PSMC6 (proteasome 26S subunit, ATPase 6) - Rat Genome Database

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Gene: PSMC6 (proteasome 26S subunit, ATPase 6) Homo sapiens
Analyze
Symbol: PSMC6
Name: proteasome 26S subunit, ATPase 6
RGD ID: 1318819
HGNC Page HGNC
Description: Exhibits identical protein binding activity. Predicted to be involved in positive regulation of RNA polymerase II transcription preinitiation complex assembly and ubiquitin-dependent ERAD pathway. Localizes to nucleus and proteasome complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 26S protease regulatory subunit 10B; 26S protease regulatory subunit S10B; 26S proteasome AAA-ATPase subunit RPT4; 26S proteasome regulatory subunit 10B; CADP44; conserved ATPase domain protein 44; epididymis secretory protein Li 73; HEL-S-73; MGC12520; p42; P44; proteasome (prosome, macropain) 26S subunit, ATPase, 6; proteasome 26S subunit ATPase 6; proteasome subunit p42; RPT5; SUG2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: PSMC6P1   PSMC6P2   PSMC6P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1452,707,178 - 52,728,590 (+)EnsemblGRCh38hg38GRCh38
GRCh381452,707,163 - 52,728,590 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371453,173,918 - 53,195,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361452,243,668 - 52,264,466 (+)NCBINCBI36hg18NCBI36
Build 341452,243,667 - 52,264,465NCBI
Celera1433,041,500 - 33,062,289 (+)NCBI
Cytogenetic Map14q22.1NCBI
HuRef1433,334,988 - 33,355,703 (+)NCBIHuRef
CHM1_11453,112,814 - 53,133,601 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anaphase-promoting complex-dependent catabolic process  (TAS)
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  (TAS)
Fc-epsilon receptor signaling pathway  (TAS)
interleukin-1-mediated signaling pathway  (TAS)
MAPK cascade  (TAS)
negative regulation of canonical Wnt signaling pathway  (TAS)
negative regulation of G2/M transition of mitotic cell cycle  (TAS)
NIK/NF-kappaB signaling  (TAS)
positive regulation of canonical Wnt signaling pathway  (TAS)
positive regulation of inclusion body assembly  (IEA,ISO)
positive regulation of proteasomal protein catabolic process  (IEA)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (IBA)
post-translational protein modification  (TAS)
pre-replicative complex assembly  (TAS)
proteasome-mediated ubiquitin-dependent protein catabolic process  (TAS)
protein deubiquitination  (TAS)
protein polyubiquitination  (TAS)
regulation of cellular amino acid metabolic process  (TAS)
regulation of hematopoietic stem cell differentiation  (TAS)
regulation of mitotic cell cycle phase transition  (TAS)
regulation of mRNA stability  (TAS)
regulation of transcription from RNA polymerase II promoter in response to hypoxia  (TAS)
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  (TAS)
stimulatory C-type lectin receptor signaling pathway  (TAS)
T cell receptor signaling pathway  (TAS)
transmembrane transport  (TAS)
tumor necrosis factor-mediated signaling pathway  (TAS)
ubiquitin-dependent ERAD pathway  (IBA,IEA)
ubiquitin-dependent protein catabolic process  (IC)
Wnt signaling pathway, planar cell polarity pathway  (TAS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Pipeline to import KEGG annotations from KEGG into RGD
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8621709   PMID:8674546   PMID:8811196   PMID:9079628   PMID:9464850   PMID:9473509   PMID:9811770   PMID:9846577   PMID:10363644   PMID:10419517   PMID:10893419   PMID:11285280  
PMID:11361004   PMID:11590019   PMID:11734547   PMID:12167863   PMID:12419264   PMID:12477932   PMID:12499840   PMID:12719574   PMID:12750511   PMID:12791267   PMID:12808465   PMID:12808466  
PMID:12809610   PMID:12830140   PMID:12840737   PMID:12859895   PMID:12914693   PMID:12920286   PMID:12970355   PMID:14527406   PMID:14528300   PMID:14528301   PMID:14550573   PMID:14557625  
PMID:14564014   PMID:14614829   PMID:15029244   PMID:15489334   PMID:15610744   PMID:15782218   PMID:15831487   PMID:16189514   PMID:16196087   PMID:16239144   PMID:16341674   PMID:16501559  
PMID:16763564   PMID:17148452   PMID:17314511   PMID:17323924   PMID:17353931   PMID:17573772   PMID:18029348   PMID:18922472   PMID:19056867   PMID:19193609   PMID:19269966   PMID:19412159  
PMID:19490896   PMID:19615732   PMID:19738201   PMID:19815544   PMID:19946888   PMID:20467437   PMID:20478047   PMID:20479273   PMID:20682791   PMID:20890303   PMID:21081666   PMID:21145461  
PMID:21151955   PMID:21319273   PMID:21320693   PMID:21516116   PMID:21630459   PMID:21873635   PMID:22268729   PMID:22275368   PMID:22645313   PMID:22810586   PMID:22863883   PMID:22939629  
PMID:22952844   PMID:23125841   PMID:23190606   PMID:23376485   PMID:23438482   PMID:23503661   PMID:23535732   PMID:23602568   PMID:24169447   PMID:24583282   PMID:24720748   PMID:24875235  
PMID:24999758   PMID:25147182   PMID:25416956   PMID:25499913   PMID:25756610   PMID:25796446   PMID:25801217   PMID:25921289   PMID:26186194   PMID:26344197   PMID:26496610   PMID:26618866  
PMID:26638075   PMID:26661414   PMID:26748699   PMID:26831064   PMID:26839216   PMID:26871637   PMID:26972000   PMID:27107014   PMID:27173435   PMID:27428775   PMID:27591049   PMID:27609421  
PMID:27684187   PMID:27705803   PMID:27880917   PMID:28190767   PMID:28292943   PMID:28302793   PMID:28514442   PMID:28533407   PMID:28539385   PMID:28581483   PMID:28675297   PMID:28685749  
PMID:28821611   PMID:29128334   PMID:29229926   PMID:29426014   PMID:29467282   PMID:29507755   PMID:29509190   PMID:29636472   PMID:29666234   PMID:29845934   PMID:29863498   PMID:29871923  
PMID:29955894   PMID:30033366   PMID:30224337   PMID:30257870   PMID:30340022   PMID:30425250   PMID:30442662   PMID:30455355   PMID:30462309   PMID:30463901   PMID:30559147   PMID:30619736  
PMID:30833792   PMID:30948266   PMID:31059266   PMID:31067453   PMID:31073040   PMID:31091453   PMID:31180492   PMID:31340145   PMID:31478661   PMID:31515488   PMID:31527615   PMID:31586073  
PMID:31732153   PMID:31740976   PMID:31901637   PMID:31950832   PMID:31980649   PMID:32017075   PMID:32129710   PMID:32203420   PMID:32296183   PMID:32694731   PMID:32814053   PMID:32877691  


Genomics

Comparative Map Data
PSMC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1452,707,178 - 52,728,590 (+)EnsemblGRCh38hg38GRCh38
GRCh381452,707,163 - 52,728,590 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371453,173,918 - 53,195,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361452,243,668 - 52,264,466 (+)NCBINCBI36hg18NCBI36
Build 341452,243,667 - 52,264,465NCBI
Celera1433,041,500 - 33,062,289 (+)NCBI
Cytogenetic Map14q22.1NCBI
HuRef1433,334,988 - 33,355,703 (+)NCBIHuRef
CHM1_11453,112,814 - 53,133,601 (+)NCBICHM1_1
Psmc6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391445,567,280 - 45,587,138 (+)NCBIGRCm39mm39
GRCm39 Ensembl1445,567,245 - 45,587,162 (+)Ensembl
GRCm381445,329,823 - 45,349,074 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1445,329,788 - 45,349,705 (+)EnsemblGRCm38mm10GRCm38
MGSCv371445,949,499 - 45,968,746 (+)NCBIGRCm37mm9NCBIm37
MGSCv361444,251,701 - 44,270,948 (+)NCBImm8
Celera1441,509,669 - 41,529,121 (+)NCBICelera
Cytogenetic Map14C1NCBI
Psmc6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21518,542,585 - 18,564,057 (+)NCBI
Rnor_6.0 Ensembl1519,667,453 - 19,688,914 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01519,667,453 - 19,688,916 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01523,631,640 - 23,653,072 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41521,217,367 - 21,239,320 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11521,217,379 - 21,238,663 (+)NCBI
Celera1518,970,916 - 18,992,439 (+)NCBICelera
Cytogenetic Map15p14NCBI
Psmc6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540910,454,210 - 10,474,872 (-)NCBIChiLan1.0ChiLan1.0
PSMC6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11451,587,467 - 51,608,044 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1451,587,467 - 51,608,044 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01433,303,689 - 33,324,502 (+)NCBIMhudiblu_PPA_v0panPan3
LOC100687259
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13235,814,756 - 35,816,311 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha326,196,263 - 6,197,815 (+)NCBI
Psmc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864076,348,572 - 76,369,833 (-)NCBI
SpeTri2.0NW_0049366972,122,727 - 2,143,988 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1182,328,521 - 182,354,958 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11182,329,070 - 182,354,959 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21202,599,698 - 202,625,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSMC6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12429,784,825 - 29,807,701 (+)NCBI
ChlSab1.1 Ensembl2429,784,826 - 29,807,490 (+)Ensembl
Psmc6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473116,386,194 - 16,414,554 (-)NCBI

Position Markers
G35668  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371453,182,220 - 53,182,315UniSTSGRCh37
Build 361452,251,970 - 52,252,065RGDNCBI36
Celera1433,049,791 - 33,049,886RGD
Cytogenetic Map14q22.1UniSTS
HuRef1433,343,205 - 33,343,300UniSTS
D14S1297  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371453,194,565 - 53,194,713UniSTSGRCh37
Build 361452,264,315 - 52,264,463RGDNCBI36
Celera1433,062,138 - 33,062,286RGD
Cytogenetic Map14q22.1UniSTS
HuRef1433,355,552 - 33,355,700UniSTS
RH68060  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37856,963,258 - 56,963,478UniSTSGRCh37
Build 36857,125,812 - 57,126,032RGDNCBI36
Celera852,955,093 - 52,955,313RGD
Cytogenetic Map8q12.1UniSTS
Cytogenetic Map14q22.1UniSTS
HuRef852,430,864 - 52,431,084UniSTS
RH80771  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371453,194,356 - 53,194,568UniSTSGRCh37
GRCh37856,962,371 - 56,962,576UniSTSGRCh37
Build 36857,124,925 - 57,125,130RGDNCBI36
Celera1433,061,929 - 33,062,141UniSTS
Celera852,954,206 - 52,954,411RGD
Cytogenetic Map8q12.1UniSTS
Cytogenetic Map14q22.1UniSTS
HuRef1433,355,343 - 33,355,555UniSTS
HuRef852,429,977 - 52,430,182UniSTS
GeneMap99-GB4 RH Map14121.7UniSTS
G43615  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37856,962,332 - 56,962,574UniSTSGRCh37
GRCh371453,194,358 - 53,194,607UniSTSGRCh37
Build 36857,124,886 - 57,125,128RGDNCBI36
Celera852,954,167 - 52,954,409RGD
Celera1433,061,931 - 33,062,180UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map8q12.1UniSTS
HuRef852,429,938 - 52,430,180UniSTS
HuRef1433,355,345 - 33,355,594UniSTS
G35813  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371453,181,560 - 53,181,783UniSTSGRCh37
Build 361452,251,310 - 52,251,533RGDNCBI36
Celera1433,049,130 - 33,049,354RGD
Cytogenetic Map14q22.1UniSTS
HuRef1433,342,543 - 33,342,767UniSTS
SHGC-59941  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371453,177,369 - 53,177,574UniSTSGRCh37
Build 361452,247,119 - 52,247,324RGDNCBI36
Celera1433,044,973 - 33,045,178RGD
Cytogenetic Map14q22.1UniSTS
HuRef1433,338,460 - 33,338,665UniSTS
TNG Radiation Hybrid Map1414758.0UniSTS
TNG Radiation Hybrid Map1414752.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2635
Count of miRNA genes:948
Interacting mature miRNAs:1154
Transcripts:ENST00000445930, ENST00000458604, ENST00000551328, ENST00000553798, ENST00000553899, ENST00000554044, ENST00000554952, ENST00000554956, ENST00000555175, ENST00000555339, ENST00000555887, ENST00000556813, ENST00000557085, ENST00000557240, ENST00000557517, ENST00000557557, ENST00000557632, ENST00000606149
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2404 2159 1673 577 1321 420 4343 2037 3029 364 1451 1610 173 1 1202 2785 6 2
Low 35 826 53 47 624 45 14 160 705 55 9 3 2 2 3
Below cutoff 6 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001366414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_158967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_943495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA846884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF006305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL133453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM788029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP384173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ840920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D78275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ224299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000445930   ⟹   ENSP00000401802
