dihydroxyflavone - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	dihydroxyflavone	go back to main search page
Accession:	CHEBI:38686	browse the term
Definition:	Any hydroxyflavone in which two ring hydrogens are replaced by hydroxy substituents.
Synonyms:	related_synonym:	dihydroxyflavones
	alt_id:	CHEBI:23779; CHEBI:25390

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Genes (547)

5,7-dihydroxy-4'-methoxyflavone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin B1

decreases expression

acacetin results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin E1

decreases expression

acacetin results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cell division cycle 25C

decreases expression

acacetin results in decreased expression of CDC25C protein

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cyclin-dependent kinase 1

decreases expression

acacetin results in decreased expression of CDK1 protein

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases expression

acacetin results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression

acacetin results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

checkpoint kinase 1

increases expression

acacetin results in increased expression of CHK1 protein

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases metabolic processing
increases expression
decreases activity

CYP1A1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1A1 mRNA
acacetin results in decreased activity of CYP1A1 protein

PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

acacetin results in decreased activity of CYP1A2 protein

PMID:21053930 PMID:32738202

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases metabolic processing
increases expression
decreases activity
multiple interactions

CYP1B1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1B1 mRNA
acacetin results in decreased activity of CYP1B1 protein
acacetin binds to and results in decreased activity of CYP1B1 protein

PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 1

decreases activity

acacetin results in decreased activity of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, subfamily 2, polypeptide 11

decreases activity

acacetin results in decreased activity of CYP2C11 protein

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

acacetin results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
multiple interactions
increases expression

acacetin results in decreased activity of CYP3A2 protein
acacetin binds to and results in decreased activity of CYP3A4 protein; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]
acacetin results in increased expression of CYP3A4 mRNA

PMID:21053930 PMID:29933105 PMID:32738202

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

Fas associated via death domain

decreases expression

acacetin results in decreased expression of FADD protein

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

acacetin results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

nuclear receptor subfamily 1, group I, member 2

increases activity
increases expression
multiple interactions

acacetin results in increased activity of NR1I2 protein
acacetin results in increased expression of NR1I2 mRNA
acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforaphane inhibits the reaction [acacetin results in increased activity of NR1I2 protein]

PMID:25455453 PMID:29933105

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

poly (ADP-ribose) polymerase 1

increases expression

acacetin results in increased expression of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

receptor interacting serine/threonine kinase 1

increases expression

acacetin results in increased expression of RIPK1 protein

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

receptor-interacting serine-threonine kinase 3

increases expression

acacetin results in increased expression of RIPK3 protein

NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121

G

UDP glucuronosyltransferase family 1 member A1

increases expression

acacetin results in increased expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

alvocidib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein; [alvocidib co-treated with Bortezomib co-treated with ABL1] results in decreased phosphorylation of CRKL protein; [alvocidib co-treated with Bortezomib] results in decreased expression of ABL1 protein

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

apoptosis inducing factor, mitochondria associated 1

increases localization

alvocidib results in increased localization of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

multiple interactions

[alvocidib co-treated with Bortezomib] results in decreased expression of AKT1 protein modified form

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2-associated agonist of cell death

multiple interactions

[Imatinib Mesylate co-treated with alvocidib] results in decreased expression of BAD protein

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 1

decreases expression

alvocidib results in decreased expression of BAG1 mRNA; alvocidib results in decreased expression of BAG1 protein; alvocidib results in decreased expression of BAG1 protein alternative form

PMID:10887097 PMID:15972445

NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075

G

BCL2 associated X, apoptosis regulator

affects localization
increases cleavage
increases expression
multiple interactions

alvocidib affects the localization of BAX protein
alvocidib results in increased cleavage of BAX protein
alvocidib results in increased expression of BAX protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of BAX protein; [alvocidib co-treated with Gemcitabine] results in increased expression of BAX protein; [alvocidib co-treated with TNFSF10 protein] results in increased localization of BAX protein; Epothilones promotes the reaction [alvocidib affects the localization of BAX protein]

PMID:12517783 PMID:12589031 PMID:12734434 PMID:15634644 PMID:15770523 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
decreases response to substance
multiple interactions
increases expression

alvocidib results in decreased expression of BCL2 mRNA; alvocidib results in decreased expression of BCL2 protein
BCL2 protein mutant form results in decreased susceptibility to alvocidib; BCL2 protein results in decreased susceptibility to alvocidib
[alvocidib co-treated with Gemcitabine] results in decreased expression of BCL2 protein; BCL2 protein mutant form inhibits the reaction [alvocidib affects the localization of CYCS protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP3 protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP9 protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of BID protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of PARP1 protein]; BCL2 protein results in decreased susceptibility to [alvocidib co-treated with Epothilones]
alvocidib results in increased expression of BCL2

PMID:10887097 PMID:10995888 PMID:12170773 PMID:12517783 PMID:12589031 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

[alvocidib co-treated with Bortezomib] results in decreased expression of BCL2L1 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in decreased expression of BCL2L1 protein; Epothilones promotes the reaction [alvocidib results in decreased expression of BCL2L1 mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of BCL2L1 protein]
alvocidib results in decreased expression of BCL2L1; alvocidib results in decreased expression of BCL2L1 mRNA; alvocidib results in decreased expression of BCL2L1 protein

PMID:12517783 PMID:15039284 PMID:15634644 PMID:16820931

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BH3 interacting domain death agonist

multiple interactions
increases cleavage

[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of BID protein; [alvocidib co-treated with TNFSF10 protein] results in decreased expression of BID protein; [Imatinib Mesylate co-treated with alvocidib] results in increased activity of BID protein; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of BID protein]; Boc-D-FMK inhibits the reaction [alvocidib results in increased cleavage of BID protein]

PMID:11464216 PMID:12170773 PMID:12231544 PMID:15634644 PMID:16951203

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 3

decreases expression
multiple interactions

alvocidib results in decreased expression of BIRC3 mRNA; alvocidib results in decreased expression of BIRC3 protein
Epothilones promotes the reaction [alvocidib results in decreased expression of BIRC3 mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of BIRC3 protein]

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression

[alvocidib co-treated with 7-hydroxystaurosporine] results in decreased expression of BIRC5 protein; [alvocidib co-treated with PBOX-6] results in decreased expression of BIRC5 protein; alvocidib inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of BIRC5 protein]; alvocidib results in decreased phosphorylation of and results in decreased expression of BIRC5 protein
alvocidib results in decreased expression of BIRC5; alvocidib results in decreased expression of BIRC5 mRNA; alvocidib results in decreased expression of BIRC5 protein

PMID:12517783 PMID:12517802 PMID:16012789 PMID:16820931 PMID:20206141

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BTG anti-proliferation factor 2

increases expression

alvocidib results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

caspase 3

affects cleavage
multiple interactions
increases cleavage
increases activity

alvocidib affects the cleavage of CASP3 protein
alvocidib inhibits the reaction [Colchicine results in increased activity of CASP3 protein]
alvocidib results in increased cleavage of CASP3 protein
alvocidib results in increased activity of CASP3 protein
[alvocidib co-treated with 7-hydroxystaurosporine] results in increased activity of CASP3 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP3 protein; [alvocidib co-treated with Gemcitabine] results in increased cleavage of CASP3 protein; [Imatinib Mesylate co-treated with alvocidib] results in increased activity of CASP3 protein; [Irinotecan co-treated with alvocidib] results in increased activity of CASP3 protein; alvocidib affects the cleavage of and results in increased activity of CASP3 protein; alvocidib promotes the reaction [Paclitaxel results in increased activity of CASP3 protein]; alvocidib promotes the reaction [romidepsin results in increased activity of CASP3 protein]; alvocidib results in increased cleavage of and results in increased activity of CASP3 protein; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP3 protein]; Boc-D-FMK inhibits the reaction [alvocidib results in increased cleavage of and results in increased activity of CASP3 protein]

PMID:9808574 PMID:10430095 PMID:10896673 PMID:11482875 PMID:11751522 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions
increases cleavage

[alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP8 protein; [alvocidib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [Imatinib Mesylate co-treated with alvocidib] results in increased activity of CASP8 protein
alvocidib results in increased cleavage of CASP8 protein

PMID:10896673 PMID:12231544 PMID:12589031 PMID:15634644 PMID:16012789 More...

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

affects cleavage
increases activity
multiple interactions

alvocidib affects the cleavage of CASP9 protein
alvocidib results in increased activity of CASP9 protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of CASP9 protein; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased activity of CASP9 protein]

PMID:10896673 PMID:12170773 PMID:15634644

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

carbonyl reductase 3

decreases expression

alvocidib results in decreased expression of CBR3 mRNA

NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875

G

cyclin A2

multiple interactions

alvocidib results in decreased expression of and results in decreased activity of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

multiple interactions
decreases expression

[alvocidib co-treated with PBOX-6] results in decreased expression of CCNB1 protein; alvocidib inhibits the reaction [Paclitaxel results in increased expression of CCNB1 protein]; alvocidib results in decreased expression of and results in decreased activity of CCNB1 protein
alvocidib results in decreased expression of CCNB1 protein

PMID:10430095 PMID:12517783 PMID:15014036 PMID:16731754 PMID:20206141

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

multiple interactions
decreases expression
decreases activity

[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in decreased expression of CCND1 protein
alvocidib results in decreased expression of CCND1 protein
alvocidib results in decreased activity of CCND1 protein

PMID:9802881 PMID:9829756 PMID:10441105 PMID:12517783 PMID:12589031 More...

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

decreases expression

alvocidib results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin-dependent kinase 1

multiple interactions
decreases expression
decreases activity

[alvocidib co-treated with PBOX-6] results in decreased activity of CDK1 protein
alvocidib results in decreased expression of CDK1 protein modified form
alvocidib results in decreased activity of CDK1 protein

PMID:9427698 PMID:9802881 PMID:12517783 PMID:16905211 PMID:20206141 More...

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases expression
decreases activity
multiple interactions

alvocidib results in decreased expression of CDK2 protein modified form
alvocidib results in decreased activity of CDK2 protein
alvocidib binds to and results in decreased activity of CDK2 protein; alvocidib inhibits the reaction [Paclitaxel results in increased activity of CDK2 protein]

PMID:9802881 PMID:10430095 PMID:12517783 PMID:16905211 PMID:24102143

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

decreases activity
multiple interactions
decreases expression

alvocidib results in decreased activity of CDK4 protein
alvocidib binds to and results in decreased activity of CDK4 protein
alvocidib results in decreased expression of CDK4 protein

PMID:12517783 PMID:12734434 PMID:24102143

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5

multiple interactions

alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein]

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase 9

multiple interactions

alvocidib binds to and results in decreased activity of CDK9 protein

NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
decreases expression
increases cleavage
increases expression
affects expression

[alvocidib co-treated with Gemcitabine] results in increased expression of CDKN1A protein; alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A promoter]; alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [alvocidib inhibits the reaction [romidepsin results in increased expression of CDKN1A protein]]
alvocidib results in decreased expression of CDKN1A protein
alvocidib results in increased cleavage of CDKN1A protein
alvocidib results in increased expression of CDKN1A protein
alvocidib affects the expression of CDKN1A protein

PMID:10537362 PMID:12734434 PMID:15014036 PMID:15180955 PMID:15770523

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases cleavage
increases expression

alvocidib results in increased cleavage of CDKN1B protein
[alvocidib results in increased expression of TP53 protein] which results in increased expression of CDKN1B protein; alvocidib results in increased expression of CDKN1B protein

PMID:10537362 PMID:12589031 PMID:15180955

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CASP8 and FADD-like apoptosis regulator

affects expression
multiple interactions
decreases expression

alvocidib affects the expression of CFLAR mRNA
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [alvocidib results in decreased expression of CFLAR protein]
alvocidib results in decreased expression of CFLAR; alvocidib results in decreased expression of CFLAR protein

PMID:16820931 PMID:16951203

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

CRK like proto-oncogene, adaptor protein

multiple interactions

[alvocidib co-treated with Bortezomib co-treated with ABL1] results in decreased phosphorylation of CRKL protein

NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238

G

cytochrome c, somatic

affects localization
multiple interactions

alvocidib affects the localization of CYCS protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of CYCS protein; BCL2 protein mutant form inhibits the reaction [alvocidib affects the localization of CYCS protein]

PMID:12170773 PMID:12517783 PMID:15634644

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

alvocidib inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

diablo, IAP-binding mitochondrial protein

affects localization
multiple interactions

alvocidib affects the localization of DIABLO protein
[alvocidib co-treated with Bortezomib] results in increased secretion of DIABLO protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of DIABLO protein; [Imatinib Mesylate co-treated with alvocidib] results in increased secretion of DIABLO protein

PMID:12231544 PMID:12517783 PMID:15039284 PMID:15634644

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

E2F transcription factor 1

increases expression
increases response to substance
decreases expression

alvocidib results in increased expression of E2F1 protein
E2F1 results in increased susceptibility to alvocidib
alvocidib results in decreased expression of E2F1 mRNA

PMID:12533675 PMID:21239698

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

H2A.X variant histone

affects expression
multiple interactions

alvocidib affects the expression of H2AX protein
alvocidib inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]

PMID:15078984 PMID:37515497

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

high mobility group AT-hook 1

decreases expression

alvocidib results in decreased expression of HMGA1 mRNA

NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752

G

HtrA serine peptidase 2

affects localization

alvocidib affects the localization of HTRA2 protein

NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095

G

interferon beta 1

multiple interactions

alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 gene]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein results in increased expression of ISG15 mRNA]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

ISG15 ubiquitin-like modifier

multiple interactions

alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 gene]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein results in increased expression of ISG15 mRNA]

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Imatinib Mesylate co-treated with alvocidib] results in increased activity of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KIT proto-oncogene receptor tyrosine kinase

decreases expression
decreases phosphorylation

alvocidib results in decreased expression of KIT mRNA; alvocidib results in decreased expression of KIT promoter
alvocidib results in decreased phosphorylation of KIT protein

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

LYN proto-oncogene, Src family tyrosine kinase

multiple interactions

[alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

mitogen activated protein kinase kinase 4

multiple interactions

alvocidib promotes the reaction [Bortezomib results in increased phosphorylation of and results in increased activity of MAP2K4 protein]

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen activated protein kinase 1

multiple interactions

alvocidib inhibits the reaction [Bortezomib results in increased expression of MAPK1 protein modified form]; alvocidib results in decreased activity of and results in decreased phosphorylation of MAPK1 protein

PMID:15014036 PMID:15039284

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased phosphorylation of and results in increased activity of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions

alvocidib inhibits the reaction [Bortezomib results in increased expression of MAPK3 protein modified form]; alvocidib results in decreased activity of and results in decreased phosphorylation of MAPK3 protein

PMID:15014036 PMID:15039284

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased phosphorylation of and results in increased activity of MAPK8 protein; alvocidib promotes the reaction [Bortezomib results in increased phosphorylation of and results in increased activity of MAPK8 protein]

PMID:15039284 PMID:15634644

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MCL1 apoptosis regulator, BCL2 family member

affects expression
decreases response to substance
decreases expression
multiple interactions

alvocidib affects the expression of MCL1 mRNA; alvocidib affects the expression of MCL1 protein
MCL1 results in decreased susceptibility to alvocidib
alvocidib results in decreased expression of MCL1 mRNA; alvocidib results in decreased expression of MCL1 protein
[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in decreased expression of MCL1 protein; [Imatinib Mesylate co-treated with alvocidib] results in decreased expression of MCL1 protein; Epothilones promotes the reaction [alvocidib results in decreased expression of MCL1 mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of MCL1 protein]

PMID:10887097 PMID:12231544 PMID:12429644 PMID:12517783 PMID:12533675 More...

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

MDM2 proto-oncogene

decreases expression

alvocidib results in decreased expression of MDM2 mRNA; alvocidib results in decreased expression of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

MX dynamin like GTPase 1

multiple interactions

alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]]

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

negative elongation factor complex member A

multiple interactions

alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]]

NCBI chr14:76,808,920...76,832,998
Ensembl chr14:76,808,870...76,832,994

G

NFKB inhibitor alpha

increases expression
multiple interactions

alvocidib results in increased expression of NFKBIA protein modified form
alvocidib promotes the reaction [Bortezomib results in increased expression of NFKBIA protein modified form]; Bortezomib promotes the reaction [alvocidib results in increased expression of NFKBIA protein modified form]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

alvocidib inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

[alvocidib co-treated with 7-hydroxystaurosporine] results in increased cleavage of PARP1 protein; [alvocidib co-treated with Bortezomib] results in increased cleavage of PARP1 protein; [alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] results in increased cleavage of PARP1 protein; [alvocidib co-treated with Gemcitabine] results in increased cleavage of PARP1 protein; alvocidib promotes the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; BCL2 protein mutant form inhibits the reaction [alvocidib results in increased cleavage of PARP1 protein]

PMID:10430095 PMID:12170773 PMID:12517783 PMID:15039284 PMID:15634644 More...

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pro-apoptotic WT1 regulator

multiple interactions

alvocidib inhibits the reaction [Colchicine results in increased expression of PAWR protein]

NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028

G

proliferating cell nuclear antigen

decreases activity

alvocidib results in decreased activity of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

p53 apoptosis effector related to PMP22

increases expression

alvocidib results in increased expression of PERP mRNA

NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511

G

RNA polymerase II subunit A

decreases expression
decreases phosphorylation
multiple interactions

alvocidib results in decreased expression of POLR2A mRNA
alvocidib results in decreased phosphorylation of POLR2A protein
alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 gene]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to ISG15 promoter]]
Bortezomib promotes the reaction [alvocidib results in decreased phosphorylation of POLR2A protein]

PMID:15039284 PMID:21239698 PMID:23589332 PMID:24102143

NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455

G

glycogen phosphorylase B

affects binding

PYGB protein binds to alvocidib

NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553

G

glycogen phosphorylase L

affects binding

PYGL protein binds to alvocidib

NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310

G

RB transcriptional corepressor 1

decreases activity
decreases response to substance
multiple interactions
decreases phosphorylation
decreases expression

alvocidib results in decreased activity of RB1 protein modified form
RB1 results in decreased susceptibility to alvocidib
[docetaxel co-treated with alvocidib] results in decreased phosphorylation of and results in decreased expression of RB1 protein
alvocidib results in decreased phosphorylation of RB1 protein
alvocidib results in decreased expression of RB1 protein; alvocidib results in decreased expression of RB1 protein modified form

PMID:9829756 PMID:10441105 PMID:15180955 PMID:15297405 PMID:16905211

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RB transcriptional corepressor like 1

decreases expression

alvocidib results in decreased expression of RBL1 protein

NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330

G

signal transducer and activator of transcription 3

multiple interactions
decreases expression

[alvocidib co-treated with Bortezomib] results in decreased phosphorylation of and results in decreased activity of STAT3 protein
alvocidib results in decreased expression of STAT3 mRNA

PMID:15039284 PMID:21239698

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

SPT5 homolog, DSIF elongation factor subunit

multiple interactions

alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to IFIT1 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to ISG15 promoter]]; alvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]]

NCBI chr 1:83,586,713...83,616,971
Ensembl chr 1:83,586,718...83,616,892

G

transforming growth factor, beta 1

decreases activity

alvocidib analog results in decreased activity of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

alvocidib inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 10b

increases expression

alvocidib results in increased expression of TNFRSF10A

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

TNF superfamily member 10

multiple interactions
increases response to substance
increases expression

[alvocidib co-treated with TNFSF10 protein] results in decreased expression of BID protein; [alvocidib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [alvocidib co-treated with TNFSF10 protein] results in increased localization of BAX protein
alvocidib results in increased susceptibility to TNFSF10
alvocidib results in increased expression of TNFSF10

PMID:16820931 PMID:16951203

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53

decreases expression
multiple interactions
increases expression

alvocidib results in decreased expression of TP53 protein
[docetaxel co-treated with alvocidib] results in increased expression of TP53 protein
[alvocidib results in increased expression of TP53 protein] which results in increased expression of CDKN1B protein; alvocidib results in increased expression of TP53 protein

PMID:9808574 PMID:10537362 PMID:12589031 PMID:15180955 PMID:15297405

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

vascular endothelial growth factor A

decreases expression

alvocidib results in decreased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

X-linked inhibitor of apoptosis

decreases expression
multiple interactions

alvocidib results in decreased expression of XIAP mRNA; alvocidib results in decreased expression of XIAP protein
[irinotecan co-treated with alvocidib] results in increased cleavage of XIAP protein; Epothilones promotes the reaction [alvocidib results in decreased expression of XIAP mRNA]; Epothilones promotes the reaction [alvocidib results in decreased expression of XIAP protein]

PMID:10887097 PMID:11751522 PMID:12517783 PMID:15385934 PMID:15972445 More...

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

apigenin 7-O-beta-D-glucoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glycophorin A

increases expression

apigetrin results in increased expression of GYPA protein

NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822

baicalin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
increases expression

baicalin results in increased expression of and results in increased activity of ACHE protein
baicalin results in increased expression of ACHE mRNA

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

aryl hydrocarbon receptor

increases activity

baicalin results in increased activity of AHR protein

PMID:17869316 PMID:26204831

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

allograft inflammatory factor 1

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein]

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

albumin

multiple interactions

baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 5-lipoxygenase

multiple interactions

baicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein]

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

angiopoietin 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of ANGPT1 mRNA]

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

activating transcription factor 2

multiple interactions

baicalin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein]

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

baicalin results in increased expression of BAX protein
baicalin affects the reaction [Rotenone results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Rotenone results in increased expression of BAX protein]
baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX protein]
baicalin inhibits the reaction [Rotenone affects the expression of BAX protein]

PMID:21457722 PMID:25423838 PMID:31021006 PMID:34333357 PMID:35088608 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

baicalin inhibits the reaction [Rotenone affects the expression of BCL2 protein]
baicalin results in decreased expression of BCL2 protein
baicalin affects the reaction [Rotenone results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]

PMID:25423838 PMID:31021006 PMID:34333357 PMID:35088608 PMID:36446982

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 1

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP1 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions

baicalin inhibits the reaction [Rotenone affects the expression of CASP3 protein]
baicalin affects the reaction [Rotenone results in decreased activity of CASP3 protein]
baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; baicalin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]

PMID:25423838 PMID:31021006 PMID:34333357 PMID:35088608 PMID:36446982

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

baicalin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]

PMID:34333357 PMID:35088608

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin A2

decreases expression

baicalin results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

increases expression
decreases expression
multiple interactions

baicalin results in increased expression of CCND1 mRNA
baicalin results in decreased expression of CCND1 protein
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of CCND1 mRNA]

PMID:19160421 PMID:21457722

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

collagen type I alpha 2 chain

multiple interactions

baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 protein]; baicalin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
baicalin results in increased expression of CYP1A1 mRNA; baicalin results in increased expression of CYP1A1 protein

PMID:18451504 PMID:26204831

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]
resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]
baicalin results in increased expression of CYP1A2 mRNA; baicalin results in increased expression of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

epidermal growth factor

multiple interactions

baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

ETS transcription factor ELK1

multiple interactions

baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

baicalin inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

forkhead box A2

decreases expression

baicalin results in decreased expression of FOXA2 mRNA; baicalin results in decreased expression of FOXA2 protein

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

glutamic-oxaloacetic transaminase 1

multiple interactions

baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]
baicalin inhibits the reaction [Arsenic Trioxide results in increased activity of GPT protein]

PMID:15645217 PMID:35088608

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

hes family bHLH transcription factor 1

increases expression
multiple interactions

baicalin results in increased expression of HES1 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes-related family bHLH transcription factor with YRPW motif 1

increases expression
multiple interactions

baicalin results in increased expression of HEY1 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]

NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions
increases expression

N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

G

heme oxygenase 1

multiple interactions
increases expression

[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HMOX1 protein]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]
baicalin results in increased expression of HMOX1 mRNA; baicalin results in increased expression of HMOX1 protein

