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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ciprofibrate
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Accession:CHEBI:50867 term browser browse the term
Definition:A cyclopropane that has formula C13H14Cl2O3.
Synonyms:exact_synonym: 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
 related_synonym: Formula=C13H14Cl2O3;   InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17);   InChIKey=KPSRODZRAIWAKH-UHFFFAOYSA-N;   SMILES=CC(C)(Oc1ccc(cc1)C1CC1(Cl)Cl)C(O)=O;   ciprofibrato;   ciprofibratum
 xref: Beilstein:1984981;   CAS:52214-84-3;   Drug_Central:658;   KEGG:D03521;   LINCS:LSM-1600
 xref_mesh: MESH:C019304
 xref: Patent:DE2343606;   Patent:US3948973;   Reaxys:1984981;   Wikipedia:Ciprofibrate


show annotations for term's descendants           Sort by:
ciprofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases expression EXP ciprofibrate results in decreased expression of ABCB11 protein CTD PMID:12381268 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression EXP ciprofibrate results in increased expression of ABCB1A mRNA CTD PMID:12381268 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP ciprofibrate results in increased expression of ABCB1B mRNA CTD PMID:12381268 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 increases expression EXP ciprofibrate results in increased expression of ABCB4 mRNA; ciprofibrate results in increased expression of ABCB4 protein CTD PMID:12381268 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 multiple interactions
increases expression		 EXP [ciprofibrate binds to PPARA protein] which results in increased expression of ABCC3 mRNA
ciprofibrate results in increased expression of ABCC3 mRNA		 CTD PMID:15833929 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Acaa1a acetyl-Coenzyme A acyltransferase 1A increases expression EXP ciprofibrate results in increased expression of ACAA1A mRNA CTD PMID:12771043 NCBI chr 9:119,170,113...119,179,361
Ensembl chr 9:119,168,742...119,179,365 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression ISO ciprofibrate results in increased expression of ACAA2 mRNA CTD PMID:27225895 NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression EXP
ISO		 ciprofibrate results in increased expression of ACOT1 mRNA CTD PMID:27225895 NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP
ISO		 ciprofibrate results in increased expression of ACOT2 mRNA CTD PMID:27225895 NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647 		JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression EXP
ISO		 ciprofibrate results in increased expression of ACOT3 mRNA CTD PMID:27225895 NCBI chr12:84,098,918...84,107,174
Ensembl chr12:84,098,918...84,107,176 		JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression EXP
ISO		 ciprofibrate results in increased expression of ACOT4 mRNA CTD PMID:27225895 NCBI chr12:84,084,028...84,091,497
Ensembl chr12:84,085,153...84,095,375 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl increases activity
increases expression
multiple interactions		 ISO
EXP		 ciprofibrate results in increased activity of ACOX1 protein
ciprofibrate results in increased expression of ACOX1 mRNA
[ciprofibrate co-treated with Fatty Acids, Unsaturated deficiency] results in increased expression of ACOX1 mRNA		 CTD PMID:8001245 PMID:11172741 PMID:12771043 PMID:19544052 PMID:24986865 More... NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO ciprofibrate results in increased expression of ACSL1 mRNA CTD PMID:27225895 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 increases expression EXP ciprofibrate results in increased expression of ADAMTS1 mRNA CTD PMID:12771043 NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001 		JBrowse link
G Aig1 androgen-induced 1 increases expression EXP ciprofibrate results in increased expression of AIG1 mRNA CTD PMID:12771043 NCBI chr10:13,522,798...13,744,980
Ensembl chr10:13,522,798...13,744,724 		JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 multiple interactions
decreases activity		 ISO ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
ciprofibrate results in decreased activity of AKR1B10 protein; ciprofibrate results in decreased activity of AKR1B10 protein mutant form		 CTD PMID:18325492 PMID:19028477 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression EXP
ISO		 ciprofibrate results in increased expression of ALDH1A1 mRNA CTD PMID:17998271 PMID:27225895 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 increases expression EXP ciprofibrate results in increased expression of ALDH1A7 mRNA CTD PMID:17998271 NCBI chr19:20,670,318...20,704,920
