Gene: Slco2a1 (solute carrier organic anion transporter family, member 2a1) Mus musculus
Analyze
Symbol:
Slco2a1
Name:
solute carrier organic anion transporter family, member 2a1
Description:
ENCODES a protein that exhibits prostaglandin transmembrane transporter activity; INVOLVED IN prostaglandin transport; ASSOCIATED WITH abnormal cell physiology; abnormal prostaglandin level; abnormal urine homeostasis; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Drug-Related Side Effects and Adverse Reactions (ortholog); primary hypertrophic osteoarthropathy (ortholog); FOUND IN integral component of membrane (inferred); integral component of plasma membrane (inferred); membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; aflatoxin B1
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
2310021C19Rik; mPgt; Pgt; prostaglandin transporter; Slc21a2; solute carrier family 21 (prostaglandin transporter), member 2; solute carrier family 21 member 2; solute carrier organic anion transporter family member 2A1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SLCO2A1 (solute carrier organic anion transporter family member 2A1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Slco2a1 (solute carrier organic anion transporter family, member 2a1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Slco2a1 (solute carrier organic anion transporter family member 2A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SLCO2A1 (solute carrier organic anion transporter family member 2A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SLCO2A1 (solute carrier organic anion transporter family member 2A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Slco2a1 (solute carrier organic anion transporter family member 2A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SLCO2A1 (solute carrier organic anion transporter family member 2A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Slco2a1 (solute carrier organic anion transporter family, member 2a1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
SLCO2A1 (solute carrier organic anion transporter family member 2A1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
slco2a1 (solute carrier organic anion transporter family, member 2A1)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, PhylomeDB, ZFIN)
Caenorhabditis elegans (roundworm):
F21G4.1
Alliance
DIOPT (OrthoFinder, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
Oatp33Ea
Alliance
DIOPT (OMA, OrthoFinder, PhylomeDB)
Caenorhabditis elegans (roundworm):
F47E1.2
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
F47E1.4
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
Y32F6B.1
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, PANTHER, PhylomeDB)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 103,007,061 - 103,096,002 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 102,910,819 - 102,990,179 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 102,866,770 - 102,944,916 (+) NCBI mm8 Celera 9 102,558,775 - 102,638,236 (+) NCBI Celera Cytogenetic Map 9 F1 NCBI cM Map 9 54.72 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Primary Hypertrophic Osteoarthropathy, Autosomal Recessive, 2 ISO RGD:736966 8554872 ClinVar Annotator: match by term: Primary hypertrophic osteoarthropathy, autosomal recessive 2 ClinVar PMID:22197487 , PMID:22553128 Primary Hypertrophic Osteoarthropathy, Autosomal Recessive, 2 ISO RGD:736966 8554872 ClinVar Annotator: match by OMIM:614441 ClinVar PMID:22331663 Primary Hypertrophic Osteoarthropathy, Autosomal Recessive, 2 ISO RGD:736966 8554872 ClinVar Annotator: match by OMIM:614441 ClinVar PMID:22197487 Primary Hypertrophic Osteoarthropathy, Autosomal Recessive, 2 ISO RGD:736966 8554872 ClinVar Annotator: match by term: Primary hypertrophic osteoarthropathy, autosomal recessive 2 ClinVar PMID:22906430 more ... Primary Hypertrophic Osteoarthropathy, Autosomal Recessive, 2 ISO RGD:736966 8554872 ClinVar Annotator: match by term: Primary hypertrophic osteoarthropathy, autosomal recessive 2 ClinVar PMID:22197487 more ... Primary Hypertrophic Osteoarthropathy, Autosomal Recessive, 2 ISO RGD:736966 8554872 ClinVar Annotator: match by term: Primary hypertrophic osteoarthropathy, autosomal recessive 2 ClinVar PMID:24153155 , PMID:25741868 Primary Hypertrophic Osteoarthropathy, Autosomal Recessive, 2 ISO RGD:736966 8554872 ClinVar Annotator: match by OMIM:614441 ClinVar PMID:22553128 Primary Hypertrophic Osteoarthropathy, Autosomal Recessive, 2 ISO RGD:736966 8554872 ClinVar Annotator: match by OMIM:614441 ClinVar PMID:16283874 , PMID:22553128
