PGF (placental growth factor) - Rat Genome Database

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Gene: PGF (placental growth factor) Homo sapiens
Analyze
Symbol: PGF
Name: placental growth factor
RGD ID: 1347328
HGNC Page HGNC:8893
Description: Enables growth factor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); epilepsy (multiple); limited scleroderma; and pancreatic endocrine carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: D12S1900; PGFL; PIGF; placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein; placental growth factor-like; PLGF; PlGF-2; SHGC-10760
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: PGF (Gene ID: 5228) and PIGF (Gene ID: 5281) share the PIGF symbol/alias in common. PIGF is a widely used alternative gene symbol for placental growth factor (PGF), which can be confused with the official symbol for phosphatidylinositol glycan anchor biosynthesis class F (PIGF). [06 Jul 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,941,830 - 74,955,764 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,941,834 - 74,955,626 (-)EnsemblGRCh38hg38GRCh38
GRCh371475,408,533 - 75,422,467 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,478,290 - 74,492,044 (-)NCBINCBI36Build 36hg18NCBI36
Build 341474,478,292 - 74,492,044NCBI
Celera1455,446,919 - 55,460,674 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,576,546 - 55,590,481 (-)NCBIHuRef
CHM1_11475,347,700 - 75,361,635 (-)NCBICHM1_1
T2T-CHM13v2.01469,150,944 - 69,164,879 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2-hydroxypropanoic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
actinomycin D  (EXP)
adenosine  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
butanal  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (EXP)
cannabidiol  (EXP)
Cannabidivarin  (EXP)
cannabigerol  (EXP)
cantharidin  (ISO)
capsazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
cisplatin  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (EXP)
corn oil  (ISO)
coumestrol  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cyfluthrin  (ISO)
DDT  (ISO)
deguelin  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
ethyl methanesulfonate  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
furosemide  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
GSK2656157  (EXP)
isoflurane  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
nitrogen dioxide  (EXP)
Nutlin-3  (EXP)
okadaic acid  (EXP)
organoselenium compound  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
Pf-06840003  (EXP)
picoxystrobin  (EXP)
pirinixic acid  (EXP)
potassium chromate  (EXP)
potassium dichromate  (EXP)
propanal  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
tebuconazole  (EXP)
temozolomide  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
thiram  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
tunicamycin  (ISO)
urethane  (EXP)
valproic acid  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Contribution of angiogenic factors in a rat model of pre-eclampsia. Agunanne EE, etal., Am J Nephrol. 2010;32(4):332-9. Epub 2010 Aug 19.
2. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. Bahtiyar MO, etal., Am J Obstet Gynecol. 2007 Jan;196(1):72.e1-6.
3. Biomarkers of inflammation and placental dysfunction are associated with subsequent preterm birth. Bastek JA, etal., J Matern Fetal Neonatal Med. 2011 Apr;24(4):600-5. Epub 2010 Sep 7.
4. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. Batchelor TT, etal., J Clin Oncol. 2010 Jun 10;28(17):2817-23. Epub 2010 May 10.
5. Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling. Beck H, etal., J Neuropathol Exp Neurol. 2002 Apr;61(4):339-50.
6. Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections. Bennuru S, etal., Am J Trop Med Hyg. 2010 Oct;83(4):884-90.
7. Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model. Binsalamah ZM, etal., Int J Nanomedicine. 2011;6:2667-78. Epub 2011 Oct 31.
8. Placental Growth Factor Contributes to Bronchial Neutrophilic Inflammation and Edema in Allergic Asthma. Bobic S, etal., Am J Respir Cell Mol Biol. 2012 Feb 3.
9. Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. Brittain JE, etal., Blood. 2010 Mar 11;115(10):2014-20. Epub 2009 Dec 29.
10. Placental growth factor regulates cardiac inflammation through the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-alpha-converting enzyme axis: crucial role for adaptive cardiac remodeling during cardiac pressure overload. Carnevale D, etal., Circulation. 2011 Sep 20;124(12):1337-50. Epub 2011 Sep 6.
11. Involvement of placental growth factor in Wallerian degeneration. Chaballe L, etal., Glia. 2011 Mar;59(3):379-96. doi: 10.1002/glia.21108. Epub 2010 Dec 6.
