Malt1 (MALT1 paracaspase) - Rat Genome Database

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Gene: Malt1 (MALT1 paracaspase) Mus musculus
Analyze
Symbol: Malt1
Name: MALT1 paracaspase
RGD ID: 1319402
MGI Page MGI
Description: Enables protease binding activity. Involved in several processes, including innate immune response; lipopolysaccharide-mediated signaling pathway; and positive regulation of immune response. Acts upstream of or within several processes, including B-1 B cell differentiation; positive regulation of NF-kappaB transcription factor activity; and regulation of T cell receptor signaling pathway. Located in cytosol. Part of polkadots. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A630046N12; D430033E09Rik; MGC124469; MGC124470; mucosa associated lymphoid tissue lymphoma translocation gene 1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; pa; paracaspase; paracaspase-1; Pc; Pcasp1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391865,564,010 - 65,612,138 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1865,564,009 - 65,612,138 (+)EnsemblGRCm39 Ensembl
GRCm381865,430,939 - 65,478,888 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1865,430,938 - 65,479,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv371865,590,651 - 65,638,446 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361865,556,366 - 65,604,161 (+)NCBIMGSCv36mm8
Celera1866,699,207 - 66,748,598 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1838.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium silicate  (EXP)
carbon nanotube  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
folic acid  (EXP)
FR900359  (ISO)
gentamycin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
LY294002  (ISO)
metam  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
o-anisidine  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tremolite asbestos  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Akagi T, etal., Oncogene. 1999 Oct 14;18(42):5785-94.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Sanchez-Izquierdo D, etal., Blood. 2003 Jun 1;101(11):4539-46. Epub 2003 Jan 30.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11387339   PMID:12477932   PMID:14576442   PMID:14614861   PMID:15489334   PMID:15741177   PMID:16141072   PMID:16141073  
PMID:16432253   PMID:16495340   PMID:16602821   PMID:16831874   PMID:16862125   PMID:17095601   PMID:17101977   PMID:17202357   PMID:17287209   PMID:17462996   PMID:17660823   PMID:18192506  
PMID:18223652   PMID:18941215   PMID:19112107   PMID:19139169   PMID:19454668   PMID:19915568   PMID:19917778   PMID:20562862   PMID:20605784   PMID:21041303   PMID:21267068   PMID:21448133  
PMID:21873235   PMID:21873635   PMID:21896478   PMID:22366302   PMID:22689981   PMID:23114599   PMID:23401595   PMID:23706741   PMID:24792914   PMID:24825920   PMID:24917592   PMID:25202022  
PMID:25282160   PMID:25319413   PMID:25456129   PMID:25605905   PMID:25748427   PMID:25762782   PMID:25826454   PMID:25965667   PMID:25982276   PMID:26377317   PMID:26386283   PMID:26392569  
PMID:26405015   PMID:26525107   PMID:26668357   PMID:26787500   PMID:26936881   PMID:27032818   PMID:27068814   PMID:27105502   PMID:27551157   PMID:27681433   PMID:27926862   PMID:28031341  
PMID:28658621   PMID:28928392   PMID:29367251   PMID:29414650   PMID:29649481   PMID:29901822   PMID:29953499   PMID:30025160   PMID:30240621   PMID:30279415   PMID:30375474   PMID:30510167  
PMID:30564895   PMID:30741923   PMID:30979818   PMID:30996332   PMID:31092922   PMID:31138793   PMID:31313375   PMID:31474984   PMID:31632405   PMID:31644910   PMID:31659015   PMID:32213560  
PMID:32343482   PMID:33042160   PMID:33092214   PMID:33419765   PMID:33827774   PMID:34668583   PMID:34767456   PMID:34826258   PMID:35850054   PMID:36479846   PMID:36761777   PMID:37108564  
PMID:37988467   PMID:38519981  


Genomics

Comparative Map Data
Malt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391865,564,010 - 65,612,138 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1865,564,009 - 65,612,138 (+)EnsemblGRCm39 Ensembl
GRCm381865,430,939 - 65,478,888 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1865,430,938 - 65,479,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv371865,590,651 - 65,638,446 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361865,556,366 - 65,604,161 (+)NCBIMGSCv36mm8
Celera1866,699,207 - 66,748,598 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1838.56NCBI
MALT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381858,671,465 - 58,754,477 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1858,671,465 - 58,754,477 (+)EnsemblGRCh38hg38GRCh38
GRCh371856,338,697 - 56,421,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361854,489,598 - 54,568,350 (+)NCBINCBI36Build 36hg18NCBI36
Build 341854,489,597 - 54,568,350NCBI
Celera1853,055,193 - 53,133,688 (+)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1853,046,774 - 53,125,499 (+)NCBIHuRef
CHM1_11856,333,855 - 56,412,584 (+)NCBICHM1_1
T2T-CHM13v2.01858,872,604 - 58,955,588 (+)NCBIT2T-CHM13v2.0
Malt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81861,212,290 - 61,266,272 (+)NCBIGRCr8
mRatBN7.21858,942,282 - 58,996,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,942,299 - 58,994,260 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01861,108,712 - 61,162,446 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1861,109,069 - 61,162,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01860,305,085 - 60,358,786 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41861,708,388 - 61,760,004 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11861,720,756 - 61,832,919 (+)NCBI
