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Gene: Ptpn6 (protein tyrosine phosphatase, non-receptor type 6) Mus musculus
Symbol: Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
Description: Exhibits several functions, including phosphotyrosine residue binding activity; protein domain specific binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of protein phosphorylation; and regulation of lymphocyte activation. Localizes to the alpha-beta T cell receptor complex and cell-cell junction. Is expressed in central nervous system; embryo; midbrain; superior colliculus; and thymus primordium. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-diaminotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 70Z-SHP; hcp; Hcph; hematopoietic cell protein-tyrosine phosphatase; hemopoietic cell phosphatase; me; motheaten; protein-tyrosine phosphatase 1C; PTP-1C; Ptp1C; PTPTY-42; SH-PTP1; SH2 phosphatase 1; SHP-1; tyrosine-protein phosphatase non-receptor type 6
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl6124,720,707 - 124,738,714 (-)Ensembl
GRCm386124,720,707 - 124,738,709 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376124,670,736 - 124,688,727 (-)NCBIGRCm37mm9NCBIm37
MGSCv366124,686,336 - 124,698,725 (-)NCBImm8
Celera6126,402,436 - 126,420,442 (-)NCBICelera
Cytogenetic Map6 F2NCBI
cM Map659.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ptpn6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1553000
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.