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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cytochalasan alkaloid
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Accession:CHEBI:75946 term browser browse the term
Definition:Any alkaloid characterized by the presence of an isoindole nucleus fused to a macrocyclic ring.
Synonyms:related_synonym: cytochalasan alkaloids



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chaetoglobosin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP chaetoglobosins results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]
CTD PMID:18040759 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP chaetoglobosins inhibits the reaction [Dieldrin results in decreased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein] CTD PMID:18040759 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
EXP chaetoglobosins results in increased phosphorylation of GSK3B protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]
CTD PMID:18040759 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:33285210 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:33285210 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:33285210 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IRF7 mRNA] CTD PMID:33285210 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP
ISO
chaetoglobosins results in increased phosphorylation of MAPK1 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:18040759 PMID:33285210 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP
ISO
chaetoglobosins results in increased phosphorylation of MAPK3 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD PMID:18040759 PMID:33285210 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA] CTD PMID:33285210 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:33285210 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:33285210 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation EXP chaetoglobosins results in decreased phosphorylation of RAF1 protein CTD PMID:18040759 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:33285210 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:33285210 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; chaetoglobosins results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 PMID:33285210 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        biochemical role 19624
          metabolite 19605
            alkaloid 5700
              cytochalasan alkaloid 16
                18-deoxycytochalasin Q 0
                19-O-acetylchaetoglobosin A 0
                Cytochalasin E 0
                Cytochalasin Npho 0
                Cytochalasin Opho 0
                Cytochalasin Ppho 0
                chaetoglobosin A + 16
                chaetoglobosin B 0
                chaetoglobosin C 0
                chaetoglobosin D 0
                chaetoglobosin E 0
                chaetoglobosin F 0
                chaetoglobosin Fex 0
                chaetoglobosin G 0
                chaetoglobosin J 0
                chaetoglobosin P 0
                chaetoglobosin Q 0
                chaetoglobosin R 0
                chaetoglobosin T 0
                chaetoglobosin U 0
                chaetoglobosin V 0
                chaetoglobosin Vb 0
                cytochalasin Z16 0
                cytoglobosin A 0
                cytoglobosin B 0
                cytoglobosin C 0
                cytoglobosin D 0
                cytoglobosin E 0
                cytoglobosin F 0
                cytoglobosin G 0
                iso-precytochalasin 0
                isochaetoglobosin D 0
                ketocytochalasin 0
                prochaetoglobosin I 0
                prochaetoglobosin II 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                organic heterocyclic compound 18799
                                  organic heteropolycyclic compound 18274
                                    organic heterobicyclic compound 17169
                                      benzopyrrole 9604
                                        isoindoles 1133
                                          cytochalasin 77
                                            cytochalasan alkaloid 16
                                              18-deoxycytochalasin Q 0
                                              19-O-acetylchaetoglobosin A 0
                                              Cytochalasin E 0
                                              Cytochalasin Npho 0
                                              Cytochalasin Opho 0
                                              Cytochalasin Ppho 0
                                              chaetoglobosin A + 16
                                              chaetoglobosin B 0
                                              chaetoglobosin C 0
                                              chaetoglobosin D 0
                                              chaetoglobosin E 0
                                              chaetoglobosin F 0
                                              chaetoglobosin Fex 0
                                              chaetoglobosin G 0
                                              chaetoglobosin J 0
                                              chaetoglobosin P 0
                                              chaetoglobosin Q 0
                                              chaetoglobosin R 0
                                              chaetoglobosin T 0
                                              chaetoglobosin U 0
                                              chaetoglobosin V 0
                                              chaetoglobosin Vb 0
                                              cytochalasin Z16 0
                                              cytoglobosin A 0
                                              cytoglobosin B 0
                                              cytoglobosin C 0
                                              cytoglobosin D 0
                                              cytoglobosin E 0
                                              cytoglobosin F 0
                                              cytoglobosin G 0
                                              iso-precytochalasin 0
                                              isochaetoglobosin D 0
                                              ketocytochalasin 0
                                              prochaetoglobosin I 0
                                              prochaetoglobosin II 0
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