PMID:16824337 PMID:18187930 PMID:38016618

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HNF1 homeobox A

multiple interactions
decreases expression

baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF1A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]
baicalin results in decreased expression of HNF1A mRNA; baicalin results in decreased expression of HNF1A protein

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

G

hepatocyte nuclear factor 4, alpha

decreases expression
multiple interactions

baicalin results in decreased expression of HNF4A protein
baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]; HNF4A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]
baicalin results in decreased expression of HNF4A mRNA; baicalin results in decreased expression of HNF4A protein

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heat shock protein family B (small) member 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of HSPB1 protein]

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

interleukin 1 beta

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B protein]; baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]
baicalin inhibits the reaction [Rotenone results in increased expression of IL1B protein]

PMID:29031535 PMID:35088608 PMID:36446982 PMID:38016618

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases expression
multiple interactions

baicalin results in decreased expression of IL6 mRNA; baicalin results in decreased expression of IL6 protein
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein]

PMID:22019745 PMID:29031535 PMID:34333357 PMID:35088608 PMID:38016618

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

integrin subunit alpha 4

multiple interactions

baicalin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]; baicalin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

Janus kinase 2

multiple interactions

baicalin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

kinase insert domain receptor

multiple interactions

baicalin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

Kelch-like ECH-associated protein 1

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KEAP1 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

mitogen activated protein kinase 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MYD88, innate immune signal transduction adaptor

decreases expression

baicalin results in decreased expression of MYD88 protein

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFE2 like bZIP transcription factor 2

multiple interactions

[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

increases expression

baicalin results in increased expression of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NLR family, pyrin domain containing 3

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]

PMID:29031535 PMID:38016618

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions
decreases expression

baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; mifobate inhibits the reaction [baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
baicalin results in decreased expression of NOS2 mRNA; baicalin results in decreased expression of NOS2 protein
baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]

PMID:18187930 PMID:22019745 PMID:24312512

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

increases activity
increases expression

baicalin results in increased activity of NOTCH1 protein
baicalin results in increased expression of NOTCH1 mRNA

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

nuclear receptor subfamily 1, group H, member 3

increases expression

Baicalin increases expression of NR1H3 mRNA and protein in foam cells

RGD

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

pyruvate kinase M1/2

increases activity

baicalin results in increased activity of PKM protein

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

peroxisome proliferator-activated receptor gamma

multiple interactions

baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and results in decreased activity of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

proline rich membrane anchor 1

increases expression

baicalin results in increased expression of PRIMA1 mRNA

NCBI chr 6:122,338,365...122,390,955
Ensembl chr 6:122,338,370...122,389,921

G

prostaglandin-endoperoxide synthase 2

decreases expression

baicalin results in decreased expression of PTGS2 mRNA; baicalin results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PYD and CARD domain containing

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

baicalin affects the localization of and results in decreased expression of RELA protein
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased phosphorylation of RELA protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]

PMID:22019745 PMID:34333357 PMID:38016618

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

synuclein alpha

multiple interactions

[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; [baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of TNF mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

signal transducer and activator of transcription 3

multiple interactions

baicalin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

TEK receptor tyrosine kinase

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of TEK mRNA]

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

transcription factor A, mitochondrial

decreases expression
multiple interactions

baicalin results in decreased expression of TFAM mRNA
baicalin inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transforming growth factor, beta 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of TGFB1 mRNA]; baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

PMID:19474275 PMID:34414639

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tyrosine hydroxylase

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

toll-like receptor 4

decreases expression
multiple interactions

baicalin results in decreased expression of TLR4 protein
baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of TLR4 protein]
baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]

PMID:22019745 PMID:24312512 PMID:34333357

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases expression

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
baicalin results in decreased expression of TNF mRNA; baicalin results in decreased expression of TNF protein
baicalin inhibits the reaction [Paraquat results in increased expression of TNF protein]

PMID:16824337 PMID:18187930 PMID:22019745 PMID:34333357 PMID:35088608 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

baicalin results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thioredoxin interacting protein

multiple interactions

baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]; dorsomorphin inhibits the reaction [baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]]

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

ubiquitin specific peptidase 27, X-linked

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased expression of USP27X protein]

NCBI chr X:15,123,620...15,126,855
Ensembl chr X:15,124,596...15,125,912

G

vascular endothelial growth factor A

multiple interactions

baicalin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor C

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of VEGFC mRNA]

NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848

G

xanthine dehydrogenase

multiple interactions

baicalin inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

casticin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 5

increases expression

casticin results in increased expression of ABCC5 mRNA

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

ADAM metallopeptidase domain 10

increases expression

casticin results in increased expression of ADAM10 mRNA

NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889

G

aftiphilin

decreases expression

casticin results in decreased expression of AFTPH mRNA

NCBI chr14:94,871,429...94,925,625
Ensembl chr14:94,871,429...94,925,376

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

decreases expression

casticin results in decreased expression of AGAP1 mRNA

NCBI chr 9:90,039,720...90,475,196
Ensembl chr 9:90,039,605...90,470,958

G

apoptosis inducing factor, mitochondria associated 1

increases expression
multiple interactions

casticin results in increased expression of AIFM1 protein
[Fluorouracil co-treated with casticin] results in increased expression of AIFM1 protein

PMID:29098808 PMID:32270916

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

akirin 2

decreases expression

casticin results in decreased expression of AKIRIN2 mRNA

NCBI chr 5:49,108,231...49,122,566
Ensembl chr 5:49,108,220...49,122,568

G

AKT serine/threonine kinase 1

decreases expression

casticin results in decreased expression of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 3

decreases expression

casticin results in decreased expression of AKT3 mRNA

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

aldehyde dehydrogenase 1 family, member A1

increases expression

casticin results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

ALX homeobox 1

decreases expression

casticin results in decreased expression of ALX1 mRNA

NCBI chr 7:38,157,626...38,177,220
Ensembl chr 7:38,147,117...38,177,220

G

apoptotic peptidase activating factor 1

increases expression

casticin results in increased expression of APAF1 protein

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

ARF like GTPase 6 interacting protein 4

decreases expression

casticin results in decreased expression of ARL6IP4 mRNA

NCBI chr12:32,479,623...32,481,768
Ensembl chr12:32,479,625...32,481,799

G

armadillo repeat containing 9

decreases expression

casticin results in decreased expression of ARMC9 mRNA

NCBI chr 9:86,802,791...86,928,611
Ensembl chr 9:86,802,868...86,928,860

G

actin related protein 2/3 complex, subunit 5-like

decreases expression

casticin results in decreased expression of ARPC5L mRNA

NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
Ensembl chr 9:22,759,876...22,767,538

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

casticin results in decreased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 5

decreases expression

casticin results in decreased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

activating transcription factor 6

increases expression

casticin results in increased expression of ATF6 protein

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ATM serine/threonine kinase

decreases expression

casticin results in decreased expression of ATM protein

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

antioxidant 1 copper chaperone

increases expression

casticin results in increased expression of ATOX1 mRNA

NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950

G

ATPase H+ transporting V1 subunit G1

decreases expression

casticin results in decreased expression of ATP6V1G1 mRNA

NCBI chr 5:76,961,462...76,967,642
Ensembl chr 5:76,961,499...76,969,463

G

ATPase phospholipid transporting 8A1

increases expression

casticin results in increased expression of ATP8A1 mRNA

NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611

G

ATR serine/threonine kinase

decreases expression

casticin results in decreased expression of ATR protein

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

ataxin 7-like 3B

decreases expression

casticin results in decreased expression of ATXN7L3B mRNA

NCBI chr 7:48,322,451...48,325,975
Ensembl chr 7:48,321,755...48,328,878

G

arginine vasopressin receptor 1A

decreases expression

casticin results in decreased expression of AVPR1A mRNA

NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215

G

axin 2

increases expression

casticin results in increased expression of AXIN2 mRNA

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

BCL2-antagonist/killer 1

increases expression

casticin results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BMP and activin membrane-bound inhibitor

increases expression

casticin results in increased expression of BAMBI mRNA

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

brain abundant, membrane attached signal protein 1

decreases expression

casticin results in decreased expression of BASP1 mRNA

NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

casticin results in increased expression of BAX protein
casticin inhibits the reaction [Fluorouracil results in increased expression of BAX protein]

PMID:27862857 PMID:29098808 PMID:32270916

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL11 transcription factor A

decreases expression

casticin results in decreased expression of BCL11A mRNA

NCBI chr14:98,029,018...98,124,181
Ensembl chr14:98,030,461...98,124,180

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

casticin results in decreased expression of BCL2 protein
[Fluorouracil co-treated with casticin] results in decreased expression of BCL2 protein

PMID:27862857 PMID:29098808 PMID:32270916

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression
multiple interactions
increases expression

casticin results in decreased expression of BCL2L1 protein
casticin promotes the reaction [Fluorouracil results in decreased expression of BCL2L1 protein]; Fluorouracil promotes the reaction [casticin results in decreased expression of BCL2L1 protein]
casticin results in increased expression of BCL2L1 mRNA

PMID:27862857 PMID:29098808 PMID:32270916

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BH3 interacting domain death agonist

increases expression
multiple interactions
decreases expression

casticin results in increased expression of BID protein
casticin inhibits the reaction [Fluorouracil results in increased expression of BID protein]
casticin results in decreased expression of BID protein

PMID:27862857 PMID:29098808 PMID:32270916

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

basic helix-loop-helix ARNT like 1

decreases expression

casticin results in decreased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

BMI1 proto-oncogene, polycomb ring finger

multiple interactions
decreases expression

casticin promotes the reaction [MIR148A mRNA results in decreased expression of BMI1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of BMI1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of BMI1 mRNA]

NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690

G

bone morphogenetic protein 4

increases expression

casticin results in increased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

BCL2 interacting protein 2

decreases expression

casticin results in decreased expression of BNIP2 mRNA

NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590

G

BRCA1, DNA repair associated

increases expression

casticin results in increased expression of BRCA1 protein

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

basic transcription factor 3

decreases expression

casticin results in decreased expression of BTF3 mRNA

NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879
Ensembl chr13:29,659,231...29,666,879

G

BTG anti-proliferation factor 1

decreases expression

casticin results in decreased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

cell adhesion molecule 1

increases expression

casticin results in increased expression of CADM1 mRNA

NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833

G

calcium binding and coiled coil domain 1

decreases expression

casticin results in decreased expression of CALCOCO1 mRNA

NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422

G

calmodulin 1

decreases expression

casticin results in decreased expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calcium/calmodulin-dependent protein kinase IV

decreases expression

casticin results in decreased expression of CAMK4 mRNA

NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487

G

calpain 1

multiple interactions

casticin results in increased expression of and results in increased cleavage of CAPN1 protein

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

calpain 2

increases expression

casticin results in increased expression of CAPN2 protein

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

caspase 2

increases expression

casticin results in increased expression of CASP2 protein

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

multiple interactions
increases activity

casticin results in increased cleavage of and results in increased activity of CASP3 protein
casticin inhibits the reaction [Fluorouracil results in increased activity of CASP3 protein]
casticin results in increased activity of CASP3 protein

PMID:27862857 PMID:29098808 PMID:32270916

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases expression

casticin results in increased expression of CASP4 protein

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 6

increases expression

casticin results in increased expression of CASP6 protein

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases expression

casticin results in increased expression of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions

casticin results in increased cleavage of and results in increased activity of CASP8 protein; casticin results in increased expression of and results in increased activity of CASP8 protein

PMID:27862857 PMID:29098808

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases activity

casticin results in increased cleavage of and results in increased activity of CASP9 protein
casticin promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]
casticin results in increased activity of CASP9 protein