Ensembl chr19:20,670,317...20,704,926 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase family 3, subfamily A2 increases expression EXP ciprofibrate results in increased expression of ALDH3A2 mRNA CTD PMID:17998271 NCBI chr11:61,114,240...61,158,267
Ensembl chr11:61,114,243...61,158,290 		JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 increases expression EXP ciprofibrate results in increased expression of ALDH9A1 mRNA CTD PMID:17998271 NCBI chr 1:167,177,560...167,196,100
Ensembl chr 1:167,177,560...167,196,101 		JBrowse link
G Anxa2 annexin A2 increases expression EXP ciprofibrate results in increased expression of ANXA2 mRNA CTD PMID:12771043 NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077 		JBrowse link
G Apcs amyloid P component, serum increases expression EXP ciprofibrate results in increased expression of APCS mRNA CTD PMID:12771043 NCBI chr 1:172,721,528...172,722,516
Ensembl chr 1:172,721,528...172,722,608 		JBrowse link
G Apoa1 apolipoprotein A-I decreases expression ISO ciprofibrate results in decreased expression of APOA1 mRNA CTD PMID:7983038 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Asgr1 asialoglycoprotein receptor 1 decreases expression ISO ciprofibrate results in decreased expression of ASGR1 protein CTD PMID:2404574 NCBI chr11:69,939,735...69,948,721
Ensembl chr11:69,944,911...69,948,720 		JBrowse link
G Baat bile acid-Coenzyme A: amino acid N-acyltransferase decreases expression EXP ciprofibrate results in decreased expression of BAAT mRNA CTD PMID:12771043 NCBI chr 4:49,489,416...49,507,915
Ensembl chr 4:49,489,422...49,506,557 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase, type 1 decreases activity
increases expression		 ISO ciprofibrate results in decreased activity of BDH1 protein
ciprofibrate results in increased expression of BDH1 mRNA		 CTD PMID:1777922 NCBI chr16:31,241,115...31,277,719
Ensembl chr16:31,241,098...31,277,719 		JBrowse link
G C4bp complement component 4 binding protein decreases expression EXP ciprofibrate results in decreased expression of C4BP mRNA CTD PMID:12771043 NCBI chr 1:130,562,510...130,589,365
Ensembl chr 1:130,562,510...130,589,369 		JBrowse link
G C9 complement component 9 decreases expression EXP ciprofibrate results in decreased expression of C9 mRNA CTD PMID:12771043 NCBI chr15:6,474,827...6,528,306
Ensembl chr15:6,474,808...6,528,232 		JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression		 ISO [Dexamethasone co-treated with ciprofibrate] results in increased expression of CAT protein
ciprofibrate results in increased activity of CAT protein
ciprofibrate results in increased expression of CAT protein		 CTD PMID:1740018 PMID:9736482 PMID:15965953 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP ciprofibrate results in increased expression of CBR1 mRNA CTD PMID:12771043 NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO ciprofibrate results in decreased expression of CCND2 mRNA; ciprofibrate results in decreased expression of CCND2 protein CTD PMID:12649303 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156 		JBrowse link
G Cd14 CD14 antigen increases expression ISO ciprofibrate results in increased expression of CD14 protein CTD PMID:12649303 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd36 CD36 molecule increases expression EXP ciprofibrate results in increased expression of CD36 mRNA CTD PMID:12771043 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd63 CD63 antigen increases expression EXP ciprofibrate results in increased expression of CD63 mRNA CTD PMID:12771043 NCBI chr10:128,731,577...128,748,691
Ensembl chr10:128,736,858...128,748,691 		JBrowse link
G Col4a2 collagen, type IV, alpha 2 increases expression EXP ciprofibrate results in increased expression of COL4A2 mRNA CTD PMID:12771043 NCBI chr 8:11,362,878...11,499,287
Ensembl chr 8:11,362,805...11,499,287 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle increases expression ISO
EXP		 ciprofibrate results in increased expression of CPT1B mRNA CTD PMID:27225895 NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression ISO
EXP		 ciprofibrate results in increased expression of CPT2 mRNA CTD PMID:27225895 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807 		JBrowse link
G Crat carnitine acetyltransferase increases expression EXP ciprofibrate results in increased expression of CRAT mRNA CTD PMID:12771043 NCBI chr 2:30,290,483...30,305,602
Ensembl chr 2:30,290,483...30,305,825 		JBrowse link
G Ctsb cathepsin B increases expression EXP ciprofibrate results in increased expression of CTSB mRNA CTD PMID:12771043 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Ctsl cathepsin L increases expression EXP ciprofibrate results in increased expression of CTSL mRNA CTD PMID:12771043 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression EXP ciprofibrate results in decreased expression of CXCL12 mRNA CTD PMID:12771043 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions		 ISO
