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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Nerve Degeneration
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Accession:DOID:9002955 term browser browse the term
Definition:Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Synonyms:exact_synonym: Nerve Degenerations;   Neuron Degeneration;   Neuron Degenerations
 related_synonym: striatal degeneration
 primary_id: MESH:D009410


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Nerve Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor EXP CTD Direct Evidence: therapeutic CTD PMID:23437309 NCBI chr 1:203,127,726...203,167,405
Ensembl chr 1:203,090,654...203,167,405 		JBrowse link
G ADRA1B adrenoceptor alpha 1B EXP CTD Direct Evidence: marker/mechanism CTD PMID:12871582 NCBI chr 5:159,865,086...159,989,205
Ensembl chr 5:159,865,080...159,973,012 		JBrowse link
G AGTPBP1 ATP/GTP binding carboxypeptidase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16952463 NCBI chr 9:85,546,539...85,805,483
Ensembl chr 9:85,546,539...85,742,029 		JBrowse link
G ANGPT1 angiopoietin 1 EXP CTD Direct Evidence: therapeutic CTD PMID:30476904 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055 		JBrowse link
G ANK2 ankyrin 2 ISO RGD PMID:12949909 RGD:1599116 NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221 		JBrowse link
G APLP2 amyloid beta precursor like protein 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11784781 NCBI chr11:130,069,894...130,144,805
Ensembl chr11:130,068,147...130,144,811 		JBrowse link
G APOE apolipoprotein E EXP CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G APP amyloid beta precursor protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:11784781 PMID:11800653 PMID:12396081 PMID:12963085 PMID:16951259 More... NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G ARG2 arginase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:30618589 NCBI chr14:67,619,920...67,651,708
Ensembl chr14:67,619,920...67,651,708 		JBrowse link
G ATP13A2 ATPase cation transporting 13A2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22847264 NCBI chr 1:16,985,958...17,011,928
Ensembl chr 1:16,985,958...17,011,928 		JBrowse link
G ATRN attractin EXP CTD Direct Evidence: marker/mechanism CTD PMID:16860906 NCBI chr20:3,471,018...3,651,118
Ensembl chr20:3,471,018...3,651,118 		JBrowse link
G ATXN3 ataxin 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:9635424 NCBI chr14:92,044,775...92,106,582
Ensembl chr14:92,044,496...92,106,621 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19740541 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator EXP CTD Direct Evidence: therapeutic CTD PMID:20385067 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator EXP CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:11146106 PMID:17967740 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BDNF brain derived neurotrophic factor ISO
EXP		 CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:8921280 PMID:8978711 PMID:15372491 PMID:19457078 PMID:19686240 More... RGD:10059347 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G BECN1 beclin 1 ISO protein:increased expression:lumbar spinal cord ventral horn RGD PMID:21436843 RGD:5685686 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G C9orf72 C9orf72-SMCR8 complex subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:33661518 NCBI chr 9:27,546,546...27,573,866
Ensembl chr 9:27,535,640...27,573,866 		JBrowse link
G CASP3 caspase 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:14999069 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CD4 CD4 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:9546790 NCBI chr12:6,789,528...6,820,799
Ensembl chr12:6,786,858...6,820,799 		JBrowse link
G CD44 CD44 molecule (IN blood group) EXP CTD Direct Evidence: marker/mechanism CTD PMID:15191797 NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402 		JBrowse link
G CD9 CD9 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr12:6,199,946...6,238,266
Ensembl chr12:6,199,715...6,238,271 		JBrowse link