Imported Annotations - CTD
Colorectal Neoplasms ISO RGD:736966 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30510241 Drug-Related Side Effects and Adverse Reactions ISO RGD:736966 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15805072 primary hypertrophic osteoarthropathy ISO RGD:736966 11554173 CTD Direct Evidence: marker/mechanism CTD
Imported Annotations - OMIM
Primary Hypertrophic Osteoarthropathy, Autosomal Recessive, 2 ISO RGD:736966 7240710 OMIM
(+)-schisandrin B multiple interactions ISO RGD:3051 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SLCO2A1 mRNA] CTD PMID:31150632 (S)-nicotine increases expression ISO RGD:736966 6480464 Nicotine results in increased expression of SLCO2A1 mRNA CTD PMID:23825647 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO RGD:736966 6480464 o, p'-DDT results in increased expression of SLCO2A1 mRNA CTD PMID:19371625 17beta-estradiol multiple interactions ISO RGD:736966 6480464 [Estradiol binds to ESR2 protein] which results in increased expression of SLCO2A1 mRNA more ... CTD PMID:20404318 more ... 17beta-estradiol increases expression ISO RGD:736966 6480464 Estradiol results in increased expression of SLCO2A1 mRNA CTD PMID:23019147 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736966 6480464 Tetrachlorodibenzodioxin results in increased expression of SLCO2A1 mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:3051 6480464 Tetrachlorodibenzodioxin results in decreased expression of SLCO2A1 mRNA CTD PMID:20959002 , PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SLCO2A1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SLCO2A1 mRNA CTD PMID:19770486 2,4-dinitrotoluene affects expression ISO RGD:3051 6480464 2, 4-dinitrotoluene affects the expression of SLCO2A1 mRNA CTD PMID:21346803 2-methoxyethanol increases expression ISO RGD:3051 6480464 methyl cellosolve results in increased expression of SLCO2A1 mRNA CTD PMID:21061450 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:3051 6480464 3 more ... CTD PMID:20959002 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of SLCO2A1 mRNA CTD PMID:28973697 5-fluorouracil affects expression ISO RGD:736966 6480464 Fluorouracil affects the expression of SLCO2A1 mRNA CTD PMID:16584549 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of SLCO2A1 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:736966 6480464 Aflatoxin B1 results in decreased methylation of SLCO2A1 intron CTD PMID:30157460 aflatoxin B1 increases methylation ISO RGD:736966 6480464 Aflatoxin B1 results in increased methylation of SLCO2A1 gene CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:736966 6480464 Tretinoin results in increased expression of SLCO2A1 mRNA CTD PMID:21934132 antirheumatic drug decreases expression ISO RGD:736966 6480464 Antirheumatic Agents results in decreased expression of SLCO2A1 mRNA CTD PMID:24449571 arsane decreases expression EXP 6480464 Arsenic results in decreased expression of SLCO2A1 mRNA CTD PMID:19654921 arsenic atom decreases expression EXP 6480464 Arsenic results in decreased expression of SLCO2A1 mRNA CTD PMID:19654921 arsenic(3+) decreases expression EXP 6480464 Arsenic results in decreased expression of SLCO2A1 mRNA CTD PMID:19654921 benzo[a]pyrene increases expression ISO RGD:736966 6480464 Benzo(a)pyrene results in increased expression of SLCO2A1 mRNA CTD PMID:20106945 benzo[a]pyrene affects methylation ISO RGD:736966 6480464 Benzo(a)pyrene affects the methylation of SLCO2A1 intron CTD PMID:30157460 benzo[a]pyrene affects expression EXP 6480464 Benzo(a)pyrene affects the expression of