PMID:27862857 PMID:29098808 PMID:32270916

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases expression
multiple interactions

casticin results in increased expression of CAT protein
Fluorouracil inhibits the reaction [casticin results in increased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

coiled-coil domain containing 122

increases expression

casticin results in increased expression of CCDC122 mRNA

NCBI chr15:52,407,717...52,470,163
Ensembl chr15:52,407,717...52,470,163

G

coiled-coil domain containing 174

decreases expression

casticin results in decreased expression of CCDC174 mRNA

NCBI chr 4:124,392,183...124,419,035
Ensembl chr 4:124,392,274...124,419,035

G

coiled-coil domain containing 90B

decreases expression

casticin results in decreased expression of CCDC90B mRNA

NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338

G

cellular communication network factor 1

increases expression

casticin results in increased expression of CCN1 mRNA

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cyclin B1

decreases expression

casticin results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

chaperonin containing TCP1 subunit 4

decreases expression

casticin results in decreased expression of CCT4 mRNA

NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267

G

CD24 molecule

increases expression

casticin results in increased expression of CD24 mRNA

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

CD44 molecule

decreases expression
multiple interactions

casticin results in decreased expression of CD44 mRNA; casticin results in decreased expression of CD44 protein
casticin affects the reaction [MIR148A mRNA affects the expression of CD44 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of CD44 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of CD44 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of CD44 protein]

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD83 molecule

decreases expression

casticin results in decreased expression of CD83 mRNA

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

cell division cycle 25C

decreases expression

casticin results in decreased expression of CDC25C protein

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 42

decreases expression

casticin results in decreased expression of CDC42 mRNA

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

cadherin 17

increases expression

casticin results in increased expression of CDH17 mRNA

NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884

G

cyclin dependent kinase 2

increases expression

casticin results in increased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

decreases expression

casticin results in decreased expression of CDKN1A mRNA; casticin results in decreased expression of CDKN1A protein

PMID:27862857 PMID:29098808

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

casticin results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2A

increases expression

casticin results in increased expression of CDKN2A protein

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

checkpoint kinase 2

increases expression

casticin results in increased expression of CHEK2 protein

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

cysteine-rich hydrophobic domain 2

decreases expression

casticin results in decreased expression of CHIC2 mRNA

NCBI chr14:33,157,669...33,192,015
Ensembl chr14:33,157,537...33,191,895

G

claudin 1

decreases expression

casticin results in decreased expression of CLDN1 mRNA

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

CCHC-type zinc finger, nucleic acid binding protein

decreases expression

casticin results in decreased expression of CNBP mRNA

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

collagen type I alpha 1 chain

decreases expression

casticin results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

carboxypeptidase E

increases expression

casticin results in increased expression of CPE mRNA

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

G

cAMP responsive element binding protein 1

increases expression

casticin results in increased expression of CREB1 mRNA

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

corticotropin releasing hormone binding protein

decreases expression

casticin results in decreased expression of CRHBP mRNA

NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710

G

cardiolipin synthase 1

decreases expression

casticin results in decreased expression of CRLS1 mRNA

NCBI chr 3:120,119,822...120,138,674
Ensembl chr 3:120,119,852...120,138,655

G

crystallin, alpha B

increases expression

casticin results in increased expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

casein kinase 1, alpha 1

decreases expression

casticin results in decreased expression of CSNK1A1 mRNA

NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271

G

cytochrome b5 reductase 1

decreases expression

casticin results in decreased expression of CYB5R1 mRNA

NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458

G

cytochrome c, somatic

increases expression

casticin results in increased expression of CYCS protein

PMID:27862857 PMID:29098808

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

DNA-damage inducible transcript 3

decreases expression

casticin results in decreased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEAD-box helicase 27

decreases expression

casticin results in decreased expression of DDX27 mRNA

NCBI chr 3:155,744,182...155,763,380
Ensembl chr 3:155,744,150...155,763,372

G

disco-interacting protein 2 homolog C

decreases expression

casticin results in decreased expression of DIP2C mRNA

NCBI chr17:60,647,346...61,032,467
Ensembl chr17:60,649,065...61,032,305

G

dickkopf WNT signaling pathway inhibitor 3

decreases expression

casticin results in decreased expression of DKK3 mRNA

NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590

G

DNA methyltransferase 1

multiple interactions
decreases activity
decreases expression

casticin affects the reaction [MIR148A mRNA affects the activity of DNMT1 protein]; casticin affects the reaction [MIR148A mRNA affects the expression of DNMT1 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased activity of DNMT1 protein]; casticin results in decreased expression of and results in decreased activity of DNMT1 protein; DNMT1 protein inhibits the reaction [casticin results in decreased activity of DNMT1 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of BMI1 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of CD44 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of EPCAM protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of NANOG protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of POU5F1 protein]; DNMT1 protein inhibits the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA affects the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA affects the reaction [casticin results in decreased expression of DNMT1 mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased activity of DNMT1 protein]

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dual specificity phosphatase 6

decreases expression

casticin results in decreased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

dual specificity tyrosine phosphorylation regulated kinase 1A

decreases expression

casticin results in decreased expression of DYRK1A mRNA

NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420

G

epidermal growth factor receptor

decreases expression

casticin results in decreased expression of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 2 subunit beta

decreases expression

casticin results in decreased expression of EIF2S2 mRNA

NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432

G

eukaryotic translation initiation factor 5

decreases expression

casticin results in decreased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

ectodermal-neural cortex 1

increases expression

casticin results in increased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

endonuclease G

decreases expression
increases expression
multiple interactions

casticin results in decreased expression of ENDOG protein
casticin results in increased expression of ENDOG protein
casticin inhibits the reaction [Fluorouracil results in increased expression of ENDOG protein]

PMID:29098808 PMID:32270916

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

E1A binding protein p300

decreases expression

casticin results in decreased expression of EP300 mRNA

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

erythrocyte membrane protein band 4.1 like 4B

decreases expression

casticin results in decreased expression of EPB41L4B mRNA

NCBI chr 5:71,691,706...71,852,583
Ensembl chr 5:71,694,331...71,851,990

G

epithelial cell adhesion molecule

multiple interactions
decreases expression

casticin promotes the reaction [MIR148A mRNA results in decreased expression of EPCAM mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of EPCAM protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of EPCAM mRNA]

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

erb-b2 receptor tyrosine kinase 3

increases expression

casticin results in increased expression of ERBB3 mRNA

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

ESF1 nucleolar pre-rRNA processing protein homolog

decreases expression

casticin results in decreased expression of ESF1 mRNA

NCBI chr 3:127,454,744...127,507,941
Ensembl chr 3:127,454,811...127,507,817

G

exosome component 3

decreases expression

casticin results in decreased expression of EXOSC3 mRNA

NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060

G

exostosin glycosyltransferase 1

increases expression

casticin results in increased expression of EXT1 mRNA

NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357

G

Fas associated via death domain

increases expression

casticin results in increased expression of FADD protein

PMID:27862857 PMID:29098808

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

family with sequence similarity 227, member A

increases expression

casticin results in increased expression of FAM227A mRNA

NCBI chr 7:111,174,362...111,216,513
Ensembl chr 7:111,174,362...111,216,483

G

Fas cell surface death receptor

increases expression

casticin results in increased expression of FAS protein

PMID:27862857 PMID:29098808

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression
decreases expression

casticin results in increased expression of FASLG protein
casticin results in decreased expression of FASLG protein

PMID:27862857 PMID:29098808

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

F-box protein 11

decreases expression

casticin results in decreased expression of FBXO11 mRNA

NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662

G

F-box protein 44

decreases expression

casticin results in decreased expression of FBXO44 mRNA

NCBI chr 5:158,583,363...158,592,510
Ensembl chr 5:158,583,366...158,592,363

G

fasciculation and elongation protein zeta 1

decreases expression

casticin results in decreased expression of FEZ1 mRNA

NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683

G

forkhead box O3

decreases expression

casticin results in decreased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box P2

decreases expression

casticin results in decreased expression of FOXP2 mRNA

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

growth arrest and DNA-damage-inducible, alpha

decreases expression

casticin results in decreased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glutamate dehydrogenase 1

decreases expression

casticin results in decreased expression of GLUD1 mRNA

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

gephyrin

decreases expression

casticin results in decreased expression of GPHN mRNA

NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612

G

G protein-coupled receptor 85

decreases expression

casticin results in decreased expression of GPR85 mRNA

NCBI chr 4:42,100,138...42,109,584
Ensembl chr 4:42,102,941...42,109,566

G

growth factor receptor bound protein 2

decreases expression

casticin results in decreased expression of GRB2 protein

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

glutamate ionotropic receptor delta type subunit 2

decreases expression

casticin results in decreased expression of GRID2 mRNA

NCBI chr 4:92,415,019...93,892,472
Ensembl chr 4:92,415,230...93,889,355

G

general transcription factor IIH subunit 2

decreases expression

casticin results in decreased expression of GTF2H2 mRNA

NCBI chr 2:31,623,752...31,652,697
Ensembl chr 2:31,624,678...31,652,592

G

hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

decreases expression

casticin results in decreased expression of HCN2 mRNA

NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841

G

homeo box B8

decreases expression

casticin results in decreased expression of HOXB8 mRNA

NCBI chr10:81,248,313...81,251,261
Ensembl chr10:81,248,887...81,250,638

G

homeo box B9

decreases expression

casticin results in decreased expression of HOXB9 mRNA

NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818

G

heat shock protein family A (Hsp70) member 4

decreases expression

casticin results in decreased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 5

increases expression

casticin results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

increases expression

casticin results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family A (Hsp70) member 9

decreases expression

casticin results in decreased expression of HSPA9 mRNA

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

interleukin 12A

decreases expression

casticin results in decreased expression of IL12A mRNA

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 6

decreases expression

casticin results in decreased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrator complex subunit 6

decreases expression

casticin results in decreased expression of INTS6 mRNA

NCBI chr15:36,908,966...37,048,043
Ensembl chr15:36,933,724...37,021,527

G

interleukin-1 receptor-associated kinase 4

increases expression

casticin results in increased expression of IRAK4 mRNA

NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837

G

interferon regulatory factor 2 binding protein 2

decreases expression

casticin results in decreased expression of IRF2BP2 mRNA

NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642

G

potassium voltage-gated channel subfamily H member 2

decreases expression

casticin results in decreased expression of KCNH2 mRNA

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium channel tetramerization domain containing 9

decreases expression

casticin results in decreased expression of KCTD9 mRNA

NCBI chr15:41,942,165...41,969,862
Ensembl chr15:41,942,381...41,969,862

G

kirre like nephrin family adhesion molecule 3

decreases expression

casticin results in decreased expression of KIRREL3 mRNA

NCBI chr 8:32,865,779...33,407,555
Ensembl chr 8:32,862,776...33,405,676

G

KLF transcription factor 9

decreases expression

casticin results in decreased expression of KLF9 mRNA

NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037

G

keratin 16

increases expression

casticin results in increased expression of KRT16 mRNA

NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799

G

lactate dehydrogenase B

decreases expression

casticin results in decreased expression of LDHB mRNA

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

lymphoid enhancer binding factor 1

decreases expression

casticin results in decreased expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

LHFPL tetraspan subfamily member 6

increases expression

casticin results in increased expression of LHFPL6 mRNA

NCBI chr 2:137,126,485...137,324,442
Ensembl chr 2:137,126,509...137,324,443

G

LIM and calponin homology domains 1

increases expression

casticin results in increased expression of LIMCH1 mRNA

NCBI chr14:41,112,579...41,425,001
Ensembl chr14:41,114,803...41,425,191

G

lipoprotein lipase

decreases expression

casticin results in decreased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

LDL receptor related protein 5

increases expression

casticin results in increased expression of LRP5 mRNA

NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581

G

LTV1 ribosome biogenesis factor

decreases expression

casticin results in decreased expression of LTV1 mRNA

NCBI chr 1:7,565,673...7,578,398
Ensembl chr 1:7,565,669...7,578,563

G

MAF bZIP transcription factor

decreases expression

casticin results in decreased expression of MAF mRNA

NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365

G

mago homolog, exon junction complex subunit

decreases expression

casticin results in decreased expression of MAGOH mRNA

NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:122,639,308...122,646,617

G

mitogen activated protein kinase kinase kinase 7

increases expression

casticin results in increased expression of MAP3K7 mRNA

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

microtubule-associated protein, RP/EB family, member 2

increases expression

casticin results in increased expression of MAPRE2 mRNA

NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044

G

microtubule affinity regulating kinase 3

decreases expression

casticin results in decreased expression of MARK3 mRNA

NCBI chr 6:130,626,612...130,716,245
Ensembl chr 6:130,627,482...130,716,647

G

MYC associated factor X

decreases expression

casticin results in decreased expression of MAX mRNA

NCBI chr 6:95,636,859...95,662,204
Ensembl chr 6:95,636,858...95,662,137

G

myelin basic protein

increases expression

casticin results in increased expression of MBP mRNA

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

casticin results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

mediator of DNA damage checkpoint 1

increases expression

casticin results in increased expression of MDC1 protein

NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240

G

MDS1 and EVI1 complex locus

decreases expression

casticin results in decreased expression of MECOM mRNA

NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590

G

mesoderm specific transcript

increases expression

casticin results in increased expression of MEST mRNA

NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145

G

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

decreases expression

casticin results in decreased expression of METTL3 mRNA

NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041

G

microRNA 148a

increases expression
multiple interactions

casticin results in increased expression of MIR148A mRNA
casticin affects the reaction [MIR148A mRNA affects the activity of DNMT1 protein]; casticin affects the reaction [MIR148A mRNA affects the expression of CD44 mRNA]; casticin affects the reaction [MIR148A mRNA affects the expression of DNMT1 mRNA]; casticin affects the reaction [MIR148A mRNA results in increased expression of MIR148A mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased activity of DNMT1 protein]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of BMI1 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of CD44 protein]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of EPCAM mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of NANOG mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of POU5F1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA affects the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA affects the reaction [casticin results in decreased expression of DNMT1 mRNA]; MIR148A mRNA affects the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of BMI1 mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of CD44 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of EPCAM mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of NANOG mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of POU5F1 mRNA]

NCBI chr 4:80,333,762...80,333,858
Ensembl chr 4:80,333,762...80,333,858

G

matrix metallopeptidase 2

decreases expression

casticin results in decreased expression of MMP2 mRNA
casticin results in decreased expression of MMP2 protein

PMID:27862857 PMID:28444820

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression

casticin results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

M-phase specific PLK1 interacting protein

decreases expression

casticin results in decreased expression of MPLKIP mRNA

NCBI chr17:47,373,624...47,376,199
Ensembl chr17:47,373,845...47,376,204

G

mitochondrial ribosomal protein L9

increases expression

casticin results in increased expression of MRPL9 mRNA

NCBI chr 2:182,082,012...182,086,758
Ensembl chr 2:182,076,369...182,087,095

G

mucin 13, cell surface associated

increases expression

casticin results in increased expression of MUC13 mRNA

NCBI chr11:66,957,208...66,980,264
Ensembl chr11:66,960,595...66,984,727

G

MYD88, innate immune signal transduction adaptor

increases expression

casticin results in increased expression of MYD88 mRNA

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

myosin VIIA

increases expression

casticin results in increased expression of MYO7A mRNA

NCBI chr 1:152,342,611...152,414,171
Ensembl chr 1:152,344,448...152,414,157

G

Nanog homeobox

multiple interactions
decreases expression

casticin promotes the reaction [MIR148A mRNA results in decreased expression of NANOG mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of NANOG protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of NANOG mRNA]

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

G

asparaginyl-tRNA synthetase 1

decreases expression

casticin results in decreased expression of NARS1 mRNA

NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622

G

NADH:ubiquinone oxidoreductase subunit S4

decreases expression

casticin results in decreased expression of NDUFS4 mRNA

NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846

G

nuclear factor kappa B subunit 1

decreases expression

casticin results in decreased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nuclear factor kappa B subunit 2

decreases expression

casticin results in decreased expression of NFKB2 mRNA

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

NFKB inhibitor alpha

decreases expression

casticin results in decreased expression of NFKBIA mRNA

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor beta

decreases expression

casticin results in decreased expression of NFKBIB mRNA

NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862

G

NFKB inhibitor delta

decreases expression

casticin results in decreased expression of NFKBID mRNA

NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447

G

NFKB inhibitor epsilon

decreases expression

casticin results in decreased expression of NFKBIE mRNA

NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437

G

nuclear transcription factor, X-box binding 1

increases expression

casticin results in increased expression of NFX1 mRNA

NCBI chr 5:56,104,945...56,162,912
Ensembl chr 5:56,105,234...56,162,912

G

NKD inhibitor of WNT signaling pathway 1

increases expression

casticin results in increased expression of NKD1 mRNA

NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380

G

NME/NM23 family member 9

increases expression

casticin results in increased expression of NME9 mRNA

NCBI chr 8:100,013,190...100,034,511

G

N-myristoyltransferase 1

decreases expression

casticin results in decreased expression of NMT1 mRNA

NCBI chr10:87,988,826...88,025,405
Ensembl chr10:87,988,826...88,022,648

G

nucleolar protein 4-like

decreases expression

casticin results in decreased expression of NOL4L mRNA

NCBI chr 3:141,884,840...142,007,668
Ensembl chr 3:141,884,840...142,008,976

G

NOP58 ribonucleoprotein

decreases expression

casticin results in decreased expression of NOP58 mRNA

NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810

G

neuronal PAS domain protein 3

decreases expression

casticin results in decreased expression of NPAS3 mRNA

NCBI chr 6:70,702,773...71,527,928
Ensembl chr 6:70,703,170...71,524,884

G

neuregulin 3

decreases expression

casticin results in decreased expression of NRG3 mRNA

NCBI chr16:14,229,270...15,352,505
Ensembl chr16:14,235,157...15,352,368

G

nucleoporin 205

decreases expression

casticin results in decreased expression of NUP205 mRNA

NCBI chr 4:63,854,934...63,920,852
Ensembl chr 4:63,854,783...63,920,844

G

nucleoporin 37

decreases expression

casticin results in decreased expression of NUP37 mRNA

NCBI chr 7:22,556,544...22,609,622
Ensembl chr 7:22,573,764...22,609,616

G

oligodendrocyte transcription factor 2

decreases expression

casticin results in decreased expression of OLIG2 mRNA

NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152

G

origin recognition complex, subunit 5

decreases expression

casticin results in decreased expression of ORC5 mRNA

NCBI chr 4:12,548,007...12,612,611
Ensembl chr 4:12,548,007...12,612,568

G

OTU deubiquitinase, ubiquitin aldehyde binding 2

decreases expression

casticin results in decreased expression of OTUB2 mRNA

NCBI chr 6:122,545,067...122,563,657
Ensembl chr 6:122,545,061...122,563,644

G

purinergic receptor P2X 7

increases expression

casticin results in increased expression of P2RX7 mRNA

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

poly(A) binding protein interacting protein 1

decreases expression

casticin results in decreased expression of PAIP1 mRNA

NCBI chr 2:51,523,190...51,550,241
Ensembl chr 2:51,522,921...51,550,241

G

p21 (RAC1) activated kinase 3

decreases expression

casticin results in decreased expression of PAK3 mRNA

NCBI chr X:107,116,308...107,374,342
Ensembl chr X:107,260,898...107,368,314

G

poly (A) polymerase alpha

decreases expression

casticin results in decreased expression of PAPOLA mRNA

NCBI chr 6:124,682,015...124,734,706
Ensembl chr 6:124,682,105...124,734,468

G

poly (ADP-ribose) polymerase 1

increases expression

casticin results in increased expression of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

protocadherin alpha 1

increases expression

casticin results in increased expression of PCDHA1 mRNA

Ensembl chr18:28,581,225...28,846,211

G

PHD finger protein 10

decreases expression

casticin results in decreased expression of PHF10 mRNA

NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038

G

phosphatidylinositol binding clathrin assembly protein

decreases expression

casticin results in decreased expression of PICALM mRNA

NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557

G

plasminogen activator, urokinase

decreases expression

casticin results in decreased expression of PLAU protein

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

peripheral myelin protein 22

increases expression

casticin results in increased expression of PMP22 mRNA

NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714

G

POU class 5 homeobox 1

multiple interactions
decreases expression

casticin promotes the reaction [MIR148A mRNA results in decreased expression of POU5F1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of POU5F1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of POU5F1 mRNA]

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator-activated receptor delta

decreases expression

casticin results in decreased expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

increases expression

casticin results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

decreases expression

casticin results in decreased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase 1, regulatory (inhibitor) subunit 11

decreases expression

casticin results in decreased expression of PPP1R11 mRNA

NCBI chr20:1,601,350...1,604,857
Ensembl chr20:1,601,346...1,604,846

G

protein phosphatase 6, regulatory subunit 3

decreases expression

casticin results in decreased expression of PPP6R3 mRNA

NCBI chr 1:200,693,128...200,807,578
Ensembl chr 1:200,693,440...200,807,548

G

protein kinase cAMP-dependent type II regulatory subunit beta

decreases expression

casticin results in decreased expression of PRKAR2B mRNA

NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

casticin results in decreased expression of PRKDC protein

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

serine protease 44

increases expression

casticin results in increased expression of PRSS44 mRNA

NCBI chr 8:110,791,698...110,805,303
Ensembl chr 8:110,791,698...110,805,303

G

protein tyrosine kinase 2

decreases expression

casticin results in decreased expression of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, receptor type, A

increases expression

casticin results in increased expression of PTPRA mRNA

NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728

G

protein tyrosine phosphatase, receptor type, D

decreases expression

casticin results in decreased expression of PTPRD mRNA

NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396

G

protein tyrosine phosphatase, receptor type, F

decreases expression

casticin results in decreased expression of PTPRF mRNA

NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023

G

QKI, KH domain containing RNA binding

decreases expression

casticin results in decreased expression of QKI mRNA

NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831

G

Rap guanine nucleotide exchange factor 4

decreases expression

casticin results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

arginyl-tRNA synthetase 1

decreases expression

casticin results in decreased expression of RARS1 mRNA

NCBI chr10:20,270,744...20,295,192
Ensembl chr10:20,270,483...20,295,196

G

RNA binding motif protein, X-linked 2

decreases expression

casticin results in decreased expression of RBMX2 mRNA

NCBI chr X:127,888,514...127,896,239
Ensembl chr X:127,888,438...127,896,869

G

REST corepressor 3

decreases expression

casticin results in decreased expression of RCOR3 mRNA

NCBI chr13:103,624,966...103,665,565
Ensembl chr13:103,624,971...103,665,565

G

RELA proto-oncogene, NF-kB subunit

decreases expression

casticin results in decreased expression of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RNA exonuclease 2

decreases expression

casticin results in decreased expression of REXO2 mRNA

NCBI chr 8:48,811,900...48,823,622
Ensembl chr 8:48,811,900...48,823,622

G

ras homolog family member A

decreases expression

casticin results in decreased expression of RHOA protein

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

ribosomal protein L22 like 1

decreases expression

casticin results in decreased expression of RPL22L1 mRNA

NCBI chr 2:111,754,687...111,756,623
Ensembl chr 2:111,754,687...111,756,625

G

S100 calcium binding protein A13

increases expression

casticin results in increased expression of S100A13 mRNA

NCBI chr 2:175,999,439...176,005,933

G

sodium voltage-gated channel beta subunit 1

increases expression

casticin results in increased expression of SCN1B mRNA

NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739

G

solute carrier family 31 member 1

increases expression

casticin results in increased expression of SLC31A1 mRNA

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 6 member 9

decreases expression

casticin results in decreased expression of SLC6A9 mRNA

NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728

G

SMAD family member 1

increases expression

casticin results in increased expression of SMAD1 mRNA

NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651

G

SMAD family member 3

increases expression

casticin results in increased expression of SMAD3 mRNA

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

small nuclear ribonucleoprotein polypeptide G

decreases expression

casticin results in decreased expression of SNRPG mRNA

NCBI chr 4:118,812,278...118,819,827
Ensembl chr 4:118,812,252...118,819,826
Ensembl chr X:118,812,252...118,819,826

