PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: T cell receptor signaling pathway
Accession: PW:0000821
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Definition: T cell receptor (TCR) signaling in developing thymocytes is important for the establishment of CD4 and CD8 lineages. Mature T cells express either CD4 or CD8 co-receptors which are essential for the interaction with peptide-bound class II or class I MHC complexes to elicit CD4 T helper (Th) or CD8 cytotoxic T lymphocyte responses, respectively. In either case, T cell-initiated signaling activates the expression of genes whose products mediate these responses.
Synonyms: related_synonym: TCR signaling; TCR signaling pathway
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Akt1
thymoma viral proto-oncogene 1
IEA
KEGG
mmu:04660
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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Akt2
thymoma viral proto-oncogene 2
IEA
KEGG
mmu:04660
NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
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Akt3
thymoma viral proto-oncogene 3
IEA
KEGG
mmu:04660
NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769
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Bcl10
B cell leukemia/lymphoma 10
IEA
KEGG
mmu:04660
NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111
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Card11
caspase recruitment domain family, member 11
IEA
KEGG
mmu:04660
NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337
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Cbl
Casitas B-lineage lymphoma
IEA
KEGG
mmu:04660
NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346
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Cblb
Casitas B-lineage lymphoma b
IEA
KEGG
mmu:04660
NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411
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Cblc
Casitas B-lineage lymphoma c
IEA
KEGG
mmu:04660
NCBI chr 7:19,513,643...19,530,734
Ensembl chr 7:19,512,806...19,530,734
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Cd247
CD247 antigen
IEA
KEGG
mmu:04660
NCBI chr 1:165,607,514...165,698,722
Ensembl chr 1:165,616,250...165,704,846
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Cd28
CD28 antigen
IEA
KEGG
mmu:04660
NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518
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Cd3d
CD3 antigen, delta polypeptide
IEA
KEGG
mmu:04660
NCBI chr 9:44,893,067...44,898,350
Ensembl chr 9:44,893,084...44,898,637
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Cd3e
CD3 antigen, epsilon polypeptide
IEA
KEGG
mmu:04660
NCBI chr 9:44,910,033...44,920,961
Ensembl chr 9:44,910,038...44,920,925
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Cd3g
CD3 antigen, gamma polypeptide
IEA
KEGG
mmu:04660
NCBI chr 9:44,880,870...44,891,729
Ensembl chr 9:44,880,870...44,891,729
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Cd4
CD4 antigen
IEA
KEGG
mmu:04660
NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184
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Cd40lg
CD40 ligand
IEA
KEGG
mmu:04660
NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402
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Cd8a
CD8 subunit alpha
IEA
KEGG
mmu:04660
NCBI chr 6:71,350,411...71,356,155
Ensembl chr 6:71,350,411...71,356,157
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Cd8b1
CD8 subunit beta 1
IEA
KEGG
mmu:04660
NCBI chr 6:71,299,772...71,314,476
Ensembl chr 6:71,299,772...71,314,478
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Cdc42
cell division cycle 42
IEA
KEGG
mmu:04660
NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031
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Cdk4
cyclin dependent kinase 4
IEA
KEGG
mmu:04660
NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
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Chp1
calcineurin-like EF hand protein 1
IEA
KEGG
mmu:04660
NCBI chr 2:119,378,172...119,417,505
Ensembl chr 2:119,378,178...119,417,508
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Chp2
calcineurin-like EF hand protein 2
IEA
KEGG
mmu:04660
NCBI chr 7:121,807,839...121,823,094
Ensembl chr 7:121,818,719...121,822,047
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Chuk
conserved helix-loop-helix ubiquitous kinase
IEA
KEGG
mmu:04660
NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
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Csf2
colony stimulating factor 2 (granulocyte-macrophage)
IEA
KEGG
mmu:04660
NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
IEA
KEGG
mmu:04660
NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
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Dlg1
discs large MAGUK scaffold protein 1
IEA
KEGG
mmu:04660
NCBI chr16:31,482,261...31,692,174
Ensembl chr16:31,482,261...31,693,947