12. Acute pyelonephritis during pregnancy changes the balance of angiogenic and anti-angiogenic factors in maternal plasma. Chaiworapongsa T, etal., J Matern Fetal Neonatal Med. 2010 Feb;23(2):167-78.
13. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Chang JD, etal., Proc Natl Acad Sci U S A. 2007 May 8;104(19):8077-82. Epub 2007 May 2.
14. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. Chen HW, etal., FASEB J. 2006 Nov;20(13):2393-5. Epub 2006 Oct 5.
15. Differential expression of placenta growth factors and their receptors in the normal and pregnancy-induced hypertensive human placentas. Cho GJ, etal., J Korean Med Sci. 2003 Jun;18(3):402-8.
16. Analysis of soluble angiogenic factors in Crohn's disease: a preliminary study. Duenas Pousa I, etal., Gastroenterol Hepatol. 2007 Nov;30(9):518-24.
17. Circulating angiopoietin and Tie-2 levels in systemic sclerosis. Dunne JV, etal., Rheumatol Int. 2012 Mar 30.
18. Improvement of cardiac function in the failing rat heart after transfer of skeletal myoblasts engineered to overexpress placental growth factor. Gmeiner M, etal., J Thorac Cardiovasc Surg. 2011 May;141(5):1238-45. Epub 2011 Feb 16.
19. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
20. A translocation involving the placental growth factor gene is identified in an epithelioid hemangioendothelioma. He M, etal., Cancer Genet Cytogenet. 2006 Jul 15;168(2):150-4.
21. Placental growth factor supports neuroendocrine tumor growth and predicts disease prognosis in patients. Hilfenhaus G, etal., Endocr Relat Cancer. 2013 May 20;20(3):305-19. doi: 10.1530/ERC-12-0223. Print 2013 Jun.
22. Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype. Hindryckx P, etal., Ann Rheum Dis. 2011 Nov;70(11):2044-8. Epub 2011 Aug 26.
23. Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury. Hindryckx P, etal., Lab Invest. 2010 Apr;90(4):566-76. Epub 2010 Feb 8.
24. PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity. Incio J, etal., Clin Cancer Res. 2016 Jun 15;22(12):2993-3004. doi: 10.1158/1078-0432.CCR-15-1839. Epub 2016 Feb 9.
25. Darbepoetin-mediated cardioprotection after myocardial infarction involves multiple mechanisms independent of erythropoietin receptor-common beta-chain heteroreceptor. Kanellakis P, etal., Br J Pharmacol. 2010 Aug;160(8):2085-96.
26. Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation. Khurana R, etal., Circulation. 2005 May 31;111(21):2828-36. Epub 2005 May 23.
27. Streptozotocin-induced diabetes decreases placenta growth factor (PlGF) levels in rat placenta. Koh PO, etal., J Vet Med Sci. 2007 Sep;69(9):877-80.
28. The functional deficiency of bone marrow mesenchymal stromal cells in ALS patients is proportional to disease progression rate. Koh SH, etal., Exp Neurol. 2012 Jan;233(1):472-80. Epub 2011 Nov 19.
29. Placental growth factor contributes to micro-vascular abnormalization and blood-retinal barrier breakdown in diabetic retinopathy. Kowalczuk L, etal., PLoS One. 2011 Mar 7;6(3):e17462.
30. Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia. Liu H, etal., Brain. 2006 Oct;129(Pt 10):2734-45. Epub 2006 Aug 10.
31. Prognostic impact of placenta growth factor and vascular endothelial growth factor A in patients with breast cancer. Maae E, etal., Breast Cancer Res Treat. 2012 May;133(1):257-65. Epub 2012 Jan 22.
32. Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair. Maes C, etal., J Clin Invest. 2006 May;116(5):1230-42. Epub 2006 Apr 13.
33. Prognostic significance of plasma placental growth factor levels in renal cell cancer: an association with clinical characteristics and vascular endothelial growth factor levels. Matsumoto K, etal., Anticancer Res. 2003 Nov-Dec;23(6D):4953-8.
34. Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia. Molvarec A, etal., Clin Chim Acta. 2011 Oct 9;412(21-22):1957-62. Epub 2011 Jul 6.
35. Placental growth factor-2 gene transfer by electroporation restores diabetic sensory neuropathy in mice. Murakami T, etal., Exp Neurol. 2011 Jan;227(1):195-202. Epub 2010 Nov 5.
36. Elevation of plasma placental growth factor in the patients with ischemic cardiomyopathy. Nakamura T, etal., Int J Cardiol. 2009 Jan 9;131(2):186-91. Epub 2008 Jan 14.
37. VEGF receptor signalling - in control of vascular function. Olsson AK, etal., Nat Rev Mol Cell Biol. 2006 May;7(5):359-71.
38. Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization. Pilarczyk K, etal., Atherosclerosis. 2008 Jan;196(1):333-40. Epub 2006 Dec 8.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Circulating endothelial cells and angiogenic proteins in patients with systemic lupus erythematosus. Robak E, etal., Lupus. 2009 Apr;18(4):332-41.
43. Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions. Roncal C, etal., Cardiovasc Res. 2010 Apr 1;86(1):29-36. Epub 2009 Dec 1.
44. Comparison of endothelial biomarkers according to reversibility of pulmonary hypertension secondary to congenital heart disease. Smadja DM, etal., Pediatr Cardiol. 2010 Jul;31(5):657-62. Epub 2010 Feb 27.
45. Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia. Suwaki N, etal., Am J Obstet Gynecol. 2006 Dec;195(6):1687-92. Epub 2006 Jun 12.
46. Evaluation of placental growth factor and soluble Fms-like tyrosine kinase 1 as predictors of all-cause and cardiovascular mortality in patients with Type 1 diabetes with and without diabetic nephropathy. Theilade S, etal., Diabet Med. 2012 Mar;29(3):337-44. doi: 10.1111/j.1464-5491.2011.03482.x.
47. Antiangiogenic treatment with Sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Tugues S, etal., Hepatology. 2007 Dec;46(6):1919-26.
48. Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice. Van Steenkiste C, etal., Hepatology. 2011 May;53(5):1629-40. doi: 10.1002/hep.24238.
49. Modulation of angiogenesis during adipose tissue development in murine models of obesity. Voros G, etal., Endocrinology. 2005 Oct;146(10):4545-54. Epub 2005 Jul 14.
50. Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro. Wang C, etal., Eur J Pharmacol. 2009 Jun 10;612(1-3):143-52. Epub 2009 Apr 6.
51. Microvasculature change and placenta growth factor expression in the early stage of a rat remnant kidney model. Wu Q, etal., Am J Nephrol. 2006;26(1):97-104. Epub 2006 Mar 14.
52. Increased expression of placental growth factor in patients with temporal lobe epilepsy and a rat model. Xu Y, etal., Brain Res. 2012 Jan 6;1429:124-33. Epub 2011 Oct 6.
53. Increased placental growth factor in cerebrospinal fluid of patients with epilepsy. Xu Y, etal., Neurochem Res. 2012 Mar;37(3):665-70. Epub 2011 Dec 8.
54. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. Yano K, etal., J Exp Med. 2006 Jun 12;203(6):1447-58. Epub 2006 May 15.
55. Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation. Yoo SA, etal., Arthritis Rheum. 2009 Feb;60(2):345-54.
56. Chimeric VEGF-ENZ7/PlGF specifically binding to VEGFR-2 accelerates skin wound healing via enhancement of neovascularization. Zheng Y, etal., Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):503-11. Epub 2006 Dec 28.
57. Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure. Zimpfer D, etal., J Thorac Cardiovasc Surg. 2009 Apr;137(4):963-70.
