Ptpn6 (protein tyrosine phosphatase, non-receptor type 6) - Rat Genome Database
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Gene: Ptpn6 (protein tyrosine phosphatase, non-receptor type 6) Mus musculus
Analyze
Symbol: Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
RGD ID: 1553000
MGI Page MGI
Description: Exhibits several functions, including phosphotyrosine residue binding activity; protein domain specific binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Localizes to alpha-beta T cell receptor complex and cell-cell junction. Is expressed in several structures, including central nervous system; retina; and thymus primordium. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 70Z-SHP; hc; hcp; Hcph; hematopoietic cell protein-tyrosine phosphatase; hemopoietic cell phosphatase; me; motheaten; protein-tyrosine phosphatase 1C; Ptp; PTP-1C; Ptp1C; PTPTY-42; SH-PTP1; SH2 phosphatase 1; SHP; SHP-1; tyrosine-protein phosphatase non-receptor type 6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,697,670 - 124,715,672 (-)NCBIGRCm39mm39
GRCm386124,720,707 - 124,738,709 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,720,707 - 124,738,714 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,670,736 - 124,688,727 (-)NCBIGRCm37mm9NCBIm37
MGSCv366124,686,336 - 124,698,725 (-)NCBImm8
Celera6126,402,447 - 126,420,442 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal B cell negative selection  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IEA)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal cell cycle  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal circulating chemokine level  (IAGP)
abnormal circulating serum amyloid protein level  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal coat appearance  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal granulocyte morphology  (IAGP)
abnormal hippocampus CA1 region morphology  (IAGP)
abnormal hippocampus development  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system cell morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lymph organ size  (IAGP)
abnormal mature B cell morphology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal Peyer's patch morphology  (IAGP)
abnormal photoreceptor inner segment morphology  (IAGP)
abnormal photoreceptor outer segment morphology  (IAGP)
abnormal plasma cell morphology  (IAGP)
abnormal pulmonary alveolar system morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal secondary ovarian follicle morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal T cell differentiation  (IEA)
abnormal T cell physiology  (IAGP)
abnormal telencephalon development  (IAGP)
abnormal thymus development  (IAGP)
abnormal thymus morphology  (IAGP)
absent limbs  (IAGP)
absent skin pigmentation  (IAGP)
autoimmune response  (IAGP)
chronic inflammation  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased apoptosis  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IEA)
decreased B-2 B cell number  (IEA)
decreased b-wave amplitude  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased brain size  (IAGP)
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased cellular sensitivity to gamma-irradiation  (IAGP)
decreased follicular B cell number  (IAGP)
decreased IgD level  (IEA)
decreased IgM level  (IAGP)
decreased immature B cell number  (IEA)
decreased marginal zone B cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased neuron number  (IAGP)
decreased retinal photoreceptor cell number  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased thymocyte number  (IAGP)
disorganized photoreceptor outer segment  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extremity edema  (IAGP)
female infertility  (IAGP)
focal hair loss  (IAGP)
increased anti-chromatin antibody level  (IAGP)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased B-1 B cell number  (IEA)
increased B-1a cell number  (IAGP)
increased B-1b cell number  (IEA)
increased CD8-positive, alpha-beta memory T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-17 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased dendritic cell number  (IEA)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased erythroid progenitor cell number  (IAGP)
increased granulocyte number  (IAGP)
increased IgA level  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased immunoglobulin level  (IAGP)
increased inflammatory response  (IEA)
increased leukocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased microglial cell activation  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased plasma cell number  (IAGP)
