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Gene: NGFR (nerve growth factor receptor) Homo sapiens
Symbol: NGFR
Name: nerve growth factor receptor
Description: Exhibits several functions, including calmodulin binding activity; death receptor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and positive regulation of macromolecule metabolic process. Localizes to the plasma membrane. Implicated in Alzheimer's disease and mental depression. Biomarker of several diseases, including Hirschsprung's disease; Lewy body dementia; artery disease (multiple); neurodegenerative disease (multiple); and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD271; Gp80-LNGFR; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; p75(NTR); p75NTR; TNFR superfamily, member 16; TNFRSF16; tumor necrosis factor receptor superfamily member 16
Mus musculus (house mouse) : Ngfr (nerve growth factor receptor (TNFR superfamily, member 16))  MGI  Alliance
Rattus norvegicus (Norway rat) : Ngfr (nerve growth factor receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ngfr (nerve growth factor receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : NGFR (nerve growth factor receptor)
Canis lupus familiaris (dog) : NGFR (nerve growth factor receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ngfr (nerve growth factor receptor)
Sus scrofa (pig) : NGFR (nerve growth factor receptor)
Chlorocebus sabaeus (green monkey) : NGFR (nerve growth factor receptor)
Heterocephalus glaber (naked mole-rat) : Ngfr (nerve growth factor receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1749,495,293 - 49,515,008 (+)Ensembl
GRCh381749,495,293 - 49,515,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371747,572,655 - 47,592,382 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,927,666 - 44,947,360 (+)NCBINCBI36hg18NCBI36
Build 341744,927,665 - 44,947,360NCBI
Celera1744,027,660 - 44,047,391 (+)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1742,937,638 - 42,957,366 (+)NCBIHuRef
CHM1_11747,637,800 - 47,657,550 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NGFR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730911
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.