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Fos
FBJ osteosarcoma oncogene
IEA
KEGG
mmu:04660
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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Fyn
Fyn proto-oncogene
IEA
KEGG
mmu:04660
NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377
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Gm12844
predicted gene 12844
IEA
KEGG
mmu:04660
NCBI chr 4:117,585,320...117,586,796
Ensembl chr 4:117,585,915...117,586,496
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Grap2
GRB2-related adaptor protein 2
IEA
KEGG
mmu:04660
NCBI chr15:80,456,798...80,537,055
Ensembl chr15:80,456,795...80,537,055
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Grb2
growth factor receptor bound protein 2
IEA
KEGG
mmu:04660
NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423
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Gsk3b
glycogen synthase kinase 3 beta
IEA
KEGG
mmu:04660
NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
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Hras
Harvey rat sarcoma virus oncogene
IEA
KEGG
mmu:04660
NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
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Icos
inducible T cell co-stimulator
IEA
KEGG
mmu:04660
NCBI chr 1:60,999,909...61,039,481
Ensembl chr 1:61,017,086...61,039,479
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Ifng
interferon gamma
IEA
KEGG
mmu:04660
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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Ikbkb
inhibitor of kappaB kinase beta
IEA
KEGG
mmu:04660
NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
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Ikbkg
inhibitor of kappaB kinase gamma
IEA
KEGG
mmu:04660
NCBI chr X:73,436,883...73,498,013
Ensembl chr X:73,436,896...73,497,460
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Il10
interleukin 10
IEA
KEGG
mmu:04660
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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Il2
interleukin 2
IEA
KEGG
mmu:04660
NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
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Il4
interleukin 4
IEA
KEGG
mmu:04660
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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Il5
interleukin 5
IEA
KEGG
mmu:04660
NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
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Itk
IL2 inducible T cell kinase
IEA
KEGG
mmu:04660
NCBI chr11:46,215,975...46,280,342
Ensembl chr11:46,215,977...46,280,342
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Jun
jun proto-oncogene
IEA
KEGG
mmu:04660
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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Kras
Kirsten rat sarcoma viral oncogene homolog
IEA
KEGG
mmu:04660
NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
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Lat
linker for activation of T cells
IEA
KEGG
mmu:04660
NCBI chr 7:125,962,999...125,968,877
Ensembl chr 7:125,962,996...125,968,742
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Lck
lymphocyte protein tyrosine kinase
IEA
KEGG
mmu:04660
NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434
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Lcp2
lymphocyte cytosolic protein 2
IEA
KEGG
mmu:04660
NCBI chr11:33,996,928...34,042,281
Ensembl chr11:33,996,920...34,042,295
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Malt1
MALT1 paracaspase
IEA
KEGG
mmu:04660
NCBI chr18:65,564,010...65,612,138
Ensembl chr18:65,564,009...65,612,138
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Map2k1
mitogen-activated protein kinase kinase 1
IEA
KEGG
mmu:04660
NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
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Map2k2
mitogen-activated protein kinase kinase 2
IEA
KEGG
mmu:04660
NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809
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Map2k7
mitogen-activated protein kinase kinase 7
IEA
KEGG
mmu:04660
NCBI chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897 Ensembl chr 8:4,288,740...4,297,897
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Map3k14
mitogen-activated protein kinase kinase kinase 14
IEA
KEGG
mmu:04660
NCBI chr11:103,110,590...103,158,227
Ensembl chr11:103,110,588...103,158,298
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Map3k7
mitogen-activated protein kinase kinase kinase 7
IEA
KEGG
mmu:04660
NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467
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Map3k8
mitogen-activated protein kinase kinase kinase 8
IEA
KEGG
mmu:04660
NCBI chr18:4,331,325...4,352,978
Ensembl chr18:4,331,327...4,353,015
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Mapk1
mitogen-activated protein kinase 1