SLCO2A1 mRNA CTD PMID:22342234 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of SLCO2A1 mRNA CTD PMID:22228805 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of SLCO2A1 mRNA CTD PMID:19770486 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 bis(2-ethylhexyl) phthalate increases expression ISO RGD:736966 6480464 Diethylhexyl Phthalate results in increased expression of SLCO2A1 mRNA CTD PMID:31163220 bisphenol A increases expression ISO RGD:736966 6480464 bisphenol A results in increased expression of SLCO2A1 mRNA CTD PMID:19371625 , PMID:23019147 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SLCO2A1 promoter CTD PMID:27312807 bisphenol A affects expression ISO RGD:3051 6480464 bisphenol A affects the expression of SLCO2A1 mRNA CTD PMID:25181051 C60 fullerene increases expression ISO RGD:3051 6480464 fullerene C60 results in increased expression of SLCO2A1 mRNA CTD PMID:19167457 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of SLCO2A1 mRNA CTD PMID:23125180 chromium(6+) affects expression EXP 6480464 chromium hexavalent ion affects the expression of SLCO2A1 mRNA CTD PMID:28472532 ciprofibrate decreases expression EXP 6480464 ciprofibrate results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 cyclosporin A decreases expression ISO RGD:736966 6480464 Cyclosporine results in decreased expression of SLCO2A1 mRNA CTD PMID:24907557 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 diazinon increases methylation ISO RGD:736966 6480464 Diazinon results in increased methylation of SLCO2A1 gene CTD PMID:22964155 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SLCO2A1 mRNA CTD PMID:21266533 dichloroacetic acid decreases expression EXP 6480464 Dichloroacetic Acid results in decreased expression of SLCO2A1 mRNA CTD PMID:28962523 diclofenac multiple interactions ISO RGD:736966 6480464 Diclofenac inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 diethyl maleate decreases expression ISO RGD:3051 6480464 diethyl maleate results in decreased expression of SLCO2A1 mRNA CTD PMID:21161181 endosulfan decreases expression ISO RGD:3051 6480464 Endosulfan results in decreased expression of SLCO2A1 mRNA CTD PMID:29391264 flutamide decreases expression ISO RGD:3051 6480464 Flutamide results in decreased expression of SLCO2A1 mRNA CTD PMID:24136188 furan decreases expression ISO RGD:3051 6480464 furan results in decreased expression of SLCO2A1 mRNA CTD PMID:25539665 genistein increases expression ISO RGD:736966 6480464 Genistein results in increased expression of SLCO2A1 mRNA CTD PMID:19371625 , PMID:23019147 indometacin multiple interactions ISO RGD:736966 6480464 Indomethacin promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 ketoprofen multiple interactions ISO RGD:736966 6480464 Ketoprofen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 lead diacetate increases expression ISO RGD:3051 6480464 lead acetate results in increased expression of SLCO2A1 mRNA CTD PMID:22641619 lumiracoxib multiple interactions ISO RGD:736966 6480464 lumiracoxib inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 methotrexate decreases expression ISO RGD:736966 6480464 Methotrexate results in decreased expression of SLCO2A1 mRNA CTD PMID:17400583 mifepristone multiple interactions ISO RGD:736966 6480464 Mifepristone promotes the reaction [Progesterone affects the expression of SLCO2A1 mRNA] CTD PMID:22414680 N-ethyl-N-nitrosourea increases mutagenesis EXP 6480464 Ethylnitrosourea results in increased mutagenesis of SLCO2A1 mRNA CTD PMID:27776689 N-nitrosodiethylamine increases expression ISO RGD:3051 6480464 Diethylnitrosamine results in increased expression of SLCO2A1 mRNA CTD PMID:20360939 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of SLCO2A1 mRNA CTD PMID:24535843 naproxen multiple interactions ISO RGD:736966 6480464 Naproxen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 nefazodone decreases expression ISO RGD:3051 6480464 nefazodone results in decreased expression of SLCO2A1 mRNA CTD PMID:24136188 nicotine increases expression ISO RGD:736966 6480464 Nicotine results in