EXP		 ciprofibrate results in decreased expression of CYP1A2 mRNA
ciprofibrate inhibits the reaction [Phenobarbital results in increased expression of CYP1A2 mRNA]		 CTD PMID:7676460 PMID:17962186 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression EXP ciprofibrate results in decreased expression of CYP26A1 mRNA CTD PMID:12771043 NCBI chr19:37,686,186...37,689,984
Ensembl chr19:37,686,246...37,689,984 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
decreases expression		 EXP ciprofibrate inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]]; ciprofibrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
ciprofibrate results in decreased expression of CYP2B10 mRNA		 CTD PMID:17962186 PMID:27225895 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 multiple interactions
increases expression		 ISO pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2B2 protein]
ciprofibrate results in increased expression of CYP2B2 mRNA		 CTD PMID:7587954 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases expression EXP ciprofibrate results in decreased expression of CYP2C29 mRNA CTD PMID:12771043 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 decreases expression EXP ciprofibrate results in decreased expression of CYP2C50 mRNA CTD PMID:12771043 NCBI chr19:40,078,123...40,102,399
Ensembl chr19:40,078,132...40,102,394 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression		 ISO [Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Thiazoles co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2E1 protein]
ciprofibrate results in increased expression of CYP2E1 mRNA		 CTD PMID:7587954 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions EXP ciprofibrate inhibits the reaction [Phenobarbital results in increased expression of CYP3A11 mRNA] CTD PMID:17962186 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774 		JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 increases expression EXP ciprofibrate results in increased expression of CYP4A10 mRNA CTD PMID:12771043 PMID:27225895 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846 		JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B increases expression
increases activity		 ISO ciprofibrate results in increased expression of CYP4A1 mRNA; ciprofibrate results in increased expression of CYP4A1 protein
ciprofibrate results in increased activity of CYP4A1 protein		 CTD PMID:2390105 PMID:7587954 PMID:7676460 PMID:19647067 PMID:27225895 NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231 		JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 increases expression EXP ciprofibrate results in increased expression of CYP4A14 mRNA CTD PMID:12771043 PMID:15919853 PMID:17627975 PMID:19144771 NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339 		JBrowse link
G Cyp4f14 cytochrome P450, family 4, subfamily f, polypeptide 14 decreases expression EXP ciprofibrate results in decreased expression of CYP4F14 mRNA CTD PMID:12771043 NCBI chr17:33,122,331...33,136,353
Ensembl chr17:33,124,044...33,136,316 		JBrowse link
G Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 decreases expression EXP ciprofibrate results in decreased expression of CYP7B1 mRNA CTD PMID:12771043 NCBI chr 3:18,126,108...18,298,054
Ensembl chr 3:18,126,114...18,297,502 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression ISO ciprofibrate results in decreased expression of DPP4 protein CTD PMID:2404574 NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575 		JBrowse link
G Ech1 enoyl coenzyme A hydratase 1, peroxisomal increases expression ISO ciprofibrate results in increased expression of ECH1 protein CTD PMID:1740018 NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO ciprofibrate results in decreased expression of EGFR protein CTD PMID:2404574 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase increases expression EXP
ISO		 ciprofibrate results in increased expression of EHHADH mRNA CTD PMID:2390105 PMID:12771043 PMID:27225895 NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557 		JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 decreases expression EXP ciprofibrate results in decreased expression of ELOVL3 mRNA CTD PMID:12771043 NCBI chr19:46,120,336...46,124,133
Ensembl chr19:46,120,336...46,124,133 		JBrowse link
G Ets2 E26 avian leukemia oncogene 2, 3' domain increases expression EXP ciprofibrate results in increased expression of ETS2 mRNA CTD PMID:12771043 NCBI chr16:95,503,274...95,522,093
Ensembl chr16:95,502,942...95,522,095 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver increases expression EXP