Celera1857,070,977 - 57,125,050 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Malt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540242,911,649 - 42,972,429 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540242,919,480 - 42,968,873 (+)NCBIChiLan1.0ChiLan1.0
MALT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21776,210,829 - 76,295,818 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11861,903,645 - 61,988,504 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01852,060,878 - 52,141,985 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11855,395,462 - 55,473,574 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1855,395,462 - 55,473,574 (+)Ensemblpanpan1.1panPan2
MALT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1117,351,458 - 17,412,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl117,354,926 - 17,403,927 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha118,335,003 - 18,396,343 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0117,231,245 - 17,291,704 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl117,232,316 - 17,291,990 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1117,292,714 - 17,350,173 (-)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.1117,272,403 - 17,281,013 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,187,356 - 17,248,249 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0117,455,416 - 17,516,194 (-)NCBIUU_Cfam_GSD_1.0
Malt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,615,326 - 30,665,178 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364975,853,870 - 5,904,266 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364975,854,361 - 5,910,719 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MALT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,076,955 - 162,144,880 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11162,076,933 - 162,144,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21179,571,906 - 179,706,232 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MALT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11820,984,985 - 21,064,198 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1820,985,819 - 21,054,554 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660604,506,132 - 4,584,611 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Malt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247924,148,453 - 4,217,548 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247924,148,258 - 4,223,431 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Malt1
1627 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:861
Count of miRNA genes:480
Interacting mature miRNAs:594
Transcripts:ENSMUST00000049248
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
12910791Pwgrq8_mpre-weaning growth rate QTL 8 (mouse)185802139969349142Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
13824986Flal2_mfatty liver accumulation QTL 2, females only (mouse)186413307166133071Mouse
10412183Sstapa2_mSuseptibility to Staphylococus aureus infection 2 (mouse)Not determined185679463066952485Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184513060468778777Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
4142239Idd21.2_minsulin dependent diabetes susceptibility 21.2 (mouse)Not determined186127244874562414Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
1302050Radpf4_mradiation pulmonary fibrosis 4 (mouse)Not determined185296615668778777Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
11039518Ltpr8_mLeishmania tropica response 8 (mouse)186387490376180241Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001365019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001782363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000049248   ⟹   ENSMUSP00000048376
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,564,020 - 65,612,138 (+)Ensembl
GRCm38.p6 Ensembl1865,430,949 - 65,479,067 (+)Ensembl
Ensembl Acc Id: ENSMUST00000224056   ⟹   ENSMUSP00000153585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,564,009 - 65,610,876 (+)Ensembl
GRCm38.p6 Ensembl1865,430,938 - 65,477,805 (+)Ensembl
Ensembl Acc Id: ENSMUST00000224229
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,581,956 - 65,588,359 (+)Ensembl
GRCm38.p6 Ensembl1865,448,885 - 65,455,288 (+)Ensembl
Ensembl Acc Id: ENSMUST00000224265   ⟹   ENSMUSP00000158550
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,564,033 - 65,593,077 (+)Ensembl
GRCm38.p6 Ensembl1865,430,962 - 65,460,006 (+)Ensembl
Ensembl Acc Id: ENSMUST00000225085
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,564,079 - 65,587,817 (+)Ensembl
GRCm38.p6 Ensembl1865,431,008 - 65,454,746 (+)Ensembl
Ensembl Acc Id: ENSMUST00000225659
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,584,602 - 65,587,258 (+)Ensembl
GRCm38.p6 Ensembl1865,451,531 - 65,454,187 (+)Ensembl
Ensembl Acc Id: ENSMUST00000235209
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,577,335 - 65,581,969 (+)Ensembl
GRCm38.p6 Ensembl1865,444,264 - 65,448,898 (+)Ensembl
Ensembl Acc Id: ENSMUST00000235999
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,603,429 - 65,609,400 (+)Ensembl
GRCm38.p6 Ensembl1865,470,358 - 65,476,329 (+)Ensembl
Ensembl Acc Id: ENSMUST00000236050
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,591,531 - 65,593,070 (+)Ensembl
GRCm38.p6 Ensembl1865,458,460 - 65,459,999 (+)Ensembl
Ensembl Acc Id: ENSMUST00000236284
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,564,445 - 65,582,045 (+)Ensembl
GRCm38.p6 Ensembl1865,431,374 - 65,448,974 (+)Ensembl
