Gene: Nck1 (non-catalytic region of tyrosine kinase adaptor protein 1) Mus musculus
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Symbol:
Nck1
Name:
non-catalytic region of tyrosine kinase adaptor protein 1
Description:
ENCODES a protein that exhibits ephrin receptor binding; eukaryotic initiation factor eIF2 binding; protein domain specific binding; INVOLVED IN actin filament organization; cell migration; ephrin receptor signaling pathway; PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH abnormal allantois morphology; abnormal axon guidance; abnormal brain commissure morphology; ASSOCIATED WITH Albuminuria (ortholog); nephrotic syndrome (ortholog); proteinuria (ortholog); FOUND IN cell-cell junction; vesicle membrane; cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
6330586M15Rik; cytoplasmic protein NCK1; D230010O13Rik; Nck; NCK adaptor protein 1; Nck-1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NCK1 (NCK adaptor protein 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Nck1 (NCK adaptor protein 1) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Nck1 (NCK adaptor protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NCK1 (NCK adaptor protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NCK1 (NCK adaptor protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nck1 (NCK adaptor protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NCK1 (NCK adaptor protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Nck1 (NCK adaptor protein 1)
Alliance
DIOPT (Hieranoid, OrthoFinder, PANTHER, PhylomeDB)
Homo sapiens (human):
NCK1 (NCK adaptor protein 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
nck1b (NCK adaptor protein 1b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Danio rerio (zebrafish):
nck1a (NCK adaptor protein 1a)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
nck-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
dock
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 100,494,302 - 100,546,134 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 100,395,422 - 100,446,472 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 100,304,355 - 100,355,405 (-) NCBI mm8 Celera 9 100,033,773 - 100,084,727 (-) NCBI Celera Cytogenetic Map 9 E3.3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1321736 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NCK1 mRNA CTD PMID:22079256 14-Deoxy-11,12-didehydroandrographolide increases expression ISO RGD:1321736 6480464 14-deoxy-11, 12-didehydroandrographolide results in increased expression of NCK1 mRNA CTD PMID:22101062 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of NCK1 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:1310688 6480464 2, 4-dinitrotoluene affects the expression of NCK1 mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:1321736 6480464 beta-methylcholine affects the expression of NCK1 mRNA CTD PMID:21179406 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of NCK1 mRNA CTD PMID:26251327 3,4-methylenedioxymethamphetamine increases methylation EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased methylation of NCK1 promoter CTD PMID:26251327 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of NCK1 mRNA CTD PMID:18648102 4-hydroxynon-2-enal decreases expression ISO RGD:1321736 6480464 4-hydroxy-2-nonenal results in decreased expression of NCK1 mRNA CTD PMID:12419474 all-trans-retinoic acid decreases expression ISO RGD:1321736 6480464 Tretinoin results in decreased expression of NCK1 mRNA CTD PMID:15498508 aristolochic acid multiple interactions ISO RGD:1321736 6480464 aristolochic acid I inhibits the reaction [SLIT2 protein results in increased expression of NCK1 mRNA] more ... CTD PMID:30381256 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1321736 6480464 7 more ... CTD PMID:19150397 bisphenol A decreases expression ISO RGD:1321736 6480464 bisphenol A results in decreased expression of NCK1 mRNA CTD PMID:20678512 bisphenol A increases expression ISO RGD:1310688 6480464 bisphenol A results in increased expression of NCK1 mRNA CTD PMID:25181051 cyclosporin A increases expression ISO RGD:1321736 6480464 Cyclosporine results in increased expression of NCK1 mRNA CTD PMID:20106945 , PMID:25562108 dicrotophos decreases expression ISO RGD:1321736 6480464 dicrotophos results in decreased expression of NCK1 mRNA CTD PMID:28302478 Diisodecyl phthalate increases expression EXP 6480464 diisodecyl phthalate results in increased expression of NCK1 mRNA CTD PMID:25270620 ethanol multiple interactions ISO RGD:1321736 6480464 [[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of NCK1 mRNA CTD PMID:29432896 gentamycin increases expression ISO RGD:1310688 6480464 Gentamicins results in increased expression of NCK1 mRNA CTD PMID:22061828 irinotecan decreases expression ISO RGD:1321736 6480464 Irinotecan metabolite results in decreased expression of NCK1 mRNA, Irinotecan results in decreased expression of NCK1 mRNA CTD PMID:15956246 methotrexate decreases expression ISO RGD:1321736 6480464 Methotrexate results in decreased expression of NCK1 mRNA CTD PMID:17400583 methoxychlor increases methylation ISO RGD:1310688 6480464 Methoxychlor results in increased methylation of NCK1 gene CTD PMID:23303685 methyl methanesulfonate decreases expression ISO RGD:1321736 6480464 Methyl Methanesulfonate results in decreased expression of NCK1 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:1321736 6480464 methylmercuric chloride results in decreased expression of NCK1 mRNA CTD PMID:28001369 phenobarbital affects expression ISO RGD:1321736 6480464 Phenobarbital affects the expression of NCK1 mRNA CTD PMID:19159669 phenylmercury acetate decreases expression ISO RGD:1321736 6480464 Phenylmercuric Acetate results in decreased expression of NCK1 mRNA CTD PMID:26272509 piroxicam decreases expression ISO RGD:1321736 6480464 Piroxicam results in decreased expression of NCK1 mRNA CTD PMID:21858171 potassium chromate decreases expression ISO RGD:1321736 6480464 potassium chromate(VI) results in decreased expression of NCK1 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:1321736 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NCK1 mRNA CTD PMID:22079256 progesterone increases expression ISO RGD:1310688 6480464 Progesterone results in increased expression of NCK1 mRNA CTD PMID:21770760 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of NCK1 mRNA CTD PMID:21278054 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of NCK1 mRNA CTD PMID:23221170 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of NCK1 mRNA CTD PMID:30953684 sodium arsenite increases expression ISO RGD:1321736 6480464 sodium arsenite results in increased expression of NCK1 mRNA CTD PMID:12016162 tamibarotene affects expression ISO RGD:1321736 6480464 tamibarotene affects the expression of NCK1 mRNA CTD PMID:15498508 trichostatin A multiple interactions ISO RGD:1321736 6480464 [decitabine co-treated with trichostatin A] results in increased expression of NCK1 mRNA CTD PMID:20678512 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of NCK1 mRNA CTD PMID:28973697 valproic acid decreases expression ISO RGD:1321736 6480464 Valproic Acid results in decreased expression of NCK1 mRNA CTD PMID:26272509 , PMID:29154799 zoledronic acid increases expression ISO RGD:1321736 6480464 zoledronic acid results in increased expression of NCK1 mRNA CTD PMID:24714768 
Gene-Chemical Interaction Annotations