ISO		 ciprofibrate results in increased expression of FABP1 mRNA CTD PMID:27225895 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte increases expression EXP ciprofibrate results in increased expression of FABP4 mRNA CTD PMID:12771043 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression EXP ciprofibrate analog results in increased expression of FOS mRNA CTD PMID:8764118 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases activity
decreases expression		 ISO ciprofibrate results in decreased activity of GCLC protein
ciprofibrate results in decreased expression of GCLC mRNA		 CTD PMID:7676460 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gjb1 gap junction protein, beta 1 multiple interactions ISO [Diethylnitrosamine co-treated with ciprofibrate] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with ciprofibrate] results in decreased expression of GJB1 protein CTD PMID:1973356 NCBI chr  X:100,419,982...100,429,235
Ensembl chr  X:100,419,984...100,429,235 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity ISO ciprofibrate results in decreased activity of GPX1 protein CTD PMID:19544052 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) decreases expression ISO ciprofibrate results in decreased expression of GSTA2 mRNA CTD PMID:7676460 NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 increases expression EXP ciprofibrate results in increased expression of GSTK1 mRNA CTD PMID:18723825 NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases expression ISO ciprofibrate results in decreased expression of GSTM1 mRNA CTD PMID:7676460 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstt2 glutathione S-transferase, theta 2 increases expression EXP ciprofibrate results in increased expression of GSTT2 mRNA CTD PMID:18723825 NCBI chr10:75,667,676...75,673,253
Ensembl chr10:75,666,948...75,673,258 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression ISO ciprofibrate results in increased expression of HADHB mRNA CTD PMID:27225895 NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591 		JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP ciprofibrate results in increased expression of HDAC1 mRNA CTD PMID:12771043 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Hgf hepatocyte growth factor increases expression ISO ciprofibrate results in increased expression of HGF protein CTD PMID:1370768 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 increases expression EXP ciprofibrate results in increased expression of HMGCS2 mRNA CTD PMID:12381268 NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054 		JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 increases expression EXP ciprofibrate results in increased expression of HSD17B11 mRNA CTD PMID:12771043 NCBI chr 5:104,137,631...104,169,662
Ensembl chr 5:104,137,628...104,169,785 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO ciprofibrate results in increased expression of HSD17B4 mRNA CTD PMID:9209713 NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336 		JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 decreases expression EXP ciprofibrate results in decreased expression of HSD3B3 mRNA CTD PMID:12771043 NCBI chr 3:98,648,792...98,672,465
Ensembl chr 3:98,648,839...98,670,443 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP ciprofibrate results in increased expression of IGFBP1 mRNA CTD PMID:12771043 NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP ciprofibrate results in increased expression of IGFBP2 mRNA CTD PMID:12771043 NCBI chr 1:72,863,650...72,891,633
Ensembl chr 1:72,863,662...72,891,633 		JBrowse link
G Il12b interleukin 12b multiple interactions EXP ciprofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15968640 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP ciprofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:15968640 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein decreases expression EXP ciprofibrate results in decreased expression of IL1RAP mRNA CTD PMID:12771043 NCBI chr16:26,400,259...26,548,878
Ensembl chr16:26,400,454...26,548,867 		JBrowse link
G Impact impact, RWD domain protein increases expression EXP ciprofibrate results in increased expression of IMPACT mRNA CTD PMID:12771043 NCBI chr18:13,087,747...13,126,007
Ensembl chr18:13,088,909...13,126,007 		JBrowse link
G Ins2 insulin II multiple interactions ISO INS protein affects the reaction [ciprofibrate results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:10215695 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Itln1 intelectin 1 (galactofuranose binding) increases expression EXP ciprofibrate results in increased expression of ITLN1 mRNA CTD PMID:12771043 NCBI chr 1:171,345,691...171,362,893
Ensembl chr 1:171,345,690...171,362,862 		JBrowse link