G

SNW domain containing 1

decreases expression

casticin results in decreased expression of SNW1 mRNA

NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536

G

superoxide dismutase 1

multiple interactions
increases expression

casticin promotes the reaction [Fluorouracil results in increased expression of SOD1 protein]; Fluorouracil promotes the reaction [casticin results in increased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

casticin results in decreased expression of SOS1 protein

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

secreted protein acidic and cysteine rich

decreases expression
increases expression

casticin results in decreased expression of SPARC mRNA
casticin results in increased expression of SPARC mRNA

PMID:27862857 PMID:28444820

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

SPARC like 1

increases expression

casticin results in increased expression of SPARCL1 mRNA

NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865

G

ST13, Hsp70 interacting protein

increases expression

casticin results in increased expression of ST13 mRNA

NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 3

decreases expression

casticin results in decreased expression of ST3GAL3 mRNA

NCBI chr 5:131,470,348...131,670,794
Ensembl chr 5:131,470,348...131,670,810

G

spermatid perinuclear RNA binding protein

decreases expression

casticin results in decreased expression of STRBP mRNA

NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949

G

SURP and G patch domain containing 1

decreases expression

casticin results in decreased expression of SUGP1 mRNA

NCBI chr16:19,352,659...19,383,533
Ensembl chr16:19,351,793...19,383,756

G

synaptotagmin binding, cytoplasmic RNA interacting protein

decreases expression

casticin results in decreased expression of SYNCRIP mRNA

NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515

G

synaptotagmin 9

decreases expression

casticin results in decreased expression of SYT9 mRNA

NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007

G

TGF-beta activated kinase 1/MAP3K7 binding protein 2

decreases expression

casticin results in decreased expression of TAB2 mRNA

NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:2,375,490...2,424,756

G

transcription factor 7

decreases expression

casticin results in decreased expression of TCF7 mRNA

NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535

G

thyroid hormone receptor alpha

decreases expression

casticin results in decreased expression of THRA mRNA

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

TIMP metallopeptidase inhibitor 2

increases expression

casticin results in increased expression of TIMP2 mRNA

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

tousled-like kinase 2

decreases expression

casticin results in decreased expression of TLK2 mRNA

NCBI chr10:90,154,449...90,248,562
Ensembl chr10:90,156,813...90,248,561

G

toll-like receptor 4

decreases expression

casticin results in decreased expression of TLR4 mRNA

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

transmembrane BAX inhibitor motif containing 4

increases expression

casticin results in increased expression of TMBIM4 mRNA

NCBI chr 7:55,718,690...55,733,277
Ensembl chr 7:55,718,699...55,742,773

G

transmembrane protein 45b

increases expression

casticin results in increased expression of TMEM45B mRNA

NCBI chr 8:29,865,276...29,910,453
Ensembl chr 8:29,865,278...29,910,453

G

thymosin, beta 10

increases expression

casticin results in increased expression of TMSB10 mRNA

NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028

G

TNF superfamily member 10

increases expression

casticin results in increased expression of TNFSF10 protein

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

transportin 1

decreases expression

casticin results in decreased expression of TNPO1 mRNA

NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375

G

torsin 1A interacting protein 2

decreases expression

casticin results in decreased expression of TOR1AIP2 mRNA

NCBI chr13:68,225,226...68,256,536
Ensembl chr13:68,230,009...68,256,536
Ensembl chr13:68,230,009...68,256,536

G

tumor protein p53

increases expression
decreases expression

casticin results in increased expression of TP53 protein modified form
casticin results in decreased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triosephosphate isomerase 1

increases expression

casticin results in increased expression of TPI1 mRNA

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

transmembrane protein adipocyte associated 1

increases expression

casticin results in increased expression of TPRA1 mRNA

NCBI chr 4:121,364,093...121,375,275
Ensembl chr 4:121,364,091...121,375,269

G

transformer 2 beta

decreases expression

casticin results in decreased expression of TRA2B mRNA

NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249

G

TNF receptor-associated protein 1

increases expression

casticin results in increased expression of TRAP1 mRNA

NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981

G

trio Rho guanine nucleotide exchange factor

increases expression

casticin results in increased expression of TRIO mRNA

NCBI chr 2:78,505,069...78,801,384
Ensembl chr 2:78,505,070...78,803,135

G

ubiquitin-conjugating enzyme E2D 3

decreases expression

casticin results in decreased expression of UBE2D3 mRNA

NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081

G

ubiquitin-conjugating enzyme E2F (putative)

decreases expression

casticin results in decreased expression of UBE2F mRNA

NCBI chr 9:91,845,975...91,881,145
Ensembl chr 9:91,845,987...91,880,594

G

ubiquitin-conjugating enzyme E2W

decreases expression

casticin results in decreased expression of UBE2W mRNA

NCBI chr 5:2,690,742...2,754,491
Ensembl chr 5:2,690,763...2,814,965

G

vascular endothelial growth factor A

decreases expression

casticin results in decreased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial zinc finger 1

decreases expression

casticin results in decreased expression of VEZF1 mRNA

NCBI chr10:72,859,669...72,876,111
Ensembl chr10:72,859,877...72,876,111

G

vimentin

decreases expression
increases expression

casticin results in decreased expression of VIM mRNA
casticin results in increased expression of VIM mRNA

PMID:27862857 PMID:28444820

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

very low density lipoprotein receptor

decreases expression

casticin results in decreased expression of VLDLR mRNA

NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920

G

WW domain containing adaptor with coiled-coil

decreases expression

casticin results in decreased expression of WAC mRNA

NCBI chr17:55,922,686...55,984,286
Ensembl chr17:55,923,123...55,982,301

G

WEE1 G2 checkpoint kinase

decreases expression

casticin results in decreased expression of WEE1 protein

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688

G

Wnt family member 5A

decreases expression

casticin results in decreased expression of WNT5A mRNA

NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234

G

WD repeat and SOCS box-containing 1

decreases expression

casticin results in decreased expression of WSB1 mRNA

NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019

G

WT1 associated protein

decreases expression

casticin results in decreased expression of WTAP mRNA

NCBI chr 1:47,665,965...47,691,067
Ensembl chr 1:47,665,965...47,691,065

G

X-box binding protein 1

increases expression

casticin results in increased expression of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

X-linked inhibitor of apoptosis

decreases expression

casticin results in decreased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

increases expression

casticin results in increased expression of YWHAB protein

NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

decreases expression

casticin results in decreased expression of YWHAG mRNA

NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827

G

zinc finger and BTB domain containing 18

decreases expression

casticin results in decreased expression of ZBTB18 mRNA

NCBI chr13:89,439,501...89,447,958
Ensembl chr13:89,439,420...89,448,862

G

zinc finger homeobox 4

decreases expression

casticin results in decreased expression of ZFHX4 mRNA

NCBI chr 2:96,224,763...96,408,245
Ensembl chr 2:96,224,767...96,408,228

G

zinc finger protein 384

decreases expression

casticin results in decreased expression of ZFP384 mRNA

NCBI chr 4:157,810,263...157,840,052
Ensembl chr 4:157,810,352...157,839,766

G

zinc finger protein 711

decreases expression

casticin results in decreased expression of ZFP711 mRNA

NCBI chr X:77,646,300...77,679,398
Ensembl chr X:77,646,558...77,678,045

G

zinc finger RNA binding protein

decreases expression

casticin results in decreased expression of ZFR mRNA

NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322

G

zinc finger with KRAB and SCAN domains 1

increases expression

casticin results in increased expression of ZKSCAN1 mRNA

NCBI chr12:16,966,287...16,987,680
Ensembl chr12:16,966,654...16,983,865

G

zinc finger and SCAN domain containing 2

increases expression

casticin results in increased expression of ZSCAN2 mRNA

NCBI chr 1:134,833,701...134,848,957
Ensembl chr 1:134,833,871...134,848,952

G

zinc finger, SWIM-type containing 6

increases expression

casticin results in increased expression of ZSWIM6 mRNA

NCBI chr 2:39,211,131...39,378,877
Ensembl chr 2:39,212,949...39,378,924

chrysin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

affects activity
decreases activity
increases expression
multiple interactions

chrysin affects the activity of ABCB1 protein
chrysin results in decreased activity of ABCB1 protein
chrysin results in increased expression of ABCB1 protein
[chrysin results in decreased activity of ABCB1 protein] which results in decreased export of Topotecan

PMID:15796199 PMID:20457140 PMID:27996361

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

multiple interactions

ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression
decreases activity

[chrysin results in decreased activity of ABCC2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]
chrysin results in increased expression of ABCC2 protein

PMID:15955639 PMID:20457140

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions

ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione]

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 5

multiple interactions
decreases expression

ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione]
chrysin results in decreased expression of ABCC5 mRNA; chrysin results in decreased expression of ABCC5 protein

PMID:21856323 PMID:23994249

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

ATP binding cassette subfamily G member 2

multiple interactions
decreases activity
decreases expression
increases expression

[chrysin results in decreased activity of ABCG2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]
chrysin results in decreased expression of ABCG2 mRNA
chrysin results in increased expression of ABCG2 mRNA; chrysin results in increased expression of ABCG2 protein

PMID:17077187 PMID:17093006 PMID:19732493 PMID:20457140 PMID:20816778

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acetylcholinesterase

multiple interactions

chrysin inhibits the reaction [Aluminum Chloride results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

actin alpha 2, smooth muscle

multiple interactions

chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adiponectin, C1Q and collagen domain containing

increases expression

chrysin results in increased expression of ADIPOQ protein

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

alpha-fetoprotein

affects binding

chrysin binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

aryl hydrocarbon receptor

affects activity
multiple interactions

chrysin affects the activity of AHR protein
[chrysin co-treated with Methylcholanthrene] affects the activity of AHR protein; [chrysin co-treated with Tetrachlorodibenzodioxin] affects the activity of AHR protein; chrysin binds to and results in increased activity of AHR protein; chrysin inhibits the reaction [AHR protein binds to CYP1A1 promoter]; chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; chrysin promotes the reaction [AHR protein binds to CYP1A1 promoter]

PMID:14644660 PMID:16972788 PMID:17256720 PMID:19286049

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member B10

decreases expression

chrysin results in decreased expression of AKR1B10 mRNA; chrysin results in decreased expression of AKR1B10 protein

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

BCL2 protein inhibits the reaction [chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; chrysin inhibits the reaction [AKT1 protein results in increased expression of MMP10 protein]; chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]; chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
chrysin results in decreased phosphorylation of AKT1 protein

PMID:16215670 PMID:18455702 PMID:24122885 PMID:30578657

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

chrysin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

apolipoprotein B

multiple interactions

chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of APOB mRNA]; chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of APOB protein]

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter]

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

arrestin, beta 2

multiple interactions

chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 protein]

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

BCL2 associated X, apoptosis regulator

multiple interactions

chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of BAX protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of BAX protein]; chrysin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]; chrysin promotes the reaction [Diethylnitrosamine results in increased expression of BAX protein]
[Cisplatin co-treated with chrysin] results in increased expression of BAX protein

PMID:21167192 PMID:25770930 PMID:29247772 PMID:33121995 PMID:38432408

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

chrysin inhibits the reaction [Aluminum Chloride results in increased activity of BCHE protein]

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

multiple interactions
decreases response to substance

BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]; BCL2 protein inhibits the reaction [chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [chrysin results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein]; chrysin inhibits the reaction [Cisplatin results in increased expression of BCL2 protein]
BCL2 protein results in decreased susceptibility to chrysin
chrysin inhibits the reaction [Iron-Dextran Complex results in decreased expression of BCL2 protein]; chrysin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]

PMID:16215670 PMID:25770930 PMID:29247772 PMID:38432408

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

brain-derived neurotrophic factor

increases expression
multiple interactions

chrysin results in increased expression of BDNF protein
chrysin inhibits the reaction [Oxidopamine results in decreased expression of BDNF protein]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

caspase 1

multiple interactions

chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CASP1 protein]
chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP1 protein]