increased splenocyte proliferation  (IAGP)
increased susceptibility to systemic lupus erythematosus  (IAGP)
increased T cell number  (IAGP)
interstitial pneumonia  (IAGP)
lung inflammation  (IAGP)
ovary atrophy  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
psoriasis  (IAGP)
respiratory distress  (IAGP)
retinal outer nuclear layer degeneration  (IAGP)
retinal photoreceptor degeneration  (IAGP)
retinal rod cell degeneration  (IAGP)
rheumatoid arthritis  (IAGP)
salivary gland inflammation  (IAGP)
short photoreceptor outer segment  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
small thymus  (IAGP)
spontaneous skin ulceration  (IAGP)
thin retinal outer nuclear layer  (IAGP)
thymus atrophy  (IAGP)
ulcerated paws  (IAGP)
References

Additional References at PubMed
PMID:56406   PMID:221571   PMID:363947   PMID:664185   PMID:1184950   PMID:1270804   PMID:1373816   PMID:1385421   PMID:1427910   PMID:1732748   PMID:1756226   PMID:1932742  
PMID:2196000   PMID:2783574   PMID:2884254   PMID:3551623   PMID:3873348   PMID:3891855   PMID:6334306   PMID:6350031   PMID:6361123   PMID:6380298   PMID:6971254   PMID:7536621  
PMID:7600299   PMID:7768898   PMID:7804149   PMID:7840851   PMID:7923924   PMID:7943179   PMID:8070815   PMID:8093859   PMID:8118868   PMID:8245788   PMID:8324828   PMID:8348149  
PMID:8632004   PMID:8636158   PMID:8666788   PMID:8673130   PMID:8781712   PMID:8822276   PMID:8863726   PMID:8875997   PMID:8943354   PMID:8962111   PMID:9034146   PMID:9047385  
PMID:9064328   PMID:9064344   PMID:9070220   PMID:9111009   PMID:9184911   PMID:9216734   PMID:9254656   PMID:9263478   PMID:9300728   PMID:9358756   PMID:9371744   PMID:9422771  
PMID:9445485   PMID:9505936   PMID:9573011   PMID:9586639   PMID:9587708   PMID:9593582   PMID:9636682   PMID:9712903   PMID:9740804   PMID:9808051   PMID:9824165   PMID:9867848  
PMID:9890995   PMID:9973385   PMID:10201897   PMID:10229823   PMID:10229828   PMID:10330148   PMID:10349636   PMID:10352248   PMID:10358768   PMID:10363996   PMID:10393854   PMID:10419485  
PMID:10435725   PMID:10477552   PMID:10477564   PMID:10495129   PMID:10556798   PMID:10585470   PMID:10590266   PMID:10611342   PMID:10698306   PMID:10903732   PMID:10922068   PMID:11042159  
PMID:11067945   PMID:11076861   PMID:11145649   PMID:11157073   PMID:11159516   PMID:11217851   PMID:11266449   PMID:11283158   PMID:11389549   PMID:11551923   PMID:11668176   PMID:11745335  
PMID:11745639   PMID:11826756   PMID:11908943   PMID:11908944   PMID:11970996   PMID:12097380   PMID:12176909   PMID:12220225   PMID:12466851   PMID:12477932   PMID:12511594   PMID:12612075  
PMID:12644021   PMID:12645942   PMID:12646217   PMID:12742656   PMID:12893283   PMID:14500659   PMID:14662855   PMID:14967925   PMID:14987753   PMID:14988381   PMID:15197735   PMID:15240733  
PMID:15339845   PMID:15364920   PMID:15456853   PMID:15489334   PMID:15634925   PMID:15661890   PMID:15701718   PMID:15723811   PMID:15728495   PMID:15905501   PMID:16141072   PMID:16141073  
PMID:16237056   PMID:16265671   PMID:16326706   PMID:16487932   PMID:16492738   PMID:16505059   PMID:16528752   PMID:16565987   PMID:16569683   PMID:16617349   PMID:16702225   PMID:16731527  
PMID:16731906   PMID:16782884   PMID:16860389   PMID:17003515   PMID:17057094   PMID:17182570   PMID:17239631   PMID:17600736   PMID:17934470   PMID:17954568   PMID:18003716   PMID:18024433  
PMID:18028878   PMID:18258420   PMID:18391954   PMID:18424711   PMID:18441283   PMID:18617527   PMID:18719282   PMID:18799693   PMID:18806225   PMID:18832698   PMID:18952289   PMID:18952567  
PMID:18981103   PMID:18987138   PMID:19120489   PMID:19171907   PMID:19201834   PMID:19380785   PMID:19419305   PMID:19647226   PMID:19727691   PMID:19789387   PMID:19875169   PMID:19948503  
PMID:19951174   PMID:20042576   PMID:20117097   PMID:20145200   PMID:20190757   PMID:20368344   PMID:20400923   PMID:20421975   PMID:20526344   PMID:20696858   PMID:20858858   PMID:20952680  
PMID:21029969   PMID:21044800   PMID:21160041   PMID:21267068   PMID:21356343   PMID:21357539   PMID:21364532   PMID:21376641   PMID:21422245   PMID:21423172   PMID:21435452   PMID:21559430  
PMID:21664461   PMID:21677750   PMID:21683628   PMID:21900501   PMID:21952243   PMID:22077594   PMID:22337713   PMID:22415018   PMID:22438258   PMID:22491248   PMID:22496641   PMID:22499584  
PMID:22509389   PMID:22539788   PMID:22553146   PMID:22555432   PMID:22698917   PMID:22724066   PMID:22798664   PMID:22798667   PMID:22826316   PMID:22952938   PMID:23001144   PMID:23112346  