G Jun jun proto-oncogene increases expression EXP ciprofibrate analog results in increased expression of JUN mRNA CTD PMID:8764118 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Junb jun B proto-oncogene multiple interactions
increases expression		 EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [ciprofibrate analog results in increased expression of JUNB mRNA] CTD PMID:8764118 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347 		JBrowse link
G Krt8 keratin 8 increases expression EXP ciprofibrate results in increased expression of KRT8 mRNA CTD PMID:12771043 NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917 		JBrowse link
G Lcn2 lipocalin 2 increases expression EXP ciprofibrate results in increased expression of LCN2 mRNA CTD PMID:12771043 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein increases expression EXP ciprofibrate results in increased expression of LGALS3BP mRNA CTD PMID:12771043 NCBI chr11:118,283,573...118,292,787
Ensembl chr11:118,283,577...118,292,918 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 increases expression EXP ciprofibrate results in increased expression of LPCAT3 mRNA CTD PMID:12771043 NCBI chr 6:124,639,887...124,681,142
Ensembl chr 6:124,639,990...124,681,381 		JBrowse link
G Lpl lipoprotein lipase increases expression
increases activity		 EXP
ISO		 ciprofibrate results in increased expression of LPL mRNA
ciprofibrate results in increased activity of LPL protein		 CTD PMID:8593127 PMID:12771043 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Ly6d lymphocyte antigen 6 family member D increases expression EXP ciprofibrate results in increased expression of LY6D mRNA CTD PMID:12771043 NCBI chr15:74,633,905...74,635,416
Ensembl chr15:74,633,905...74,635,469 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression EXP ciprofibrate results in increased expression of MGST1 mRNA CTD PMID:18723825 NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753 		JBrowse link
G Mup1 major urinary protein 1 decreases expression EXP ciprofibrate results in decreased expression of MUP1 mRNA CTD PMID:12771043 NCBI chr 4:60,454,011...60,457,959
Ensembl chr 4:60,454,011...60,457,959 		JBrowse link
G Myb myeloblastosis oncogene decreases expression ISO ciprofibrate results in decreased expression of MYB mRNA; ciprofibrate results in decreased expression of MYB protein CTD PMID:12649303 NCBI chr10:21,000,829...21,036,883
Ensembl chr10:21,000,834...21,036,883 		JBrowse link
G Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult decreases expression EXP ciprofibrate results in decreased expression of MYH1 mRNA CTD PMID:12771043 NCBI chr11:67,090,922...67,115,401
Ensembl chr11:67,090,878...67,115,401 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases activity EXP ciprofibrate results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 increases response to substance EXP NFKB1 results in increased susceptibility to ciprofibrate CTD PMID:16434500 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO ciprofibrate results in increased expression of NQO1 mRNA CTD PMID:7676460 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression EXP ciprofibrate results in decreased expression of NR1H3 mRNA CTD PMID:12771043 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
increases activity
increases expression
multiple interactions		 EXP
ISO		 ciprofibrate affects the localization of NR1I3 protein
ciprofibrate results in increased activity of NR1I3 protein
ciprofibrate results in increased expression of NR1I3 mRNA
ciprofibrate results in increased expression of NR1I3 mRNA; ciprofibrate results in increased expression of NR1I3 protein
ciprofibrate inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]]		 CTD PMID:17962186 PMID:20208394 PMID:25949234 PMID:30203046 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Oat ornithine aminotransferase decreases expression EXP ciprofibrate results in decreased expression of OAT mRNA CTD PMID:12771043 NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127 		JBrowse link
G Orm2 orosomucoid 2 decreases expression EXP ciprofibrate results in decreased expression of ORM2 mRNA CTD PMID:12771043 NCBI chr 4:63,280,543...63,284,114
Ensembl chr 4:63,280,686...63,284,115 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression EXP ciprofibrate results in decreased expression of PAH mRNA CTD PMID:12771043 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998 		JBrowse link
G Palmd palmdelphin increases expression EXP ciprofibrate results in increased expression of PALMD mRNA CTD PMID:12771043 NCBI chr 3:116,711,911...116,762,896
Ensembl chr 3:116,711,907...116,762,636 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 increases expression EXP