Additional References at PubMed
PMID:1924389   PMID:7681160   PMID:7929268   PMID:8148155   PMID:8466755   PMID:8786112   PMID:9111514   PMID:9116151   PMID:9207183   PMID:9452434   PMID:9467961   PMID:10748121  
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PMID:12477932   PMID:12508121   PMID:12543719   PMID:12548207   PMID:12548214   PMID:12618519   PMID:12673673   PMID:12714517   PMID:12796773   PMID:12824270   PMID:13678785   PMID:14568550  
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PMID:23799978   PMID:23841853   PMID:23844967   PMID:23905610   PMID:23939615   PMID:23957293   PMID:23966056   PMID:24035323   PMID:24118824   PMID:24166749   PMID:24190934   PMID:24227191  
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PMID:27874074   PMID:27899144   PMID:27980400   PMID:27983995   PMID:27996093   PMID:28119994   PMID:28121958   PMID:28126966   PMID:28326518   PMID:28397162   PMID:28427198   PMID:28494189  
PMID:28501276   PMID:28552862   PMID:28587682   PMID:28609172   PMID:28613009   PMID:28627965   PMID:28635072   PMID:28676532   PMID:28714317   PMID:28714779   PMID:28737473   PMID:28797294  
PMID:28861767   PMID:28926825   PMID:28927814   PMID:28963486   PMID:29054861   PMID:29267975   PMID:29277266   PMID:29277778   PMID:29416013   PMID:29455633   PMID:29523269   PMID:29523274  
PMID:29523275   PMID:29575299   PMID:29587776   PMID:29643276   PMID:29674192   PMID:29674208   PMID:29676528   PMID:29769799   PMID:29991059   PMID:30173595   PMID:30177039   PMID:30177064  
PMID:30177066   PMID:30195493   PMID:30203564   PMID:30413130   PMID:30587700   PMID:30591201   PMID:30594309   PMID:30758082   PMID:30760000   PMID:30831776   PMID:30902388   PMID:30950008  
PMID:31034502   PMID:31129598   PMID:31148230   PMID:31249451   PMID:31312859   PMID:31358848   PMID:31377148   PMID:31444934   PMID:31545526   PMID:31559879   PMID:31585507   PMID:31653890  
PMID:31734756   PMID:31924819   PMID:32028495   PMID:32056542   PMID:32248765   PMID:32374047   PMID:32393512   PMID:32413589   PMID:32505096   PMID:32513696   PMID:32583963   PMID:32657162  
PMID:32707515   PMID:32718871   PMID:32916477   PMID:32992124   PMID:33010604   PMID:33012203   PMID:33109108   PMID:33123910   PMID:33153436   PMID:33218096   PMID:33268513   PMID:33278298  
PMID:33401341   PMID:33463910   PMID:33619227   PMID:33677420   PMID:33770588   PMID:33789295   PMID:33973302   PMID:34010327   PMID:34119877   PMID:34283894   PMID:34381074   PMID:34413389  
PMID:34418751   PMID:34470571   PMID:34516333   PMID:34605122   PMID:34653921   PMID:34697976   PMID:34871241   PMID:34915395   PMID:34937509   PMID:34979346   PMID:34998223   PMID:35092264  
PMID:35208556   PMID:35275947   PMID:35603727   PMID:35609518   PMID:35843203   PMID:35943054   PMID:35970387   PMID:36096720   PMID:36193031   PMID:36437340   PMID:36613090   PMID:36990308  
PMID:37168313   PMID:37512044   PMID:37679252   PMID:37712421   PMID:37787982   PMID:37878035   PMID:38115361   PMID:38166739   PMID:38217598   PMID:38247274  


Genomics

Comparative Map Data
PGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,941,830 - 74,955,764 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,941,834 - 74,955,626 (-)EnsemblGRCh38hg38GRCh38
GRCh371475,408,533 - 75,422,467 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,478,290 - 74,492,044 (-)NCBINCBI36Build 36hg18NCBI36
Build 341474,478,292 - 74,492,044NCBI
Celera1455,446,919 - 55,460,674 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,576,546 - 55,590,481 (-)NCBIHuRef
CHM1_11475,347,700 - 75,361,635 (-)NCBICHM1_1
T2T-CHM13v2.01469,150,944 - 69,164,879 (-)NCBIT2T-CHM13v2.0
Pgf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,213,413 - 85,224,087 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,213,409 - 85,224,564 (-)EnsemblGRCm39 Ensembl
GRCm381285,166,637 - 85,177,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,166,635 - 85,177,790 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,507,591 - 86,518,235 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,055,744 - 86,066,388 (-)NCBIMGSCv36mm8
Celera1286,623,655 - 86,634,299 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.58NCBI
Pgf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,547,165 - 110,557,747 (-)NCBIGRCr8