PMID:23341629   PMID:23390550   PMID:23427253   PMID:23479228   PMID:23509158   PMID:23509253   PMID:23521885   PMID:23531619   PMID:23640895   PMID:23708968   PMID:23766558   PMID:23793062  
PMID:23797092   PMID:23840825   PMID:23896411   PMID:23904162   PMID:24029230   PMID:24327268   PMID:24360797   PMID:24466030   PMID:24590766   PMID:24819344   PMID:24824657   PMID:24841652  
PMID:24899508   PMID:24978161   PMID:24990897   PMID:25057927   PMID:25090641   PMID:25187664   PMID:25355530   PMID:25404734   PMID:25681345   PMID:25769611   PMID:25881561   PMID:25915125  
PMID:25919645   PMID:26002917   PMID:26101325   PMID:26416283   PMID:26669445   PMID:26878112   PMID:27020408   PMID:27114609   PMID:27221212   PMID:27354309   PMID:27396328   PMID:27548433  
PMID:27614023   PMID:27670070   PMID:27742545   PMID:27841348   PMID:27926878   PMID:27930667   PMID:27933336   PMID:28250424   PMID:28378742   PMID:28389241   PMID:28410990   PMID:28465325  
PMID:28533521   PMID:28550200   PMID:28875936   PMID:29074590   PMID:29113698   PMID:29629899   PMID:29669741   PMID:29776962   PMID:29891536   PMID:30033153   PMID:30082320   PMID:30333137  
PMID:30413615   PMID:30796181   PMID:30823936   PMID:30929511   PMID:30961932   PMID:30979083   PMID:31076529   PMID:31597758   PMID:31819256   PMID:31932808   PMID:32004441   PMID:32075800  
PMID:32092146   PMID:32290105   PMID:32325033   PMID:32343611  


Genomics

Comparative Map Data
Ptpn6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,697,670 - 124,715,672 (-)NCBIGRCm39mm39
GRCm386124,720,707 - 124,738,709 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,720,707 - 124,738,714 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,670,736 - 124,688,727 (-)NCBIGRCm37mm9NCBIm37
MGSCv366124,686,336 - 124,698,725 (-)NCBImm8
Celera6126,402,447 - 126,420,442 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
PTPN6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl126,946,468 - 6,961,316 (+)EnsemblGRCh38hg38GRCh38
GRCh38126,946,577 - 6,961,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,055,740 - 7,070,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,926,001 - 6,940,740 (+)NCBINCBI36hg18NCBI36
Build 34126,930,762 - 6,940,740NCBI
Celera128,674,361 - 8,691,497 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,911,844 - 6,928,943 (+)NCBIHuRef
CHM1_1127,054,727 - 7,069,431 (+)NCBICHM1_1
Ptpn6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,526,034 - 157,550,783 (-)NCBI
Rnor_6.0 Ensembl4157,239,142 - 157,263,890 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04157,239,141 - 157,263,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,256,737 - 224,281,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,843,699 - 160,868,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14161,088,634 - 161,113,792 (-)NCBI
Celera4146,264,696 - 146,289,049 (-)NCBICelera
Cytogenetic Map4q42NCBI
Ptpn6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,525,954 - 4,547,177 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,525,954 - 4,547,177 (+)NCBIChiLan1.0ChiLan1.0
PTPN6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1126,991,099 - 7,008,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,991,099 - 7,008,830 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0127,075,879 - 7,093,041 (+)NCBIMhudiblu_PPA_v0panPan3
PTPN6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2738,084,980 - 38,101,937 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12738,084,976 - 38,101,552 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ptpn6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936709864,206 - 884,630 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,762,112 - 63,808,350 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,762,109 - 63,779,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,198,250 - 66,215,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,977,480 - 6,994,525 (+)NCBI
ChlSab1.1 Ensembl116,984,710 - 6,994,545 (+)Ensembl
Ptpn6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248603,580,225 - 3,595,403 (+)NCBI

Position Markers
M68902  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386124,720,717 - 124,720,887UniSTSGRCm38
MGSCv376124,670,735 - 124,670,905UniSTSGRCm37
Celera6126,402,446 - 126,402,616UniSTS
Cytogenetic Map6F2UniSTS
cM Map660.22UniSTS
Whitehead_YAC6 UniSTS
AI411273  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386124,721,149 - 124,721,653UniSTSGRCm38
MGSCv376124,671,167 - 124,671,671UniSTSGRCm37
Celera6126,402,878 - 126,403,382UniSTS
Cytogenetic Map6F2UniSTS
cM Map660.22UniSTS
Hcph  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386124,720,790 - 124,721,198UniSTSGRCm38
