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Gene: Dlg1 (discs large MAGUK scaffold protein 1) Mus musculus
Symbol: Dlg1
Name: discs large MAGUK scaffold protein 1
Description: Exhibits molecular adaptor activity and potassium channel regulator activity. Involved in several processes, including animal organ development; negative regulation of cell population proliferation; and regulation of potassium ion transmembrane transport. Localizes to several cellular components, including the immunological synapse; lateral loop; and lateral plasma membrane. Predicted to colocalize with the ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and surface ectoderm. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B130052P05Rik; discs, large homolog 1; discs, large homolog 1 (Drosophila); disks large homolog 1; Dlgh1; E-dlg/SAP97; embryo-dlg/synapse-associated protein 97; KIAA4187; mKIAA4187; SAP-97; SAP97; synapse-associated protein 97
Homo sapiens (human) : DLG1 (discs large MAGUK scaffold protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dlg1 (discs large MAGUK scaffold protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg1 (discs large MAGUK scaffold protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG1 (discs large MAGUK scaffold protein 1)
Canis lupus familiaris (dog) : DLG1 (discs large MAGUK scaffold protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg1 (discs large MAGUK scaffold protein 1)
Sus scrofa (pig) : DLG1 (discs large MAGUK scaffold protein 1)
Chlorocebus sabaeus (African green monkey) : DLG1 (discs large MAGUK scaffold protein 1)
Heterocephalus glaber (naked mole-rat) : Dlg1 (discs large MAGUK scaffold protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1631,663,443 - 31,875,129 (+)Ensembl
GRCm381631,663,443 - 31,873,356 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371631,664,125 - 31,873,432 (+)NCBIGRCm37mm9NCBIm37
MGSCv361631,583,786 - 31,793,093 (+)NCBImm8
Celera1632,161,016 - 32,367,224 (+)NCBICelera
Cytogenetic Map16 B2NCBI
cM Map1622.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Dlg1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10475
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.