ISO		 ciprofibrate results in increased expression of PDK4 mRNA CTD PMID:12771043 PMID:27225895 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309 		JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha increases expression EXP ciprofibrate results in increased expression of PEX11A mRNA CTD PMID:12771043 NCBI chr 7:79,385,705...79,392,879
Ensembl chr 7:79,385,705...79,392,879 		JBrowse link
G Phlda1 pleckstrin homology like domain, family A, member 1 decreases expression EXP ciprofibrate results in decreased expression of PHLDA1 mRNA CTD PMID:12771043 NCBI chr10:111,342,147...111,344,510
Ensembl chr10:111,342,147...111,344,506 		JBrowse link
G Plin2 perilipin 2 increases expression EXP
ISO		 ciprofibrate results in increased expression of PLIN2 mRNA CTD PMID:12771043 PMID:23737761 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297 		JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression EXP ciprofibrate results in increased expression of PLSCR1 mRNA CTD PMID:12771043 NCBI chr 9:92,132,265...92,154,034
Ensembl chr 9:92,131,803...92,154,331 		JBrowse link
G Pon1 paraoxonase 1 decreases expression EXP ciprofibrate results in decreased expression of PON1 mRNA CTD PMID:22653878 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Pon2 paraoxonase 2 decreases expression EXP ciprofibrate results in decreased expression of PON2 mRNA CTD PMID:22653878 NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity
increases expression
affects response to substance		 ISO
EXP		 ciprofibrate binds to and results in increased activity of PPARA protein
ciprofibrate results in increased activity of PPARA protein
ciprofibrate results in increased expression of PPARA mRNA
PPARA protein affects the susceptibility to ciprofibrate
[ciprofibrate binds to PPARA protein] which results in increased expression of ABCC3 mRNA; ciprofibrate binds to and results in increased activity of PPARA protein		 CTD PMID:9688458 PMID:15833929 PMID:15853379 PMID:15919853 PMID:15968640 More... NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP ciprofibrate analog results in increased expression of PTGS2 mRNA; ciprofibrate analog results in increased expression of PTGS2 protein CTD PMID:9013627 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rbm3 RNA binding motif (RNP1, RRM) protein 3 increases expression EXP ciprofibrate results in increased expression of RBM3 mRNA CTD PMID:12771043 NCBI chr  X:8,005,214...8,012,119
Ensembl chr  X:8,005,214...8,012,119 		JBrowse link
G Retsat retinol saturase (all trans retinol 13,14 reductase) increases expression ISO
EXP		 ciprofibrate results in increased expression of RETSAT mRNA CTD PMID:27225895 NCBI chr 6:72,575,585...72,584,471
Ensembl chr 6:72,575,458...72,585,408 		JBrowse link
G Rpl12 ribosomal protein L12 increases expression EXP ciprofibrate results in increased expression of RPL12 mRNA CTD PMID:12771043 NCBI chr 2:32,851,724...32,854,057
Ensembl chr 2:32,851,571...32,855,357 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 multiple interactions ISO ciprofibrate promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of SCD1 mRNA]; ciprofibrate results in increased expression of and results in increased degradation of SCD1 mRNA; Dactinomycin inhibits the reaction [ciprofibrate results in increased expression of SCD1 mRNA] CTD PMID:11172741 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303 		JBrowse link
G Selenbp2 selenium binding protein 2 decreases expression EXP ciprofibrate results in decreased expression of SELENBP2 mRNA CTD PMID:12771043 NCBI chr 3:94,600,880...94,611,713
Ensembl chr 3:94,600,863...94,611,720 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression EXP ciprofibrate results in decreased expression of SLC10A1 protein CTD PMID:12381268 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 increases expression EXP ciprofibrate results in increased expression of SLC16A1 mRNA CTD PMID:12771043 NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778 		JBrowse link
G Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 increases expression ISO ciprofibrate results in increased expression of SLC25A20 mRNA CTD PMID:27225895 NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840 		JBrowse link
G Slc25a34 solute carrier family 25, member 34 increases expression EXP
ISO		 ciprofibrate results in increased expression of SLC25A34 mRNA CTD PMID:27225895 NCBI chr 4:141,346,130...141,351,202
Ensembl chr 4:141,346,135...141,351,132 		JBrowse link
G Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 decreases expression EXP ciprofibrate results in decreased expression of SLC37A4 mRNA CTD PMID:12771043 NCBI chr 9:44,308,243...44,314,263
Ensembl chr 9:44,308,149...44,314,265 		JBrowse link