MGSCv376124,670,808 - 124,671,216UniSTSGRCm37
Celera6126,402,519 - 126,402,927UniSTS
Cytogenetic Map6F2UniSTS
cM Map660.22UniSTS
Ptpn6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F2UniSTS
cM Map660.22UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698242853132242977Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698506837145935444Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698717516132717715Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698931748132940036Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699155128133155267Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103777444136423692Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104503360127042975Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104503360136423692Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110838217144838360Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111165485145165578Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112269957125356785Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112269957147052561Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114368732145656013Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115242853146429238Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115569842149572401Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115569842149572401Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115569842149572401Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115601042149601187Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115717516132601187Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116664897128519025Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116852888149736546Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117082986149736546Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120439808149736546Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124357314145656013Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3058
Count of miRNA genes:768
Interacting mature miRNAs:1019
Transcripts:ENSMUST00000004377, ENSMUST00000112484, ENSMUST00000171549, ENSMUST00000172613, ENSMUST00000172690, ENSMUST00000172770, ENSMUST00000173228, ENSMUST00000173315, ENSMUST00000173647, ENSMUST00000174265, ENSMUST00000174787
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001077705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC002397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC164157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY035180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY747031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M68902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M90389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S63763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S63764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S63803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000004377   ⟹   ENSMUSP00000004377
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,720,707 - 124,738,625 (-)Ensembl
RefSeq Acc Id: ENSMUST00000112484   ⟹   ENSMUSP00000108103
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,720,707 - 124,733,154 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171549   ⟹   ENSMUSP00000129124
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,720,707 - 124,738,714 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172613
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,727,747 - 124,728,708 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172690   ⟹   ENSMUSP00000134638
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,725,287 - 124,727,461 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172770
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,732,655 - 124,733,110 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173228
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,728,901 - 124,732,771 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173315   ⟹   ENSMUSP00000134274
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,720,720 - 124,721,842 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173647   ⟹   ENSMUSP00000133747
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,732,362 - 124,733,082 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174265   ⟹   ENSMUSP00000133991
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,721,108 - 124,738,584 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174787   ⟹   ENSMUSP00000133429
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6124,725,335 - 124,727,411 (-)Ensembl
