Plscr1 (phospholipid scramblase 1) - Rat Genome Database
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Gene: Plscr1 (phospholipid scramblase 1) Mus musculus
Analyze
Symbol: Plscr1
Name: phospholipid scramblase 1
RGD ID: 731879
MGI Page MGI
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including phosphatidylserine biosynthetic process; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Localizes to cytosol; nucleus; and plasma membrane. Is expressed in hindgut; midgut; renal calyx; and renal pelvis. Orthologous to human PLSCR1 (phospholipid scramblase 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ca(2+)-dependent phospholipid scramblase 1; mg(2+)-dependent nuclease; MmTR; MmTRA; MmTRA1a; MmTRA1b; MuPL; N; Nor1; PL scramblase 1; TR; Tra1; Tra1a; Tra1b; transplantability-associated protein 1; Tras1; Tras2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm5530  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39992,132,243 - 92,154,614 (+)NCBIGRCm39mm39
GRCm38992,250,194 - 92,272,561 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl992,249,750 - 92,272,278 (+)EnsemblGRCm38mm10GRCm38
MGSCv37992,145,032 - 92,167,399 (+)NCBIGRCm37mm9NCBIm37
MGSCv36992,063,114 - 92,075,746 (+)NCBImm8
Celera991,837,716 - 91,860,050 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
andrographolide  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoates  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (EXP)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (EXP)
furan  (ISO)
indole-3-methanol  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP)
mercury dibromide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naphthalenes  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxycodone  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenacetin  (ISO)
phenobarbital  (EXP,ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rottlerin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium dichromate  (ISO)
streptozocin  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
undecane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. MGD data from the GO Consortium
2. MGD IEA
3. RGD automated import pipeline
4. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9108418   PMID:9485382   PMID:9712717   PMID:10349636   PMID:10930526   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11259432   PMID:12010804   PMID:12031645   PMID:12466851  
PMID:12477932   PMID:12509439   PMID:14610273   PMID:15308695   PMID:15328404   PMID:15863367   PMID:16091359   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16611984   PMID:17355638  
PMID:17590392   PMID:18799693   PMID:21247419   PMID:21267068   PMID:21447647   PMID:21873635   PMID:22264514   PMID:22453241   PMID:22598484   PMID:23426682   PMID:26216936   PMID:27626380  
PMID:28111081   PMID:28282470   PMID:29467473   PMID:32110987  


Genomics

Comparative Map Data
Plscr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39992,132,243 - 92,154,614 (+)NCBIGRCm39mm39
GRCm38992,250,194 - 92,272,561 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl992,249,750 - 92,272,278 (+)EnsemblGRCm38mm10GRCm38
MGSCv37992,145,032 - 92,167,399 (+)NCBIGRCm37mm9NCBIm37
MGSCv36992,063,114 - 92,075,746 (+)NCBImm8
Celera991,837,716 - 91,860,050 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
PLSCR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3146,515,180 - 146,544,856 (-)EnsemblGRCh38hg38GRCh38
GRCh383146,515,178 - 146,544,805 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373146,232,967 - 146,262,628 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363147,715,658 - 147,745,186 (-)NCBINCBI36hg18NCBI36
Build 343147,715,665 - 147,745,194NCBI
Celera3144,649,990 - 144,679,651 (-)NCBI
Cytogenetic Map3q24NCBI
HuRef3143,609,792 - 143,639,453 (-)NCBIHuRef
CHM1_13146,196,031 - 146,225,691 (-)NCBICHM1_1
Plscr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0899,625,523 - 99,645,882 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl899,625,545 - 99,725,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0899,108,895 - 99,129,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4897,206,388 - 97,226,725 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1897,225,842 - 97,246,179 (+)NCBI
Celera892,307,776 - 92,328,258 (+)NCBICelera
Cytogenetic Map8q31NCBI
Plscr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495547410,953,381 - 10,989,100 (+)NCBIChiLan1.0ChiLan1.0
PLSCR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13151,111,622 - 151,141,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3151,112,483 - 151,132,964 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03143,528,967 - 143,558,468 (-)NCBIMhudiblu_PPA_v0panPan3
PLSCR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2341,599,843 - 41,669,112 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12341,639,938 - 41,668,972 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Plscr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365198,759,702 - 8,790,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLSCR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1386,649,586 - 86,869,297 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11386,836,288 - 86,869,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLSCR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11544,160,017 - 44,189,056 (+)NCBI
ChlSab1.1 Ensembl1544,160,200 - 44,188,195 (+)Ensembl


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95911710593117252Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95911710593117252Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95946266493462846Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95946266493462846Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95946266493462846Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96224248596242599Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96513390995640755Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:86
Interacting mature miRNAs:95
Transcripts:ENSMUST00000093801
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000093801   ⟹   ENSMUSP00000091318
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl992,249,750 - 92,272,278 (+)Ensembl
RefSeq Acc Id: ENSMUST00000186364   ⟹   ENSMUSP00000139479
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl992,250,342 - 92,271,975 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187952
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl992,266,295 - 92,271,977 (+)Ensembl
RefSeq Acc Id: NM_011636   ⟹   NP_035766
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39992,132,247 - 92,154,614 (+)NCBI
GRCm38992,250,194 - 92,272,561 (+)NCBI
MGSCv37992,145,032 - 92,167,399 (+)RGD
Celera991,837,716 - 91,860,050 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511052   ⟹   XP_006511115
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39992,132,243 - 92,154,034 (+)NCBI
GRCm38992,250,335 - 92,271,981 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035766   ⟸   NM_011636
- UniProtKB: Q9JJ00 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511115   ⟸   XM_006511052
- Peptide Label: isoform X1
- UniProtKB: Q9JJ00 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000139479   ⟸   ENSMUST00000186364
RefSeq Acc Id: ENSMUSP00000091318   ⟸   ENSMUST00000093801

Promoters
RGD ID:6844961
Promoter ID:MM_KWN:58367
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000093801,   NM_011636
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36992,144,934 - 92,145,434 (+)MPROMDB
RGD ID:8670438
Promoter ID:EPDNEW_M13250
Type:initiation region
Name:Plscr1_1
Description:Mus musculus phospholipid scramblase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38992,250,212 - 92,250,272EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:893575 AgrOrtholog
Ensembl Genes ENSMUSG00000032369 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000091318 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139479 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000093801 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000186364 UniProtKB/Swiss-Prot
InterPro Scramblase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22038 UniProtKB/Swiss-Prot
MGD MGI:893575 ENTREZGENE
NCBI Gene 22038 ENTREZGENE
PANTHER PTHR23248 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Scramblase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plscr1 PhenoGen
UniProt PLS1_MOUSE UniProtKB/Swiss-Prot
  Q3UDV5_MOUSE UniProtKB/TrEMBL
  Q4FK16_MOUSE UniProtKB/TrEMBL
  Q99M50_MOUSE UniProtKB/TrEMBL
  Q9JJ00 ENTREZGENE
UniProt Secondary O54730 UniProtKB/Swiss-Prot
  O54731 UniProtKB/Swiss-Prot
  Q9D1F8 UniProtKB/Swiss-Prot