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Gene: Cd3e (CD3 antigen, epsilon polypeptide) Mus musculus
Symbol: Cd3e
Name: CD3 antigen, epsilon polypeptide
Description: Predicted to have SH3 domain binding activity; protein dimerization activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of cell-cell adhesion; positive regulation of cytokine production; and regulation of signal transduction. Localizes to several cellular components, including the alpha-beta T cell receptor complex; external side of plasma membrane; and immunological synapse. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in colon and hemolymphoid system. Orthologous to human CD3E (CD3e molecule); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; Chagas disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP; aluminium trifluoride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI504783; CD3; CD3epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3e
Homo sapiens (human) : CD3E (CD3e molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd3e (CD3e molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd3e (CD3e molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD3E (CD3e molecule)
Canis lupus familiaris (dog) : CD3E (CD3e molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd3e (CD3e molecule)
Sus scrofa (pig) : CD3E (CD3e molecule)
Chlorocebus sabaeus (green monkey) : CD3E (CD3e molecule)
Heterocephalus glaber (naked mole-rat) : Cd3e (CD3e molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl944,998,740 - 45,009,627 (-)Ensembl
GRCm38944,998,735 - 45,009,663 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37944,806,826 - 44,817,673 (-)NCBIGRCm37mm9NCBIm37
MGSCv36944,749,738 - 44,760,585 (-)NCBImm8
Celera942,267,117 - 42,278,016 (-)NCBICelera
Cytogenetic Map9 A5.2NCBI
cM Map924.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cd3e
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319443
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.