Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Map3k14 (mitogen-activated protein kinase kinase kinase 14) Mus musculus
Symbol: Map3k14
Name: mitogen-activated protein kinase kinase kinase 14
Description: Exhibits NF-kappaB-inducing kinase activity. Involved in I-kappaB kinase/NF-kappaB signaling and immune response. Predicted to localize to the cytosol; fibrillar center; and nucleoplasm. Used to study Sjogren's syndrome and primary biliary cirrhosis. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and skeleton. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14); PARTICIPATES IN nuclear factor kappa B signaling pathway; apoptotic cell death pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aly; alymphoplasia; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; Nik; protein kinase; serine/threonine-protein kinase NIK
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl11103,219,762 - 103,267,472 (-)Ensembl
GRCm3811103,219,764 - 103,267,401 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711103,081,078 - 103,128,715 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611103,035,854 - 103,083,491 (-)NCBImm8
Celera11114,933,508 - 114,981,179 (-)NCBICelera
Cytogenetic Map11 E1NCBI
cM Map1166.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Map3k14
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321417
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.