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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cytochalasin
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Accession:CHEBI:23528 term browser browse the term
Synonyms:related_synonym: cytochalasins
 xref: Wikipedia:Cytochalasin



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chaetoglobosin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions
ISO chaetoglobosins results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]
CTD PMID:18040759 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO chaetoglobosins inhibits the reaction [Dieldrin results in decreased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein] CTD PMID:18040759 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO chaetoglobosins results in increased phosphorylation of GSK3B protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]
CTD PMID:18040759 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:33285210 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:33285210 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:33285210 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions EXP chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IRF7 mRNA] CTD PMID:33285210 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
chaetoglobosins results in increased phosphorylation of MAPK1 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:18040759 PMID:33285210 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
chaetoglobosins results in increased phosphorylation of MAPK3 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD PMID:18040759 PMID:33285210 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions EXP chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA] CTD PMID:33285210 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:33285210 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:33285210 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 decreases phosphorylation ISO chaetoglobosins results in decreased phosphorylation of RAF1 protein CTD PMID:18040759 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:33285210 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:33285210 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; chaetoglobosins results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 PMID:33285210 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
cytochalasin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cytochalasin B results in increased expression of BAX protein] CTD PMID:27640744 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cytochalasin B results in decreased expression of BCL2 protein] CTD PMID:27640744 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Cytochalasin B results in increased cleavage of CASP3 protein CTD PMID:27640744 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Cytochalasin B results in increased cleavage of CASP9 protein CTD PMID:27640744 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions ISO Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of CAT protein] CTD PMID:20166893 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Cytochalasin B results in decreased expression of CCNB1 protein CTD PMID:27640744 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Cdk1 cyclin dependent kinase 1 decreases expression ISO Cytochalasin B results in decreased expression of CDK1 protein CTD PMID:27640744 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO Cytochalasin B results in increased expression of CDKN1A protein CTD PMID:27640744 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO Cytochalasin B results in increased expression of CDKN1B protein CTD PMID:27640744 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO Cytochalasin B inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Cytochalasin B inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cytochalasin B inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Elane elastase, neutrophil expressed multiple interactions ISO [Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein; pirinixic acid analog inhibits the reaction [[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein] CTD PMID:19686721 NCBI chr10:79,722,146...79,724,050
Ensembl chr10:79,722,081...79,724,049
JBrowse link
G Epo erythropoietin multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein; [Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein; Dexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression ISO Cytochalasin B results in increased expression of FIS1 protein CTD PMID:26732598 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO [Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein; IMMLG5521 inhibits the reaction [[Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein] CTD PMID:23850278 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890
JBrowse link
G Hc hemolytic complement multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein; Dexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450
JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO Cytochalasin B results in increased expression of HSPA5 protein CTD PMID:26732598 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cytochalasin B inhibits the reaction [[Alum Compounds co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form]; Cytochalasin B inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; Cytochalasin B inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]] CTD PMID:9698594 PMID:17404311 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Ins1 insulin I multiple interactions EXP
