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Gene: PTPN5 (protein tyrosine phosphatase non-receptor type 5) Homo sapiens
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Symbol: PTPN5
Name: protein tyrosine phosphatase non-receptor type 5
Description: Exhibits phosphotyrosine residue binding activity. Predicted to be involved in cellular response to cytokine stimulus and protein dephosphorylation. Predicted to localize to integral component of membrane and nucleoplasm. Biomarker of Alzheimer's disease; PARTICIPATES IN dopamine signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH aflatoxin B1; aflatoxin B2; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ14427; neural-specific protein-tyrosine phosphatase; protein-tyrosine phosphatase striatum-enriched; PTPSTEP; STEP; STEP61; striatal-enriched protein tyrosine phosphatase; striatum-enriched protein-tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 5
Orthologs:
Mus musculus (house mouse) : Ptpn5 (protein tyrosine phosphatase, non-receptor type 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptpn5 (protein tyrosine phosphatase, non-receptor type 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpn5 (protein tyrosine phosphatase non-receptor type 5)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPN5 (protein tyrosine phosphatase non-receptor type 5)
Canis lupus familiaris (dog) : PTPN5 (protein tyrosine phosphatase non-receptor type 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpn5 (protein tyrosine phosphatase non-receptor type 5)
Sus scrofa (pig) : PTPN5 (protein tyrosine phosphatase non-receptor type 5)
Chlorocebus sabaeus (African green monkey) : PTPN5 (protein tyrosine phosphatase non-receptor type 5)
Heterocephalus glaber (naked mole-rat) : Ptpn5 (protein tyrosine phosphatase non-receptor type 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1118,727,928 - 18,792,721 (-)EnsemblGRCh38hg38GRCh38
GRCh381118,727,928 - 18,792,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371118,749,475 - 18,814,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,706,051 - 18,769,965 (-)NCBINCBI36hg18NCBI36
Build 341118,706,052 - 18,769,874NCBI
Celera1118,885,312 - 18,948,746 (-)NCBI
Cytogenetic Map11p15.1NCBI
HuRef1118,434,330 - 18,498,764 (-)NCBIHuRef
CHM1_11118,748,812 - 18,813,611 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PTPN5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736589
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.