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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cytochalasin D
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Accession:CHEBI:529996 term browser browse the term
Definition:An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.
Synonyms:exact_synonym: (3S,3aR,4S,6S,7E,10S,12R,13E,15R,15aR)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
 related_synonym: 7,18-Dihydroxy-10-phenyl-5,16,18-trimethyl-(11)cytochalas-21-acetoxy-6(12),13,19-trien-17-one;   Cytohalasin D;   Formula=C30H37NO6;   InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22?,23-,24+,25-,26+,29+,30+/m0/s1;   InChIKey=SDZRWUKZFQQKKV-FJUULPFHSA-N;   Lygosporin A;   SMILES=[H][C@]12[C@H](Cc3ccccc3)NC(=O)[C@]11[C@H](OC(C)=O)\\C=C\\[C@@](C)(O)C(=O)[C@@H](C)C\\C=C\\C1[C@H](O)C(=C)[C@H]2C;   Zygosporin A
 xref: CAS:22144-77-0
 xref_mesh: MESH:D015638
 xref: PDBeChem:CY9;   PMID:20010439;   PMID:22305779;   PMID:22684244;   PMID:22728040;   PMID:23615686;   PMID:5800426;   PMID:7199049;   Reaxys:1632828;   Wikipedia:Cytochalasin_D



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cytochalasin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
ISO EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 NCBI chr 3:35,377,587...35,480,843 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO
EXP
Cytochalasin D inhibits the reaction [Oxygen results in increased expression of ACTA2 mRNA]; Cytochalasin D inhibits the reaction [Oxygen results in increased expression of ACTA2 protein]
Cytochalasin D results in increased expression of ACTA2 mRNA
CTD PMID:11035001 PMID:23517783 NCBI chr 1:241,159,723...241,172,503 JBrowse link
G Actg1 actin, gamma 1 multiple interactions ISO Cytochalasin D inhibits the reaction [UPF1 protein binds to ACTG1 protein]; Cytochalasin D inhibits the reaction [UPF2 protein binds to ACTG1 protein]; Cytochalasin D inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr10:106,118,106...106,120,951 JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO [Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein; RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein]
Cytochalasin D results in increased expression of CDH1 mRNA; Cytochalasin D results in increased expression of CDH1 protein
CTD PMID:25756282 NCBI chr19:51,402,178...51,471,572 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA] CTD PMID:23517783 NCBI chr10:80,380,458...80,397,461 JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA] CTD PMID:23517783 NCBI chr 4:33,518,557...33,553,484 JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Cytochalasin D inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; Cytochalasin D inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein] CTD PMID:10645887 NCBI chr10:38,887,692...38,889,673 JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR1 protein] CTD PMID:11145710 NCBI chr 9:83,216,040...83,220,225 JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR2 protein] CTD PMID:11145710 NCBI chr 9:75,729,493...75,735,868 JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 NCBI chr 2:220,893,660...220,976,331 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cytochalasin D inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr14:95,378,626...95,551,358 JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Cytochalasin D inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA] CTD PMID:25858758 NCBI chr 2:212,511,675...212,523,375 JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO Cytochalasin D affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:117,905,462...117,906,588 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein] CTD PMID:15034928 NCBI chr 8:27,829,688...27,841,618 JBrowse link
G Ifng interferon gamma multiple interactions ISO Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
multiple interactions
ISO Cytochalasin D results in increased phosphorylation of IKBKB protein
Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr16:76,021,968...76,075,717 JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Cytochalasin D inhibits the reaction [Quartz results in increased import of IL1A protein]; Cytochalasin D promotes the reaction [Quartz results in increased secretion of IL1A protein] CTD PMID:36840754 NCBI chr 3:136,979,804...136,990,236 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with aluminum sulfate] results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [titanium dioxide results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Cytochalasin D inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of IL1B mRNA]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]
CTD PMID:12799187 PMID:18403674 PMID:18604214 PMID:24158569 PMID:24760326 More... NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il6 interleukin 6 decreases chemical synthesis
increases stability
ISO Cytochalasin D results in decreased chemical synthesis of IL6 protein
Cytochalasin D results in increased stability of IL6 mRNA
CTD PMID:16499908 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Ivns1abp influenza virus NS1A binding protein increases response to substance ISO IVNS1ABP gene mutant form results in increased susceptibility to Cytochalasin D CTD PMID:15485691 NCBI chr13:65,977,069...65,996,685 JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Cytochalasin D inhibits the reaction [Quartz results in increased activity of and results in increased secretion of LDHA protein] CTD PMID:36840754 NCBI chr 1:97,371,823...97,381,247 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA] CTD PMID:17560598 NCBI chr 3:174,103,474...174,111,434 JBrowse link
