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alvocidib - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alvocidib
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Accession:CHEBI:47344 term browser browse the term
Definition:A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.
Synonyms:related_synonym: (-)-cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one;   2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one;   Flavopiridol;   Formula=C21H20ClNO5;   HMR-1274;   InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1;   InChIKey=BIIVYFLTOXDAOV-YVEFUNNKSA-N;   L 86-8275;   L 868275;   L86-8275;   SMILES=C=12OC(=CC(C1C(=CC(=C2[C@@H]3[C@@H](CN(CC3)C)O)O)O)=O)C4=C(C=CC=C4)Cl;   alvocidibum
 xref: CAS:146426-40-6;   DrugBank:DB03496;   KEGG:D09868;   LINCS:LSM-1011
 xref_mesh: MESH:C077990
 xref: PDBeChem:CPB;   PMID:10441105;   PMID:1279187;   PMID:18209094;   PMID:21541623;   PMID:23959599;   PMID:25118834;   PMID:25216351;   PMID:25351763;   PMID:25623777;   PMID:25860066;   PMID:25989942;   PMID:26022709;   PMID:26521988;   PMID:26599132;   PMID:8002990;   PMID:9269999;   PMID:9815683;   Patent:EP241003;   Patent:US4900727;   Wikipedia:Alvocidib
 cyclic_relationship: is_conjugate_base_of CHEBI:90997

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alvocidib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein; [alvocidib co-treated with Bortezomib co-treated with ABL1] results in decreased phosphorylation of CRKL protein; [alvocidib co-treated with Bortezomib] results in decreased expression of ABL1 protein CTD PMID:15039284 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization ISO alvocidib results in increased localization of AIFM1 protein CTD PMID:12734434 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [alvocidib co-treated with Bortezomib] results in decreased expression of AKT1 protein modified form CTD PMID:15039284 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Imatinib Mesylate co-treated with alvocidib] results in decreased expression of BAD protein CTD PMID:12231544 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bag1 BAG cochaperone 1 decreases expression ISO alvocidib results in decreased expression of BAG1 mRNA; alvocidib results in decreased expression of BAG1 protein; alvocidib results in decreased expression of BAG1 protein alternative form CTD PMID:10887097 PMID:15972445 NCBI chr 5:60,864,476...60,877,059
Ensembl chr 5:56,068,494...56,081,075 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
multiple interactions
increases expression
increases cleavage		 ISO alvocidib affects the localization of BAX protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of BAX protein; [alvocidib co-treated with Gemcitabine] results in increased expression of BAX protein; [alvocidib co-treated with TNFSF10 protein] results in increased localization of BAX protein; Epothilones promotes the reaction [alvocidib affects the localization of BAX protein]
alvocidib results in increased expression of BAX protein
alvocidib results in increased cleavage of BAX protein		 CTD PMID:12517783 PMID:12589031 PMID:12734434 PMID:15634644 PMID:15770523 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions
decreases response to substance		 ISO alvocidib results in decreased expression of BCL2 mRNA; alvocidib results in decreased expression of BCL2 protein
alvocidib results in increased expression of BCL2
[alvocidib co-treated with Gemcitabine] results in decreased expression of BCL2 protein; BCL2 protein mutant form inhibits the reaction [alvocidib affects the localization of CYCS protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP3 protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP9 protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of BID protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of PARP1 protein]; BCL2 protein results in decreased susceptibility to [alvocidib co-treated with Epothilones]
BCL2 protein mutant form results in decreased susceptibility to alvocidib; BCL2 protein results in decreased susceptibility to alvocidib		 CTD PMID:10887097 PMID:10995888 PMID:12170773 PMID:12517783 PMID:12589031 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO [alvocidib co-treated with Bortezomib] results in decreased expression of BCL2L1 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in decreased expression of BCL2L1 protein; Epothilones promotes the reaction [alvocidib results in decreased expression of BCL2L1 mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of BCL2L1 protein]
alvocidib results in decreased expression of BCL2L1; alvocidib results in decreased expression of BCL2L1 mRNA; alvocidib results in decreased expression of BCL2L1 protein		 CTD PMID:12517783 PMID:15039284 PMID:15634644 PMID:16820931 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage		 ISO [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of BID protein; [alvocidib co-treated with TNFSF10 protein] results in decreased expression of BID protein; [Imatinib Mesylate co-treated with alvocidib] results in increased activity of BID protein; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of BID protein]; Boc-D-FMK inhibits the reaction [alvocidib results in increased cleavage of BID protein] CTD PMID:11464216 PMID:12170773 PMID:12231544 PMID:15634644 PMID:16951203 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression
multiple interactions		 ISO alvocidib results in decreased expression of BIRC3 mRNA; alvocidib results in decreased expression of BIRC3 protein
Epothilones promotes the reaction [alvocidib results in decreased expression of BIRC3 mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of BIRC3 protein]		 CTD PMID:12517783 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO [alvocidib co-treated with 7-hydroxystaurosporine] results in decreased expression of BIRC5 protein; [alvocidib co-treated with PBOX-6] results in decreased expression of BIRC5 protein; alvocidib inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of BIRC5 protein]; alvocidib results in decreased phosphorylation of and results in decreased expression of BIRC5 protein
alvocidib results in decreased expression of BIRC5; alvocidib results in decreased expression of BIRC5 mRNA; alvocidib results in decreased expression of BIRC5 protein		 CTD PMID:12517783 PMID:12517802 PMID:16012789 PMID:16820931 PMID:20206141 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO alvocidib results in increased expression of BTG2 mRNA CTD PMID:21382384 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Casp3 caspase 3 affects cleavage
multiple interactions
increases activity
increases cleavage		 ISO
EXP		 alvocidib affects the cleavage of CASP3 protein
[alvocidib co-treated with 7-hydroxystaurosporine] results in increased activity of CASP3 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP3 protein; [alvocidib co-treated with Gemcitabine] results in increased cleavage of CASP3 protein; [Imatinib Mesylate co-treated with alvocidib] results in increased activity of CASP3 protein; [Irinotecan co-treated with alvocidib] results in increased activity of CASP3 protein; alvocidib affects the cleavage of and results in increased activity of CASP3 protein; alvocidib promotes the reaction [Paclitaxel results in increased activity of CASP3 protein]; alvocidib promotes the reaction [romidepsin results in increased activity of CASP3 protein]; alvocidib results in increased cleavage of and results in increased activity of CASP3 protein; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP3 protein]; Boc-D-FMK inhibits the reaction [alvocidib results in increased cleavage of and results in increased activity of CASP3 protein]
alvocidib results in increased cleavage of CASP3 protein
alvocidib inhibits the reaction [Colchicine results in increased activity of CASP3 protein]		 CTD PMID:9808574 PMID:10430095 PMID:10896673 PMID:11482875 PMID:11751522 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage		 ISO [alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP8 protein; [alvocidib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [Imatinib Mesylate co-treated with alvocidib] results in increased activity of CASP8 protein
alvocidib results in increased cleavage of CASP8 protein		 CTD PMID:10896673 PMID:12231544 PMID:12589031 PMID:15634644 PMID:16012789 More... NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 affects cleavage
multiple interactions
increases activity		 ISO alvocidib affects the cleavage of CASP9 protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP9 protein; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP9 protein]		 CTD PMID:10896673 PMID:12170773 PMID:15634644 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cbr3 carbonyl reductase 3 decreases expression ISO alvocidib results in decreased expression of CBR3 mRNA CTD PMID:21382384 NCBI chr11:46,478,295...46,486,555
Ensembl chr11:33,008,615...33,016,875 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO alvocidib results in decreased expression of and results in decreased activity of CCNA2 protein CTD PMID:16731754 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression		 ISO [alvocidib co-treated with PBOX-6] results in decreased expression of CCNB1 protein; alvocidib inhibits the reaction [Paclitaxel results in increased expression of CCNB1 protein]; alvocidib results in decreased expression of and results in decreased activity of CCNB1 protein
alvocidib results in decreased expression of CCNB1 protein		 CTD PMID:10430095 PMID:12517783 PMID:15014036 PMID:16731754 PMID:20206141 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
decreases activity		 ISO [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in decreased expression of CCND1 protein
alvocidib results in decreased expression of CCND1 protein
alvocidib results in decreased activity of CCND1 protein		 CTD PMID:9802881 PMID:9829756 PMID:10441105 PMID:12517783 PMID:12589031 More... NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO alvocidib results in decreased expression of CCNE1 protein CTD PMID:15014036 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases activity