G Slc4a4 solute carrier family 4 (anion exchanger), member 4 increases expression EXP ciprofibrate results in increased expression of SLC4A4 mRNA CTD PMID:12771043 NCBI chr 5:88,941,717...89,387,515
Ensembl chr 5:89,034,345...89,387,512 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases expression EXP ciprofibrate results in decreased expression of SLCO1A1 mRNA; ciprofibrate results in decreased expression of SLCO1A1 protein CTD PMID:12381268 PMID:15919853 NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 decreases expression EXP ciprofibrate results in decreased expression of SLCO1B2 mRNA CTD PMID:15919853 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression EXP ciprofibrate results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 NCBI chr 9:102,885,686...102,973,201
Ensembl chr 9:102,865,911...102,973,201 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression EXP ciprofibrate results in decreased expression of SLCO2B1 mRNA CTD PMID:15919853 NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547 		JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression
increases activity		 ISO ciprofibrate results in increased expression of SOD1 mRNA
ciprofibrate results in increased activity of SOD1 protein		 CTD PMID:7676460 PMID:19544052 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases activity ISO ciprofibrate results in decreased activity of SOD2 protein CTD PMID:19544052 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sqstm1 sequestosome 1 increases expression EXP ciprofibrate results in increased expression of SQSTM1 mRNA CTD PMID:12771043 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity EXP ciprofibrate results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550 		JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 multiple interactions
increases expression		 ISO ciprofibrate results in increased expression of and results in increased activity of SULT2A1 protein
ciprofibrate results in increased expression of SULT2A1 mRNA		 CTD PMID:15635043 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334 		JBrowse link
G Tagln2 transgelin 2 increases expression EXP ciprofibrate results in increased expression of TAGLN2 mRNA CTD PMID:12771043 NCBI chr 1:172,327,813...172,334,942
Ensembl chr 1:172,327,614...172,334,947 		JBrowse link
G Tm4sf4 transmembrane 4 superfamily member 4 increases expression EXP ciprofibrate results in increased expression of TM4SF4 mRNA CTD PMID:12771043 NCBI chr 3:57,332,831...57,349,098
Ensembl chr 3:57,332,735...57,349,098 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP ciprofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:15968640 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 decreases expression EXP ciprofibrate results in decreased expression of TRPV2 mRNA CTD PMID:12771043 NCBI chr11:62,465,312...62,491,131
Ensembl chr11:62,465,312...62,491,341 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression EXP ciprofibrate results in increased expression of UGT1A1 mRNA CTD PMID:19144771 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases expression EXP ciprofibrate results in increased expression of UGT1A6 mRNA CTD PMID:19144771 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases expression EXP ciprofibrate results in increased expression of UGT1A9 mRNA CTD PMID:19144771 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation ISO UGT2B1 protein results in increased glucuronidation of ciprofibrate CTD PMID:8302279 NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389 		JBrowse link
G Ugt2b36 UDP glucuronosyltransferase 2 family, polypeptide B36 increases expression EXP ciprofibrate results in increased expression of UGT2B36 mRNA CTD PMID:19144771 NCBI chr 5:87,213,786...87,240,414
Ensembl chr 5:87,213,786...87,240,414 		JBrowse link
G Vnn3 vanin 3 increases expression EXP ciprofibrate results in increased expression of VNN3 mRNA CTD PMID:12771043 NCBI chr10:23,727,360...23,745,741
Ensembl chr10:23,727,360...23,745,741 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      application 21764
        pharmaceutical 21179
          drug 21179
            antilipemic drug 9556
              ciprofibrate 145
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21921
                        carbon atom 21847
                          organic molecular entity 21847
                            heteroorganic entity 21503
                              organochalcogen compound 20992
                                organooxygen compound 20834
                                  carbon oxoacid 19625
                                    carboxylic acid 19621
                                      monocarboxylic acid 18999
                                        ciprofibrate 145
paths to the root