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Gene: Mrtfa (myocardin related transcription factor A) Mus musculus
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Symbol: Mrtfa
Name: myocardin related transcription factor A
RGD ID: 1312565
Description: Exhibits actin monomer binding activity; transcription regulator activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of apoptotic process; nervous system development; and positive regulation of transcription via serum response element binding activity. Localizes to cytoplasm and nucleus. Is expressed in cerebellum; early conceptus; liver; oocyte; and telencephalon. Human ortholog(s) of this gene implicated in immunodeficiency 66 and megakaryocytic leukemia. Orthologous to human MRTFA (myocardin related transcription factor A); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; buta-1,3-diene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI852829; AMKL; AW743281; AW821984; basic SAP and coiled-coil domains; basic SAP coiled-coil transcription activator; Bs; Bsac; M; Mal; megakaryoblastic leukemia (translocation) 1 homolog; megakaryoblastic leukemia 1 protein homolog; megakaryocytic acute leukemia protein homolog; Mkl; MKL (megakaryoblastic leukemia)/myocardin-like 1; MKL/myocardin-like protein 1; Mkl1; MRTF; Mrtf-A; myocardial related transcription factor A; myocardin-related transcription factor A
Orthologs:
Homo sapiens (human) : MRTFA (myocardin related transcription factor A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mrtfa (myocardin related transcription factor A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mrtfa (myocardin related transcription factor A)
Pan paniscus (bonobo/pygmy chimpanzee) : MRTFA (myocardin related transcription factor A)
Canis lupus familiaris (dog) : MRTFA (myocardin related transcription factor A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mrtfa (myocardin related transcription factor A)
Sus scrofa (pig) : MRTFA (myocardin related transcription factor A)
Chlorocebus sabaeus (African green monkey) : MRTFA (myocardin related transcription factor A)
Heterocephalus glaber (naked mole-rat) : Mrtfa (myocardin related transcription factor A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,896,482 - 81,074,937 (-)NCBI
GRCm381581,012,281 - 81,190,736 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,012,281 - 81,190,757 (-)EnsemblGRCm38mm10GRCm38
MGSCv371580,842,711 - 81,021,187 (-)NCBIGRCm37mm9NCBIm37
MGSCv361580,840,540 - 80,932,073 (-)NCBImm8
Celera1583,132,403 - 83,308,218 (-)NCBICelera
Cytogenetic Map15E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Mrtfa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312565
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.