Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MECP2 (methyl-CpG binding protein 2) Homo sapiens
Analyze
Symbol: MECP2
Name: methyl-CpG binding protein 2
Description: Exhibits double-stranded methylated DNA binding activity; protein N-terminus binding activity; and protein domain specific binding activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; positive regulation of microtubule nucleation; and regulation of nucleobase-containing compound metabolic process. Localizes to centrosome; heterochromatin; and nucleoplasm. Implicated in Rett syndrome; X-linked intellectual disability-psychosis-macroorchidism syndrome; autistic disorder; and syndromic X-linked intellectual disability Lubs type.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AUTSX3; DKFZp686A24160; meCp-2 protein; mental retardation, X-linked 16; mental retardation, X-linked 79; methyl CpG binding protein 2; methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; mutant methyl CpG binding protein 2; mutant methyl CpG binding protein 2 transcript 1; mutant methyl CpG binding protein 2 variant 1; PPMX; RS; RTS; RTT; testis tissue sperm-binding protein Li 41a
Orthologs:
Mus musculus (house mouse) : Mecp2 (methyl CpG binding protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mecp2 (methyl CpG binding protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mecp2 (methyl-CpG binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MECP2 (methyl-CpG binding protein 2)
Canis lupus familiaris (dog) : MECP2 (methyl-CpG binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mecp2 (methyl-CpG binding protein 2)
Sus scrofa (pig) : MECP2 (methyl-CpG binding protein 2)
Chlorocebus sabaeus (African green monkey) : MECP2 (methyl-CpG binding protein 2)
Heterocephalus glaber (naked mole-rat) : Mecp2 (methyl-CpG binding protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX154,021,573 - 154,137,103 (-)EnsemblGRCh38hg38GRCh38
GRCh38X154,021,573 - 154,097,731 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,287,025 - 153,363,188 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,940,458 - 153,016,323 (-)NCBINCBI36hg18NCBI36
Build 34X152,808,110 - 152,883,976NCBI
CeleraX153,520,969 - 153,596,868 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,928,231 - 142,007,659 (-)NCBIHuRef
CHM1_1X153,161,670 - 153,237,718 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers