Pentoxifylline - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Pentoxifylline	go back to main search page
Accession:	CHEBI:7986	browse the term
Definition:	An oxopurine that has formula C13H18N4O3.
Synonyms:	related_synonym:	Formula=C13H18N4O3; InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3; InChIKey=BYPFEZZEUUWMEJ-UHFFFAOYSA-N; SMILES=CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O; azupentat; dimethyloxohexylxanthine; oxpentifylline; pentoxifyllin
	xref:	CAS:6493-05-6; Drug_Central:2099; HMDB:HMDB0014944; KEGG:C07424; KEGG:D00501; LINCS:LSM-3285
	xref_mesh:	MESH:D010431
	xref:	PDBeChem:PNX

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Genes (88)

Pentoxifylline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

decreases expression
multiple interactions

Pentoxifylline results in decreased expression of ABCB1 protein
[Pentoxifylline co-treated with Doxorubicin] results in decreased expression of ABCB1 protein

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

multiple interactions

[Pentoxifylline co-treated with Doxorubicin] results in decreased expression of ABCC1 protein

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

acetylcholinesterase (Yt blood group)

decreases activity

Pentoxifylline results in decreased activity of ACHE protein

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

Pentoxifylline results in decreased expression of ACTA2 protein
Pentoxifylline promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]

PMID:14996430 PMID:18207697

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339

G

BCL2 associated X, apoptosis regulator

multiple interactions

Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of BAX protein]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions

[Rolipram co-treated with Pentoxifylline] inhibits the reaction [Streptozocin results in increased expression of BCL2 protein]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of BCL2 protein]

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

multiple interactions
decreases expression

[Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein
Pentoxifylline results in decreased expression of BCL2L1 mRNA; Pentoxifylline results in decreased expression of BCL2L1 protein

PMID:18851957 PMID:20804743

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

BH3 interacting domain death agonist

multiple interactions

Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of BID protein]

NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770

G

baculoviral IAP repeat containing 2

multiple interactions

[Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC2 protein

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

baculoviral IAP repeat containing 3

multiple interactions

[Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC3 protein

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

G

B-Raf proto-oncogene, serine/threonine kinase

multiple interactions

[Pentoxifylline results in increased abundance of Cyclic AMP] which results in increased activity of BRAF protein

NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929

G

caspase 1

multiple interactions

Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of CASP1 protein]

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

multiple interactions
increases activity

Pentoxifylline inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
Pentoxifylline results in increased activity of CASP3 protein
[Pentoxifylline co-treated with Doxorubicin] results in increased cleavage of CASP3 protein
[Rolipram co-treated with Pentoxifylline] inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Pentoxifylline inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]

PMID:16317704 PMID:18851957 PMID:33775688 PMID:37431890

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

multiple interactions

Pentoxifylline promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions

[Pentoxifylline co-treated with TNFSF10 protein] results in increased activity of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

multiple interactions

[Melatonin co-treated with Pentoxifylline] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Pentoxifylline inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
Pentoxifylline inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Pentoxifylline inhibits the reaction [Malathion results in increased activity of CAT protein]

PMID:16703270 PMID:20194575 PMID:23695977

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression
decreases secretion

Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]
Pentoxifylline results in decreased expression of CCL2 mRNA
Pentoxifylline results in decreased secretion of CCL2 protein

PMID:14993492 PMID:18617301 PMID:19921414

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-C motif chemokine ligand 5

decreases expression

Pentoxifylline results in decreased expression of CCL5 mRNA

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

cellular communication network factor 2

decreases expression

Pentoxifylline results in decreased expression of CCN2 mRNA

NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372

G

cyclin A2

multiple interactions

Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]]

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin B1

multiple interactions

Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]]

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

CD69 molecule

decreases expression

Pentoxifylline results in decreased expression of CD69 protein

NCBI chr12:9,752,486...9,760,901
Ensembl chr12:9,752,486...9,760,901

G

cyclin dependent kinase 1

multiple interactions

Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]]

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase 2

multiple interactions

Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]]

NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789

G

cyclin dependent kinase inhibitor 1B

multiple interactions

[Pentoxifylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

CASP8 and FADD like apoptosis regulator

multiple interactions
decreases expression

[Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein
Pentoxifylline results in decreased expression of CFLAR protein

PMID:18851957 PMID:20804743

NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687

G

creatine kinase, M-type

multiple interactions

Pentoxifylline inhibits the reaction [Glycerol results in increased secretion of CKM protein]

NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875

G

collagen type I alpha 1 chain

multiple interactions
decreases expression

Pentoxifylline inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA]
Pentoxifylline results in decreased expression of COL1A1 mRNA
Pentoxifylline promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]

PMID:7617123 PMID:11788567 PMID:12419648 PMID:14993492 PMID:17952619 More...

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type III alpha 1 chain

decreases expression

Pentoxifylline results in decreased expression of COL3A1 protein

NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746

G

C-reactive protein

decreases expression

Pentoxifylline results in decreased expression of CRP protein

NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589

G

C-X-C motif chemokine ligand 2

multiple interactions

Pentoxifylline inhibits the reaction [[Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein]

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

G

C-X-C motif chemokine ligand 8

decreases expression

Pentoxifylline decreases expression of CXCL8 mRNA in peripheral blood mononuclear cells

RGD

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

cytochrome c, somatic

increases secretion
multiple interactions

Pentoxifylline results in increased secretion of CYCS protein
Pentoxifylline promotes the reaction [TNFSF10 protein results in increased secretion of CYCS protein]

PMID:18851957 PMID:20804743

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

Pentoxifylline results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

Fas cell surface death receptor

increases expression
decreases expression

Pentoxifylline results in increased expression of FAS mRNA; Pentoxifylline results in increased expression of FAS protein
Pentoxifylline results in decreased expression of FAS protein

PMID:14970111 PMID:18851957

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Pentoxifylline results in increased expression of FOS mRNA

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190

G

growth arrest and DNA damage inducible alpha

increases expression

Pentoxifylline results in increased expression of GADD45A mRNA

NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334

G

gasdermin D

multiple interactions

Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of GSDMD protein]

NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062

G

hepatitis A virus cellular receptor 1

multiple interactions

Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of and results in increased secretion of HAVCR1 protein]

NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396

G

heme oxygenase 1

decreases expression

Pentoxifylline results in decreased expression of HMOX1 protein

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

intercellular adhesion molecule 1

decreases expression

Pentoxifylline results in decreased expression of ICAM1 mRNA

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interleukin 10

multiple interactions

Pentoxifylline promotes the reaction [Zymosan results in increased expression of IL10 protein]

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 1 beta

multiple interactions

Pentoxifylline promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of IL1B protein]; Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of IL1B protein]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]

PMID:15711975 PMID:16133968 PMID:17167242 PMID:17698507 PMID:23695977 More...

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2 receptor subunit alpha

multiple interactions
decreases expression
decreases secretion

N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [Pentoxifylline results in decreased expression of IL2RA protein]
Pentoxifylline results in decreased expression of IL2RA mRNA; Pentoxifylline results in decreased expression of IL2RA protein
Pentoxifylline results in decreased secretion of IL2RA protein

PMID:1709825 PMID:25433234

NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370

G

interleukin 4

increases expression

Pentoxifylline results in increased expression of IL4 mRNA

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 6

multiple interactions
decreases expression

Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Acetaldehyde promotes the reaction [Pentoxifylline results in decreased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Acetaldehyde results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]

PMID:12419648 PMID:15711975 PMID:17167242 PMID:17698507 PMID:17952619 More...

