Ephb2 (Eph receptor B2) - Rat Genome Database

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Gene: Ephb2 (Eph receptor B2) Mus musculus
Analyze
Symbol: Ephb2
Name: Eph receptor B2
RGD ID: 1617631
MGI Page MGI
Description: Enables several functions, including amyloid-beta binding activity; identical protein binding activity; and transmembrane signaling receptor activity. Involved in several processes, including plasma membrane bounded cell projection organization; regulation of signal transduction; and regulation of synaptic plasticity. Acts upstream of or within several processes, including ephrin receptor signaling pathway; generation of neurons; and optic nerve morphogenesis. Located in axon; dendrite; and neuronal cell body. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neural ectoderm; and sensory organ. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EPHB2 (EPH receptor B2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Cek5; Dr; Drt; ephrin type-B receptor 2; Er; Erk; ETECK; Hek5; neural kinase; Nu; Nuk; nuk receptor tyrosine kinase; Prk; Prkm5; Qek5; Sek; Sek3; Tyr; Tyro5; tyrosine-protein kinase receptor EPH-3; tyrosine-protein kinase receptor SEK-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394136,374,850 - 136,563,637 (-)NCBIGRCm39mm39
GRCm39 Ensembl4136,374,850 - 136,563,299 (-)Ensembl
GRCm384136,647,536 - 136,836,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,647,539 - 136,835,988 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,209,523 - 136,391,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv364135,925,684 - 136,108,011 (-)NCBImm8
Celera4134,853,290 - 135,040,552 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brodifacoum  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
columbamine  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
diethyl malate  (EXP)
dorsomorphin  (ISO)
fenpyroximate  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
nitrogen dioxide  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
propanal  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
triazines  (EXP)
trichostatin A  (ISO)
triptonide  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA,IMP)
animal organ morphogenesis  (IMP)
axon guidance  (IBA,IDA,IMP)
axonal fasciculation  (IMP)
B cell activation  (ISO)
camera-type eye morphogenesis  (IMP)
cell morphogenesis  (IGI)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (ISO)
central nervous system projection neuron axonogenesis  (IBA,IMP)
commissural neuron axon guidance  (IMP)
corpus callosum development  (IMP)
dendritic spine development  (IMP)
dendritic spine morphogenesis  (IDA,IMP)
ephrin receptor signaling pathway  (IDA)
hindbrain tangential cell migration  (ISO)
inner ear morphogenesis  (IMP)
learning  (IMP)
learning or memory  (IGI)
negative regulation of axonogenesis  (IDA)
negative regulation of cell adhesion  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of ERK1 and ERK2 cascade  (IDA)
negative regulation of NMDA glutamate receptor activity  (IMP)
negative regulation of protein kinase activity  (IDA)
negative regulation of protein phosphorylation  (IDA)
negative regulation of Ras protein signal transduction  (IDA)
nervous system development  (IEA)
neuron projection retraction  (IDA)
optic nerve morphogenesis  (IMP)
peptidyl-tyrosine phosphorylation  (IDA,IMP)
phosphorylation  (IDA)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of long-term neuronal synaptic plasticity  (IMP)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of NMDA glutamate receptor activity  (IMP)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of synapse assembly  (IDA,IMP,ISO)
positive regulation of synaptic plasticity  (IGI)
positive regulation of tumor necrosis factor production  (ISO)
postsynaptic membrane assembly  (ISO)
protein phosphorylation  (IDA)
regulation of axonogenesis  (IDA)
regulation of behavioral fear response  (ISO)
regulation of blood coagulation  (ISO)
regulation of body fluid levels  (IMP)
regulation of filopodium assembly  (ISO)
regulation of neuronal synaptic plasticity  (IMP)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of synapse assembly  (EXP,IDA,IMP)
regulation of T-helper 17 type immune response  (ISO)
retinal ganglion cell axon guidance  (IDA)
roof of mouth development  (IMP)
tight junction assembly  (ISO)
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission  (IMP)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,IDA)
urogenital system development  (IMP)
vesicle-mediated intercellular transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bundesen LQ, etal., J Neurosci. 2003 Aug 27;23(21):7789-800.
