Nck1 (non-catalytic region of tyrosine kinase adaptor protein 1) - Rat Genome Database
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Gene: Nck1 (non-catalytic region of tyrosine kinase adaptor protein 1) Mus musculus
Analyze
Symbol: Nck1
Name: non-catalytic region of tyrosine kinase adaptor protein 1
RGD ID: 1321737
MGI Page MGI
Description: Exhibits ephrin receptor binding activity; eukaryotic initiation factor eIF2 binding activity; and protein domain specific binding activity. Involved in several processes, including plasma membrane bounded cell projection assembly; regulation of cellular macromolecule biosynthetic process; and regulation of response to endoplasmic reticulum stress. Localizes to cell-cell junction and vesicle membrane. Is expressed in several structures, including extraembryonic component; heart; hemolymphoid system gland; nervous system; and somite. Orthologous to human NCK1 (NCK adaptor protein 1); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6330586M15Rik; cytoplasmic protein NCK1; D230010O13Rik; Nc; Nck; NCK adaptor protein 1; Nck-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399100,376,047 - 100,428,187 (-)NCBIGRCm39mm39
GRCm389100,494,302 - 100,546,134 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9100,492,293 - 100,546,134 (-)EnsemblGRCm38mm10GRCm38
MGSCv379100,395,422 - 100,446,472 (-)NCBIGRCm37mm9NCBIm37
MGSCv369100,304,355 - 100,355,405 (-)NCBImm8
Celera9100,033,773 - 100,084,727 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1409582   PMID:7517397   PMID:8438166   PMID:8635998   PMID:8702917   PMID:9032297   PMID:9163738   PMID:9233798   PMID:9346925   PMID:9737977   PMID:10349636   PMID:10669731  
PMID:10967110   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11470823   PMID:11959995   PMID:12093790   PMID:12147689   PMID:12477932   PMID:12520002   PMID:12637565   PMID:12808099  
PMID:12904583   PMID:14580336   PMID:14610273   PMID:14676213   PMID:14757753   PMID:15110774   PMID:15148308   PMID:15201339   PMID:15608642   PMID:15684033   PMID:15782199   PMID:15972658  
PMID:16141072   PMID:16141073   PMID:16525419   PMID:16543952   PMID:16769879   PMID:16777958   PMID:16835242   PMID:16919269   PMID:16966330   PMID:17481396   PMID:17923684   PMID:18093944  
PMID:18765673   PMID:18799693   PMID:19242519   PMID:19371741   PMID:19414610   PMID:19443634   PMID:19505147   PMID:19596797   PMID:19778379   PMID:19917259   PMID:20129698   PMID:20332103  
PMID:20587749   PMID:20697350   PMID:20709959   PMID:21078909   PMID:21267068   PMID:21677750   PMID:22454526   PMID:22613834   PMID:22840396   PMID:22966049   PMID:23267019   PMID:23280595  
PMID:23444376   PMID:23707428   PMID:23793062   PMID:23913047   PMID:24371088   PMID:24470497   PMID:25468995   PMID:25691664   PMID:25714462   PMID:25913325   PMID:25995205   PMID:26434994  
PMID:26621720   PMID:26659946   PMID:30208322   PMID:32325033   PMID:32446368  


Genomics

Comparative Map Data
Nck1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399100,376,047 - 100,428,187 (-)NCBIGRCm39mm39
GRCm389100,494,302 - 100,546,134 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9100,492,293 - 100,546,134 (-)EnsemblGRCm38mm10GRCm38
MGSCv379100,395,422 - 100,446,472 (-)NCBIGRCm37mm9NCBIm37
MGSCv369100,304,355 - 100,355,405 (-)NCBImm8
Celera9100,033,773 - 100,084,727 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
NCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3136,862,208 - 136,951,606 (+)EnsemblGRCh38hg38GRCh38
GRCh383136,862,208 - 136,951,606 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373136,581,050 - 136,670,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363138,063,763 - 138,150,658 (+)NCBINCBI36hg18NCBI36
Build 343138,063,770 - 138,150,665NCBI
Celera3135,007,352 - 135,094,246 (+)NCBI
Cytogenetic Map3q22.3NCBI
HuRef3133,957,144 - 134,043,755 (+)NCBIHuRef
CHM1_13136,544,712 - 136,634,091 (+)NCBICHM1_1
Nck1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08108,787,797 - 108,847,779 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8108,787,798 - 108,847,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08108,204,372 - 108,264,127 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48105,346,933 - 105,409,843 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18105,365,785 - 105,380,767 (-)NCBI
Celera8100,416,045 - 100,476,576 (-)NCBICelera
Cytogenetic Map8q31NCBI
Nck1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555011,867,956 - 1,963,091 (-)NCBIChiLan1.0ChiLan1.0
NCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13141,362,407 - 141,451,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3141,427,870 - 141,451,444 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03133,902,463 - 133,990,414 (+)NCBIMhudiblu_PPA_v0panPan3
NCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2333,297,756 - 33,372,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12333,297,660 - 33,374,025 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nck1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365299,647,161 - 9,718,512 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1377,863,701 - 77,986,156 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11377,863,655 - 77,940,944 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21385,560,199 - 85,580,490 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NCK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1553,500,623 - 53,523,576 (-)Ensembl
ChlSab1.11553,501,152 - 53,595,500 (-)NCBI
Nck1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473013,271,575 - 13,366,930 (+)NCBI

