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Gene: Ptpn6 (protein tyrosine phosphatase, non-receptor type 6) Mus musculus
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Symbol: Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
Description: Exhibits several functions, including phosphotyrosine residue binding activity; protein domain specific binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of protein phosphorylation; and regulation of lymphocyte activation. Localizes to the alpha-beta T cell receptor complex and cell-cell junction. Is expressed in central nervous system; embryo; midbrain; superior colliculus; and thymus primordium. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-diaminotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 70Z-SHP; hcp; Hcph; hematopoietic cell protein-tyrosine phosphatase; hemopoietic cell phosphatase; me; motheaten; protein-tyrosine phosphatase 1C; PTP-1C; Ptp1C; PTPTY-42; SH-PTP1; SH2 phosphatase 1; SHP-1; tyrosine-protein phosphatase non-receptor type 6
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl6124,720,707 - 124,738,714 (-)Ensembl
GRCm386124,720,707 - 124,738,709 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376124,670,736 - 124,688,727 (-)NCBIGRCm37mm9NCBIm37
MGSCv366124,686,336 - 124,698,725 (-)NCBImm8
Celera6126,402,436 - 126,420,442 (-)NCBICelera
Cytogenetic Map6 F2NCBI
cM Map659.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ptpn6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1553000
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.