G CDH1 cadherin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12387456 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CDH2 cadherin 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12387456 NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946 		JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17581637 NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit EXP CTD Direct Evidence: therapeutic CTD PMID:21715663 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit EXP CTD Direct Evidence: therapeutic CTD PMID:21715663 NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO
EXP		 CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:11517236 PMID:24211273 PMID:18313855 RGD:10059347 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G CNTF ciliary neurotrophic factor EXP CTD Direct Evidence: therapeutic CTD PMID:15372491 NCBI chr11:58,622,665...58,625,733
Ensembl chr11:58,622,665...58,625,733 		JBrowse link
G CP ceruloplasmin EXP CTD Direct Evidence: therapeutic CTD PMID:18804145 NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829 		JBrowse link
G CTNNB1 catenin beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12387456 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G DAG1 dystroglycan 1 ISO RGD PMID:16228655 RGD:11537480 NCBI chr 3:49,468,948...49,535,615
Ensembl chr 3:49,468,713...49,535,618 		JBrowse link
G DDC dopa decarboxylase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405 		JBrowse link
G DDIT4 DNA damage inducible transcript 4 EXP CTD Direct Evidence: therapeutic CTD PMID:17005863 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036 		JBrowse link
G EEF1A2 eukaryotic translation elongation factor 1 alpha 2 ISO protein:increased expression:CA1&CA3 fields of hippocampus: RGD PMID:8750861 RGD:10401216 NCBI chr20:63,488,014...63,499,083
Ensembl chr20:63,488,013...63,499,239 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:16492139 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516 		JBrowse link
G EPO erythropoietin EXP CTD Direct Evidence: therapeutic CTD PMID:17010629 PMID:17166730 PMID:19497871 PMID:30837834 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700 		JBrowse link
G EPOR erythropoietin receptor EXP CTD Direct Evidence: therapeutic CTD PMID:19497871 NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342 		JBrowse link
G ETS2 ETS proto-oncogene 2, transcription factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr21:38,805,183...38,824,955
Ensembl chr21:38,805,183...38,824,955 		JBrowse link
G F2 coagulation factor II, thrombin EXP CTD Direct Evidence: marker/mechanism CTD PMID:19969022 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506 		JBrowse link
G FGF2 fibroblast growth factor 2 EXP CTD Direct Evidence: therapeutic CTD PMID:10203697 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide EXP CTD Direct Evidence: therapeutic CTD PMID:19429016 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947 		JBrowse link
G GRIN2D glutamate ionotropic receptor NMDA type subunit 2D EXP CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr19:48,393,668...48,444,931
Ensembl chr19:48,393,668...48,444,931 		JBrowse link
G GRM4 glutamate metabotropic receptor 4 EXP CTD Direct Evidence: therapeutic CTD PMID:17446080 NCBI chr 6:34,018,643...34,155,622
Ensembl chr 6:34,018,643...34,155,622 		JBrowse link
G GRN granulin precursor EXP CTD Direct Evidence: therapeutic CTD PMID:21820214 NCBI chr17:44,345,302...44,353,106
Ensembl chr17:44,345,246...44,353,106 		JBrowse link
G HOTAIR HOX transcript antisense RNA EXP CTD Direct Evidence: therapeutic CTD PMID:32968928 NCBI chr12:53,962,312...53,974,954
Ensembl chr12:53,962,308...53,975,055 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO protein:decreased expression:spinal cord RGD PMID:21436843 RGD:5685686 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G IFNG interferon gamma EXP CTD Direct Evidence: marker/mechanism CTD PMID:15153526 PMID:16307444 PMID:19457078 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IGF1 insulin like growth factor 1 EXP CTD Direct Evidence: therapeutic CTD PMID:9452187 PMID:10203697 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF2 insulin like growth factor 2 EXP CTD Direct Evidence: therapeutic CTD PMID:24667322 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391 		JBrowse link