Position Markers
PMC164855P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389100,508,517 - 100,508,726UniSTSGRCm38
MGSCv379100,408,936 - 100,409,145UniSTSGRCm37
Celera9100,047,221 - 100,047,430UniSTS
Cytogenetic Map9E3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:892
Count of miRNA genes:509
Interacting mature miRNAs:589
Transcripts:ENSMUST00000112874, ENSMUST00000116522
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000112874   ⟹   ENSMUSP00000108495
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9100,495,003 - 100,506,856 (-)Ensembl
RefSeq Acc Id: ENSMUST00000116522   ⟹   ENSMUSP00000112221
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9100,492,293 - 100,546,134 (-)Ensembl
RefSeq Acc Id: ENSMUST00000186591   ⟹   ENSMUSP00000140971
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9100,497,577 - 100,546,122 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188670   ⟹   ENSMUSP00000140143
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9100,497,800 - 100,545,731 (-)Ensembl
RefSeq Acc Id: NM_001324530   ⟹   NP_001311459
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399100,376,355 - 100,388,909 (-)NCBI
GRCm389100,494,302 - 100,506,856 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010878   ⟹   NP_035008
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399100,376,355 - 100,428,187 (-)NCBI
GRCm389100,494,302 - 100,546,134 (-)NCBI
MGSCv379100,395,422 - 100,446,472 (-)RGD
Celera9100,033,773 - 100,084,727 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510840   ⟹   XP_006510903
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399100,376,047 - 100,427,894 (-)NCBI
GRCm389100,494,988 - 100,545,841 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035008   ⟸   NM_010878
- Peptide Label: isoform 1
- UniProtKB: Q99M51 (UniProtKB/Swiss-Prot),   Q8BH99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510903   ⟸   XM_006510840
- Peptide Label: isoform X1
- UniProtKB: Q99M51 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001311459   ⟸   NM_001324530
- Peptide Label: isoform 2
- UniProtKB: Q8BH99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000140971   ⟸   ENSMUST00000186591
RefSeq Acc Id: ENSMUSP00000108495   ⟸   ENSMUST00000112874
RefSeq Acc Id: ENSMUSP00000140143   ⟸   ENSMUST00000188670
RefSeq Acc Id: ENSMUSP00000112221   ⟸   ENSMUST00000116522
Protein Domains
SH2   SH3

Promoters
RGD ID:6844866
Promoter ID:MM_KWN:58521
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6
Transcripts:OTTMUST00000049789
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369100,406,941 - 100,407,441 (-)MPROMDB
RGD ID:6844864
Promoter ID:MM_KWN:58524
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   Kidney,   Liver,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000116522
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369100,446,399 - 100,446,899 (-)MPROMDB
RGD ID:8670586
Promoter ID:EPDNEW_M13323
Type:initiation region
Name:Nck1_1
Description:Mus musculus non-catalytic region of tyrosine kinase adaptorprotein 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389100,546,109 - 100,546,169EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109601 AgrOrtholog
Ensembl Genes ENSMUSG00000032475 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000108495 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000112221 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000140143 UniProtKB/TrEMBL
  ENSMUSP00000140971 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000112874 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000116522 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000186591 UniProtKB/TrEMBL
  ENSMUST00000188670 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nck1_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nck1_SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nck1_SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nck1_SH3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17973 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109601 ENTREZGENE
NCBI Gene 17973 ENTREZGENE
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nck1 PhenoGen
PIRSF Cytoplasmic_NCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.181485 ENTREZGENE
UniProt A0A087WQD1_MOUSE UniProtKB/TrEMBL
  A0A087WSB1_MOUSE UniProtKB/TrEMBL
  NCK1_MOUSE UniProtKB/Swiss-Prot
  Q8BH99 ENTREZGENE, UniProtKB/TrEMBL
  Q8BMV0_MOUSE UniProtKB/TrEMBL
  Q99M51 ENTREZGENE
UniProt Secondary O55032 UniProtKB/Swiss-Prot
  Q9Z279 UniProtKB/Swiss-Prot