154,148
Ensembl chr 8:94,152,607...94,154,146
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression
multiple interactions
EXP
ISO
Nitrogen Dioxide results in increased expression of NOS2 mRNA
[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of NOS2 gene
CTD PMID:10715624, PMID:26778509 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of NOS3 protein CTD PMID:30090456 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 affects response to substance ISO NQO1 gene polymorphism affects the susceptibility to Nitrogen Dioxide CTD PMID:20049212 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nudt1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 increases expression ISO Nitrogen Dioxide results in increased expression of NUDT1 mRNA CTD PMID:27206323 NCBI chr 5:140,321,622...140,338,137
Ensembl chr 5:140,321,656...140,338,137
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of OPA1 protein CTD PMID:27521637 NCBI chr16:29,579,281...29,663,127
Ensembl chr16:29,579,334...29,654,884
JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of P2RX4 gene CTD PMID:29935799 NCBI chr 5:122,707,518...122,729,739
Ensembl chr 5:122,707,544...122,729,738
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP Nitrogen Dioxide results in decreased expression of PCNA protein CTD PMID:12600834 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of PIEZO1 gene CTD PMID:29935799 NCBI chr 8:122,481,698...122,551,329
Ensembl chr 8:122,481,698...122,551,329
JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) affects expression ISO Nitrogen Dioxide affects the expression of PLA2G7 CTD PMID:21356620 NCBI chr17:43,567,994...43,612,202
Ensembl chr17:43,568,098...43,612,201
JBrowse link
G Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 increases expression ISO Nitrogen Dioxide results in increased expression of PREX1 mRNA CTD PMID:27206323 NCBI chr 2:166,566,345...166,713,832
Ensembl chr 2:166,566,342...166,713,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Nitrogen Dioxide results in increased expression of PTGS2 mRNA CTD PMID:27206323 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation EXP Nitrogen Dioxide results in decreased phosphorylation of RB1 protein CTD PMID:12600834 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Rnf2 ring finger protein 2 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of RNF2 5' UTR CTD PMID:28843141 NCBI chr 1:151,469,398...151,500,991
Ensembl chr 1:151,458,004...151,500,955
JBrowse link
G Selp selectin, platelet increases expression ISO Nitrogen Dioxide results in increased expression of SELP protein modified form CTD PMID:18629312 NCBI chr 1:164,115,264...164,150,026
Ensembl chr 1:164,115,264...164,150,026
JBrowse link
G Slc25a28 solute carrier family 25, member 28 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of SLC25A28 gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased methylation of SLC25A28 gene CTD PMID:27448387 NCBI chr19:43,663,801...43,675,006
Ensembl chr19:43,663,801...43,674,881
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression
decreases activity
decreases expression
multiple interactions
ISO Nitrogen Dioxide results in increased expression of SOD1 mRNA
Nitrogen Dioxide results in decreased activity of SOD1 protein
Nitrogen Dioxide results in decreased expression of SOD1 protein
[[SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites] which results in increased chemical synthesis of Nitrogen Dioxide
CTD PMID:15336314, PMID:18629312, PMID:19243126, PMID:22621880 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases activity
multiple interactions
ISO Nitrogen Dioxide results in decreased activity of SOD2 protein
[[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of SOD2 promoter] which affects the methylation of SOD2 promoter; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of SOD2 promoter
CTD PMID:22621880, PMID:31220783 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Ozone co-treated with Nitrogen Dioxide] results in increased expression of TGFB1 mRNA CTD PMID:10986008 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Thap1 THAP domain containing, apoptosis associated protein 1 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of THAP1 3' UTR CTD PMID:28843141 NCBI chr 8:26,158,169...26,164,151
Ensembl chr 8:26,158,141...26,164,151
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
decreases secretion
affects response to substance
ISO [Ozone co-treated with Nitrogen Dioxide] results in increased expression of TNF protein
TNF gene SNP results in increased susceptibility to [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide]
Nitrogen Dioxide results in increased expression of TNF mRNA
Nitrogen Dioxide results in increased secretion of TNF protein
Nitrogen Dioxide results in decreased secretion of TNF protein
TNF gene polymorphism affects the susceptibility to Nitrogen Dioxide
CTD PMID:8398164, PMID:9363475, PMID:10986008, PMID:20049212, PMID:28669936, PMID:29624745 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b increases expression ISO Nitrogen Dioxide results in increased expression of TNFRSF1B protein modified form CTD PMID:18629312 NCBI chr 4:145,212,368...145,246,870
Ensembl chr 4:145,213,463...145,246,870
JBrowse link
G Tpo thyroid peroxidase multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of TPO gene; [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased expression of TPO mRNA; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of TPO gene; [Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased expression of TPO mRNA CTD PMID:27448387 NCBI chr12:30,054,659...30,132,984
Ensembl chr12:30,054,659...30,132,624
JBrowse link
G Trmt10a tRNA methyltransferase 10A multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased methylation of TRMT10A CTD PMID:28843141 NCBI chr 3:138,143,448...138,159,821
Ensembl chr 3:138,143,448...138,159,821
JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions
ISO
EXP
Nitrogen Dioxide results in increased expression of TP53 mRNA; Nitrogen Dioxide results in increased expression of TP53 protein
[Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in increased expression of TRP53 protein
CTD PMID:22621880, PMID:27521637 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Ttn titin increases expression ISO Nitrogen Dioxide results in increased expression of TTN mRNA CTD PMID:27206323 NCBI chr 2:76,703,980...76,982,557
Ensembl chr 2:76,703,980...76,982,547
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [Ozone co-treated with Nitrogen Dioxide] results in increased expression of TXN1 mRNA CTD PMID:10986008 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txndc2 thioredoxin domain containing 2 (spermatozoa) increases expression ISO Nitrogen Dioxide results in increased expression of TXNDC2 mRNA CTD PMID:27206323 NCBI chr17:65,637,505...65,648,874
Ensembl chr17:65,637,507...65,642,168
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Nitrogen Dioxide results in increased expression of TXNRD1 mRNA CTD PMID:27206323 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Nitrogen Dioxide results in increased expression of VCAM1 mRNA CTD PMID:22331494 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
G Zfp617 zinc finger protein 617 multiple interactions ISO [Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects the methylation of ZNF563 gene CTD PMID:29935799 NCBI chr 8:71,922,825...71,934,630
Ensembl chr 8:71,908,635...71,934,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21450
    chemical entity 21448
      molecular entity 21430
        inorganic molecular entity 21076
          inorganic oxide 7707
            nitrogen oxide 415
              nitrogen dioxide 120
Path 2
Term Annotations click to browse term
  CHEBI ontology 21450
    subatomic particle 21434
      composite particle 21434
        hadron 21434
          baryon 21434
            nucleon 21434
              atomic nucleus 21434
                atom 21434
                  main group element atom 21329
                    p-block element atom 21329
                      chalcogen 20424
                        oxygen atom 20400
                          oxygen molecular entity 20400
                            oxide 12175
                              inorganic oxide 7707
                                nitrogen oxide 415
                                  nitrogen dioxide 120
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.