decreases expression		 ISO [alvocidib co-treated with PBOX-6] results in decreased activity of CDK1 protein
alvocidib results in decreased activity of CDK1 protein
alvocidib results in decreased expression of CDK1 protein modified form		 CTD PMID:9427698 PMID:9802881 PMID:12517783 PMID:16905211 PMID:20206141 More... NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions
decreases activity		 ISO alvocidib results in decreased expression of CDK2 protein modified form
alvocidib binds to and results in decreased activity of CDK2 protein; alvocidib inhibits the reaction [Paclitaxel results in increased activity of CDK2 protein]
alvocidib results in decreased activity of CDK2 protein		 CTD PMID:9802881 PMID:10430095 PMID:12517783 PMID:16905211 PMID:24102143 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases activity
decreases expression
multiple interactions		 ISO alvocidib results in decreased activity of CDK4 protein
alvocidib results in decreased expression of CDK4 protein
alvocidib binds to and results in decreased activity of CDK4 protein		 CTD PMID:12517783 PMID:12734434 PMID:24102143 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 multiple interactions EXP alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein] CTD PMID:12941380 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cdk9 cyclin-dependent kinase 9 multiple interactions ISO alvocidib binds to and results in decreased activity of CDK9 protein CTD PMID:24102143 NCBI chr 3:36,394,168...36,399,016
Ensembl chr 3:15,996,468...16,002,410 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
affects expression
decreases expression
increases expression
increases cleavage		 ISO [alvocidib co-treated with Gemcitabine] results in increased expression of CDKN1A protein; alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A promoter]; alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A protein]]
alvocidib affects the expression of CDKN1A protein
alvocidib results in decreased expression of CDKN1A protein
alvocidib results in increased expression of CDKN1A protein
alvocidib results in increased cleavage of CDKN1A protein		 CTD PMID:10537362 PMID:12734434 PMID:15014036 PMID:15180955 PMID:15770523 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases cleavage
increases expression		 ISO alvocidib results in increased cleavage of CDKN1B protein
[alvocidib results in increased expression of TP53 protein] which results in increased expression of CDKN1B protein; alvocidib results in increased expression of CDKN1B protein		 CTD PMID:10537362 PMID:12589031 PMID:15180955 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator affects expression
decreases expression
multiple interactions		 ISO alvocidib affects the expression of CFLAR mRNA
alvocidib results in decreased expression of CFLAR; alvocidib results in decreased expression of CFLAR protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [alvocidib results in decreased expression of CFLAR protein]		 CTD PMID:16820931 PMID:16951203 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein multiple interactions ISO [alvocidib co-treated with Bortezomib co-treated with ABL1] results in decreased phosphorylation of CRKL protein CTD PMID:15039284 NCBI chr11:97,033,033...97,067,457
Ensembl chr11:83,526,530...83,563,238 		JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions		 ISO alvocidib affects the localization of CYCS protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of CYCS protein; BCL2 protein mutant form inhibits the reaction [alvocidib affects the localization of CYCS protein]		 CTD PMID:12170773 PMID:12517783 PMID:15634644 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO alvocidib inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] CTD PMID:37515497 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization
multiple interactions		 ISO alvocidib affects the localization of DIABLO protein
[alvocidib co-treated with Bortezomib] results in increased secretion of DIABLO protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of DIABLO protein; [Imatinib Mesylate co-treated with alvocidib] results in increased secretion of DIABLO protein		 CTD PMID:12231544 PMID:12517783 PMID:15039284 PMID:15634644 NCBI chr12:38,716,668...38,731,285
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression
decreases expression
increases response to substance		 ISO alvocidib results in increased expression of E2F1 protein
alvocidib results in decreased expression of E2F1 mRNA
E2F1 results in increased susceptibility to alvocidib		 CTD PMID:12533675 PMID:21239698 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G H2ax H2A.X variant histone affects expression
multiple interactions		 ISO alvocidib affects the expression of H2AX protein
alvocidib inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]		 CTD PMID:15078984 PMID:37515497 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO alvocidib results in decreased expression of HMGA1 mRNA CTD PMID:21239698 NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,611,694...5,618,752 		JBrowse link
G Htra2 HtrA serine peptidase 2 affects localization ISO alvocidib affects the localization of HTRA2 protein CTD PMID:12517783 NCBI chr 4:117,114,631...117,117,793
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 gene]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein results in increased expression of ISG15 mRNA] CTD PMID:23589332 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier multiple interactions ISO alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 gene]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein results in increased expression of ISG15 mRNA] CTD PMID:23589332 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Imatinib Mesylate co-treated with alvocidib] results in increased activity of JUN protein CTD PMID:12231544 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
decreases phosphorylation		 ISO alvocidib results in decreased expression of KIT mRNA; alvocidib results in decreased expression of KIT promoter
alvocidib results in decreased phosphorylation of KIT protein		 CTD PMID:16740725 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein CTD PMID:15039284 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO alvocidib promotes the reaction [Bortezomib results in increased phosphorylation of and results in increased activity of MAP2K4 protein] CTD PMID:15039284 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO alvocidib inhibits the reaction [Bortezomib results in increased expression of MAPK1 protein modified form]; alvocidib results in decreased activity of and results in decreased phosphorylation of MAPK1 protein CTD PMID:15014036 PMID:15039284 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:15634644 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO alvocidib inhibits the reaction [Bortezomib results in increased expression of MAPK3 protein modified form]; alvocidib results in decreased activity of and results in decreased phosphorylation of MAPK3 protein CTD PMID:15014036 PMID:15039284 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased phosphorylation of and results in increased activity of MAPK8 protein; alvocidib promotes the reaction [Bortezomib results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:15039284 PMID:15634644 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression
multiple interactions
decreases expression
decreases response to substance		 ISO alvocidib affects the expression of MCL1 mRNA; alvocidib affects the expression of MCL1 protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in decreased expression of MCL1 protein; [Imatinib Mesylate co-treated with alvocidib] results in decreased expression of MCL1 protein; Epothilones promotes the reaction [alvocidib results in decreased expression of MCL1 mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of MCL1 protein]
alvocidib results in decreased expression of MCL1 mRNA; alvocidib results in decreased expression of MCL1 protein
MCL1 results in decreased susceptibility to alvocidib		 CTD PMID:10887097 PMID:12231544 PMID:12429644 PMID:12517783 PMID:12533675 More... NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO alvocidib results in decreased expression of MDM2 mRNA; alvocidib results in decreased expression of MDM2 protein CTD PMID:12589031 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mx1 MX dynamin like GTPase 1 multiple interactions ISO alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]] CTD PMID:23589332 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Nelfa negative elongation factor complex member A multiple interactions ISO alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]] CTD PMID:23589332 NCBI chr14:81,033,470...81,057,546
Ensembl chr14:76,808,870...76,832,994 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions		 ISO alvocidib results in increased expression of NFKBIA protein modified form
alvocidib promotes the reaction [Bortezomib results in increased expression of NFKBIA protein modified form]; Bortezomib promotes the reaction [alvocidib results in increased expression of NFKBIA protein modified form]		 CTD PMID:15039284 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO alvocidib inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO [alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of PARP1 protein; [alvocidib co-treated with Bortezomib] results in increased cleavage of PARP1 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of PARP1 protein; [alvocidib co-treated with Gemcitabine] results in increased cleavage of PARP1 protein; alvocidib promotes the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of PARP1 protein] CTD PMID:10430095 PMID:12170773 PMID:12517783 PMID:15039284 PMID:15634644 More... NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions EXP alvocidib inhibits the reaction [Colchicine results in increased expression of PAWR protein] CTD PMID:12941380 NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases activity ISO alvocidib results in decreased activity of PCNA protein CTD PMID:10441105 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO alvocidib results in increased expression of PERP mRNA CTD PMID:21382384 NCBI chr 1:15,361,784...15,374,230