mRatBN7.26104,816,102 - 104,826,685 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,816,104 - 104,826,685 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,985,728 - 104,996,309 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,284,901 - 105,295,482 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,654,265 - 104,664,846 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,994,016 - 109,004,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,994,018 - 109,004,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,552,660 - 116,563,242 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,215,540 - 109,226,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,218,997 - 109,229,578 (-)NCBI
Celera6102,639,061 - 102,649,643 (-)NCBICelera
RH 3.4 Map6731.99RGD
Cytogenetic Map6q31NCBI
Pgf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523616,154 - 627,713 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955523616,196 - 627,055 (+)NCBIChiLan1.0ChiLan1.0
PGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,024,811 - 76,038,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,241,311 - 75,255,228 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,494,152 - 55,508,066 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,338,976 - 74,352,964 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,338,976 - 74,352,964 (-)Ensemblpanpan1.1panPan2
PGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,059,554 - 48,110,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,059,552 - 48,075,170 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,743,752 - 47,795,118 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,287,229 - 48,338,603 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1847,958,057 - 48,009,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,979,365 - 48,030,910 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,377,990 - 48,429,367 (-)NCBIUU_Cfam_GSD_1.0
Pgf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,957,791 - 27,970,740 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,098,225 - 4,111,142 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,098,187 - 4,111,108 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,148,994 - 98,162,741 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,149,510 - 98,162,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,993,598 - 104,006,849 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,160,904 - 52,174,493 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,161,787 - 52,173,989 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,391,564 - 40,405,145 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,751,530 - 26,764,242 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,751,986 - 26,764,154 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PGF
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q24.3(chr14:73877072-78042422)x1 copy number loss See cases [RCV000051548] Chr14:73877072..78042422 [GRCh38]
Chr14:74343775..78508765 [GRCh37]
Chr14:73413528..77578518 [NCBI36]
Chr14:14q24.3		 pathogenic
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2		 pathogenic
GRCh37/hg19 14q24.2-q24.3(chr14:73152115..77698582) deletion Intellectual disability, mild [RCV000190520] Chr14:73152115..77698582 [GRCh37]
Chr14:14q24.2-24.3		 pathogenic|likely pathogenic
GRCh38/hg38 14q24.1-31.1(chr14:69562099-81975384)x1 copy number loss See cases [RCV000134154] Chr14:69562099..81975384 [GRCh38]
Chr14:70028816..82441728 [GRCh37]
Chr14:69098569..81511481 [NCBI36]
Chr14:14q24.1-31.1		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:73343213-78835059)x1 copy number loss See cases [RCV000143265] Chr14:73343213..78835059 [GRCh38]
Chr14:73809921..79301402 [GRCh37]
Chr14:72879674..78371155 [NCBI36]
Chr14:14q24.3-31.1		 pathogenic|likely pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
NM_002632.6(PGF):c.362C>T (p.Thr121Met) single nucleotide variant not specified [RCV004300933] Chr14:74948537 [GRCh38]
Chr14:75415240 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3 copy number gain See cases [RCV000512497] Chr14:73750741..107285437 [GRCh37]
Chr14:14q24.2-32.33		 pathogenic
GRCh37/hg19 14q24.3(chr14:74040231-76368547) copy number loss not provided [RCV000767572] Chr14:74040231..76368547 [GRCh37]
Chr14:14q24.3		 likely pathogenic
GRCh37/hg19 14q24.3(chr14:75205276-75507538)x3 copy number gain not provided [RCV001006649] Chr14:75205276..75507538 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q22.2-24.3(chr14:54654001-75828024)x3 copy number gain 14q22.2q24.3 duplication [RCV001506967] Chr14:54654001..75828024 [GRCh37]
Chr14:14q22.2-24.3		 likely pathogenic
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33		 pathogenic