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,200 - 52,728,590 (+)Ensembl
RefSeq Acc Id: ENST00000458604
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,184 - 52,718,688 (+)Ensembl
RefSeq Acc Id: ENST00000551328
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,718,507 - 52,720,978 (+)Ensembl
RefSeq Acc Id: ENST00000553798   ⟹   ENSP00000451241
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,231 - 52,708,666 (+)Ensembl
RefSeq Acc Id: ENST00000553899   ⟹   ENSP00000452511
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,202 - 52,713,902 (+)Ensembl
RefSeq Acc Id: ENST00000554044   ⟹   ENSP00000451340
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,209 - 52,718,339 (+)Ensembl
RefSeq Acc Id: ENST00000554952
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,202 - 52,710,335 (+)Ensembl
RefSeq Acc Id: ENST00000554956
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,201 - 52,708,833 (+)Ensembl
RefSeq Acc Id: ENST00000555175   ⟹   ENSP00000452388
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,718,231 - 52,727,994 (+)Ensembl
RefSeq Acc Id: ENST00000555339   ⟹   ENSP00000452048
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,219 - 52,718,339 (+)Ensembl
RefSeq Acc Id: ENST00000555887
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,178 - 52,709,089 (+)Ensembl
RefSeq Acc Id: ENST00000556813   ⟹   ENSP00000451156
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,222 - 52,724,036 (+)Ensembl
RefSeq Acc Id: ENST00000557085
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,710,546 - 52,714,032 (+)Ensembl
RefSeq Acc Id: ENST00000557240   ⟹   ENSP00000452072
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,192 - 52,718,302 (+)Ensembl
RefSeq Acc Id: ENST00000557517   ⟹   ENSP00000452253
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,287 - 52,709,607 (+)Ensembl
RefSeq Acc Id: ENST00000557557
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,721,500 - 52,727,990 (+)Ensembl
RefSeq Acc Id: ENST00000557632
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,723,745 - 52,727,817 (+)Ensembl
RefSeq Acc Id: ENST00000612399   ⟹   ENSP00000484998
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,707,178 - 52,727,995 (+)Ensembl
RefSeq Acc Id: NM_001366414   ⟹   NP_001353343
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,707,200 - 52,728,590 (+)NCBI
RefSeq Acc Id: NM_002806   ⟹   NP_002797
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,707,200 - 52,728,590 (+)NCBI
GRCh371453,173,894 - 53,194,716 (+)NCBI
Build 361452,243,668 - 52,264,466 (+)NCBI Archive
HuRef1433,334,988 - 33,355,703 (+)ENTREZGENE
CHM1_11453,112,814 - 53,133,601 (+)NCBI
Sequence:
RefSeq Acc Id: NR_158967
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,707,200 - 52,728,590 (+)NCBI
RefSeq Acc Id: XR_943495
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,707,163 - 52,727,996 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002797   ⟸   NM_002806
- Peptide Label: isoform 1
- Sequence:
RefSeq Acc Id: NP_001353343   ⟸   NM_001366414
- Peptide Label: isoform 2
RefSeq Acc Id: ENSP00000452388   ⟸   ENST00000555175
RefSeq Acc Id: ENSP00000452048   ⟸   ENST00000555339
RefSeq Acc Id: ENSP00000451156   ⟸   ENST00000556813
RefSeq Acc Id: ENSP00000452072   ⟸   ENST00000557240
RefSeq Acc Id: ENSP00000452253   ⟸   ENST00000557517
RefSeq Acc Id: ENSP00000484998   ⟸   ENST00000612399
RefSeq Acc Id: ENSP00000401802   ⟸   ENST00000445930
RefSeq Acc Id: ENSP00000451241   ⟸   ENST00000553798
RefSeq Acc Id: ENSP00000452511   ⟸   ENST00000553899
RefSeq Acc Id: ENSP00000451340   ⟸   ENST00000554044
Protein Domains
AAA   ATPase_AAA_core   Prot_ATP_ID_OB

Promoters
RGD ID:6791916
Promoter ID:HG_KWN:19385
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000276904,   UC010AOG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361452,242,966 - 52,243,667 (+)MPROMDB
