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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:guggulsterone
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Accession:CHEBI:135338 term browser browse the term
Synonyms:related_synonym: Formula=C21H28O2;   InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/t15-,17+,18+,20+,21-/m1/s1;   InChIKey=WDXRGPWQVHZTQJ-NRJJLHBYSA-N;   SMILES=C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(CC3)=CC(CC4)=O)[H])[H])(CC(C2=CC)=O)[H];   Z/E-Guggulsterone
 xref: CAS:95975-55-6;   Drug_Central:3953
 xref_mesh: MESH:C023617


show annotations for term's descendants           Sort by:
guggulsterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression		 EXP
ISO		 [pregna-4,17-diene-3,16-dione co-treated with Chenodeoxycholic Acid] results in increased expression of ABCB11 mRNA; [pregna-4,17-diene-3,16-dione co-treated with GW 4064] results in increased expression of ABCB11 mRNA; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of ABCB11 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Bile Acids and Salts results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1H4 protein results in increased expression of ABCB11 mRNA]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Abcb11 protein in liver]]
pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]
pregna-4,17-diene-3,16-dione results in increased expression of ABCB11 mRNA		 CTD
RGD		 PMID:12525500 PMID:12705905 PMID:25278094 PMID:25655198 PMID:26040663 More... RGD:15036816 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA]] CTD PMID:25655198 NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA] CTD PMID:25655198 PMID:26040663 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCG5 ATP binding cassette subfamily G member 5 multiple interactions
decreases expression		 EXP GW 4064 inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased expression of ABCG5 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of ABCG5 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA] CTD PMID:34767876 PMID:35523117 NCBI chr 2:43,806,211...43,839,231
Ensembl chr 2:43,812,472...43,838,865 		JBrowse link
G ABCG8 ATP binding cassette subfamily G member 8 multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of ABCG8 protein] CTD PMID:35523117 NCBI chr 2:43,838,971...43,882,988
Ensembl chr 2:43,831,942...43,882,988 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein]] CTD PMID:27773935 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ACADS acyl-CoA dehydrogenase short chain multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of ACADS mRNA]] CTD PMID:27773935 NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008 		JBrowse link
G ACLY ATP citrate lyase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [Palmitic Acid results in increased expression of ACLY mRNA] CTD PMID:31421115 NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions EXP
ISO		 pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of ACTA2 protein]
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]		 CTD PMID:35123992 PMID:37573684 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339 		JBrowse link
G ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide multiple interactions
decreases expression		 EXP GW 4064 inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased expression of ADH1A mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [GW 4064 results in increased expression of ADH1A mRNA] CTD PMID:34767876 NCBI chr 4:99,276,369...99,290,985
Ensembl chr 4:99,276,369...99,291,003 		JBrowse link
G ALPL alkaline phosphatase, biomineralization associated multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein]] CTD PMID:37573684 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA] CTD PMID:15322087 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA] CTD PMID:15322087 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G BID BH3 interacting domain death agonist increases cleavage EXP pregna-4,17-diene-3,16-dione results in increased cleavage of BID protein CTD PMID:17475222 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 multiple interactions
decreases expression 		EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]
Guggulsterone decreases expression of BIRC2 protein in colon cancer cells		 CTD
RGD		 PMID:15322087 PMID:19232820 RGD:152998981 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 decreases expression EXP Guggulsterone decreases expression of BIRC3 protein in colon cancer cells RGD PMID:19232820 RGD:152998981 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC5 mRNA] CTD PMID:15322087 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G CASP3 caspase 3 increases activity EXP pregna-4,17-diene-3,16-dione results in increased activity of CASP3 protein CTD PMID:17475222 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases activity EXP pregna-4,17-diene-3,16-dione results in increased activity of CASP8 protein CTD PMID:17475222 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity EXP pregna-4,17-diene-3,16-dione results in increased activity of CASP9 protein CTD PMID:17475222 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CBR3 carbonyl reductase 3 increases expression EXP pregna-4,17-diene-3,16-dione results in increased expression of CBR3 mRNA CTD PMID:20806931 NCBI chr21:36,135,079...36,146,562
Ensembl chr21:36,135,079...36,146,562 		JBrowse link
G CCNB1 cyclin B1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of CCNB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 protein]] CTD PMID:25278094 PMID:29660435 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCND1 cyclin D1 decreases expression
multiple interactions		 EXP
ISO		 pregna-4,17-diene-3,16-dione results in decreased expression of CCND1 protein
pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of CCND1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 protein]]
pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]		 CTD PMID:15322087 PMID:17475222 PMID:25278094 PMID:29660435 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression EXP pregna-4,17-diene-3,16-dione results in decreased expression of CDK1 protein CTD PMID:17475222 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP pregna-4,17-diene-3,16-dione results in increased expression of CDKN1A protein CTD PMID:17475222 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP pregna-4,17-diene-3,16-dione results in increased expression of CDKN1B protein CTD PMID:17475222 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA] CTD PMID:15322087 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]] CTD PMID:37573684 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased secretion of COL3A1 protein]] CTD PMID:37573684 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CPT1A mRNA]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of CPT1a mRNA and protein in liver]]		 CTD
RGD		 PMID:27773935 PMID:27939985 RGD:15036816 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CYC1 cytochrome c1 affects localization EXP pregna-4,17-diene-3,16-dione affects the localization of CYC1 protein CTD PMID:17475222 NCBI chr 8:144,095,076...144,097,525
Ensembl chr 8:144,095,039...144,097,525 		JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of CYP27A1 protein] CTD PMID:35523117 NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 affects expression ISO pregna-4,17-diene-3,16-dione affects the expression of CYP2B10 mRNA CTD PMID:15833898 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression EXP pregna-4,17-diene-3,16-dione results in increased expression of CYP3A4 mRNA CTD PMID:15075359 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP
ISO		 pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in decreased expression of CYP7A1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I2 protein results in increased expression of CYP7A1 mRNA]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Cyp7a1 protein in liver]]
pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]]		 CTD
RGD		 PMID:12705905 PMID:25655198 PMID:26040663 PMID:29660435 PMID:35523117 More... RGD:15036816 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of CYP7B1 protein] CTD PMID:35523117 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737 		JBrowse link
G CYP8B1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO
EXP		 pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [Ethinyl Estradiol results in decreased expression of CYP8B1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP8B1 mRNA]
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in decreased expression of CYP8B1 protein]		 CTD PMID:25655198 PMID:26040663 PMID:35523117 NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898 		JBrowse link
G DNMT1 DNA methyltransferase 1 decreases expression EXP pregna-4,17-diene-3,16-dione results in decreased expression of DNMT1 mRNA; pregna-4,17-diene-3,16-dione results in decreased expression of DNMT1 protein CTD PMID:23593078 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha decreases expression EXP pregna-4,17-diene-3,16-dione results in decreased expression of DNMT3A mRNA CTD PMID:23593078 NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression EXP pregna-4,17-diene-3,16-dione results in decreased expression of DNMT3B mRNA CTD PMID:23593078 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359 		JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions
decreases expression		 ISO Calcitriol promotes the reaction [pregna-4,17-diene-3,16-dione results in decreased expression of FABP4 protein]; pregna-4,17-diene-3,16-dione promotes the reaction [Calcitriol results in decreased expression of FABP4 protein] CTD PMID:17959142 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236 		JBrowse link
G FAS Fas cell surface death receptor multiple interactions ISO Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Fas mRNA and protein in liver]] RGD PMID:27939985 RGD:15036816 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASN fatty acid synthase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FASN protein]] CTD PMID:27773935 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FGF19 fibroblast growth factor 19 multiple interactions ISO Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of FGF19 protein in liver and intestine]] RGD PMID:27939985 RGD:15036816 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022 		JBrowse link
G FOXM1 forkhead box M1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of FOXM1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein]] CTD PMID:25278094 PMID:29660435 NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,680...2,877,174 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression ISO
EXP		 pregna-4,17-diene-3,16-dione results in increased expression of GCLC mRNA CTD PMID:22851183 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression EXP
ISO		 pregna-4,17-diene-3,16-dione results in increased expression of GCLM mRNA CTD PMID:22851183 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased activity of GOT1 protein]] CTD PMID:37573684 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]] CTD PMID:37573684 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G HDAC1 histone deacetylase 1 decreases expression EXP pregna-4,17-diene-3,16-dione results in decreased expression of HDAC1 protein CTD PMID:23593078 NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO		 pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of RELA protein]
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]		 CTD PMID:15322087 PMID:29660435 PMID:37573684 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]] CTD PMID:37573684 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KL klotho multiple interactions EXP KL protein affects the reaction [pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in decreased expression of KL protein] CTD PMID:35123992 NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143 		JBrowse link
G LPL lipoprotein lipase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of LPL mRNA]] CTD PMID:27773935 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G LRP2 LDL receptor related protein 2 multiple interactions
increases expression		 ISO NR1H4 protein promotes the reaction [pregna-4,17-diene-3,16-dione results in increased expression of LRP2 protein] CTD PMID:15375181 NCBI chr 2:169,127,109...169,362,534
Ensembl chr 2:169,127,109...169,362,534 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases activity EXP pregna-4,17-diene-3,16-dione results in increased activity of MAPK8 protein CTD PMID:17475222 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MECP2 methyl-CpG binding protein 2 decreases expression EXP pregna-4,17-diene-3,16-dione results in decreased expression of MECP2 protein CTD PMID:23593078 NCBI chr  X:154,021,573...154,097,717