G ITGAM integrin subunit alpha M EXP CTD Direct Evidence: therapeutic CTD PMID:32375810 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G KCNJ4 potassium inwardly rectifying channel subfamily J member 4 EXP CTD Direct Evidence: therapeutic CTD PMID:18619942 NCBI chr22:38,426,327...38,455,199
Ensembl chr22:38,426,327...38,455,199 		JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15256069 NCBI chr21:37,607,373...37,916,457
Ensembl chr21:37,607,373...38,121,345 		JBrowse link
G LAMC1 laminin subunit gamma 1 EXP CTD Direct Evidence: therapeutic CTD PMID:30476904 NCBI chr 1:183,023,420...183,145,592
Ensembl chr 1:183,023,420...183,145,592 		JBrowse link
G LEP leptin EXP CTD Direct Evidence: therapeutic CTD PMID:17993459 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LRP8 LDL receptor related protein 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18172410 NCBI chr 1:53,242,364...53,328,070
Ensembl chr 1:53,242,364...53,328,469 		JBrowse link
G LRRK2 leucine rich repeat kinase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19741132 NCBI chr12:40,224,997...40,369,285
Ensembl chr12:40,196,744...40,369,285 		JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha ISO protein:increased expression:lumbar spinal cord ventral horn RGD PMID:21436843 RGD:5685686 NCBI chr20:34,546,844...34,560,345
Ensembl chr20:34,546,854...34,560,345 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MIR204 microRNA 204 EXP CTD Direct Evidence: therapeutic CTD PMID:36177783 NCBI chr 9:70,809,975...70,810,084
Ensembl chr 9:70,809,975...70,810,084 		JBrowse link
G MPZ myelin protein zero EXP CTD Direct Evidence: marker/mechanism CTD PMID:16676325 NCBI chr 1:161,303,600...161,309,968
Ensembl chr 1:161,304,735...161,309,968 		JBrowse link
G MT1X metallothionein 1X ISO CTD Direct Evidence: therapeutic CTD PMID:11835189 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196 		JBrowse link
G MT2A metallothionein 2A ISO CTD Direct Evidence: therapeutic CTD PMID:11835189 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497 		JBrowse link
G NGF nerve growth factor EXP CTD Direct Evidence: therapeutic CTD PMID:22666365 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NGFR nerve growth factor receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:10436046 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008 		JBrowse link
G NOS1 nitric oxide synthase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:9436549 PMID:10791088 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170 		JBrowse link
G NRG1 neuregulin 1 ISO mRNA:decreased expression:median nerve RGD PMID:28059646 RGD:405255649 NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666 		JBrowse link
G NTF3 neurotrophin 3 EXP CTD Direct Evidence: therapeutic CTD PMID:8921280 PMID:8978711 NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536 		JBrowse link
G NTF4 neurotrophin 4 ISO
EXP		 CTD Direct Evidence: therapeutic CTD PMID:8921280 NCBI chr19:49,058,284...49,065,035
Ensembl chr19:49,061,066...49,065,076 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase EXP CTD Direct Evidence: marker/mechanism CTD PMID:26629949 NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219 		JBrowse link
G OTC ornithine transcarbamylase EXP CTD Direct Evidence: marker/mechanism CTD PMID:24161480 NCBI chr  X:38,327,684...38,422,928
Ensembl chr  X:38,327,598...38,422,908 		JBrowse link
G OTX2 orthodenticle homeobox 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20573704 NCBI chr14:56,799,905...56,810,479
Ensembl chr14:56,799,905...56,816,693 		JBrowse link
G PANK1 pantothenate kinase 1 EXP CTD Direct Evidence: therapeutic CTD PMID:35589691 NCBI chr10:89,579,495...89,645,242
Ensembl chr10:89,579,497...89,645,242 		JBrowse link
G PANK2 pantothenate kinase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20493851 NCBI chr20:3,888,781...3,929,887
Ensembl chr20:3,888,839...3,929,887 		JBrowse link
