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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cytochalasin B
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Accession:CHEBI:23527 term browser browse the term
Definition:An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.
Synonyms:exact_synonym: (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
 related_synonym: Formula=C29H37NO5;   InChI=1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1;   InChIKey=GBOGMAARMMDZGR-TYHYBEHESA-N;   Phomin;   SMILES=[H][C@@]12\\C=C\\C[C@H](C)CCC[C@@H](O)\\C=C\\C(=O)O[C@]11C(=O)N[C@@H](Cc3ccccc3)[C@]1([H])[C@H](C)C(=C)[C@H]2O
 xref: CAS:14930-96-2;   KEGG:C19954;   LIPID_MAPS_instance:LMPK11000002
 xref_mesh: MESH:D003571
 xref: PMID:22882828;   Reaxys:1096210;   Wikipedia:Cytochalasin_B


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cytochalasin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cytochalasin B results in increased expression of BAX protein] CTD PMID:27640744 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cytochalasin B results in decreased expression of BCL2 protein] CTD PMID:27640744 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C5 complement C5 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein; Dexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Cytochalasin B results in increased cleavage of CASP3 protein CTD PMID:27640744 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Cytochalasin B results in increased cleavage of CASP9 protein CTD PMID:27640744 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of CAT protein] CTD PMID:20166893 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Cytochalasin B results in decreased expression of CCNB1 protein CTD PMID:27640744 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Cytochalasin B results in decreased expression of CDK1 protein CTD PMID:27640744 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Cytochalasin B results in increased expression of CDKN1A protein CTD PMID:27640744 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Cytochalasin B results in increased expression of CDKN1B protein CTD PMID:27640744 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Cytochalasin B inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Cytochalasin B inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cytochalasin B inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Elane elastase, neutrophil expressed multiple interactions ISO [Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein; pirinixic acid analog inhibits the reaction [[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein] CTD PMID:19686721 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Epo erythropoietin multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein; [Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein; Dexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP Cytochalasin B results in increased expression of FIS1 protein CTD PMID:26732598 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP [Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein; IMMLG5521 inhibits the reaction [[Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein] CTD PMID:23850278 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Cytochalasin B results in increased expression of HSPA5 protein CTD PMID:26732598 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cytochalasin B inhibits the reaction [[Alum Compounds co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form]; Cytochalasin B inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; Cytochalasin B inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]] CTD PMID:9698594 PMID:17404311 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Lpl lipoprotein lipase decreases activity ISO Cytochalasin B results in decreased activity of LPL protein CTD PMID:9414485 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:18776917 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18776917 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects folding
affects binding
multiple interactions
ISO Cytochalasin B affects the folding of SLC2A1 protein
Cytochalasin B binds to SLC2A1 protein
Cytochalasin B inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]
oxophenylarsine inhibits the reaction [Cytochalasin B binds to SLC2A1 protein]
CTD PMID:8457197 PMID:19686715 PMID:22363641 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
affects binding
ISO
EXP
Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]
Cytochalasin B binds to SLC2A2 protein
Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]; Mercuric Chloride inhibits the reaction [Cytochalasin B binds to SLC2A2 protein]
CTD PMID:8457197 PMID:10825458 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO Cytochalasin B inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose] CTD PMID:8457197 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of SOD2 protein] CTD PMID:20166893 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Cytochalasin B results in increased expression of TP53 protein CTD PMID:27640744 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

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  CHEBI ontology 19781
    role 19726
      biological role 19726
        biochemical role 19319
          metabolite 19301
            cytochalasin B 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      carboxylic acid 18202
                                        carboacyl group 17418
                                          univalent carboacyl group 17418
                                            carbamoyl group 17216
                                              carboxamide 17216
                                                lactam 8048
                                                  cytochalasin B 27
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