Ensembl chr  X:154,021,573...154,137,103 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] CTD PMID:15322087 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MYC mRNA] CTD PMID:15322087 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NCOA1 nuclear receptor coactivator 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; pregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:15833898 NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,254...24,770,702 		JBrowse link
G NCOA2 nuclear receptor coactivator 2 multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 8:70,109,782...70,456,446
Ensembl chr 8:70,109,782...70,403,808 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 affects response to substance
multiple interactions		 ISO NFE2L2 protein affects the susceptibility to pregna-4,17-diene-3,16-dione
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA]]		 CTD PMID:22851183 PMID:37573684 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO		 pregna-4,17-diene-3,16-dione inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Okadaic Acid results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Z-guggulsterone prevents the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Nf-kB protein in liver]]		 CTD
RGD		 PMID:15322087 PMID:27939985 RGD:15036816 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP
ISO		 pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nfkbia protein in liver]]		 CTD
RGD		 PMID:15322087 PMID:27939985 RGD:15036816 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver]] RGD PMID:27939985 RGD:15036816 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP
ISO		 pregna-4,17-diene-3,16-dione results in increased expression of NQO1 mRNA CTD PMID:22851183 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 multiple interactions EXP
ISO		 pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of NR0B2 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Imatinib Mesylate results in increased expression of NR0B2 mRNA]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr0b2 protein in liver and intestine]]
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [Ethinyl Estradiol results in increased expression of NR0B2 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of NR0B2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [Ethinyl Estradiol results in increased expression of NR0B2 mRNA]		 CTD
RGD		 PMID:22414727 PMID:25278094 PMID:25655198 PMID:26040663 PMID:35523117 More... RGD:15036816 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 multiple interactions ISO pregna-4,17-diene-3,16-dione promotes the reaction [Palmitic Acid results in decreased expression of NR1H2 mRNA] CTD PMID:31421115 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions
decreases expression
decreases activity		 EXP
ISO		 2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; 22,23-dihydroavermectin B(1)a inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; abamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Albendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; albendazole sulfoxide inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; alvocidib inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Apigenin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; benidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Benomyl inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; bifenthrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; biochanin A inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Bortezomib inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; carbendazim inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; chrysin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; ciclobendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cilnidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Colchicine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cyfluthrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cyhalothrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cypermethrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Dactinomycin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Daunorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; decamethrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Digoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; diphenadione inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Dipyridamole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Docetaxel inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; doramectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Doxorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; emamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Emetine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; enzastaurin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Epirubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Estradiol inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ethacridine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ethinyl Estradiol inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ethylestrenol inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Fenbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; fenvalerate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; flucythrinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; fluvalinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Fulvestrant inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Genistein inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Griseofulvin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Idarubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Isotretinoin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; kadethrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; lacidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; lercanidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Lithocholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; manidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Mebendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; methoxy-morpholinyl-doxorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Mitomycin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; moxidectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nicardipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nifedipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nimodipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nisoldipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nocodazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; NR1H4 