RGD ID:6853420
Promoter ID:EP74535
Type:multiple initiation site
Name:HS_PSMC6
Description:Proteasome (prosome, macropain) 26S subunit, ATPase, 6.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361452,243,674 - 52,243,734EPD
RGD ID:7227625
Promoter ID:EPDNEW_H19559
Type:initiation region
Name:PSMC6_1
Description:proteasome 26S subunit, ATPase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,707,209 - 52,707,269EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q22.1-22.3(chr14:50591011-56286919)x1 copy number loss See cases [RCV000051519] Chr14:50591011..56286919 [GRCh38]
Chr14:51057729..56753637 [GRCh37]
Chr14:50127479..55823390 [NCBI36]
Chr14:14q22.1-22.3
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q22.1-22.3(chr14:51544846-55320598)x1 copy number loss See cases [RCV000135883] Chr14:51544846..55320598 [GRCh38]
Chr14:52011564..55787316 [GRCh37]
Chr14:51081314..54857069 [NCBI36]
Chr14:14q22.1-22.3
pathogenic
GRCh38/hg38 14q21.1-22.3(chr14:39196172-56714461)x3 copy number gain See cases [RCV000140717] Chr14:39196172..56714461 [GRCh38]
Chr14:39665376..57181179 [GRCh37]
Chr14:38735127..56250932 [NCBI36]
Chr14:14q21.1-22.3
likely pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-22.2(chr14:23164384-54733411)x3 copy number gain See cases [RCV000447658] Chr14:23164384..54733411 [GRCh37]
Chr14:14q11.2-22.2
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q22.1(chr14:53077252-53557861)x3 copy number gain not provided [RCV000683607] Chr14:53077252..53557861 [GRCh37]
Chr14:14q22.1
uncertain significance
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q22.1(chr14:52890163-53288450)x1 copy number loss not provided [RCV000751015] Chr14:52890163..53288450 [GRCh37]
Chr14:14q22.1
benign
NM_002806.5(PSMC6):c.-4C>T single nucleotide variant not provided [RCV000890488] Chr14:52707216 [GRCh38]
Chr14:53173934 [GRCh37]
Chr14:14q22.1
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9553 AgrOrtholog
COSMIC PSMC6 COSMIC
Ensembl Genes ENSG00000100519 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000401802 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000451156 UniProtKB/TrEMBL
  ENSP00000451241 UniProtKB/TrEMBL
  ENSP00000451340 UniProtKB/TrEMBL
  ENSP00000452048 UniProtKB/TrEMBL
  ENSP00000452072 UniProtKB/TrEMBL
  ENSP00000452253 UniProtKB/TrEMBL
  ENSP00000452388 UniProtKB/TrEMBL
  ENSP00000452511 UniProtKB/TrEMBL
  ENSP00000484998 UniProtKB/TrEMBL
Ensembl Transcript ENST00000445930 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000553798 UniProtKB/TrEMBL
  ENST00000553899 UniProtKB/TrEMBL
  ENST00000554044 UniProtKB/TrEMBL
  ENST00000555175 UniProtKB/TrEMBL
  ENST00000555339 UniProtKB/TrEMBL
  ENST00000556813 UniProtKB/TrEMBL
  ENST00000557240 UniProtKB/TrEMBL
  ENST00000557517 UniProtKB/TrEMBL
  ENST00000612399 UniProtKB/TrEMBL
GTEx ENSG00000100519 GTEx
HGNC ID HGNC:9553 ENTREZGENE
Human Proteome Map PSMC6 Human Proteome Map
InterPro 26S_Psome_P45-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PSMC6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5706 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5706 ENTREZGENE
OMIM 602708 OMIM
PANTHER PTHR23073:SF76 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33898 PharmGKB
PROSITE AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs 26Sp45 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087X2I1_HUMAN UniProtKB/TrEMBL
  H0YJC0_HUMAN UniProtKB/TrEMBL
  H0YJD2_HUMAN UniProtKB/TrEMBL
  H0YJE9_HUMAN UniProtKB/TrEMBL
  H0YJS8_HUMAN UniProtKB/TrEMBL
  H0YJT1_HUMAN UniProtKB/TrEMBL
  H0YJW2_HUMAN UniProtKB/TrEMBL
  H0YJX2_HUMAN UniProtKB/TrEMBL
  H0YJY8_HUMAN UniProtKB/TrEMBL
  P62333 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2R975 UniProtKB/Swiss-Prot
  P49719 UniProtKB/Swiss-Prot
  Q6IBU3 UniProtKB/Swiss-Prot
  Q92524 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-18 PSMC6  proteasome 26S subunit, ATPase 6    proteasome (prosome, macropain) 26S subunit, ATPase, 6  Symbol and/or name change 5135510 APPROVED