G PARK7 Parkinsonism associated deglycase EXP CTD Direct Evidence: therapeutic CTD PMID:29649621 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505 		JBrowse link
G PDE8B phosphodiesterase 8B IAGP ClinVar Annotator: match by term: Striatal Degeneration ClinVar PMID:25741868 NCBI chr 5:77,086,715...77,428,256
Ensembl chr 5:77,210,449...77,428,256
Ensembl chr 5:77,210,449...77,428,256 		JBrowse link
G PINK1 PTEN induced kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24161480 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
G PLAT plasminogen activator, tissue type EXP CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma EXP CTD Direct Evidence: therapeutic CTD PMID:18289512 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase EXP CTD Direct Evidence: marker/mechanism CTD PMID:17687034 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775 		JBrowse link
G PSEN1 presenilin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19522546 PMID:33971107 NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691 		JBrowse link
G PTPN5 protein tyrosine phosphatase non-receptor type 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17360923 NCBI chr11:18,727,928...18,792,721
Ensembl chr11:18,727,928...18,792,721 		JBrowse link
G SELENOP selenoprotein P EXP CTD Direct Evidence: marker/mechanism CTD PMID:18172410 NCBI chr 5:42,799,880...42,811,892
Ensembl chr 5:42,799,880...42,887,392 		JBrowse link
G SIRT1 sirtuin 1 EXP CTD Direct Evidence: therapeutic CTD PMID:17581637 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18643795 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430 		JBrowse link
G SLC1A1 solute carrier family 1 member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28703795 NCBI chr 9:4,490,468...4,587,469
Ensembl chr 9:4,490,468...4,587,469 		JBrowse link
G SLC1A2 solute carrier family 1 member 2 EXP CTD Direct Evidence: therapeutic CTD PMID:22645130 NCBI chr11:35,251,205...35,420,507
Ensembl chr11:35,251,205...35,420,063 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12871582 PMID:18206288 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440 		JBrowse link
G SNCA synuclein alpha EXP CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21039522 PMID:23106139 PMID:27585560 PMID:34562559 PMID:38311184 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
G SNCG synuclein gamma ISO RGD PMID:19246516 RGD:6478696 NCBI chr10:86,955,759...86,963,258
Ensembl chr10:86,958,599...86,963,258 		JBrowse link
G SOD1 superoxide dismutase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17581637 PMID:19243126 PMID:24885036 PMID:24918341 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 EXP CTD Direct Evidence: therapeutic CTD PMID:11146106 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G TF transferrin resistance ISO RGD PMID:17010319 RGD:1601536 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641 		JBrowse link
G TFEB transcription factor EB EXP CTD Direct Evidence: therapeutic CTD PMID:34562559 NCBI chr 6:41,683,978...41,736,223
Ensembl chr 6:41,683,978...41,736,259 		JBrowse link
G TGFA transforming growth factor alpha EXP CTD Direct Evidence: therapeutic CTD PMID:9263032 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193 		JBrowse link
G TH tyrosine hydroxylase EXP CTD Direct Evidence: marker/mechanism CTD PMID:12871582 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase EXP CTD Direct Evidence: therapeutic CTD PMID:33359019 NCBI chr12:4,321,213...4,360,028
Ensembl chr12:4,307,763...4,360,028 		JBrowse link
G TNF tumor necrosis factor EXP CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9710261 PMID:15153526 PMID:22921461 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TSC2 TSC complex subunit 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21419848 NCBI chr16:2,047,985...2,089,491
Ensembl chr16:2,047,967...2,089,491 		JBrowse link
G UCHL3 ubiquitin C-terminal hydrolase L3 ISO RGD PMID:11555633 RGD:1302546 NCBI chr13:75,549,502...75,606,020
Ensembl chr13:75,549,483...75,606,020 		JBrowse link