protein promotes the reaction [pregna-4,17-diene-3,16-dione results in increased abundance of Lipids]; oxfendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; oxibendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; parbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; phenothrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; picropodophyllin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; pirarubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Podophyllotoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate results in increased expression of NR1H4 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Imatinib Mesylate results in increased activity of NR1H4 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1H4 protein results in increased expression of ABCB11 mRNA]; Proflavine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; selamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Simendan inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; ST 1481 inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; surinabant inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Tretinoin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Vinblastine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Vincristine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Vinorelbine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine]]
guggulsterone decreases expression of nr1h4 mRNA in rat embryonic liver cells
NR1H4 protein promotes the reaction [pregna-4,17-diene-3,16-dione results in increased expression of LRP2 protein]; pregna-4,17-diene-3,16-dione binds to and results in decreased activity of NR1H4 protein; pregna-4,17-diene-3,16-dione promotes the reaction [Palmitic Acid results in decreased expression of NR1H4 mRNA]		 CTD
RGD		 PMID:12705905 PMID:15375181 PMID:20079722 PMID:22414727 PMID:25257666 More... RGD:15036816, RGD:15042872 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
decreases expression
increases activity
decreases activity		 EXP
ISO		 pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I2 protein results in increased expression of CYP7A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [Thapsigargin results in decreased expression of NR1I2 mRNA]
pregna-4,17-diene-3,16-dione results in decreased expression of NR1I2 mRNA
pregna-4,17-diene-3,16-dione results in increased activity of NR1I2 protein
pregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein]
pregna-4,17-diene-3,16-dione results in decreased activity of NR1I2 protein		 CTD PMID:12705905 PMID:15075359 PMID:15833898 PMID:25616597 PMID:29933105 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions ISO pregna-4,17-diene-3,16-dione binds to and results in decreased activity of NR1I3 protein; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I3 protein binds to NCOA1 protein] CTD PMID:15833898 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of PPARA mRNA]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Ppara mRNA and protein in liver]]		 CTD
RGD		 PMID:27773935 PMID:27939985 RGD:15036816 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] CTD PMID:15322087 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 pregna-4,17-diene-3,16-dione inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]
pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA]		 CTD PMID:15322087 PMID:29660435 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLC10A1 solute carrier family 10 member 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Slc10a1 protein in liver]]		 CTD
RGD		 PMID:25655198 PMID:26040663 PMID:29660435 PMID:27939985 RGD:15036816 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 protein]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Srebf1 mRNA and protein in liver]]		 CTD
RGD		 PMID:27773935 PMID:27939985 RGD:15036816 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of TGFB1 protein] CTD PMID:35123992 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases activity		 EXP
ISO		 pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC5 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Tnf protein in liver]]
pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]
pregna-4,17-diene-3,16-dione results in increased activity of TNF protein		 CTD
RGD		 PMID:15322087 PMID:29660435 PMID:27939985 RGD:15036816 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions EXP KL protein affects the reaction [pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein] CTD PMID:35123992 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TRAF1 TNF receptor associated factor 1 multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA] CTD PMID:15322087 NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173 		JBrowse link
G VDR vitamin D receptor multiple interactions ISO pregna-4,17-diene-3,16-dione promotes the reaction [Calcitriol results in increased expression of VDR protein] CTD PMID:17959142 NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] CTD PMID:15322087 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions EXP pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of XIAP mRNA] CTD PMID:15322087 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
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  CHEBI ontology 26040
    role 25956
      biological role 25935
        molecular messenger 20269
          hormone 19883
            sex hormone 19696
              androgen 5804
                guggulsterone 83
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  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic polycyclic compound 18790
                                  steroid 15858
                                    hydroxy steroid 15536
                                      3-hydroxy steroid 13526
                                        guggulsterone 83
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