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Gene: FCGR2A (Fc fragment of IgG receptor IIa) Homo sapiens
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Symbol: FCGR2A
Name: Fc fragment of IgG receptor IIa
Description: Predicted to have IgG binding activity. Predicted to be involved in Fc-gamma receptor signaling pathway involved in phagocytosis and neutrophil degranulation. Localizes to the Golgi apparatus and plasma membrane. Implicated in several diseases, including arthritis (multiple); autoimmune hypersensitivity disease (multiple); dengue disease (multiple); hematologic cancer (multiple); and leukopenia (multiple). Biomarker of several diseases, including asthma; atopic dermatitis; autoimmune hypersensitivity disease (multiple); chronic myeloid leukemia; and common variable immunodeficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD32; CD32A; CDw32; Fc fragment of IgG, low affinity IIa, receptor (CD32); fc fragment of igg, low affinity iia, receptor for (cd32); Fc gamma receptor IIa; Fc gamma receptor RIIa3; fc-gamma RII-a; fc-gamma-RIIa; FCG2; FcGR; FCGR2; FCGR2A1; fcRII-a; IGFR2; igG Fc receptor II-a; Immunoglobulin G Fc receptor II; low affinity immunoglobulin gamma Fc region receptor II-a; MGC23887; MGC30032
Orthologs:
Mus musculus (house mouse) : Fcgr3 (Fc receptor, IgG, low affinity III)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fcgr2a (Fc fragment of IgG receptor IIa)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : FCGR2A (Fc fragment of IgG receptor IIa)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1161,505,430 - 161,524,013 (+)Ensembl
GRCh381161,505,430 - 161,524,048 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371161,475,205 - 161,489,360 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,741,844 - 159,755,984 (+)NCBINCBI36hg18NCBI36
Build 341158,288,274 - 158,302,415NCBI
Celera1134,682,428 - 134,687,972 (+)NCBI
Celera1134,591,741 - 134,592,404 (-)NCBI
Cytogenetic Map1q23.3NCBI
HuRef1132,800,353 - 132,814,372 (+)NCBIHuRef
CHM1_11162,897,042 - 162,911,192 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on FCGR2A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316933
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.