IEA
KEGG
mmu:04660
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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Mapk11
mitogen-activated protein kinase 11
IEA
KEGG
mmu:04660
NCBI chr15:89,026,685...89,033,809
Ensembl chr15:89,026,689...89,033,831
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Mapk12
mitogen-activated protein kinase 12
IEA
KEGG
mmu:04660
NCBI chr15:89,014,787...89,025,270
Ensembl chr15:89,014,787...89,024,906
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Mapk13
mitogen-activated protein kinase 13
IEA
KEGG
mmu:04660
NCBI chr17:28,988,260...28,997,678
Ensembl chr17:28,988,271...28,999,207
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Mapk14
mitogen-activated protein kinase 14
IEA
KEGG
mmu:04660
NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
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Mapk3
mitogen-activated protein kinase 3
IEA
KEGG
mmu:04660
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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Mapk9
mitogen-activated protein kinase 9
IEA
KEGG
mmu:04660
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
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Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
IEA
KEGG
mmu:04660
NCBI chr 9:100,376,047...100,428,187
Ensembl chr 9:100,374,346...100,428,187
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Nck2
non-catalytic region of tyrosine kinase adaptor protein 2
IEA
KEGG
mmu:04660
NCBI chr 1:43,484,643...43,609,678
Ensembl chr 1:43,483,739...43,609,675
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Nfat5
nuclear factor of activated T cells 5
IEA
KEGG
mmu:04660
NCBI chr 8:108,020,072...108,106,149
Ensembl chr 8:108,020,102...108,106,149
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Nfatc1
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
IEA
KEGG
mmu:04660
NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286
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Nfatc2
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
IEA
KEGG
mmu:04660
NCBI chr 2:168,318,330...168,443,900
Ensembl chr 2:168,318,330...168,443,577
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Nfatc3
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
IEA
KEGG
mmu:04660
NCBI chr 8:106,785,450...106,857,169
Ensembl chr 8:106,785,472...106,857,169
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Nfatc4
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
IEA
KEGG
mmu:04660
NCBI chr14:56,062,252...56,071,400
Ensembl chr14:56,060,601...56,071,400
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Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
IEA
KEGG
mmu:04660
NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
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Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
IEA
KEGG
mmu:04660
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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Nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
IEA
KEGG
mmu:04660
NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937
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Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
IEA
KEGG
mmu:04660
NCBI chr17:45,866,626...45,874,095
Ensembl chr17:45,866,629...45,874,095
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Nras
neuroblastoma ras oncogene
IEA
KEGG
mmu:04660
NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230
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Pak1
p21 (RAC1) activated kinase 1
IEA
KEGG
mmu:04660
NCBI chr 7:97,437,748...97,561,588
Ensembl chr 7:97,437,748...97,561,588
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Pak2
p21 (RAC1) activated kinase 2
IEA
KEGG
mmu:04660
NCBI chr16:31,835,108...31,898,160
Ensembl chr16:31,835,108...31,898,160
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Pak3
p21 (RAC1) activated kinase 3
IEA
KEGG
mmu:04660
NCBI chr X:142,301,370...142,580,792
Ensembl chr X:142,301,587...142,580,792
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Pak4
p21 (RAC1) activated kinase 4
IEA
KEGG
mmu:04660
NCBI chr 7:28,258,244...28,297,609
Ensembl chr 7:28,258,244...28,297,610
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Pak5
p21 (RAC1) activated kinase 5
IEA
KEGG
mmu:04660
NCBI chr 2:135,923,008...136,229,899
Ensembl chr 2:135,923,024...136,229,887
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Pak6
p21 (RAC1) activated kinase 6
IEA
KEGG
mmu:04660
NCBI chr 2:118,493,531...118,528,501
Ensembl chr 2:118,493,784...118,528,501
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Pdcd1
programmed cell death 1
IEA
KEGG
mmu:04660
NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278
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Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1
IEA
KEGG
mmu:04660
NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
IEA
KEGG
mmu:04660
NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635
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Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
IEA
KEGG
mmu:04660
NCBI chr 9:98,920,455...99,022,264
Ensembl chr 9:98,918,707...99,022,674
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Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
IEA
KEGG
mmu:04660
NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
IEA
KEGG
mmu:04660
NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
IEA
KEGG
mmu:04660
NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725
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Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
IEA
KEGG
mmu:04660
NCBI chr 8:71,220,820...71,229,356
Ensembl chr 8:71,220,820...71,229,357
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
IEA
KEGG
mmu:04660
NCBI chr 4:116,078,593...116,160,253
Ensembl chr 4:116,078,815...116,160,253 Ensembl chr 4:116,078,815...116,160,253
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Pik3r5
phosphoinositide-3-kinase regulatory subunit 5
IEA
KEGG
mmu:04660
NCBI chr11:68,322,951...68,388,675
Ensembl chr11:68,322,947...68,388,675
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Plcg1
phospholipase C, gamma 1
IEA
KEGG
mmu:04660
NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680
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Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
IEA
KEGG
mmu:04660
NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488
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Ppp3cb
protein phosphatase 3, catalytic subunit, beta isoform
IEA
KEGG
mmu:04660
NCBI chr14:20,549,432...20,596,641
Ensembl chr14:20,549,432...20,596,641
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Ppp3cc
protein phosphatase 3, catalytic subunit, gamma isoform
IEA
KEGG
mmu:04660
NCBI chr14:70,455,314...70,526,979
Ensembl chr14:70,455,314...70,526,920
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Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
IEA
KEGG
mmu:04660
NCBI chr11:17,109,298...17,150,380
Ensembl chr11:17,109,263...17,150,375
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Ppp3r2
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)
IEA
KEGG
mmu:04660
NCBI chr 4:49,678,747...49,681,983
Ensembl chr 4:49,678,747...49,682,024
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Prkcq
protein kinase C, theta
IEA
KEGG
mmu:04660
NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033
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Ptpn6
protein tyrosine phosphatase, non-receptor type 6
IEA
KEGG
mmu:04660
NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677
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Ptprc
protein tyrosine phosphatase receptor type C
IEA
KEGG
mmu:04660
NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446
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Raf1
v-raf-leukemia viral oncogene 1
IEA
KEGG
mmu:04660
NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
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Rasgrp1
RAS guanyl releasing protein 1
IEA
KEGG
mmu:04660
NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
IEA
KEGG
mmu:04660
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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Rhoa
ras homolog family member A
IEA
KEGG
mmu:04660
NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
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Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
IEA
KEGG
mmu:04660
NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882
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Sos2
SOS Ras/Rho guanine nucleotide exchange factor 2
IEA
KEGG
mmu:04660
NCBI chr12:69,630,535...69,728,626
Ensembl chr12:69,630,536...69,728,626
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Tec
tec protein tyrosine kinase
IEA
KEGG
mmu:04660
NCBI chr 5:72,913,061...73,025,997
Ensembl chr 5:72,913,059...73,025,826
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Tnf
tumor necrosis factor
IEA
KEGG
mmu:04660
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Vav1
vav 1 oncogene
IEA
KEGG
mmu:04660
NCBI chr17:57,586,080...57,636,236
Ensembl chr17:57,586,100...57,635,031
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Vav2
vav 2 oncogene
IEA
KEGG
mmu:04660
NCBI chr 2:27,152,116...27,317,620
Ensembl chr 2:27,152,116...27,317,045
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Vav3
vav 3 oncogene
IEA
KEGG
mmu:04660
NCBI chr 3:109,247,757...109,593,010
Ensembl chr 3:109,247,969...109,593,014
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Zap70
zeta-chain (TCR) associated protein kinase
IEA
KEGG
mmu:04660
NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899
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