ISO
Cytochalasin B inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Cytochalasin B inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]]
Cytochalasin B inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]
CTD PMID:15172182 PMID:25543134 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Lpl lipoprotein lipase decreases activity EXP Cytochalasin B results in decreased activity of LPL protein CTD PMID:9414485 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:18776917 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18776917 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 affects folding
affects binding
multiple interactions
ISO
EXP
Cytochalasin B affects the folding of SLC2A1 protein
Cytochalasin B binds to SLC2A1 protein
Cytochalasin B inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]
oxophenylarsine inhibits the reaction [Cytochalasin B binds to SLC2A1 protein]
CTD PMID:8457197 PMID:19686715 PMID:22363641 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions
affects binding
ISO Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]
Cytochalasin B binds to SLC2A2 protein
Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]; Mercuric Chloride inhibits the reaction [Cytochalasin B binds to SLC2A2 protein]
CTD PMID:8457197 PMID:10825458 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508
JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 multiple interactions ISO Cytochalasin B inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose] CTD PMID:8457197 NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of SOD2 protein] CTD PMID:20166893 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Cytochalasin B results in increased expression of TP53 protein CTD PMID:27640744 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
cytochalasin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
EXP EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions
increases expression
ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of ACTA2 mRNA]; Cytochalasin D inhibits the reaction [Oxygen results in increased expression of ACTA2 protein]
Cytochalasin D results in increased expression of ACTA2 mRNA
CTD PMID:11035001 PMID:23517783 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Actg1 actin, gamma, cytoplasmic 1 multiple interactions ISO Cytochalasin D inhibits the reaction [UPF1 protein binds to ACTG1 protein]; Cytochalasin D inhibits the reaction [UPF2 protein binds to ACTG1 protein]; Cytochalasin D inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr11:120,236,513...120,239,321
Ensembl chr11:120,236,516...120,239,368
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO Cytochalasin D results in increased expression of CDH1 mRNA; Cytochalasin D results in increased expression of CDH1 protein
[Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein; RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein]
CTD PMID:25756282 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA] CTD PMID:23517783 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col1a2 collagen, type I, alpha 2 multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA] CTD PMID:23517783 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO Cytochalasin D inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; Cytochalasin D inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein] CTD PMID:10645887 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
increases stability
ISO Cytochalasin D inhibits the reaction [Asbestos, Serpentine results in increased secretion of CXCL8 protein]; Cytochalasin D inhibits the reaction [Particulate Matter results in increased expression of CXCL8 protein]; Cytochalasin D inhibits the reaction [Smoke results in increased expression of CXCL8 mRNA]; Cytochalasin D inhibits the reaction [Smoke results in increased secretion of CXCL8 protein]; Cytochalasin D inhibits the reaction [Titanium results in increased secretion of CXCL8 protein]; Cytochalasin D inhibits the reaction [Vehicle Emissions results in increased expression of CXCL8 mRNA]; Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR1 protein]; Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR2 protein]
Cytochalasin D results in increased stability of CXCL8 mRNA
CTD PMID:8089496 PMID:11145710 PMID:16392133 PMID:16499908 PMID:23670201 More... NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR1 protein] CTD PMID:11145710 NCBI chr 1:74,228,862...74,233,867
Ensembl chr 1:74,230,944...74,233,790
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR2 protein] CTD PMID:11145710 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405
JBrowse link
G Egf epidermal growth factor multiple interactions EXP EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cytochalasin D inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G F3 coagulation factor III multiple interactions ISO Cytochalasin D inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA] CTD PMID:25858758 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO Cytochalasin D affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein] CTD PMID:15034928 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Ifng interferon gamma multiple interactions ISO Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta increases phosphorylation
multiple interactions
ISO Cytochalasin D results in increased phosphorylation of IKBKB protein
Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP Cytochalasin D inhibits the reaction [Quartz results in increased import of IL1A protein]; Cytochalasin D promotes the reaction [Quartz results in increased secretion of IL1A protein] CTD PMID:36840754 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with aluminum sulfate] results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [titanium dioxide results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 PMID:18403674 PMID:18604214 PMID:24158569 PMID:24760326 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 decreases chemical synthesis
increases stability
ISO Cytochalasin D results in decreased chemical synthesis of IL6 protein
Cytochalasin D results in increased stability of IL6 mRNA
CTD PMID:16499908 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ivns1abp influenza virus NS1A binding protein increases response to substance EXP IVNS1ABP gene mutant form results in increased susceptibility to Cytochalasin D CTD PMID:15485691 NCBI chr 1:151,220,237...151,240,196
Ensembl chr 1:151,220,228...151,240,173
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP Cytochalasin D inhibits the reaction [Quartz results in increased activity of and results in increased secretion of LDHA protein] CTD PMID:36840754 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA] CTD PMID:17560598 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mrtfa myocardin related transcription factor A multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen affects the localization of MRTFA protein] CTD PMID:23517783 NCBI chr15:80,896,482...81,074,937
Ensembl chr15:80,896,482...81,074,958
JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 decreases localization ISO Cytochalasin D results in decreased localization of NFATC4 protein CTD PMID:17044076 NCBI chr14:56,062,252...56,071,400
Ensembl chr14:56,060,601...56,071,400
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha increases phosphorylation
multiple interactions
ISO Cytochalasin D results in increased phosphorylation of NFKBIA protein
Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 decreases activity ISO Cytochalasin D results in decreased activity of P2RX1 protein CTD PMID:21757694 NCBI chr11:72,889,882...72,906,026
Ensembl chr11:72,889,929...72,906,026
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases uptake ISO Cytochalasin D results in decreased uptake of PDX1 protein CTD PMID:16405074 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658
JBrowse link
G Plat plasminogen activator, tissue increases expression ISO Cytochalasin D results in increased expression of PLAT CTD PMID:12371961 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein; RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein] CTD PMID:25756282 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Rs1 retinoschisis (X-linked, juvenile) 1 (human) decreases secretion ISO Cytochalasin D results in decreased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:159,548,815...159,584,800
Ensembl chr  X:159,551,009...159,582,659
JBrowse link
G Slc31a1 solute carrier family 31, member 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] CTD PMID:17108132 NCBI chr 4:62,278,821...62,310,006
Ensembl chr 4:62,278,964...62,310,006
JBrowse link
G Smad1 SMAD family member 1 affects localization ISO Cytochalasin D affects the localization of SMAD1 protein CTD PMID:25756282 NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147
JBrowse link
G Smad2 SMAD family member 2 affects localization ISO Cytochalasin D affects the localization of SMAD2 protein CTD PMID:25756282 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034
JBrowse link
G Smad3 SMAD family member 3 affects localization ISO Cytochalasin D affects the localization of SMAD3 protein CTD PMID:25756282 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276
JBrowse link
G Snai1 snail family zinc finger 1 affects localization ISO Cytochalasin D affects the localization of SNAI1 protein CTD PMID:25756282 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Cytochalasin D deficiency results in decreased activity of and affects the localization of STAT1 protein CTD PMID:28086195 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Cytochalasin D deficiency results in decreased activity of and affects the localization of STAT3 protein CTD PMID:28086195 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Tagln transgelin increases expression ISO Cytochalasin D results in increased expression of TAGLN mRNA CTD PMID:11035001 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA]
Cytochalasin D inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Cytochalasin D inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:8409756 PMID:12799187 PMID:15034928 PMID:17560598 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Cadmium Chloride affects the localization of TXN protein] CTD PMID:22961094 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Upf1 UPF1 RNA helicase and ATPase multiple interactions
affects localization
ISO Cytochalasin D inhibits the reaction [UPF1 protein binds to ACTG1 protein]
Cytochalasin D affects the localization of UPF1 protein
CTD PMID:28743738 NCBI chr 8:70,784,143...70,806,418
Ensembl chr 8:70,784,175...70,805,928
JBrowse link
G Upf2 UPF2 regulator of nonsense transcripts homolog (yeast) multiple interactions ISO Cytochalasin D inhibits the reaction [UPF2 protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr 2:5,956,218...6,061,514
Ensembl chr 2:5,956,280...6,061,514
JBrowse link
G Upf3b UPF3 regulator of nonsense transcripts homolog B (yeast) multiple interactions ISO Cytochalasin D inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr  X:36,355,331...36,374,124
Ensembl chr  X:36,355,331...36,373,975
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:15034928 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22192
    chemical entity 22191
      atom 22184
        nonmetal atom 22069
          nitrogen atom 20022
            nitrogen molecular entity 20022
              organonitrogen compound 19828
                organonitrogen heterocyclic compound 19087
                  benzopyrrole 9703
                    isoindoles 1235
                      cytochalasin 81
                        (1S,2R,3R,6S,7R,8S,11S,14S,15S,18R)-18-hydroxy-5,6,15-trimethyl-8-(2-methylpropyl)-19-oxa-9-azapentacyclo[13.3.1.02,14.03,11.07,11]nonadec-4-ene-10,12-dione 0
                        (3E,9E)-5,6-Dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-3,9,12-triene-2,18-dione 0
                        (9E)-4,6-Dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,5,18-trione 0
                        (9E)-5,6-Dihydroxy-4-methoxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,18-dione 0
                        (9E)-5-Hydroxy-4-methoxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,18-dione 0
                        16-hydroxymethylaspergillin PZ 0
                        16alpha-methylaspochalasin J 0
                        18-oxo-19,20-dihydrophomacin C 0
                        18-oxo-19-hydroxyl-19,20-dihydrophomacin C 0
                        18-oxo-19-methoxy-19,20-dihydrophomacin C 0
                        19,20-dihydrophomacin C 0
                        19-hydroxyl-19,20-dihydrophomacin C 0
                        19-methoxy-19,20-dihydrophomacin C 0
                        20-Deoxycytochalasin F 0
                        6-hydroxy-10,14,15-trimethyl-17-(2-methylpropyl)-2-oxa-18-azatricyclo[10.7.0.01,16]nonadeca-4,10,13-triene-3,19-dione 0
                        Alachalasin A 0
                        Alachalasin D 0
                        Amiaspochalasin D 0
                        Amiaspochalasin E 0
                        Amiaspochalasin H 0
                        Asperchalasine D 0
                        Asperchalasine I 0
                        Aspochalamin A 0
                        Aspochalamin C 0
                        Aspochalamin D 0
                        Aspochalasin D 0
                        Aspochalasin E 0
                        Aspochalasin G 0
                        Aspochalasin I 0
                        Aspochalasin J 0
                        Aspochalasin K 0
                        Aspochalasin L 0
                        Aspochalasin N 0
                        Aspochalasin O 0
                        Aspochalasin P 0
                        Aspochalasin V 0
                        Aspochalasin Z 0
                        Bisaspochalasin A 0
                        Bisaspochalasin B 0
                        Bisaspochalasin C 0
                        Chaetoglobosin K 0
                        Cytochalasin A 0
                        Cytochalasin B6 0
                        Cytochalasin X 0
                        Cytochalasin Y 0
                        Cytochalasin Z4 0
                        Cytochalasin Z6 0
                        Cytochalazin Z3 0
                        Flavichalasine A 0
                        Flavichalasine B 0
                        Flavichalasine C 0
                        Flavichalasine D 0
                        Flavichalasine E 0
                        Flavichalasine F 0
                        Flavichalasine G 0
                        Flavichalasine H 0
                        Flavichalasine I 0
                        Flavichalasine J 0
                        Flavichalasine K 0
                        Flavichalasine L 0
                        Flavichalasine M 0
                        LSM-6235 0
                        Phomacin D 0
                        Phomacin E 0
                        Phomacin F 0
                        Phomopsisin B 0
                        Phomopsisin C 0
                        Pyrichalasin H 0
                        Spicarin A 0
                        Spicarin B 0
                        Xylarisin 0
                        cytochalasan alkaloid + 16
                        cytochalasin B 28
                        cytochalasin D 46
                        phomacin A 0
                        phomacin B 0
                        phomacin C 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22192
    subatomic particle 22184
      composite particle 22184
        hadron 22184
          baryon 22184
            nucleon 22184
              atomic nucleus 22184
                atom 22184
                  main group element atom 22118
                    p-block element atom 22118
                      carbon group element atom 21918
                        carbon atom 21844
                          organic molecular entity 21844
                            organic molecule 21660
                              organic cyclic compound 21266
                                organic heterocyclic compound 20339
                                  organic heteropolycyclic compound 19634
                                    organic heterobicyclic compound 18202
                                      benzopyrrole 9703
                                        isoindoles 1235
                                          cytochalasin 81
                                            (1S,2R,3R,6S,7R,8S,11S,14S,15S,18R)-18-hydroxy-5,6,15-trimethyl-8-(2-methylpropyl)-19-oxa-9-azapentacyclo[13.3.1.02,14.03,11.07,11]nonadec-4-ene-10,12-dione 0
                                            (3E,9E)-5,6-Dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-3,9,12-triene-2,18-dione 0
                                            (9E)-4,6-Dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,5,18-trione 0
                                            (9E)-5,6-Dihydroxy-4-methoxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,18-dione 0
                                            (9E)-5-Hydroxy-4-methoxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,18-dione 0
                                            16-hydroxymethylaspergillin PZ 0
                                            16alpha-methylaspochalasin J 0
                                            18-oxo-19,20-dihydrophomacin C 0
                                            18-oxo-19-hydroxyl-19,20-dihydrophomacin C 0
                                            18-oxo-19-methoxy-19,20-dihydrophomacin C 0
                                            19,20-dihydrophomacin C 0
                                            19-hydroxyl-19,20-dihydrophomacin C 0
                                            19-methoxy-19,20-dihydrophomacin C 0
                                            20-Deoxycytochalasin F 0
                                            6-hydroxy-10,14,15-trimethyl-17-(2-methylpropyl)-2-oxa-18-azatricyclo[10.7.0.01,16]nonadeca-4,10,13-triene-3,19-dione 0
                                            Alachalasin A 0
                                            Alachalasin D 0
                                            Amiaspochalasin D 0
                                            Amiaspochalasin E 0
                                            Amiaspochalasin H 0
                                            Asperchalasine D 0
                                            Asperchalasine I 0
                                            Aspochalamin A 0
                                            Aspochalamin C 0
                                            Aspochalamin D 0
                                            Aspochalasin D 0
                                            Aspochalasin E 0
                                            Aspochalasin G 0
                                            Aspochalasin I 0
                                            Aspochalasin J 0
                                            Aspochalasin K 0
                                            Aspochalasin L 0
                                            Aspochalasin N 0
                                            Aspochalasin O 0
                                            Aspochalasin P 0
                                            Aspochalasin V 0
                                            Aspochalasin Z 0
                                            Bisaspochalasin A 0
                                            Bisaspochalasin B 0
                                            Bisaspochalasin C 0
                                            Chaetoglobosin K 0
                                            Cytochalasin A 0
                                            Cytochalasin B6 0
                                            Cytochalasin X 0
                                            Cytochalasin Y 0
                                            Cytochalasin Z4 0
                                            Cytochalasin Z6 0
                                            Cytochalazin Z3 0
                                            Flavichalasine A 0
                                            Flavichalasine B 0
                                            Flavichalasine C 0
                                            Flavichalasine D 0
                                            Flavichalasine E 0
                                            Flavichalasine F 0
                                            Flavichalasine G 0
                                            Flavichalasine H 0
                                            Flavichalasine I 0
                                            Flavichalasine J 0
                                            Flavichalasine K 0
                                            Flavichalasine L 0
                                            Flavichalasine M 0
                                            LSM-6235 0
                                            Phomacin D 0
                                            Phomacin E 0
                                            Phomacin F 0
                                            Phomopsisin B 0
                                            Phomopsisin C 0
                                            Pyrichalasin H 0
                                            Spicarin A 0
                                            Spicarin B 0
                                            Xylarisin 0
                                            cytochalasan alkaloid + 16
                                            cytochalasin B 28
                                            cytochalasin D 46
                                            phomacin A 0
                                            phomacin B 0
                                            phomacin C 0
paths to the root