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Gene: Map3k14 (mitogen-activated protein kinase kinase kinase 14) Mus musculus
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Symbol: Map3k14
Name: mitogen-activated protein kinase kinase kinase 14
Description: Exhibits NF-kappaB-inducing kinase activity. Involved in I-kappaB kinase/NF-kappaB signaling and immune response. Predicted to localize to the cytosol; fibrillar center; and nucleoplasm. Used to study Sjogren's syndrome and primary biliary cirrhosis. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and skeleton. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14); PARTICIPATES IN nuclear factor kappa B signaling pathway; apoptotic cell death pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aly; alymphoplasia; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; Nik; protein kinase; serine/threonine-protein kinase NIK
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl11103,219,762 - 103,267,472 (-)Ensembl
GRCm3811103,219,764 - 103,267,401 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711103,081,078 - 103,128,715 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611103,035,854 - 103,083,491 (-)NCBImm8
Celera11114,933,508 - 114,981,179 (-)NCBICelera
Cytogenetic Map11 E1NCBI
cM Map1166.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Map3k14
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321417
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.