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

integrin subunit beta 2

affects expression

Pentoxifylline affects the expression of ITGB2

NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989

G

microtubule associated protein 1 light chain 3 beta

multiple interactions

Pentoxifylline inhibits the reaction [Cisplatin results in decreased expression of MAP1LC3B protein modified form]

NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779

G

mitogen-activated protein kinase kinase kinase 7

multiple interactions
affects binding

Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MAP3K7 protein]
Pentoxifylline binds to MAP3K7 protein

NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086

G

mitogen-activated protein kinase 1

multiple interactions

Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

increases expression

Pentoxifylline results in increased expression of MAPK8 protein; Pentoxifylline results in increased expression of MAPK8 protein modified form

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

increases expression

Pentoxifylline results in increased expression of MAPK9 protein; Pentoxifylline results in increased expression of MAPK9 protein modified form

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

MCL1 apoptosis regulator, BCL2 family member

increases expression

Pentoxifylline results in increased expression of MCL1 mRNA

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

microRNA 26b

multiple interactions

Pentoxifylline inhibits the reaction [Cisplatin results in decreased expression of MIR26B mRNA]

NCBI chr 2:218,402,646...218,402,722
Ensembl chr 2:218,402,646...218,402,722

G

microRNA 34a

multiple interactions

Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MIR34A mRNA]

NCBI chr 1:9,151,668...9,151,777
Ensembl chr 1:9,151,668...9,151,777

G

microRNA let-7b

multiple interactions

Pentoxifylline inhibits the reaction [Cisplatin results in decreased expression of MIRLET7B mRNA]

NCBI chr22:46,113,686...46,113,768
Ensembl chr22:46,113,686...46,113,768

G

myeloperoxidase

multiple interactions

Pentoxifylline inhibits the reaction [Indomethacin results in increased activity of MPO protein]

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

mechanistic target of rapamycin kinase

multiple interactions

Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MTOR protein]

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

Pentoxifylline inhibits the reaction [Glycerol results in increased expression of MYC protein]

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

nuclear factor kappa B subunit 1

multiple interactions

Pentoxifylline inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]]

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor alpha

multiple interactions

Pentoxifylline inhibits the reaction [Acetaldehyde results in decreased expression of NFKBIA protein]; Pentoxifylline inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

NLR family pyrin domain containing 3

multiple interactions

Pentoxifylline inhibits the reaction [Glycerol results in increased expression of NLRP3 protein]

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108

G

nitric oxide synthase 2

multiple interactions

Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of NOS2 protein]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

natriuretic peptide B

decreases expression

Pentoxifylline results in decreased expression of NPPB protein

NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945

G

poly(ADP-ribose) polymerase 1

multiple interactions
increases cleavage

[Pentoxifylline co-treated with Doxorubicin] results in increased cleavage of PARP1 protein; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
Pentoxifylline results in increased cleavage of PARP1 protein

PMID:18851957 PMID:20804743 PMID:33775688

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

perforin 1

decreases secretion

Pentoxifylline results in decreased secretion of PRF1 protein

NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759

G

proteasome 20S subunit alpha 1

multiple interactions

Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA1 mRNA]

NCBI chr11:14,504,876...14,643,662
Ensembl chr11:14,504,211...14,643,635

G

proteasome 20S subunit alpha 3

multiple interactions

Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA3 mRNA]

NCBI chr14:58,244,843...58,272,004
Ensembl chr14:58,244,843...58,272,012

G

proteasome 26S subunit, ATPase 6

multiple interactions

Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMC6 mRNA]

NCBI chr14:52,707,200...52,728,590
Ensembl chr14:52,707,178...52,728,590

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Pentoxifylline inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RAP1B, member of RAS oncogene family

multiple interactions

[Pentoxifylline results in increased abundance of Cyclic AMP] results in increased abundance of [RAP1B protein binds to Guanosine Triphosphate]

NCBI chr12:68,610,899...68,671,901
Ensembl chr12:68,610,855...68,671,901

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Pentoxifylline inhibits the reaction and results in decreased activity of Ethanol inhibits the reaction and results in decreased activity of RELA protein
Pentoxifylline inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]]; Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of RELA protein]
[Pentoxifylline co-treated with Doxorubicin] results in decreased phosphorylation of RELA protein

PMID:16317704 PMID:17952619 PMID:32777238 PMID:33775688

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

serpin family E member 1

multiple interactions

Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

secreted phosphoprotein 1

decreases expression

Pentoxifylline results in decreased expression of SPP1 mRNA

NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532

G

transforming growth factor alpha

decreases expression

Pentoxifylline results in decreased expression of TGFA mRNA

NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193

G

transforming growth factor beta 1

decreases expression
multiple interactions

Pentoxifylline results in decreased expression of TGFB1 mRNA
Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]

PMID:11788567 PMID:32777238

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

transforming growth factor beta 2

increases expression

Pentoxifylline results in increased expression of TGFB2 mRNA

NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619

G

transforming growth factor beta receptor 1

multiple interactions
affects binding

Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of TGFBR1 mRNA]; Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein]
Pentoxifylline binds to TGFBR1 protein

NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192

G

TIMP metallopeptidase inhibitor 1

increases expression

Pentoxifylline results in increased expression of TIMP1 mRNA

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

toll like receptor 4

multiple interactions

Pentoxifylline inhibits the reaction [Glycerol results in increased expression of TLR4 protein]

NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735

G

tumor necrosis factor

decreases expression
multiple interactions
decreases secretion
increases expression

Pentoxifylline results in decreased expression of TNF mRNA; Pentoxifylline results in decreased expression of TNF protein
Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Pentoxifylline results in decreased secretion of TNF protein
Pentoxifylline results in increased expression of TNF protein
[Pentoxifylline results in decreased expression of TNF mRNA] results in decreased susceptibility to [lipopolysaccharide, E coli O55-B5 co-treated with trovafloxacin]; Pentoxifylline inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Ethanol results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; Pentoxifylline inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Pentoxifylline inhibits the reaction [Zymosan results in increased expression of TNF protein]
Pentoxifylline inhibits the reaction [Ceruletide results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Glycerol results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]

PMID:1593221 PMID:7589090 PMID:7769305 PMID:8741040 PMID:10773043 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 10a

increases expression

Pentoxifylline results in increased expression of TNFRSF10A protein

NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102

G

TNF receptor superfamily member 10b

increases expression

Pentoxifylline results in increased expression of TNFRSF10B protein

NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031

G

TNF superfamily member 10

multiple interactions
increases expression

[Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC2 protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC3 protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [Pentoxifylline co-treated with TNFSF10 protein] results in increased activity of CASP9 protein; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of BID protein]; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased secretion of CYCS protein]
Pentoxifylline results in increased expression of TNFSF10 mRNA

PMID:18851957 PMID:20804743

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

vascular cell adhesion molecule 1

decreases expression

Pentoxifylline results in decreased expression of VCAM1 mRNA

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

G

vascular endothelial growth factor A

decreases expression

Pentoxifylline results in decreased expression of VEGFA mRNA

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

X-linked inhibitor of apoptosis

multiple interactions

[Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of XIAP protein

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26502
chemical entity	26474
atom	26478
nonmetal atom	25730
nitrogen atom	22686
nitrogen molecular entity	22686
organonitrogen compound	22115
organonitrogen heterocyclic compound	20372
imidazopyrimidine	8115
purines	8114
oxopurine	6660
Pentoxifylline	88
Path 2
Term	Annotations
CHEBI ontology	26502
subatomic particle	26470
composite particle	26478
hadron	26478
baryon	26478
nucleon	26470
atomic nucleus	26478
atom	26478
main group element atom	26206
p-block element atom	26206
carbon group element atom	25649
carbon atom	25611
organic molecular entity	25611
organic molecule	25362
organic cyclic compound	24410
organic heterocyclic compound	22422
organic heteropolycyclic compound	21420
organic heterobicyclic compound	18578
imidazopyrimidine	8115
purines	8114
oxopurine	6660
Pentoxifylline	88

paths to the root