PMID:21515303 PMID:38432408

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases cleavage

[Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [chrysin results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein]; chrysin inhibits the reaction [Topotecan results in increased activity of CASP3 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP3 protein]; chrysin results in increased cleavage of and results in increased activity of CASP3 protein
chrysin results in increased cleavage of CASP3 protein
[Diethylnitrosamine co-treated with chrysin] results in increased expression of CASP3 protein; chrysin inhibits the reaction [Acetaminophen results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Testosterone results in decreased cleavage of CASP3 protein]; chrysin inhibits the reaction [Thioacetamide results in increased expression of CASP3 protein]

PMID:16215670 PMID:18331776 PMID:19397994 PMID:20457140 PMID:21167192 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions
increases cleavage

[Cisplatin co-treated with chrysin] results in increased cleavage of CASP8 protein; chrysin inhibits the reaction [Topotecan results in increased activity of CASP8 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]
chrysin results in increased cleavage of CASP8 protein

PMID:20457140 PMID:21195158 PMID:25770930

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases cleavage
multiple interactions

chrysin results in increased cleavage of CASP9 protein
[Cisplatin co-treated with chrysin] results in increased cleavage of CASP9 protein

PMID:18331776 PMID:25770930

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity

chrysin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; chrysin inhibits the reaction [Isoniazid results in decreased activity of CAT protein]; chrysin inhibits the reaction [Testosterone results in decreased activity of CAT protein]
chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased activity of CAT protein]; chrysin inhibits the reaction [Aluminum Chloride results in decreased activity of CAT protein]
chrysin results in decreased activity of CAT protein

PMID:10647909 PMID:23194824 PMID:28682524 PMID:29247772 PMID:30273961 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin B1

decreases expression

chrysin results in decreased expression of CCNB1 mRNA; chrysin results in decreased expression of CCNB1 protein

PMID:18331776 PMID:19397994

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cadherin 1

increases expression

chrysin results in increased expression of CDH1 protein

PMID:24122885 PMID:30578657

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

decreases expression

chrysin results in decreased expression of CDH2 protein

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

chrysin results in increased expression of CDKN1A mRNA; chrysin results in increased expression of CDKN1A protein
chrysin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA]

PMID:19397994 PMID:29247772

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2C

decreases expression

chrysin results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

CCAAT/enhancer binding protein alpha

increases expression

chrysin results in increased expression of CEBPA protein

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

catenin beta 1

multiple interactions

chrysin inhibits the reaction [Topotecan results in increased cleavage of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 10

multiple interactions

chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; chrysin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity
multiple interactions

chrysin results in decreased activity of CYP19A1 protein
chrysin binds to and results in decreased activity of CYP19A1 protein

PMID:9435150 PMID:10403137 PMID:15319488

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases oxidation
increases expression
increases metabolic processing
decreases activity
increases activity

[CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; chrysin inhibits the reaction [AHR protein binds to CYP1A1 promoter]; chrysin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; chrysin promotes the reaction [AHR protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]
CYP1A1 protein results in increased oxidation of chrysin
chrysin results in increased expression of CYP1A1 mRNA
chrysin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
chrysin results in increased expression of CYP1A1 mRNA; chrysin results in increased expression of CYP1A1 protein
chrysin results in decreased activity of CYP1A1 protein
chrysin results in increased activity of CYP1A1 protein

PMID:11752233 PMID:16972788 PMID:17012224 PMID:17256720 PMID:19666078 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases metabolic processing
increases oxidation
multiple interactions
decreases activity

CYP1A2 protein results in increased metabolism of chrysin
CYP1A2 protein results in increased oxidation of chrysin
[CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein
chrysin results in decreased activity of CYP1A2 protein

PMID:19666078 PMID:20806393 PMID:21053930 PMID:30964977

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases oxidation
increases metabolic processing
decreases activity

[CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; chrysin binds to and results in decreased activity of CYP1B1 protein
CYP1B1 protein alternative form results in increased oxidation of chrysin
chrysin results in decreased activity of CYP1B1 protein

PMID:19666078 PMID:21053930 PMID:21482471 PMID:30964977

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases oxidation

CYP2A13 protein results in increased oxidation of chrysin

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions

chrysin results in increased expression of CYP2B6 mRNA
chrysin results in increased expression of CYP2B10 mRNA
NR1I3 gene mutant form inhibits the reaction [chrysin results in increased expression of CYP2B10 mRNA]

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases activity
multiple interactions

chrysin results in increased activity of CYP3A4 protein
[[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; chrysin binds to and results in decreased activity of CYP3A4 protein; chrysin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein]

PMID:19766177 PMID:21053930 PMID:31756459

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

endothelin 1

increases expression

chrysin results in increased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor

multiple interactions

chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

ETS transcription factor ELK1

multiple interactions

chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

erythropoietin

increases expression

chrysin results in increased expression of EPO mRNA

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

estrogen receptor 1

multiple interactions

chrysin binds to and results in increased activity of ESR1 protein; chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter]

PMID:9751507 PMID:16972788 PMID:29162470 PMID:33049310

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

affects binding
multiple interactions

chrysin binds to ESR2 protein
chrysin binds to and results in increased activity of ESR2 protein

PMID:9751507 PMID:12224631 PMID:33049310

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

fatty acid desaturase 2

decreases expression

chrysin results in decreased expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

Fas ligand

multiple interactions

chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of FASLG mRNA]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fructose-bisphosphatase 1

decreases expression

chrysin results in decreased expression of FBP1 mRNA

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

fibronectin 1

increases expression

chrysin results in increased expression of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box P3

multiple interactions

chrysin inhibits the reaction [Diazinon results in decreased expression of FOXP3 mRNA]

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

follicle stimulating hormone subunit beta

multiple interactions

chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of FSHB protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

growth arrest and DNA-damage-inducible, beta

increases expression

chrysin results in increased expression of GADD45B mRNA; chrysin results in increased expression of GADD45B protein

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

GATA binding protein 3

multiple interactions

chrysin inhibits the reaction [Diazinon results in increased expression of GATA3 mRNA]

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]
chrysin results in increased expression of GCLC mRNA; chrysin results in increased expression of GCLC protein

PMID:22864849 PMID:33121995

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLM mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]
chrysin results in increased expression of GCLM mRNA; chrysin results in increased expression of GCLM protein

PMID:22864849 PMID:33121995

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glial cell derived neurotrophic factor

multiple interactions

chrysin inhibits the reaction [Oxidopamine results in decreased expression of GDNF protein]

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glial fibrillary acidic protein

multiple interactions

chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP mRNA]; chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP protein]

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glutamic-oxaloacetic transaminase 1

multiple interactions

chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

chrysin inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; chrysin inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of GPT protein]

PMID:28682524 PMID:30794797 PMID:31625388 PMID:38432408

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

growth factor receptor bound protein 2

decreases expression

chrysin results in decreased expression of GRB2 protein

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

growth regulating estrogen receptor binding 1

multiple interactions
increases expression

Fulvestrant inhibits the reaction [chrysin results in increased expression of GREB1 mRNA]

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

glutathione-disulfide reductase

decreases activity

chrysin results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

chrysin results in decreased degradation of and results in increased expression of HIF1A protein modified form
chrysin results in increased expression of HIF1A mRNA; chrysin results in increased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

multiple interactions
decreases expression
increases expression

[chrysin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; chrysin inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
chrysin results in decreased expression of HMOX1 mRNA; chrysin results in decreased expression of HMOX1 protein
chrysin results in increased expression of HMOX1 mRNA; chrysin results in increased expression of HMOX1 protein

PMID:22864849 PMID:23994249 PMID:33121995

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

multiple interactions

chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased phosphorylation of and affects the localization of HNF4A protein]
chrysin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HNF4A mRNA]; chrysin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of HNF4A protein]

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

intercellular adhesion molecule 1

multiple interactions

chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

PMID:15322261 PMID:16987811

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

multiple interactions

chrysin inhibits the reaction [Diazinon results in decreased expression of IFNG mRNA]; chrysin inhibits the reaction [Diazinon results in decreased expression of IFNG protein]; chrysin inhibits the reaction [Oxidopamine results in increased expression of IFNG protein]

PMID:29054324 PMID:36114367

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions

chrysin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

multiple interactions

chrysin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

multiple interactions

chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL10 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in decreased expression of IL10 protein]
chrysin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]
chrysin inhibits the reaction [Diazinon results in increased expression of IL10 mRNA]; chrysin inhibits the reaction [Oxidopamine results in decreased expression of IL10 protein]

PMID:24932515 PMID:29054324 PMID:30016632 PMID:36114367 PMID:37263553

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 15

decreases expression

chrysin results in decreased expression of IL15 mRNA

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 17A

multiple interactions

chrysin inhibits the reaction [Diazinon results in increased expression of IL17A mRNA]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 1 beta

multiple interactions
decreases expression

chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL1B mRNA]; chrysin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; chrysin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL1B protein]
chrysin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of IL1B protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL1B mRNA]
chrysin results in decreased expression of IL1B mRNA

PMID:18377686 PMID:20816778 PMID:21515303 PMID:28682524 PMID:29054324 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

decreases expression

chrysin results in decreased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 4

multiple interactions

chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 mRNA]
chrysin inhibits the reaction [Diazinon results in increased expression of IL4 mRNA]

PMID:21515303 PMID:36114367

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression
decreases expression

chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL6 protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of IL6 protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
chrysin results in increased expression of IL6 mRNA
chrysin results in decreased expression of IL6 mRNA

PMID:18457675 PMID:20816778 PMID:21515303 PMID:23194824 PMID:29054324 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [chrysin inhibits the reaction [Fructose results in increased expression of INS1 protein]]; chrysin inhibits the reaction [Fructose results in increased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

interferon regulatory factor 3

multiple interactions

chrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases phosphorylation

chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; chrysin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]
chrysin results in decreased phosphorylation of JUN protein

PMID:15322261 PMID:30578657

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KLF transcription factor 4

multiple interactions

chrysin inhibits the reaction [angiotensin II increases expression of KLF4 protein in vascular smooth muscle cells]

RGD

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

laminin subunit beta 2

increases expression

chrysin results in increased expression of LAMB2 protein

NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549

G

leptin

decreases expression

chrysin results in decreased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

luteinizing hormone subunit beta

multiple interactions

chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

chrysin inhibits the reaction [Acetaminophen results in increased expression of MAP1LC3B protein]; chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]

PMID:28682524 PMID:30273961

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
increases activity

MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
[chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK1 protein
chrysin results in increased phosphorylation of MAPK1 protein
chrysin results in increased activity of MAPK1 protein

PMID:22864849 PMID:25770930

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

chrysin inhibits the reaction [Cyclophosphamide results in increased expression of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

[chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK3 protein
chrysin results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 1

decreases expression

chrysin results in decreased expression of MMP1 protein

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 10

multiple interactions
decreases expression

chrysin inhibits the reaction [AKT1 protein results in increased expression of MMP10 protein]
chrysin results in decreased expression of MMP10 protein

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 2

multiple interactions
decreases activity

chrysin results in decreased expression of and results in decreased activity of MMP2 protein
chrysin results in decreased activity of MMP2 protein

PMID:26408079 PMID:30578657

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

chrysin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

chrysin inhibits the reaction [Freund's Adjuvant results in increased activity of MPO protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of MPO protein]

PMID:24932515 PMID:38432408

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MYB proto-oncogene like 1

increases expression
multiple interactions

chrysin results in increased expression of MYBL1 mRNA
Fulvestrant inhibits the reaction [chrysin results in increased expression of MYBL1 mRNA]

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYD88, innate immune signal transduction adaptor

multiple interactions

chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 protein]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression

chrysin affects the localization of and results in increased activity of NFE2L2 protein; chrysin inhibits the reaction [Isoniazid results in increased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
chrysin inhibits the reaction [NFE2L2 protein results in decreased susceptibility to Doxorubicin]
chrysin results in decreased expression of NFE2L2 mRNA; chrysin results in decreased expression of NFE2L2 protein

PMID:22864849 PMID:23994249 PMID:33121995

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

chrysin inhibits the reaction [Isoniazid results in increased expression of NFKB1 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of NFKB1 protein]

PMID:30500344 PMID:33121995

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions
decreases expression

chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased degradation of NFKBIA protein]; chrysin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]
chrysin results in decreased expression of NFKBIA protein