2. Cissé M, etal., Nature. 2011 Jan 6;469(7328):47-52. doi: 10.1038/nature09635. Epub 2010 Nov 28.
3. He YD, etal., Zhonghua Yi Xue Za Zhi. 2005 Sep 7;85(34):2395-9.
4. Ma P, etal., Pain. 2020 Jul;161(7):1584-1596. doi: 10.1097/j.pain.0000000000001855.
5. Mimche PN, etal., Hepatology. 2015 Sep;62(3):900-14. doi: 10.1002/hep.27792. Epub 2015 Apr 22.
6. OMIM Disease Annotation Pipeline
7. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. RGD automated import pipeline for gene-chemical interactions
10. Sun CL, etal., Pain Res Manag. 2021 Apr 7;2021:7582494. doi: 10.1155/2021/7582494. eCollection 2021.
11. Sun W, etal., J Immunol. 2021 Apr 1;206(7):1419-1423. doi: 10.4049/jimmunol.2001373. Epub 2021 Mar 8.
12. Wang DJ, etal., J Pediatr Surg. 2009 Mar;44(3):592-9. doi: 10.1016/j.jpedsurg.2008.08.017.
13. Wu J, etal., CNS Neurosci Ther. 2021 Jun;27(6):714-724. doi: 10.1111/cns.13641. Epub 2021 Apr 1.
14. Xing S, etal., Brain Res. 2008 Sep 16;1230:237-46. doi: 10.1016/j.brainres.2008.06.097. Epub 2008 Jul 2.
15. Yu T, etal., Stem Cell Res Ther. 2021 Mar 15;12(1):181. doi: 10.1186/s13287-021-02232-w.
16. Yuferov V, etal., J Neuroimmune Pharmacol. 2013 Mar;8(1):333-44. doi: 10.1007/s11481-012-9429-1. Epub 2013 Jan 12.
17. Zhang L, etal., FASEB J. 2019 Dec;33(12):13644-13659. doi: 10.1096/fj.201901192R. Epub 2019 Oct 25.
Additional References at PubMed
PMID:1825055   PMID:7542761   PMID:7601466   PMID:7651410   PMID:7947319   PMID:8134103   PMID:8206383   PMID:8552593   PMID:8617223   PMID:8672140   PMID:8689685   PMID:8878483  
PMID:8947026   PMID:8954633   PMID:8954774   PMID:9233798   PMID:9267020   PMID:9321682   PMID:9630219   PMID:9853759   PMID:9883737   PMID:9990854   PMID:10349636   PMID:10495276  
PMID:10683176   PMID:10704386   PMID:10839360   PMID:10932185   PMID:11042159   PMID:11062179   PMID:11076861   PMID:11114734   PMID:11163240   PMID:11217851   PMID:11301003   PMID:11403717  
PMID:11439183   PMID:11493560   PMID:11532925   PMID:11572780   PMID:11580899   PMID:11585923   PMID:11754835   PMID:11754836   PMID:11780069   PMID:11784715   PMID:11830578   PMID:11830579  
PMID:11983165   PMID:12048246   PMID:12052960   PMID:12165470   PMID:12165850   PMID:12217323   PMID:12389031   PMID:12435358   PMID:12466851   PMID:12477932   PMID:12486127   PMID:12654290  
PMID:12684176   PMID:12684184   PMID:12904583   PMID:12919674   PMID:12923530   PMID:12971893   PMID:12973358   PMID:14501676   PMID:14610273   PMID:14681479   PMID:14691139   PMID:14988728  
PMID:15014111   PMID:15030763   PMID:15044550   PMID:15073150   PMID:15107857   PMID:15162501   PMID:15184386   PMID:15223334   PMID:15240555   PMID:15590741   PMID:15632069   PMID:15681612  
PMID:15753214   PMID:15804564   PMID:15848800   PMID:15965473   PMID:16141072   PMID:16141073   PMID:16208538   PMID:16230531   PMID:16298995   PMID:16421308   PMID:16446123   PMID:16469829  
PMID:16514057   PMID:16602821   PMID:16611695   PMID:16777604   PMID:16777849   PMID:16786562   PMID:16854408   PMID:16889766   PMID:16943546   PMID:16964983   PMID:16968134   PMID:16977320  
PMID:16989802   PMID:17122040   PMID:17145500   PMID:17158005   PMID:17234965   PMID:17304517   PMID:17310244   PMID:17428795   PMID:17440041   PMID:17526730   PMID:17668899   PMID:17686994  
PMID:17884558   PMID:17942722   PMID:18055806   PMID:18057206   PMID:18287559   PMID:18295889   PMID:18397270   PMID:18410519   PMID:18614029   PMID:18614674   PMID:18651661   PMID:18694996  
PMID:18713744   PMID:18772347   PMID:19032981   PMID:19047466   PMID:19109910   PMID:19182796   PMID:19193989   PMID:19289155   PMID:19515977   PMID:19542359   PMID:19542617   PMID:19553453  
PMID:19554387   PMID:19571816   PMID:19598115   PMID:19661068   PMID:19731361   PMID:19769959   PMID:19914164   PMID:20112066   PMID:20176802   PMID:20410461   PMID:20436479   PMID:20499360  
PMID:20504947   PMID:20513444   PMID:20549726   PMID:20616004   PMID:20652952   PMID:20660266   PMID:20844017   PMID:20851768   PMID:20869108   PMID:21029865   PMID:21092311   PMID:21098570  
PMID:21127290   PMID:21243004   PMID:21246652   PMID:21267068   PMID:21465626   PMID:21508957   PMID:21539827   PMID:21559471   PMID:21832177   PMID:21847105   PMID:21873635   PMID:21932443  
PMID:21964490   PMID:21976438   PMID:22021100   PMID:22022561   PMID:22064993   PMID:22065784   PMID:22103419   PMID:22144690   PMID:22171039   PMID:22201756   PMID:22233626   PMID:22282599  
PMID:22371266   PMID:22434763   PMID:22475621   PMID:22484060   PMID:22579729   PMID:22622783   PMID:22792203   PMID:22951731   PMID:23129351   PMID:23143520   PMID:23146940   PMID:23147113  
PMID:23318582   PMID:23326536   PMID:23379484   PMID:23408838   PMID:23426374   PMID:23578932   PMID:23623938   PMID:23874863   PMID:23881165   PMID:24056079   PMID:24238961   PMID:24360543  
PMID:24469634   PMID:24583262   PMID:24632612   PMID:24891614   PMID:24952961   PMID:24982128   PMID:25051176   PMID:25082703   PMID:25091710   PMID:25100655   PMID:25203207   PMID:25299585  
PMID:25302779   PMID:25370417   PMID:25467980   PMID:25480914   PMID:25480918   PMID:25789706   PMID:25810451   PMID:25834110   PMID:25907274   PMID:25920569   PMID:25923646   PMID:25933092  
