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Gene: DNMT1 (DNA methyltransferase 1) Homo sapiens
Symbol: DNMT1
Name: DNA methyltransferase 1
Description: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADCADN; AIM; CXXC finger protein 9; CXXC-type zinc finger protein 9; CXXC9; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; DNMT; FLJ16293; HSN1E; m.HsaI; MCMT; MGC104992
Mus musculus (house mouse) : Dnmt1 (DNA methyltransferase (cytosine-5) 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnmt1 (DNA methyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnmt1 (DNA methyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DNMT1 (DNA methyltransferase 1)
Canis lupus familiaris (dog) : DNMT1 (DNA methyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnmt1 (DNA methyltransferase 1)
Sus scrofa (pig) : DNMT1 (DNA methyltransferase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,133,346 - 10,194,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,244,021 - 10,305,783 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,105,022 - 10,166,811 (-)NCBINCBI36hg18NCBI36
Build 341910,105,022 - 10,166,811NCBI
Celera1910,139,454 - 10,201,147 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,824,670 - 9,886,268 (-)NCBIHuRef
CHM1_11910,244,305 - 10,306,077 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DNMT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1354178
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.