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Gene: Cd3e (CD3 antigen, epsilon polypeptide) Mus musculus
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Symbol: Cd3e
Name: CD3 antigen, epsilon polypeptide
Description: Predicted to have SH3 domain binding activity; protein dimerization activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of cell-cell adhesion; positive regulation of cytokine production; and regulation of signal transduction. Localizes to several cellular components, including the alpha-beta T cell receptor complex; external side of plasma membrane; and immunological synapse. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in colon and hemolymphoid system. Orthologous to human CD3E (CD3e molecule); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; Chagas disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP; aluminium trifluoride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI504783; CD3; CD3epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3e
Orthologs:
Homo sapiens (human) : CD3E (CD3e molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd3e (CD3e molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd3e (CD3e molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD3E (CD3e molecule)
Canis lupus familiaris (dog) : CD3E (CD3e molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd3e (CD3e molecule)
Sus scrofa (pig) : CD3E (CD3e molecule)
Chlorocebus sabaeus (green monkey) : CD3E (CD3e molecule)
Heterocephalus glaber (naked mole-rat) : Cd3e (CD3e molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl944,998,740 - 45,009,627 (-)Ensembl
GRCm38944,998,735 - 45,009,663 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37944,806,826 - 44,817,673 (-)NCBIGRCm37mm9NCBIm37
MGSCv36944,749,738 - 44,760,585 (-)NCBImm8
Celera942,267,117 - 42,278,016 (-)NCBICelera
Cytogenetic Map9 A5.2NCBI
cM Map924.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cd3e
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319443
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.