Ensembl Acc Id: ENSMUST00000236314   ⟹   ENSMUSP00000158449
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,586,746 - 65,603,609 (+)Ensembl
GRCm38.p6 Ensembl1865,453,675 - 65,470,538 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237488   ⟹   ENSMUSP00000158079
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,580,624 - 65,608,323 (+)Ensembl
GRCm38.p6 Ensembl1865,447,553 - 65,475,252 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237739
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1865,564,082 - 65,574,289 (+)Ensembl
GRCm38.p6 Ensembl1865,431,011 - 65,441,218 (+)Ensembl
RefSeq Acc Id: NM_001365019   ⟹   NP_001351948
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391865,564,061 - 65,612,138 (+)NCBI
GRCm381865,430,990 - 65,478,825 (+)NCBI
Sequence:
RefSeq Acc Id: NM_172833   ⟹   NP_766421
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391865,564,061 - 65,612,138 (+)NCBI
GRCm381865,430,990 - 65,478,825 (+)NCBI
MGSCv371865,590,651 - 65,638,446 (+)RGD
Celera1866,699,207 - 66,748,598 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006525940   ⟹   XP_006526003
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391865,589,935 - 65,611,959 (+)NCBI
GRCm381865,456,542 - 65,478,888 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006525941   ⟹   XP_006526004
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391865,581,993 - 65,611,959 (+)NCBI
GRCm381865,448,922 - 65,478,888 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161140   ⟹   XP_036017033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391865,589,523 - 65,611,959 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161142   ⟹   XP_036017035
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391865,564,010 - 65,595,896 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001782363
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391865,564,010 - 65,611,959 (+)NCBI
GRCm381865,430,939 - 65,478,888 (+)NCBI
Sequence:
RefSeq Acc Id: NP_766421   ⟸   NM_172833
- Peptide Label: isoform 1
- UniProtKB: Q2TBA3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526003   ⟸   XM_006525940
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006526004   ⟸   XM_006525941
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001351948   ⟸   NM_001365019
- Peptide Label: isoform 2
- UniProtKB: Q8BFT0 (UniProtKB/Swiss-Prot),   Q811E3 (UniProtKB/Swiss-Prot),   Q2TBA3 (UniProtKB/Swiss-Prot),   Q2TBA2 (UniProtKB/Swiss-Prot),   Q8C7N9 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000158079   ⟸   ENSMUST00000237488
Ensembl Acc Id: ENSMUSP00000158449   ⟸   ENSMUST00000236314
Ensembl Acc Id: ENSMUSP00000048376   ⟸   ENSMUST00000049248
Ensembl Acc Id: ENSMUSP00000153585   ⟸   ENSMUST00000224056
Ensembl Acc Id: ENSMUSP00000158550   ⟸   ENSMUST00000224265
RefSeq Acc Id: XP_036017035   ⟸   XM_036161142
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036017033   ⟸   XM_036161140
- Peptide Label: isoform X1
Protein Domains
Caspase family p20   Death   Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2TBA3-F1-model_v2 AlphaFold Q2TBA3 1-832 view protein structure

Promoters
RGD ID:13678030
Promoter ID:EPDNEW_M23164
Type:initiation region
Name:Malt1_1
Description:Mus musculus MALT1 paracaspase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381865,431,024 - 65,431,084EPDNEW
RGD ID:6829349
Promoter ID:MM_KWN:25504
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000102868,   OTTMUST00000035418,   UC008FEX.1,   UC008FEY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361865,590,221 - 65,590,862 (+)MPROMDB
RGD ID:6829348
Promoter ID:MM_KWN:25505
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC008FFB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361865,629,106 - 65,630,407 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2445027 AgrOrtholog
Ensembl Genes ENSMUSG00000032688 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049248 ENTREZGENE
  ENSMUST00000049248.7 UniProtKB/Swiss-Prot
  ENSMUST00000224056 ENTREZGENE
  ENSMUST00000224056.3 UniProtKB/Swiss-Prot
  ENSMUST00000224265.2 UniProtKB/TrEMBL
  ENSMUST00000236314.2 UniProtKB/TrEMBL
  ENSMUST00000237488.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.3360 UniProtKB/Swiss-Prot
  3.40.50.1460 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Caspase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase-related_regulators UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MALT1 UniProtKB/Swiss-Prot
  MALT1_Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MALT1_Ig UniProtKB/Swiss-Prot
  Pept_C14_caspase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:240354 UniProtKB/Swiss-Prot
MGD MGI:2445027 ENTREZGENE
NCBI Gene 240354 ENTREZGENE
PANTHER MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22576:SF40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MALT1_Ig UniProtKB/Swiss-Prot
  Peptidase_C14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Malt1 PhenoGen
PROSITE CASPASE_P20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BAG3_MOUSE UniProtKB/TrEMBL
  A0A494BBB5_MOUSE UniProtKB/TrEMBL
  A0A494BBJ5_MOUSE UniProtKB/TrEMBL
  MALT1_MOUSE UniProtKB/Swiss-Prot
  Q2TBA2 ENTREZGENE
  Q2TBA3 ENTREZGENE
  Q811E3 ENTREZGENE
  Q8BFT0 ENTREZGENE
  Q8BRB5_MOUSE UniProtKB/TrEMBL
  Q8C7N9 ENTREZGENE
UniProt Secondary Q2TBA2 UniProtKB/Swiss-Prot
  Q811E3 UniProtKB/Swiss-Prot
  Q8BFT0 UniProtKB/Swiss-Prot
  Q8C7N9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-18 Malt1  MALT1 paracaspase    mucosa associated lymphoid tissue lymphoma translocation gene 1  Symbol and/or name change 5135510 APPROVED