PMID:25953347   PMID:26027930   PMID:26114424   PMID:26148571   PMID:26165136   PMID:26243870   PMID:26407069   PMID:26408450   PMID:26549443   PMID:26589795   PMID:26764128   PMID:26799631  
PMID:26830346   PMID:26839344   PMID:26906676   PMID:27034231   PMID:27035151   PMID:27103064   PMID:27122172   PMID:27344203   PMID:27348588   PMID:27480037   PMID:27565439   PMID:27626668  
PMID:27631552   PMID:27664421   PMID:27683910   PMID:27748998   PMID:27810913   PMID:27881781   PMID:28017833   PMID:28027321   PMID:28077917   PMID:28358367   PMID:28558017   PMID:28595615  
PMID:28919206   PMID:28931592   PMID:29027839   PMID:29031500   PMID:29360039   PMID:29416088   PMID:29638158   PMID:29700203   PMID:29731254   PMID:29768201   PMID:29867988   PMID:29874574  
PMID:30185604   PMID:30501625   PMID:30570432   PMID:30722785   PMID:30820459   PMID:31412026   PMID:31577955   PMID:31633063   PMID:31661464   PMID:31836902   PMID:31882185   PMID:31926216  
PMID:32092051   PMID:32404061   PMID:32506584   PMID:32561725   PMID:32620380   PMID:32987403   PMID:32989254   PMID:33168800   PMID:33253166   PMID:33299176   PMID:33649502   PMID:34360793  
PMID:34462781   PMID:34553752   PMID:34638814   PMID:34757798  


Genomics

Comparative Map Data
Ephb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394136,374,850 - 136,563,637 (-)NCBIGRCm39mm39
GRCm39 Ensembl4136,374,850 - 136,563,299 (-)Ensembl
GRCm384136,647,536 - 136,836,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,647,539 - 136,835,988 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,209,523 - 136,391,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv364135,925,684 - 136,108,011 (-)NCBImm8
Celera4134,853,290 - 135,040,552 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.0NCBI
EPHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl122,710,839 - 22,921,500 (+)EnsemblGRCh38hg38GRCh38
GRCh38122,710,770 - 22,921,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37123,037,331 - 23,247,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,909,918 - 23,114,410 (+)NCBINCBI36hg18NCBI36
Celera121,361,651 - 21,563,983 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef121,351,920 - 21,485,793 (+)NCBIHuRef
CHM1_1123,149,831 - 23,354,155 (+)NCBICHM1_1
Ephb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25148,889,574 - 149,077,027 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5148,897,246 - 149,077,059 (-)Ensembl
Rnor_6.05155,024,478 - 155,143,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,022,493 - 155,204,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05156,786,985 - 156,811,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05158,789,192 - 158,907,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45155,423,035 - 155,605,384 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5147,297,353 - 147,415,432 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ephb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,844,713 - 2,980,445 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,844,713 - 2,986,790 (+)NCBIChiLan1.0ChiLan1.0
EPHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,914,584 - 23,054,752 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBIMhudiblu_PPA_v0panPan3
EPHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,427,112 - 76,551,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,428,203 - 76,612,786 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBI
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBI
ROS_Cfam_1.0 Ensembl276,985,696 - 77,172,430 (-)Ensembl
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBI
UNSW_CanFamBas_1.0274,815,673 - 74,940,002 (-)NCBI
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBI
Ephb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505842,251,873 - 42,378,453 (+)NCBI
SpeTri2.0NW_0049364748,109,800 - 8,203,106 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,649,143 - 80,843,567 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,649,098 - 80,849,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,689,973 - 74,878,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120109,747,883 - 109,954,936 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20109,746,925 - 109,890,777 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660336,358,996 - 6,570,523 (+)NCBIVero_WHO_p1.0
Ephb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247647,421,818 - 7,599,800 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138615442Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465800000146500000Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined89063832140740892Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined89063832140740892Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined89063832140740892Mouse
1357529Lvrq8_mliver weight QTL 8 (mouse)Not determined489063832140740892Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)489063832140740892Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
13208562Wght7_mweight 7 (mouse)491000000148000000Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105812001139812001Mouse