GRCh37/hg19 14q24.3(chr14:75353951-75424406)x1 copy number loss not provided [RCV002473598] Chr14:75353951..75424406 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.376G>A (p.Val126Ile) single nucleotide variant not specified [RCV004197756] Chr14:74948523 [GRCh38]
Chr14:75415226 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.329G>T (p.Arg110Leu) single nucleotide variant not specified [RCV004133119] Chr14:74948570 [GRCh38]
Chr14:75415273 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.505C>T (p.Arg169Trp) single nucleotide variant not specified [RCV004212663] Chr14:74942714 [GRCh38]
Chr14:75409417 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.400C>T (p.Arg134Trp) single nucleotide variant not specified [RCV004083691] Chr14:74946401 [GRCh38]
Chr14:75413104 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.398T>A (p.Leu133Gln) single nucleotide variant not specified [RCV004175441] Chr14:74946403 [GRCh38]
Chr14:75413106 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.443G>A (p.Gly148Glu) single nucleotide variant not specified [RCV004250009] Chr14:74946255 [GRCh38]
Chr14:75412958 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.385G>A (p.Glu129Lys) single nucleotide variant not specified [RCV004365325] Chr14:74948514 [GRCh38]
Chr14:75415217 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q24.3(chr14:74883763-77219310)x1 copy number loss not provided [RCV003483211] Chr14:74883763..77219310 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3 copy number gain not provided [RCV003485036] Chr14:58894502..107227240 [GRCh37]
Chr14:14q23.1-32.33		 pathogenic
NM_002632.6(PGF):c.296C>T (p.Thr99Met) single nucleotide variant not specified [RCV004498654] Chr14:74949376 [GRCh38]
Chr14:75416079 [GRCh37]
Chr14:14q24.3		 uncertain significance
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
NM_002632.6(PGF):c.352G>A (p.Val118Met) single nucleotide variant not specified [RCV004498655] Chr14:74948547 [GRCh38]
Chr14:75415250 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.161C>T (p.Ala54Val) single nucleotide variant not specified [RCV004498652] Chr14:74949511 [GRCh38]
Chr14:75416214 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.430C>T (p.Pro144Ser) single nucleotide variant not specified [RCV004655814] Chr14:74946268 [GRCh38]
Chr14:75412971 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.380G>A (p.Arg127His) single nucleotide variant not specified [RCV004655815] Chr14:74948519 [GRCh38]
Chr14:75415222 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.493G>A (p.Asp165Asn) single nucleotide variant not specified [RCV004836807] Chr14:74942726 [GRCh38]
Chr14:75409429 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.68C>T (p.Pro23Leu) single nucleotide variant not specified [RCV004836805] Chr14:74955175 [GRCh38]
Chr14:75421878 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.35A>C (p.Gln12Pro) single nucleotide variant not specified [RCV004836806] Chr14:74955208 [GRCh38]
Chr14:75421911 [GRCh37]
Chr14:14q24.3		 uncertain significance
NM_002632.6(PGF):c.181G>A (p.Val61Ile) single nucleotide variant not specified [RCV004498653] Chr14:74949491 [GRCh38]
Chr14:75416194 [GRCh37]
Chr14:14q24.3		 likely benign
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR125B1hsa-miR-125b-5pOncomiRDBexternal_infoNANA21703189
MIR125B2hsa-miR-125b-5pOncomiRDBexternal_infoNANA21703189

Predicted Target Of
Summary Value
Count of predictions:3020
Count of miRNA genes:828
Interacting mature miRNAs:1008
Transcripts:ENST00000238607, ENST00000405431, ENST00000553716, ENST00000555234, ENST00000555253, ENST00000555567, ENST00000556939, ENST00000557748
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597144358GWAS1240432_Hsocial deprivation, COVID-19 QTL GWAS1240432 (human)4e-08social deprivation, COVID-19147495274174952742Human
597334294GWAS1430368_Hmetabolic disease, COVID-19 QTL GWAS1430368 (human)0.0000003metabolic disease, COVID-19147495274174952742Human
597336775GWAS1432849_Hsex interaction measurement, COVID-19 QTL GWAS1432849 (human)3e-08sex interaction measurement, COVID-19147495274174952742Human

Markers in Region
G10734  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,423,265 - 75,423,405UniSTSGRCh37
Build 361474,493,018 - 74,493,158RGDNCBI36
Celera1455,461,648 - 55,461,788RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,591,279 - 55,591,419UniSTS
RH70005  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,408,570 - 75,408,696UniSTSGRCh37
Build 361474,478,323 - 74,478,449RGDNCBI36
Celera1455,446,952 - 55,447,078RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,576,583 - 55,576,709UniSTS