G Mrtfa myocardin related transcription factor A multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen affects the localization of MRTFA protein] CTD PMID:23517783 NCBI chr 7:112,544,305...112,714,418 JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 decreases localization ISO Cytochalasin D results in decreased localization of NFATC4 protein CTD PMID:17044076 NCBI chr15:33,256,912...33,284,522 JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
ISO Cytochalasin D results in increased phosphorylation of NFKBIA protein
Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression
multiple interactions
ISO Cytochalasin D results in decreased expression of NLRP3 mRNA
Cytochalasin D inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NLRP3 mRNA]
CTD PMID:37062408 NCBI chr10:44,826,299...44,853,373 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr10:64,313,335...64,349,221 JBrowse link
G P2rx1 purinergic receptor P2X 1 decreases activity ISO Cytochalasin D results in decreased activity of P2RX1 protein CTD PMID:21757694 NCBI chr10:57,618,586...57,633,648 JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases uptake ISO Cytochalasin D results in decreased uptake of PDX1 protein CTD PMID:16405074 NCBI chr12:12,793,957...12,799,156 JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Cytochalasin D results in increased expression of PLAT CTD PMID:12371961 NCBI chr16:75,943,061...76,022,037 JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein; RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein] CTD PMID:25756282 NCBI chr 8:117,870,548...117,904,303 JBrowse link
G Rs1 retinoschisin 1 decreases secretion ISO Cytochalasin D results in decreased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:37,771,135...37,800,894 JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] CTD PMID:17108132 NCBI chr 5:75,814,744...75,844,241 JBrowse link
G Smad1 SMAD family member 1 affects localization ISO Cytochalasin D affects the localization of SMAD1 protein CTD PMID:25756282 NCBI chr19:45,417,430...45,477,962 JBrowse link
G Smad2 SMAD family member 2 affects localization ISO Cytochalasin D affects the localization of SMAD2 protein CTD PMID:25756282 NCBI chr18:72,124,792...72,193,345 JBrowse link
G Smad3 SMAD family member 3 affects localization ISO Cytochalasin D affects the localization of SMAD3 protein CTD PMID:25756282 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Snai1 snail family transcriptional repressor 1 affects localization ISO Cytochalasin D affects the localization of SNAI1 protein CTD PMID:25756282 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Cytochalasin D deficiency results in decreased activity of and affects the localization of STAT1 protein CTD PMID:28086195 NCBI chr 9:56,911,522...56,951,926 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Cytochalasin D deficiency results in decreased activity of and affects the localization of STAT3 protein CTD PMID:28086195 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Tagln transgelin increases expression EXP Cytochalasin D results in increased expression of TAGLN mRNA CTD PMID:11035001 NCBI chr 8:55,121,647...55,127,121 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA]
Cytochalasin D inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Cytochalasin D inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:8409756 PMID:12799187 PMID:15034928 PMID:17560598 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Cadmium Chloride affects the localization of TXN protein] CTD PMID:22961094 NCBI chr 5:77,507,455...77,519,685 JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization
multiple interactions
ISO Cytochalasin D affects the localization of UPF1 protein
Cytochalasin D inhibits the reaction [UPF1 protein binds to ACTG1 protein]
CTD PMID:28743738 NCBI chr16:19,076,594...19,097,365 JBrowse link
G Upf2 UPF2, regulator of nonsense mediated mRNA decay multiple interactions ISO Cytochalasin D inhibits the reaction [UPF2 protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr17:72,224,575...72,335,896 JBrowse link
G Upf3b UPF3B, regulator of nonsense mediated mRNA decay multiple interactions ISO Cytochalasin D inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr  X:116,335,308...116,353,332 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:15034928 NCBI chr 2:206,723,050...206,742,783 JBrowse link

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  CHEBI ontology 19898
    role 19869
      biological role 19867
        inhibitor 18949
          actin polymerisation inhibitor 84
            cytochalasin D 46
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      carboacyl group 17726
                                        univalent carboacyl group 17726
                                          carbamoyl group 17570
                                            carboxamide 17570
                                              lactam 8401
                                                gamma-lactam 6661
                                                  cytochalasin D 46
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