G VEGFA vascular endothelial growth factor A treatment IDA associated with Diabetes Mellitus, Experimental; RGD PMID:26201024 RGD:11079183 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VPS54 VPS54 subunit of GARP complex EXP CTD Direct Evidence: marker/mechanism CTD PMID:19693665 NCBI chr 2:63,892,150...64,019,428
Ensembl chr 2:63,892,146...64,019,428 		JBrowse link
G XDH xanthine dehydrogenase EXP CTD Direct Evidence: marker/mechanism CTD PMID:9147382 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742 		JBrowse link
G ZMAT3 zinc finger matrin-type 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17234339 NCBI chr 3:179,017,223...179,072,513
Ensembl chr 3:178,960,121...179,072,215 		JBrowse link
G ZNF274 zinc finger protein 274 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18815271 NCBI chr19:58,183,061...58,213,562
Ensembl chr19:58,183,029...58,213,562 		JBrowse link
Retrograde Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QB complement C1q B chain ISO mRNA:increased expression RGD PMID:16934480 RGD:1599508 NCBI chr 1:22,653,236...22,661,637
Ensembl chr 1:22,652,762...22,661,637 		JBrowse link
G NGF nerve growth factor ISO RGD PMID:29609077 RGD:402463965 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NGFR nerve growth factor receptor ISO protein:decreased expression:forebrain RGD PMID:29609077 RGD:402463965 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO protein:decreased expression:forebrain RGD PMID:29609077 RGD:402463965 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,636...156,881,850 		JBrowse link
Skeletal Dysplasia And Progressive Central Nervous System Degeneration, Lethal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPV4 transient receptor potential cation channel subfamily V member 4 IAGP ClinVar Annotator: match by term: Skeletal dysplasia and progressive central nervous system degeneration, lethal ClinVar PMID:20425821 PMID:20577006 PMID:21573172 PMID:22791502 PMID:25741868 More... NCBI chr12:109,783,087...109,833,398
Ensembl chr12:109,783,087...109,833,406 		JBrowse link
striatal degeneration 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE10A phosphodiesterase 10A IAGP ClinVar Annotator: match by term: Striatal degeneration, autosomal dominant 2 OMIM
ClinVar		 PMID:25741868 PMID:27058447 PMID:28492532 PMID:29159890 PMID:29165877 NCBI chr 6:165,327,289...165,988,052
Ensembl chr 6:165,327,287...165,988,117 		JBrowse link
Striatal Degeneration, Autosomal Dominant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE8B phosphodiesterase 8B EXP CTD Direct Evidence: marker/mechanism CTD NCBI chr 5:77,086,715...77,428,256
Ensembl chr 5:77,210,449...77,428,256
Ensembl chr 5:77,210,449...77,428,256 		JBrowse link
Striatal Degeneration, Autosomal Dominant 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE8B phosphodiesterase 8B IAGP ClinVar Annotator: match by term: Striatal degeneration, autosomal dominant 1 ClinVar
OMIM		 PMID:24033266 PMID:25741868 PMID:26475694 PMID:26769607 PMID:28492532 NCBI chr 5:77,086,715...77,428,256
Ensembl chr 5:77,210,449...77,428,256
Ensembl chr 5:77,210,449...77,428,256 		JBrowse link
Subacute Combined Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD40 CD40 molecule treatment ISO RGD PMID:16716410 PMID:16716410 RGD:2313422, RGD:2313422 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863 		JBrowse link
G CD40LG CD40 ligand treatment ISO protein:increased expression:cerebrospinal fluid RGD PMID:16716410 PMID:16716410 RGD:2313422, RGD:2313422 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390 		JBrowse link
Thiamine Metabolism Dysfunction Syndrome 4 (Bilateral Striatal Degeneration and Progressive Polyneuropathy Type) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIF4GD-DT MIF4GD divergent transcript IAGP ClinVar Annotator: match by term: Striatal necrosis, bilateral, and progressive polyneuropathy ClinVar PMID:18414213 PMID:25741868 PMID:26467025 PMID:28492532 PMID:31295743 NCBI chr17:75,271,299...75,273,895
Ensembl chr17:75,271,369...75,273,895 		JBrowse link
G SLC25A19 solute carrier family 25 member 19 IAGP ClinVar Annotator: match by term: Striatal necrosis, bilateral, and progressive polyneuropathy