GeneMap99-GB4 RH Map14198.97UniSTS
PGF_2125  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,408,515 - 75,409,367UniSTSGRCh37
Build 361474,478,268 - 74,479,120RGDNCBI36
Celera1455,446,897 - 55,447,750RGD
HuRef1455,576,528 - 55,577,381UniSTS
D14S850  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,408,590 - 75,408,710UniSTSGRCh37
Build 361474,478,343 - 74,478,463RGDNCBI36
Celera1455,446,972 - 55,447,092RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,576,603 - 55,576,723UniSTS
Whitehead-YAC Contig Map14 UniSTS
D12S1900  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,409,214 - 75,409,358UniSTSGRCh37
Build 361474,478,967 - 74,479,111RGDNCBI36
Celera1455,447,597 - 55,447,741RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,577,228 - 55,577,372UniSTS
Stanford-G3 RH Map12596.0UniSTS
NCBI RH Map12160.2UniSTS
GeneMap99-G3 RH Map12596.0UniSTS
RH70836  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,408,800 - 75,408,943UniSTSGRCh37
Build 361474,478,553 - 74,478,696RGDNCBI36
Celera1455,447,182 - 55,447,325RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,576,813 - 55,576,956UniSTS
GeneMap99-GB4 RH Map14199.17UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4973 1726 2351 5 624 1944 465 2270 7298 6464 53 3733 1 852 1744 1617 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001207012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047431476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054376219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A18411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC006530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL543693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX248289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX356823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ858316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS067234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS172367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS367406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU332861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC040687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX512453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC862732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S57152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000238607   ⟹   ENSP00000238607
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1474,941,858 - 74,955,577 (-)Ensembl
Ensembl Acc Id: ENST00000405431   ⟹   ENSP00000385365
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1474,942,706 - 74,955,242 (-)Ensembl
Ensembl Acc Id: ENST00000553716   ⟹   ENSP00000451413
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1474,941,841 - 74,955,626 (-)Ensembl
Ensembl Acc Id: ENST00000555234
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1474,948,400 - 74,955,597 (-)Ensembl
Ensembl Acc Id: ENST00000555253
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1474,944,564 - 74,948,215 (-)Ensembl
Ensembl Acc Id: ENST00000555567   ⟹   ENSP00000451040
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1474,941,834 - 74,955,597 (-)Ensembl
Ensembl Acc Id: ENST00000556939
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1474,948,129 - 74,955,597 (-)Ensembl
Ensembl Acc Id: ENST00000557748
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1474,942,494 - 74,954,234 (-)Ensembl
RefSeq Acc Id: NM_001207012   ⟹   NP_001193941
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381474,941,830 - 74,955,764 (-)NCBI
GRCh371475,408,533 - 75,422,467 (-)ENTREZGENE
HuRef1455,576,546 - 55,590,481 (-)ENTREZGENE
CHM1_11475,347,700 - 75,361,635 (-)NCBI
T2T-CHM13v2.01469,150,944 - 69,164,879 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001293643   ⟹   NP_001280572
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381474,941,830 - 74,955,764 (-)NCBI
CHM1_11475,347,700 - 75,361,635 (-)NCBI
T2T-CHM13v2.01469,150,944 - 69,164,879 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002632   ⟹   NP_002623
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381474,941,834 - 74,955,597 (-)NCBI
GRCh371475,408,533 - 75,422,467 (-)ENTREZGENE
Build 361474,478,290 - 74,492,044 (-)NCBI Archive
HuRef1455,576,546 - 55,590,481 (-)ENTREZGENE
CHM1_11475,347,700 - 75,361,635 (-)NCBI
T2T-CHM13v2.01469,150,948 - 69,164,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047431476   ⟹   XP_047287432
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381474,941,830 - 74,955,764 (-)NCBI