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Polr2a RNA polymerase II subunit A decreases expression
decreases phosphorylation
multiple interactions		 ISO alvocidib results in decreased expression of POLR2A mRNA
alvocidib results in decreased phosphorylation of POLR2A protein
Bortezomib promotes the reaction [alvocidib results in decreased phosphorylation of POLR2A protein]
alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 gene]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 promoter]]		 CTD PMID:15039284 PMID:21239698 PMID:23589332 PMID:24102143 NCBI chr10:54,951,162...54,977,179
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
G Pygb glycogen phosphorylase B affects binding ISO PYGB protein binds to alvocidib CTD PMID:11368340 NCBI chr 3:160,072,141...160,118,930
Ensembl chr 3:139,611,749...139,663,553 		JBrowse link
G Pygl glycogen phosphorylase L affects binding ISO PYGL protein binds to alvocidib CTD PMID:11368340 NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases activity
decreases expression
decreases phosphorylation
multiple interactions
decreases response to substance		 ISO alvocidib results in decreased activity of RB1 protein modified form
alvocidib results in decreased expression of RB1 protein; alvocidib results in decreased expression of RB1 protein modified form
alvocidib results in decreased phosphorylation of RB1 protein
[docetaxel co-treated with alvocidib] results in decreased phosphorylation of and results in decreased expression of RB1 protein
RB1 results in decreased susceptibility to alvocidib		 CTD PMID:9829756 PMID:10441105 PMID:15180955 PMID:15297405 PMID:16905211 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO alvocidib results in decreased expression of RBL1 protein CTD PMID:9829756 NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression		 ISO [alvocidib co-treated with Bortezomib] results in decreased phosphorylation of and results in decreased activity of STAT3 protein
alvocidib results in decreased expression of STAT3 mRNA		 CTD PMID:15039284 PMID:21239698 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Supt5h SPT5 homolog, DSIF elongation factor subunit multiple interactions ISO alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]] CTD PMID:23589332 NCBI chr 1:92,714,276...92,745,489
Ensembl chr 1:83,586,718...83,616,892 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO alvocidib analog results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alvocidib inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21204955 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO alvocidib results in increased expression of TNFRSF10A CTD PMID:16820931 NCBI chr15:51,249,883...51,278,091
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases expression
increases response to substance		 ISO [alvocidib co-treated with TNFSF10 protein] results in decreased expression of BID protein; [alvocidib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [alvocidib co-treated with TNFSF10 protein] results in increased localization of BAX protein
alvocidib results in increased expression of TNFSF10
alvocidib results in increased susceptibility to TNFSF10		 CTD PMID:16820931 PMID:16951203 NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
multiple interactions		 ISO alvocidib results in decreased expression of TP53 protein
[alvocidib results in increased expression of TP53 protein] which results in increased expression of CDKN1B protein; alvocidib results in increased expression of TP53 protein
[docetaxel co-treated with alvocidib] results in increased expression of TP53 protein		 CTD PMID:9808574 PMID:10537362 PMID:12589031 PMID:15180955 PMID:15297405 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO alvocidib results in decreased expression of VEGFA mRNA CTD PMID:21239698 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression
multiple interactions		 ISO alvocidib results in decreased expression of XIAP mRNA; alvocidib results in decreased expression of XIAP protein
[irinotecan co-treated with alvocidib] results in increased cleavage of XIAP protein; Epothilones promotes the reaction [alvocidib results in decreased expression of XIAP mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of XIAP protein]		 CTD PMID:10887097 PMID:11751522 PMID:12517783 PMID:15385934 PMID:15972445 More... NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          apoptosis inducer 13666
            alvocidib 70
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  oxacycle 17906
                                    benzopyran 11990
                                      1-benzopyran 11744
                                        flavonoid 7234
                                          anthoxanthin 4587
                                            flavones 4587
                                              hydroxyflavone 4564
                                                dihydroxyflavone 552
                                                  alvocidib 70
paths to the root