increased expression of SLCO2A1 mRNA CTD PMID:23825647 nimesulide decreases expression ISO RGD:3051 6480464 nimesulide results in decreased expression of SLCO2A1 mRNA CTD PMID:24136188 ozone decreases expression ISO RGD:3051 6480464 Ozone results in decreased expression of SLCO2A1 mRNA CTD PMID:16716893 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of SLCO2A1 mRNA CTD PMID:17562736 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of SLCO2A1 mRNA CTD PMID:19482888 phenobarbital increases expression ISO RGD:736966 6480464 Phenobarbital results in increased expression of SLCO2A1 mRNA CTD PMID:19084549 phenobarbital multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of SLCO2A1 mRNA, NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SLCO2A1 mRNA] CTD PMID:19482888 , PMID:24535843 pirinixic acid increases expression ISO RGD:3051 6480464 pirinixic acid results in increased expression of SLCO2A1 mRNA CTD PMID:19162173 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of SLCO2A1 mRNA CTD PMID:17426115 , PMID:23811191 pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 progesterone multiple interactions ISO RGD:736966 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of SLCO2A1 mRNA, Mifepristone promotes the reaction [Progesterone affects the expression of SLCO2A1 mRNA] CTD PMID:20660070 , PMID:22414680 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of SLCO2A1 mRNA CTD PMID:22238285 prostaglandin E2 multiple interactions ISO RGD:736966 6480464 Diclofenac inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] more ... CTD PMID:19843975 prostaglandin E2 increases transport ISO RGD:736966 6480464 SLCO2A1 protein results in increased transport of Dinoprostone CTD PMID:19843975 quercetin increases uptake ISO RGD:736966 6480464 SLCO2A1 protein results in increased uptake of Quercetin CTD PMID:24947867 resveratrol increases expression ISO RGD:736966 6480464 resveratrol results in increased expression of SLCO2A1 mRNA CTD PMID:19371625 rifampicin multiple interactions ISO RGD:736966 6480464 Rifampin inhibits the reaction [decitabine results in increased expression of SLCO2A1 mRNA] CTD PMID:23137910 sodium arsenite increases expression ISO RGD:736966 6480464 sodium arsenite results in increased expression of SLCO2A1 mRNA CTD PMID:29301061 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of SLCO2A1 mRNA CTD PMID:27862939 spironolactone decreases expression EXP 6480464 Spironolactone results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of SLCO2A1 mRNA CTD PMID:25123088 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of SLCO2A1 mRNA CTD PMID:17484886 tetrachloromethane multiple interactions EXP 6480464 [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SLCO2A1 mRNA CTD PMID:29987408 tetrachloromethane decreases expression ISO RGD:3051 6480464 Carbon Tetrachloride results in decreased expression of SLCO2A1 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:3051 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SLCO2A1 mRNA] CTD PMID:31150632 thioacetamide decreases expression ISO RGD:3051 6480464 Thioacetamide results in decreased expression of SLCO2A1 mRNA CTD PMID:23411599 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of SLCO2A1 mRNA CTD PMID:25549359 triclosan decreases expression ISO RGD:736966 6480464 Triclosan results in decreased expression of SLCO2A1 mRNA CTD PMID:30510588 tunicamycin increases expression ISO RGD:736966 6480464 Tunicamycin results in increased expression of SLCO2A1 mRNA CTD PMID:29453283 valdecoxib decreases expression ISO RGD:3051 6480464 valdecoxib results in decreased expression of SLCO2A1 mRNA CTD PMID:24136188 vinclozolin affects expression ISO RGD:3051 6480464 vinclozolin affects the expression of SLCO2A1 mRNA CTD PMID:19015723 zidovudine decreases expression ISO RGD:736966 6480464 Zidovudine results in decreased expression of SLCO2A1 mRNA CTD PMID:24292225 zoledronic acid increases expression ISO RGD:736966 6480464 zoledronic acid results in increased expression of SLCO2A1 mRNA CTD PMID:24714768
Gene-Chemical Interaction Annotations