RefSeq Acc Id: XM_054376219   ⟹   XP_054232194
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01469,150,944 - 69,164,879 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001193941 (Get FASTA)   NCBI Sequence Viewer  
  NP_001280572 (Get FASTA)   NCBI Sequence Viewer  
  NP_002623 (Get FASTA)   NCBI Sequence Viewer  
  XP_047287432 (Get FASTA)   NCBI Sequence Viewer  
  XP_054232194 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB25832 (Get FASTA)   NCBI Sequence Viewer  
  AAB30462 (Get FASTA)   NCBI Sequence Viewer  
  AAD30179 (Get FASTA)   NCBI Sequence Viewer  
  AAH01422 (Get FASTA)   NCBI Sequence Viewer  
  AAH07255 (Get FASTA)   NCBI Sequence Viewer  
  AAH07789 (Get FASTA)   NCBI Sequence Viewer  
  AAP35846 (Get FASTA)   NCBI Sequence Viewer  
  ABY87550 (Get FASTA)   NCBI Sequence Viewer  
  AGC09600 (Get FASTA)   NCBI Sequence Viewer  
  CAA01393 (Get FASTA)   NCBI Sequence Viewer  
  CAA38698 (Get FASTA)   NCBI Sequence Viewer  
  CAD62617 (Get FASTA)   NCBI Sequence Viewer  
  CAH23419 (Get FASTA)   NCBI Sequence Viewer  
  CAI84580 (Get FASTA)   NCBI Sequence Viewer  
  CAJ32891 (Get FASTA)   NCBI Sequence Viewer  
  CAL32761 (Get FASTA)   NCBI Sequence Viewer  
  CBH30536 (Get FASTA)   NCBI Sequence Viewer  
  EAW81207 (Get FASTA)   NCBI Sequence Viewer  
  EAW81208 (Get FASTA)   NCBI Sequence Viewer  
  EAW81209 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000238607
  ENSP00000385365.2
  ENSP00000451040
  ENSP00000451040.1
  ENSP00000451413
  ENSP00000451413.1
GenBank Protein P49763 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001193941   ⟸   NM_001207012
- Peptide Label: isoform 2 precursor
- UniProtKB: P49763 (UniProtKB/Swiss-Prot),   Q86TW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_002623   ⟸   NM_002632
- Peptide Label: isoform 1 precursor
- UniProtKB: Q53XY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280572   ⟸   NM_001293643
- Peptide Label: isoform 3 precursor
- UniProtKB: G3XA84 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000451040   ⟸   ENST00000555567
Ensembl Acc Id: ENSP00000385365   ⟸   ENST00000405431
Ensembl Acc Id: ENSP00000238607   ⟸   ENST00000238607
Ensembl Acc Id: ENSP00000451413   ⟸   ENST00000553716
RefSeq Acc Id: XP_047287432   ⟸   XM_047431476
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054232194   ⟸   XM_054376219
- Peptide Label: isoform X1
Protein Domains
Platelet-derived growth factor (PDGF) family

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49763-F1-model_v2 AlphaFold P49763 1-221 view protein structure

Promoters
RGD ID:6791796
Promoter ID:HG_KWN:19803
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:ENST00000405431,   NM_002632,   UC001XRA.1,   UC001XRB.1,   UC010ASE.1,   UC010ASF.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361474,491,784 - 74,492,284 (-)MPROMDB
RGD ID:7228155
Promoter ID:EPDNEW_H19824
Type:initiation region
Name:PGF_1
Description:placental growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381474,955,597 - 74,955,657EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8893 AgrOrtholog
COSMIC PGF COSMIC
Ensembl Genes ENSG00000119630 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000238607 ENTREZGENE
  ENST00000405431.2 UniProtKB/Swiss-Prot
  ENST00000553716 ENTREZGENE
  ENST00000553716.5 UniProtKB/Swiss-Prot
  ENST00000555567 ENTREZGENE
  ENST00000555567.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
GTEx ENSG00000119630 GTEx
HGNC ID HGNC:8893 ENTREZGENE
Human Proteome Map PGF Human Proteome Map
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  PD_growth_factor_CS UniProtKB/Swiss-Prot
  PDGF/VEGF_dom UniProtKB/Swiss-Prot
  PDGF/VEGF_growth_factor UniProtKB/Swiss-Prot
KEGG Report hsa:5228 UniProtKB/Swiss-Prot
NCBI Gene 5228 ENTREZGENE
OMIM 601121 OMIM
PANTHER PLACENTA GROWTH FACTOR UniProtKB/Swiss-Prot
  VASCULAR ENDOTHELIAL GROWTH FACTOR UniProtKB/Swiss-Prot
Pfam PDGF UniProtKB/Swiss-Prot
PharmGKB PA33231 PharmGKB
PROSITE PDGF_1 UniProtKB/Swiss-Prot
  PDGF_2 UniProtKB/Swiss-Prot
SMART PDGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt G3XA84 ENTREZGENE, UniProtKB/TrEMBL
  P49763 ENTREZGENE, UniProtKB/Swiss-Prot
  Q53XY6 ENTREZGENE, UniProtKB/TrEMBL
  Q86TW6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q07101 UniProtKB/Swiss-Prot
  Q9BV78 UniProtKB/Swiss-Prot
  Q9Y6S8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 PGF  placental growth factor  PGFL  placental growth factor-like  Data merged from RGD:1349691 737654 PROVISIONAL