RefSeq Acc Id: NM_001077705   ⟹   NP_001071173
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396124,697,670 - 124,715,672 (-)NCBI
GRCm386124,720,707 - 124,738,709 (-)NCBI
MGSCv376124,670,736 - 124,688,727 (-)RGD
Celera6126,402,436 - 126,420,442 (-)NCBI
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_013545   ⟹   NP_038573
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396124,697,670 - 124,710,117 (-)NCBI
GRCm386124,720,707 - 124,733,154 (-)NCBI
MGSCv376124,670,736 - 124,688,727 (-)RGD
Celera6126,402,436 - 126,420,442 (-)NCBI
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001071173   ⟸   NM_001077705
- Peptide Label: isoform b
- UniProtKB: P29351 (UniProtKB/Swiss-Prot),   Q3UB72 (UniProtKB/TrEMBL),   Q3UCJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_038573   ⟸   NM_013545
- Peptide Label: isoform a
- UniProtKB: P29351 (UniProtKB/Swiss-Prot),   Q3UB72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000134638   ⟸   ENSMUST00000172690
RefSeq Acc Id: ENSMUSP00000108103   ⟸   ENSMUST00000112484
RefSeq Acc Id: ENSMUSP00000129124   ⟸   ENSMUST00000171549
RefSeq Acc Id: ENSMUSP00000133429   ⟸   ENSMUST00000174787
RefSeq Acc Id: ENSMUSP00000133991   ⟸   ENSMUST00000174265
RefSeq Acc Id: ENSMUSP00000134274   ⟸   ENSMUST00000173315
RefSeq Acc Id: ENSMUSP00000133747   ⟸   ENSMUST00000173647
RefSeq Acc Id: ENSMUSP00000004377   ⟸   ENSMUST00000004377
Promoters
RGD ID:6848843
Promoter ID:MM_TRO:8522
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:MTR006068.6.2338.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366124,670,881 - 124,671,487 (-)MPROMDB
RGD ID:6848024
Promoter ID:MM_ACW:42701
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:PTPN6.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366124,678,311 - 124,678,811 (-)MPROMDB
RGD ID:6839805
Promoter ID:MM_KWN:47558
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000004377,   ENSMUST00000112484
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366124,682,854 - 124,683,354 (-)MPROMDB
RGD ID:6839806
Promoter ID:MM_KWN:47559
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:NM_001077705,   UC009DRJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366124,688,691 - 124,689,442 (-)MPROMDB
RGD ID:6890976
Promoter ID:EPDNEW_M8939
Type:initiation region
Name:Ptpn6_1
Description:Mus musculus protein tyrosine phosphatase, non-receptor type6 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8940  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386124,733,110 - 124,733,170EPDNEW
RGD ID:6890978
Promoter ID:EPDNEW_M8940
Type:initiation region
Name:Ptpn6_2
Description:Mus musculus protein tyrosine phosphatase, non-receptor type6 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8939  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386124,738,661 - 124,738,721EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96055 AgrOrtholog
Ensembl Genes ENSMUSG00000004266 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000004377 UniProtKB/Swiss-Prot
  ENSMUSP00000108103 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000129124 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000133429 UniProtKB/TrEMBL
  ENSMUSP00000133747 UniProtKB/TrEMBL
  ENSMUSP00000133991 UniProtKB/Swiss-Prot
  ENSMUSP00000134274 UniProtKB/TrEMBL
  ENSMUSP00000134638 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000004377 UniProtKB/Swiss-Prot
  ENSMUST00000112484 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000171549 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000172690 UniProtKB/TrEMBL
  ENSMUST00000173315 UniProtKB/TrEMBL
  ENSMUST00000173647 UniProtKB/TrEMBL
  ENSMUST00000174265 UniProtKB/Swiss-Prot
  ENSMUST00000174787 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-6/11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96055 ENTREZGENE
NCBI Gene 15170 ENTREZGENE
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PTPN6 RGD
PhenoGen Ptpn6 PhenoGen
PIRSF Tyr-Ptase_nr_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3UWU7_MOUSE UniProtKB/TrEMBL
  G3UXM2_MOUSE UniProtKB/TrEMBL
  G3UYY5_MOUSE UniProtKB/TrEMBL
  G3UZU6_MOUSE UniProtKB/TrEMBL
  P29351 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3TE70_MOUSE UniProtKB/TrEMBL
  Q3UB72 ENTREZGENE, UniProtKB/TrEMBL
  Q3UCJ0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O35128 UniProtKB/Swiss-Prot
  Q63872 UniProtKB/Swiss-Prot
  Q63873 UniProtKB/Swiss-Prot
  Q63874 UniProtKB/Swiss-Prot
  Q921G3 UniProtKB/Swiss-Prot
  Q9QVA6 UniProtKB/Swiss-Prot
  Q9QVA7 UniProtKB/Swiss-Prot
  Q9QVA8 UniProtKB/Swiss-Prot
  Q9R0V6 UniProtKB/Swiss-Prot