PMID:18377686 PMID:21515303 PMID:30016632 PMID:30578657

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

multiple interactions

chrysin inhibits the reaction [Oxidopamine results in decreased expression of NGF protein]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

NLR family, pyrin domain containing 3

multiple interactions

chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of NLRP3 protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions

chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of NOS2 protein]

PMID:11343698 PMID:16934226 PMID:17570322 PMID:23194824 PMID:24932515 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

chrysin inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 mRNA]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

chrysin inhibits the reaction [Isoniazid results in increased expression of NQO1 mRNA]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group H, member 3

increases expression

Chrysin increases expression of Nr1h3 mRNA in macrophages

RGD

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

chrysin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

chrysin binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

affects localization
multiple interactions

chrysin affects the localization of NR1I3 protein
NR1I3 gene mutant form inhibits the reaction [chrysin results in increased expression of CYP2B10 mRNA]

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

chrysin results in increased cleavage of PARP1 protein
[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein]
chrysin inhibits the reaction [Cyclophosphamide results in increased expression of PARP1 protein]

PMID:18455702 PMID:25770930 PMID:37263553

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

multiple interactions

chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; chrysin inhibits the reaction [Testosterone results in increased expression of PCNA protein]

PMID:23194824 PMID:29247772

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

phosphogluconate dehydrogenase

decreases activity

chrysin results in decreased activity of PGD protein

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

plasminogen activator, urokinase

decreases expression

chrysin results in decreased expression of PLAU protein

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

phospholipase C, gamma 1

multiple interactions
increases degradation

BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein]

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

cytochrome p450 oxidoreductase

multiple interactions

[CYP2A6 protein co-treated with POR protein] results in increased oxidation of chrysin

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

peroxisome proliferator activated receptor alpha

decreases expression

chrysin results in decreased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

chrysin binds to and results in increased activity of PPARG protein; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
chrysin inhibits the reaction [Iron-Dextran Complex results in decreased expression of PPARG protein]

PMID:11343698 PMID:33049310 PMID:38432408

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostate stem cell antigen

decreases expression

chrysin results in decreased expression of PSCA mRNA

NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

chrysin results in increased expression of PTGS2 mRNA
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]
chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]

PMID:11343698 PMID:18457675 PMID:21167192 PMID:23194824 PMID:24932515

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

decreases phosphorylation

chrysin results in decreased phosphorylation of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

PYD and CARD domain containing

multiple interactions

chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of PYCARD protein]

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

retinol binding protein 4

decreases expression

chrysin results in decreased expression of RBP4 protein

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression
increases activity

Acetylcysteine inhibits the reaction [chrysin results in increased activity of RELA protein]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of RELA protein]; chrysin inhibits the reaction [nickel chloride affects the localization of RELA protein]; SB 203580 inhibits the reaction [chrysin results in increased activity of RELA protein]
chrysin results in decreased expression of RELA protein
chrysin inhibits the reaction [Oxidopamine results in increased phosphorylation of RELA protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in increased localization of and results in increased acetylation of RELA protein]; chrysin inhibits the reaction [Testosterone results in increased activity of RELA protein]

PMID:18457675 PMID:21167192 PMID:21515303 PMID:23194824 PMID:29054324 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

decreases expression

chrysin results in decreased expression of RHOA protein

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

RAR-related orphan receptor C

multiple interactions

chrysin inhibits the reaction [Diazinon results in increased expression of RORC mRNA]

NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907

G

RT1 class II, locus Da

decreases expression

chrysin results in decreased expression of HLA-DRA mRNA

NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455

G

S100 calcium binding protein B

multiple interactions

chrysin inhibits the reaction [Oxidopamine results in increased expression of S100B protein]

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

sterol-C5-desaturase

decreases expression

chrysin results in decreased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

stearoyl-CoA desaturase

decreases expression

chrysin results in decreased expression of SCD mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

selectin E

multiple interactions

chrysin inhibits the reaction [TNF protein results in increased expression of SELE protein]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

stratifin

increases expression

chrysin results in increased expression of SFN mRNA; chrysin results in increased expression of SFN protein

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

serum/glucocorticoid regulated kinase 1

increases expression
multiple interactions

chrysin results in increased expression of SGK1 mRNA
Fulvestrant inhibits the reaction [chrysin results in increased expression of SGK1 mRNA]

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

sex hormone binding globulin

affects binding

chrysin binds to SHBG protein

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

sirtuin 1

multiple interactions

chrysin inhibits the reaction [Iron-Dextran Complex results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 16 member 1

multiple interactions

[chrysin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

SMAD family member 2

multiple interactions

chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA]

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

multiple interactions

chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

snail family transcriptional repressor 1

decreases expression
multiple interactions

chrysin results in decreased expression of SNAI1 protein
chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]

PMID:24122885 PMID:30578657

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

decreases expression

chrysin results in decreased expression of SNAI2 protein

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

chrysin results in decreased expression of SOS1 protein

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

steroidogenic acute regulatory protein

multiple interactions

chrysin inhibits the reaction [Freund's Adjuvant results in decreased expression of STAR mRNA]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 3

multiple interactions

chrysin inhibits the reaction [Cyclophosphamide results in increased phosphorylation of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

sulfotransferase family 1A member 1

increases sulfation

SULT1A1 protein SNP results in increased sulfation of chrysin

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1E member 1

multiple interactions

SULT1E1 protein results in increased sulfation of and results in decreased activity of chrysin

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

TANK-binding kinase 1

decreases activity

chrysin results in decreased activity of TBK1 protein

NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892

G

T-box transcription factor 21

multiple interactions

chrysin inhibits the reaction [Diazinon results in decreased expression of TBX21 mRNA]

NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831

G

trefoil factor 1

multiple interactions

chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter]

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor, beta 1

multiple interactions

chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; chrysin inhibits the reaction [Diazinon results in increased expression of TGFB1 mRNA]

PMID:26297989 PMID:36114367

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

thyroid hormone receptor alpha

multiple interactions

chrysin binds to and results in increased activity of THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

thyroid hormone receptor beta

multiple interactions

chrysin binds to and results in increased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

toll-like receptor 4

multiple interactions

chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 protein]
chrysin inhibits the reaction [Thioacetamide results in increased expression of TLR4 mRNA]

PMID:30016632 PMID:30500344

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases expression

chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; chrysin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of SELE protein]; chrysin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
chrysin results in decreased expression of TNF protein
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein]; chrysin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of TNF protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of TNF protein]; chrysin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Silymarin promotes the reaction [chrysin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]]
chrysin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; chrysin inhibits the reaction [Oxidopamine results in increased expression of TNF protein]

PMID:15322261 PMID:16934226 PMID:16987811 PMID:21515303 PMID:23194824 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 10

multiple interactions
increases response to substance

chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP3 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]
chrysin results in increased susceptibility to TNFSF10 protein

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53

increases degradation
affects activity
multiple interactions

chrysin results in increased degradation of TP53 protein
chrysin affects the activity of TP53 protein
[Cisplatin co-treated with chrysin] affects the localization of TP53 protein; [Cisplatin co-treated with chrysin] results in increased phosphorylation of and results in increased expression of TP53 protein; chrysin results in increased phosphorylation of and affects the localization of TP53 protein; U 0126 inhibits the reaction [[Cisplatin co-treated with chrysin] affects the localization of TP53 protein]; U 0126 inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased phosphorylation of TP53 protein]
[Diethylnitrosamine co-treated with chrysin] results in increased expression of TP53 protein; chrysin inhibits the reaction [Diethylnitrosamine results in decreased expression of TP53 mRNA]; chrysin inhibits the reaction [Testosterone results in decreased expression of TP53 mRNA]

PMID:14634213 PMID:21167192 PMID:25770930 PMID:29247772 PMID:35435491

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 inducible protein 3

increases expression

chrysin results in increased expression of TP53I3 mRNA; chrysin results in increased expression of TP53I3 protein

PMID:18331776 PMID:19397994

NCBI chr 6:27,818,327...27,825,753

G

tumor protein p63

increases expression

chrysin results in increased expression of TP63 protein

PMID:18331776 PMID:19397994

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

G

tumor protein p73

increases expression

chrysin results in increased expression of TP73 protein

PMID:18331776 PMID:19397994

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

G

tyrosinase

increases expression

chrysin results in increased expression of TYR mRNA

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions
affects glucuronidation
increases glucuronidation
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Ethinyl Estradiol]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Quercetin]; pyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; SB 203580 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; U 0126 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]
UGT1A1 protein affects the glucuronidation of chrysin
UGT1A1 protein results in increased glucuronidation of chrysin
chrysin results in increased expression of UGT1A1; chrysin results in increased expression of UGT1A1 mRNA; chrysin results in increased expression of UGT1A1 protein

PMID:10950852 PMID:11442279 PMID:14557274 PMID:15104253 PMID:16003560 More...

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

affects glucuronidation

UGT1A6 protein affects the glucuronidation of chrysin

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A7C

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of chrysin

NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A8

increases glucuronidation

UGT1A8 protein results in increased glucuronidation of chrysin

NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation
affects glucuronidation

UGT1A9 protein results in increased glucuronidation of chrysin
UGT1A9 protein affects the glucuronidation of chrysin

PMID:10950852 PMID:14557274

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

utrophin

increases expression

chrysin results in increased expression of UTRN mRNA

NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313

G

vascular cell adhesion molecule 1

increases expression
multiple interactions

chrysin results in increased expression of VCAM1 mRNA
chrysin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]

PMID:16987811 PMID:18457675

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

decreases expression
multiple interactions

chrysin results in decreased expression of VEGFA protein
chrysin inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA mRNA]

PMID:30578657 PMID:30974023

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

decreases expression

chrysin results in decreased expression of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

X-linked inhibitor of apoptosis

decreases expression
multiple interactions

chrysin results in decreased expression of XIAP protein
BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

chrysin 5,7-dimethyl ether

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5,7-dimethoxyflavone inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

BCL2 associated X, apoptosis regulator

multiple interactions

[5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl2-like 1

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

caspase 3

multiple interactions

5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

C-C motif chemokine ligand 2

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

casein kinase 2 beta

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B protein]

NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133

G

catenin beta 1

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine affects the localization of CTNNB1 protein modified form]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity

5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1A1 protein

PMID:15661813 PMID:15905203 PMID:16484233

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
decreases activity

5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1B1 protein

PMID:15905203 PMID:16484233 PMID:16530937

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

glycogen synthase kinase 3 beta

multiple interactions

5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

interleukin 1 beta

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

nitric oxide synthase 2

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

prostaglandin-endoperoxide synthase 2

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein modified form]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

tumor protein p53

multiple interactions

[5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

Wnt family member 3A

multiple interactions

5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein]

NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324

chrysosplenetin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

chrysosplenetin results in decreased activity of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects activity

chrysosplenetin affects the activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

cirsilineol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 2

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 protein]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

interleukin 1 beta

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MCL1 protein]

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

myeloperoxidase

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MYD88, innate immune signal transduction adaptor

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MYD88 protein]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

nitric oxide synthase 2

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

prostaglandin-endoperoxide synthase 2

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

toll-like receptor 4

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; cirsilineol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

eupatilin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

multiple interactions

eupatilin inhibits the reaction [[potassium oxonate co-treated with Hypoxanthine] results in decreased expression of ABCG2 protein]

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

C-C motif chemokine ligand 2

multiple interactions

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases activity

[[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

interleukin 1 beta

multiple interactions

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]
eupatilin inhibits the reaction [[potassium oxonate co-treated with Hypoxanthine] results in increased secretion of IL1B protein]

PMID:21565208 PMID:38052408

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]
eupatilin inhibits the reaction [[potassium oxonate co-treated with Hypoxanthine] results in increased secretion of IL6 protein]

PMID:21565208 PMID:38052408

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

NFKB inhibitor alpha

multiple interactions

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

prostaglandin-endoperoxide synthase 2

multiple interactions

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 2 member 1

multiple interactions