ClinVar Annotator: match by term: BILATERAL STRIATAL DEGENERATION AND PROGRESSIVE POLYNEUROPATHY | ClinVar Annotator: match by term: Striatal necrosis, bilateral, and progressive polyneuropathy		 ClinVar
OMIM		 PMID:18414213 PMID:19798730 PMID:25741868 PMID:26467025 PMID:28492532 More... NCBI chr17:75,272,992...75,289,433
Ensembl chr17:75,272,981...75,289,510 		JBrowse link
Wallerian Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCAR2 cell cycle and apoptosis regulator 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24252177 NCBI chr 8:22,604,757...22,621,514
Ensembl chr 8:22,604,757...22,620,964 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:9030624 RGD:68774 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:9030624 RGD:68774 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505 		JBrowse link
G FCGR2A Fc gamma receptor IIa ISO mRNA:increased expression:sciatic nerve, macrophage RGD PMID:1533683 RGD:2316290 NCBI chr 1:161,505,457...161,524,048
Ensembl chr 1:161,505,430...161,524,013 		JBrowse link
G IL18 interleukin 18 ISO mRNA, protein:increased expression:macrophage, microglia: RGD PMID:11494369 RGD:4889526 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096 		JBrowse link
G MAG myelin associated glycoprotein ISO RGD PMID:12730963 RGD:9685301 NCBI chr19:35,292,161...35,313,807
Ensembl chr19:35,292,125...35,313,807 		JBrowse link
G NEFH neurofilament heavy chain ISO protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390 		JBrowse link
G NEFL neurofilament light chain ISO protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721 		JBrowse link
G NEFM neurofilament medium chain ISO protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098 		JBrowse link
G NF1 neurofibromin 1 ISO protein:increased expression:sciatic nerve: RGD PMID:8847098 RGD:12790590 NCBI chr17:31,094,927...31,377,677
Ensembl chr17:31,094,927...31,382,116 		JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 EXP CTD Direct Evidence: therapeutic CTD PMID:27822499 NCBI chr 1:9,942,923...9,996,892
Ensembl chr 1:9,943,428...9,985,501 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ISO RGD PMID:10320723 RGD:1642322 NCBI chr 4:163,323,962...163,344,689
Ensembl chr 4:163,323,962...163,344,832 		JBrowse link
G PGF placental growth factor ISO RGD PMID:21264946 RGD:6483582 NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626 		JBrowse link
G PLA2G4A phospholipase A2 group IVA ISO RGD PMID:14664823 PMID:18718965 RGD:1642469, RGD:6482738 NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981 		JBrowse link
G PLA2G6 phospholipase A2 group VI ISO RGD PMID:18718965 RGD:6482738 NCBI chr22:38,111,495...38,181,830
Ensembl chr22:38,111,495...38,214,778 		JBrowse link
G RXRA retinoid X receptor alpha ISO mRNA:increased expression:sciatic nerve RGD PMID:16782282 RGD:1643108 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585 		JBrowse link
G SIRT1 sirtuin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24252177 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SRSF3 serine and arginine rich splicing factor 3 ISO associated with Sciatic Neuropathy RGD PMID:8568916 RGD:10059662 NCBI chr 6:36,594,362...36,605,600
Ensembl chr 6:36,594,353...36,605,911 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO mRNA:increased expression:optic (II) nerve, sciatic nerve RGD PMID:14997937 RGD:2302105 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB2 transforming growth factor beta 2 ISO protein:decreased expression:sciatic nerve RGD PMID:14997937 RGD:2302105 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO mRNA, protein:increased expression:dorsal root ganglion RGD PMID:16683235 RGD:1600154 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO mRNA, protein:increased expression:dorsal root ganglion RGD PMID:16683235 RGD:1600154 NCBI chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:18003835 RGD:2312723 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:18003835 RGD:2312723 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G UBE4B ubiquitination factor E4B EXP CTD Direct Evidence: therapeutic CTD PMID:27822499 NCBI chr 1:10,032,958...10,181,239
Ensembl chr 1:10,032,832...10,181,239 		JBrowse link
Term paths to the root