15039378Adip30_madiposity 30 (mouse)4105812001139812001Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105812001139812001Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105978113141706527Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105978113141706527Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105978113141706527Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105978113141706527Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107161300141161387Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107371164141371360Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107371164141371360Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107371164141371360Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107897771141897963Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108583899142583899Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108583899142583899Mouse
10755521Hct1_mhematocrit 1 (mouse)4108583899142583899Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111115258145115487Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111115258145115487Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112288593146288593Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112629696146629696Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112930596146930596Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116427367150427471Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117673830151673964Mouse
14746982Manh56_mmandible shape 56 (mouse)4118088606152088606Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4120137122154137225Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4120137122154137225Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120890537154890684Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120890537154890684Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120946694154946840Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120946694154946840Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121615338155615442Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121615338155615442Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121615338155615442Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4124100000144600000Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124161300141845481Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124161300142711450Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124371164142504390Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124371164150592401Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse
1301793Tlsr3_mthymic lymphoma suppressor region 3 (mouse)Not determined4129572018137137225Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129572018151570093Mouse
4141154Nba1_mNew Zealand Black autoimmunity 1 (mouse)Not determined131923413141151964Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4132926037156508116Mouse
4142082Psds2_mpsoriasis-like skin disease severity 2 (mouse)Not determined4133427367137890684Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133427367150704994Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133592276156508116Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134569994156508116Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134569994156508116Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4386
Count of miRNA genes:944
Interacting mature miRNAs:1307
Transcripts:ENSMUST00000059287, ENSMUST00000105845, ENSMUST00000105846, ENSMUST00000144573, ENSMUST00000151502, ENSMUST00000156558
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001290753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006538531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006538533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006538534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030253190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030253191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK017630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL627214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL627345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ067955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ180821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X76011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000059287   ⟹   ENSMUSP00000058135
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4136,380,919 - 136,563,267 (-)Ensembl
GRCm38.p6 Ensembl4136,653,608 - 136,835,956 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105845   ⟹   ENSMUSP00000101471
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4136,374,850 - 136,563,299 (-)Ensembl
GRCm38.p6 Ensembl4136,647,539 - 136,835,988 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105846   ⟹   ENSMUSP00000101472
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4136,381,957 - 136,563,154 (-)Ensembl
GRCm38.p6 Ensembl4136,654,646 - 136,835,843 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144573
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4136,496,703 - 136,563,285 (-)Ensembl
GRCm38.p6 Ensembl4136,769,392 - 136,835,974 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151502
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4136,386,998 - 136,388,963 (-)Ensembl
GRCm38.p6 Ensembl4136,659,687 - 136,661,652 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156558   ⟹   ENSMUSP00000116350
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4136,388,774 - 136,421,351 (-)Ensembl
