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Gene: CD40LG (CD40 ligand) Homo sapiens
Symbol: CD40LG
Name: CD40 ligand
RGD ID: 1352959
Description: Exhibits CD40 receptor binding activity and integrin binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and regulation of apoptotic process. Localizes to cell surface. Implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic cancer (multiple); and lupus nephritis. Biomarker of several diseases, including allergic rhinitis; autoimmune disease (multiple); cardiovascular system disease (multiple); diabetes mellitus (multiple); and hematologic cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD154; CD40 antigen ligand; CD40-L; CD40L; gp39; hCD40L; HIGM1; IGM; IMD3; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TRAP; tumor necrosis factor (ligand) superfamily member 5
Mus musculus (house mouse) : Cd40lg (CD40 ligand)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd40lg (CD40 ligand)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd40lg (CD40 ligand)
Pan paniscus (bonobo/pygmy chimpanzee) : CD40LG (CD40 ligand)
Canis lupus familiaris (dog) : CD40LG (CD40 ligand)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd40lg (CD40 ligand)
Sus scrofa (pig) : CD40LG (CD40 ligand)
Chlorocebus sabaeus (African green monkey) : CD40LG (CD40 ligand)
Heterocephalus glaber (naked mole-rat) : Cd40lg (CD40 ligand)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX136,648,158 - 136,660,390 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX136,648,193 - 136,660,390 (+)EnsemblGRCh38hg38GRCh38
GRCh38X136,648,158 - 136,660,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X135,730,281 - 135,742,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,558,002 - 135,570,215 (+)NCBINCBI36hg18NCBI36
Build 34X135,455,855 - 135,468,068NCBI
CeleraX136,094,012 - 136,106,224 (+)NCBI
Cytogenetic MapXq26.3NCBI
HuRefX125,001,305 - 125,013,640 (+)NCBIHuRef
CHM1_1X135,641,985 - 135,654,211 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CD40LG
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352959
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.