GRCm38.p6 Ensembl4136,661,463 - 136,694,040 (-)Ensembl
RefSeq Acc Id: NM_001290753   ⟹   NP_001277682
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394136,374,850 - 136,563,323 (-)NCBI
GRCm384136,647,539 - 136,836,012 (-)NCBI
Celera4134,853,290 - 135,040,628 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010142   ⟹   NP_034272
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394136,374,850 - 136,563,323 (-)NCBI
GRCm384136,647,539 - 136,836,012 (-)NCBI
MGSCv374136,209,523 - 136,391,850 (-)RGD
Celera4134,853,290 - 135,040,628 (-)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006538531   ⟹   XP_006538594
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394136,381,594 - 136,563,321 (-)NCBI
GRCm384136,647,536 - 136,836,010 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006538533   ⟹   XP_006538596
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394136,381,594 - 136,563,321 (-)NCBI
GRCm384136,647,536 - 136,836,010 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006538534   ⟹   XP_006538597
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394136,374,850 - 136,563,321 (-)NCBI
GRCm384136,647,536 - 136,836,011 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030253190   ⟹   XP_030109050
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394136,381,594 - 136,563,637 (-)NCBI
GRCm384136,647,536 - 136,836,326 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030253191   ⟹   XP_030109051
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394136,381,594 - 136,563,321 (-)NCBI
GRCm384136,647,536 - 136,836,010 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034272   ⟸   NM_010142
- Peptide Label: isoform 2 precursor
- UniProtKB: P54763 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006538597   ⟸   XM_006538534
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006538596   ⟸   XM_006538533
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006538594   ⟸   XM_006538531
- Peptide Label: isoform X2
- UniProtKB: P54763 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001277682   ⟸   NM_001290753
- Peptide Label: isoform 1 precursor
- UniProtKB: P54763 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030109050   ⟸   XM_030253190
- Peptide Label: isoform X3
RefSeq Acc Id: XP_030109051   ⟸   XM_030253191
- Peptide Label: isoform X5
RefSeq Acc Id: ENSMUSP00000101471   ⟸   ENSMUST00000105845
RefSeq Acc Id: ENSMUSP00000101472   ⟸   ENSMUST00000105846
RefSeq Acc Id: ENSMUSP00000058135   ⟸   ENSMUST00000059287
RefSeq Acc Id: ENSMUSP00000116350   ⟸   ENSMUST00000156558
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM

Promoters
RGD ID:6835274
Promoter ID:MM_KWN:40231
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000022614
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364136,249,616 - 136,250,116 (-)MPROMDB
RGD ID:6835273
Promoter ID:MM_KWN:40232
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   MEF_B6
Transcripts:ENSMUST00000059287,   ENSMUST00000105846,   OTTMUST00000022611,   OTTMUST00000022615
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364136,392,126 - 136,392,626 (-)MPROMDB
RGD ID:6885130
Promoter ID:EPDNEW_M6016
Type:multiple initiation site
Name:Ephb2_1
Description:Mus musculus Eph receptor B2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384136,835,974 - 136,836,034EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99611 AgrOrtholog
Ensembl Genes ENSMUSG00000028664 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000058135 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000101471 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000101472 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000116350 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000059287 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000105845 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000105846 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000156558 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EphB2_rcpt_lig-bd UniProtKB/Swiss-Prot
  Ephrin_rcpt_lig-bd_dom UniProtKB/Swiss-Prot
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_ephrin_rcpt UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_V_CS UniProtKB/Swiss-Prot
KEGG Report mmu:13844 UniProtKB/Swiss-Prot
MGD MGI:99611 ENTREZGENE
NCBI Gene 13844 ENTREZGENE
Pfam EphA2_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/Swiss-Prot
  Ephrin_rec_like UniProtKB/Swiss-Prot
  fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot
  SAM_1 UniProtKB/Swiss-Prot
PhenoGen Ephb2 PhenoGen
PIRSF TyrPK_ephrin_receptor UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE EPH_LBD UniProtKB/Swiss-Prot
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_V_1 UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_V_2 UniProtKB/Swiss-Prot
  SAM_DOMAIN UniProtKB/Swiss-Prot
SMART EPH_lbd UniProtKB/Swiss-Prot
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt EPHB2_MOUSE UniProtKB/Swiss-Prot
  F6Q4H2_MOUSE UniProtKB/TrEMBL
  P54763 ENTREZGENE
UniProt Secondary A3KG00 UniProtKB/Swiss-Prot
  A3KG01 UniProtKB/Swiss-Prot
  A3KG02 UniProtKB/Swiss-Prot
  A3KG89 UniProtKB/Swiss-Prot
  A3KG90 UniProtKB/Swiss-Prot
  Q62213 UniProtKB/Swiss-Prot
  Q6GTQ7 UniProtKB/Swiss-Prot
  Q6P5F1 UniProtKB/Swiss-Prot
  Q9QVY4 UniProtKB/Swiss-Prot